2151acd2e4d9368f0cbc056c38efe317 froimm_a2017v8p1a1042iENG.pdf 0f75f9925c7c7bd0f8c0de4b043d6b6dc9558a24 froimm_a2017v8p1a1042iENG.pdf d4a40c52d446e7a0957283d7589abc864532f44c7b9b38650a13ecd7ccdf96cd froimm_a2017v8p1a1042iENG.pdf Title: Inflammatory Conditions Dictate the Effect of Mesenchymal Stem or Stromal Cells on B Cell Function Subject: The immunomodulatory capacity of mesenchymal stem or stromal cells (MSC) makes them a promising tool for treatment of immune disease and organ transplantation. Keywords: B cell, immunomodulation, mesenchymal stem cell, plasmablast, regulatory B cell, indoleamine 2,3-dioxygenase Author: Marcella Franquesa Creator: Adobe InDesign CS6 (Windows) Producer: Adobe PDF Library 10.0.1 CreationDate: Tue Aug 22 14:31:58 2017 CEST ModDate: Wed Aug 23 09:42:48 2017 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 6920502 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OCEPEW+HelveticaNeueLTStd-Lt Type 1C Custom yes yes yes 419 0 FMONIO+HelveticaNeueLTStd-Bd Type 1C Custom yes yes yes 420 0 VXOFYI+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes yes 428 0 PORVSU+HelveticaNeueLTStd-LtIt Type 1C Custom yes yes yes 429 0 GYBOWM+HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes yes yes 430 0 CSDQSU+STIXGeneral-Regular Type 1C Custom yes yes yes 436 0 PWPQSU+MinionPro-Regular Type 1C Custom yes yes yes 437 0 JNNGMG+MinionPro-It Type 1C Custom yes yes yes 351 0 OCEPEW+HelveticaNeueLTStd-Lt Type 1C WinAnsi yes yes yes 348 0 EDACUQ+STIXGeneral-Bold Type 1C Custom yes yes yes 360 0 OCEPEW+HelveticaNeueLTStd-Lt Type 1C WinAnsi yes yes yes 363 0 YUYSOC+MinionPro-Bold Type 1C Custom yes yes yes 364 0 VNKAYI+HelveticaNeueLTStd-Lt-SC700 Type 1C WinAnsi yes yes yes 369 0 Jhove (Rel. 1.6, 2011-01-04) Date: 2019-02-14 18:16:53 CET RepresentationInformation: froimm_a2017v8p1a1042iENG.pdf ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22) LastModified: 2018-10-24 16:23:21 CEST Size: 6920502 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 549 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Inflammatory Conditions Dictate the Effect of Mesenchymal Stem or Stromal Cells on B Cell Function Children: Item: Title: Introduction Item: Title: Materials and Methods Children: Item: Title: Isolation and Culture of Human Subcutaneous Adipose Tissue MSC Item: Title: Stimulation of MSC Item: Title: IDO Activity Measurement Item: Title: Isolation of B Cells from Spleens Item: Title: B Cell Stimulation Item: Title: Transwell (TW) Cultures Item: Title: Heat Inactivated MSC Item: Title: B Cell Subset Characterization Item: Title: Measurement of Cytokine Secretion Item: Title: IgG ELISA Item: Title: RNA Expression Quantification Item: Title: Statistical Analysis Item: Title: Results Children: Item: Title: IFN-γ-Pretreated MSC Inhibit B Cell Proliferation Item: Title: IFN-γ-Pretreated MSC Inhibit IgG Production by B Cells Item: Title: IFN-γ Conditioned MSC Are Poor Breg Inducers Item: Title: The Reduction of B Cell Proliferation by IFN-γ-Pretreated MSC Requires Close Proximity Item: Title: The Reduction of B Cell Proliferation Requires Metabolically Active MSC–IFN-γ Item: Title: Inhibition of B Cell Proliferation by IFN-γ Stimulated MSC Is Largely Dependent on TRP Catabolism by IDO Item: Title: TRP Supplementation Rescues Breg Induction by IFN-γ Stimulated MSC Item: Title: Discussion Item: Title: Author Contributions Item: Title: Acknowledgments Item: Title: Supplementary Material Item: Title: References Info: Title: Inflammatory Conditions Dictate the Effect of Mesenchymal Stem or Stromal Cells on B Cell Function Author: Marcella Franquesa Subject: The immunomodulatory capacity of mesenchymal stem or stromal cells (MSC) makes them a promising tool for treatment of immune disease and organ transplantation. 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