01ac264e7e0b65c968772fb37e83b039 pmc_28577489.pdf 54007e22c56135c1230e8de827c5a99e18b2ba30 pmc_28577489.pdf 6e3439327471e1d0aacb586b784503c6b3ba2003b4c8725002433cc9dce5990e pmc_28577489.pdf Title: European contribution to the study of ROS_ A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS) Subject: Redox Biology, 13 (2017) 94-162. doi:10.1016/j.redox.2017.05.007 Keywords: Reactive oxygen species; Reactive nitrogen species; Redox signaling; Oxidative stress; Antioxidants; Redox therapeutics Author: Javier Egea Creator: Elsevier CreationDate: Mon Aug 21 10:01:31 2017 CEST ModDate: Mon Aug 21 10:01:31 2017 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 69 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 5099458 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- 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Title: European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS) Destination: mk:title Children: Item: Title: Introduction Destination: mk:H1_1 Children: Item: Title: Mission, structure and major achievements of EU-ROS consortium Destination: mk:H2_2 Item: Title: Redox biology and oxidative stress: the EU-ROS approach Destination: mk:H2_3 Item: Title: Conceptual and mechanistic aspects of ROS and oxidative stress Destination: mk:H1_4 Children: Item: Title: Background and terminology Destination: mk:H2_5 Item: Title: ROS sources and their activation Destination: mk:H2_6 Item: Title: ROS sources in microbiota Destination: mk:H2_7 Item: Title: Redox regulation via redox modifications of biomolecules and altered phosphorylation Destination: mk:H2_8 Item: Title: Oxidative stress and adaptation processes Destination: mk:H2_9 Item: Title: Microparticles and reactive oxygen species Destination: mk:H2_10 Item: Title: Conclusions Destination: mk:H2_11 Item: Title: ROS as signaling molecules Destination: mk:H1_12 Children: Item: Title: Introduction Destination: mk:H2_13 Item: Title: Role of ROS in VEGF and TGF signaling Destination: mk:H2_14 Item: Title: Redox regulation of fundamental cellular processes such as cell death Destination: mk:H2_15 Item: Title: Redox regulation involving mitochondria Destination: mk:H2_16 Item: Title: Role of ROS in hypoxia Destination: mk:H2_17 Item: Title: Redox regulation of gene expression via modulation of transcription factors and epigenetic pathways Destination: mk:H2_18 Item: Title: Redox signaling via RONS-derived electrophiles such as oxidized lipids Destination: mk:H2_19 Item: Title: Interaction of the gasotransmitter H2S with ROS and RNS Destination: mk:H2_20 Item: Title: Redox biomarkers Destination: mk:H1_21 Children: Item: Title: Introduction Destination: mk:H2_22 Item: Title: Protein oxidation products as redox biomarkers Destination: mk:H2_23 Item: Title: Lipid oxidation products as redox biomarkers Destination: mk:H2_24 Item: Title: Nucleic acid oxidation products as redox biomarkers Destination: mk:H2_25 Item: Title: Conclusion Destination: mk:H2_26 Item: Title: Optimizing ROS detection using EPR or fluorescence: in vivo applications to mammalian cells, tissues and plant biology Destination: mk:H1_27 Children: Item: Title: Introduction Destination: mk:H2_28 Item: Title: Spin trapping coupled to EPR is an under used specific method to measure oxidative stress in biological systems Destination: mk:H2_29 Item: Title: Electrochemistry and EPR to investigate antioxidant and prooxidant systems Destination: mk:H2_30 Item: Title: H2O2 detection using genetically encoded probes and nanoparticles Destination: mk:H2_31 Item: Title: High throughput assays for superoxide and hydrogen peroxide for rigorous and specific activity of NADPH oxidases Destination: mk:H2_32 Item: Title: Chemical and genetic tools for plant sulfenomics Destination: mk:H2_33 Item: Title: Conclusions Destination: mk:H2_34 Item: Title: Reactive oxygen and nitrogen species in cardiovascular pathologies Destination: mk:H1_35 Children: Item: Title: Introduction Destination: mk:H2_36 Item: Title: Oxidative stress and redox processes in atherogenesis and angiogenesis Destination: mk:H2_37 Item: Title: RONS formation in ischemic preconditioning, cardiac cycle, ischemia/reperfusion and cardiomyopathy Destination: mk:H2_38 Item: Title: RONS formation in cerebral ischemia and stroke Destination: mk:H2_39 Item: Title: Therapeutic targeting of eNOS uncoupling and cardiovascular oxidative stress and inflammation Destination: mk:H2_40 Item: Title: Conclusion Destination: mk:H2_41 Item: Title: ROS and the aging process Destination: mk:H1_42 Children: Item: Title: Introduction Destination: mk:H2_43 Item: Title: NADPH oxidases in aging and age-associated diseases Destination: mk:H2_44 Item: Title: Protein aggregates as redox signaling mediators in aging Destination: mk:H2_45 Item: Title: Proteasome activation as an anti-aging and anti-aggregation strategy Destination: mk:H2_46 Item: Title: Free radical theory of aging – dead or alive? Destination: mk:H2_47 Item: Title: ROS and frailty. Understanding the mechanisms of disability in older people Destination: mk:H2_48 Item: Title: ROS and inflammation in health and disease Destination: mk:H1_49 Children: Item: Title: Introduction Destination: mk:H2_50 Item: Title: Dual actions of NOX2-derived ROS Destination: mk:H2_51 Item: Title: Chronic Granulomatous Disease (CGD): implication of NOX2 Destination: mk:H2_52 Item: Title: Neuromodulatory actions of nitric oxide Destination: mk:H2_53 Item: Title: Thiol redox homeostasis in astrocytes Destination: mk:H2_54 Item: Title: Regulation of the oxidative and inflammatory response by microglial α7 cholinergic receptors Destination: mk:H2_55 Item: Title: Regulatory mechanisms of ROS in the motor neuron Destination: mk:H2_56 Item: Title: Inflammation and ROS in cancer Destination: mk:H2_57 Item: Title: Summary and conclusions Destination: mk:H2_58 Item: Title: The emerging roles of redox networks in tumor cell proliferation, hearing loss, neuropsychiatric disorders and cardiovascular pharmacology Destination: mk:H1_59 Children: Item: Title: Introduction Destination: mk:H2_60 Item: Title: Cancer Destination: mk:H2_61 Children: Item: Title: Redox regulation of tumor cell migration Destination: mk:H2_62 Item: Title: Role of NADPH oxidases in fibrogenesis and cancer Destination: mk:H2_63 Item: Title: Neurological and psychiatric disorders Destination: mk:H2_64 Children: Item: Title: Redox imbalance in the pathogenesis of schizophrenia Destination: mk:H2_65 Item: Title: Role of NOX3 in inner ear pathologies Destination: mk:H2_66 Item: Title: Metabolic diseases and diabetes Destination: mk:H2_67 Children: Item: Title: Importance of setting superoxide/nitric oxide ratio in diabetes. Role of L-arginine Destination: mk:H2_68 Item: Title: Regulation of insulin degradation by redox-related pathways Destination: mk:H2_69 Item: Title: Lipohormesis and lipotoxicity in pancreatic beta cells Destination: mk:H2_70 Item: Title: Redox regulation of white adipose tissue remodeling Destination: mk:H2_71 Item: Title: Cardiovascular pathologies Destination: mk:H2_72 Children: Item: Title: Drug-induced oxidative stress – the case of nitroglycerin Destination: mk:H2_73 Item: Title: Regulation of renal hemodynamics in chronic kidney disease Destination: mk:H2_74 Item: Title: Vascular effects related to chronic hypoxia of lungs and placenta Destination: mk:H2_75 Item: Title: Conclusions Destination: mk:H2_76 Item: Title: Toxin and bacteria-mediated ROS formation and antioxidant strategies in ROS-related diseases Destination: mk:H1_77 Children: Item: Title: Introduction Destination: mk:H2_78 Item: Title: A toxin and its action via ROS Destination: mk:H2_79 Item: Title: Are ROS usage and antioxidant reactions conserved? Destination: mk:H2_80 Item: Title: Involvement of ROS and antioxidant mechanisms in human diseases Destination: mk:H2_81 Children: Item: Title: ROS and malignant disease Destination: mk:H2_82 Item: Title: ROS and non-malignant disease Destination: mk:H2_83 Item: Title: ROS, antioxidants and therapeutic options Destination: mk:H2_84 Item: Title: Conclusion Destination: mk:H2_85 Item: Title: Concluding remarks Destination: mk:H1_86 Item: Title: Acknowledgements Destination: mk:H1_87 Item: Title: References Destination: mk:H1_88 Info: Title: European contribution to the study of ROS_ A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS) Author: Javier Egea Subject: Redox Biology, 13 (2017) 94-162. doi:10.1016/j.redox.2017.05.007 Keywords: Reactive oxygen species; Reactive nitrogen species; Redox signaling; Oxidative stress; Antioxidants; Redox therapeutics Creator: Elsevier CreationDate: Mon Aug 21 10:01:31 CEST 2017 ModDate: Mon Aug 21 10:01:31 CEST 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Frapart Pietro Ghezzi Agnes Görlach Thomas Kietzmann Kateryna Kubaichuk Ulla G. Knaus Manuela G. Lopez Gloria Olaso-Gonzalez Andreas Petry Rainer Schulz Jose Vina Paul Winyard Kahina Abbas Opeyemi S. Ademowo Catarina B. Afonso Ioanna Andreadou Haike Antelmann Fernando Antunes Mutay Aslan Markus M. Bachschmid Rui M. Barbosa Vsevolod Belousov Carsten Berndt David Bernlohr Esther Bertrán Alberto Bindoli Serge P. Bottari Paula M. Brito Guia Carrara Ana I. Casas Afroditi Chatzi Niki Chondrogianni Marcus Conrad Marcus S. Cooke João G. Costa Antonio Cuadrado Pham My-Chan Dang Barbara De Smet Bilge Debelec–Butuner Irundika H.K. Dias Joe Dan Dunn Amanda J. Edson Mariam El Assar Jamel El-Benna Péter Ferdinandy Ana S. Fernandes Kari E. Fladmark Ulrich Förstermann Rashid Giniatullin Zoltán Giricz Anikó Görbe Helen Griffiths Vaclav Hampl Alina Hanf Jan Herget Pablo Hernansanz-Agustín Melanie Hillion Jingjing Huang Serap Ilikay Pidder Jansen-Dürr Vincent Jaquet Jaap A. Joles Balaraman Kalyanaraman Danylo Kaminskyy Mahsa Karbaschi Marina Kleanthous Lars-Oliver Klotz Bato Korac Kemal Sami Korkmaz Rafal Koziel Damir Kračun Karl-Heinz Krause Vladimír Křen Thomas Krieg João Laranjinha Antigone Lazou Huige Li Antonio Martínez-Ruiz Reiko Matsui Gethin J. McBean Stuart P. Meredith Joris Messens Verónica Miguel Yuliya Mikhed Irina Milisav Lidija Milković Antonio Miranda-Vizuete Miloš Mojović María Monsalve Pierre-Alexis Mouthuy John Mulvey Thomas Münzel Vladimir Muzykantov Isabel T.N. Nguyen Matthias Oelze Nuno G. Oliveira Carlos M. Palmeira Nikoletta Papaevgeniou Aleksandra Pavićević Brandán Pedre Fabienne Peyrot Marios Phylactides Gratiela G. Pircalabioru Andrew R. Pitt Henrik E. Poulsen Ignacio Prieto Maria Pia Rigobello Natalia Robledinos-Antón Leocadio Rodríguez-Mañas Anabela P. Rolo Francis Rousset Tatjana Ruskovska Nuno Saraiva Shlomo Sasson Katrin Schröder Khrystyna Semen Tamara Seredenina Anastasia Shakirzyanova Geoffrey L. Smith Thierry Soldati Bebiana C. Sousa Corinne M. Spickett Ana Stancic Marie José Stasia Holger Steinbrenner Višnja Stepanić Sebastian Steven Kostas Tokatlidis Erkan Tuncay Belma Turan Fulvio Ursini Jan Vacek Olga Vajnerova Kateřina Valentová Frank Van Breusegem Lokman Varisli Elizabeth A. Veal A. Suha Yalçın Olha Yelisyeyeva Neven Žarković Martina Zatloukalová Jacek Zielonka Rhian M. Touyz Andreas Papapetropoulos Tilman Grune Santiago Lamas Harald H.H.W. Schmidt Fabio Di Lisa Andreas Daiber Reactive oxygen species Reactive nitrogen species Redox signaling Oxidative stress Antioxidants Redox therapeutics Elsevier B.V. Redox Biology, 13 (2017) 94-162. doi:10.1016/j.redox.2017.05.007 journal Redox Biology © 2017 The Authors. Published by Elsevier B.V. 2213-2317 13 October 2017 94-162 94 162 10.1016/j.redox.2017.05.007 http://dx.doi.org/10.1016/j.redox.2017.05.007 2010-04-23 true 10.1016/j.redox.2017.05.007 elsevier.com sciencedirect.com 6.5 10.1016/j.redox.2017.05.007 2010-04-23 true noindex elsevier.com sciencedirect.com VoR Elsevier 2017-08-21T08:01:31Z 2017-08-21T08:01:31Z 2017-08-21T08:01:31Z True Reactive oxygen species; Reactive nitrogen species; Redox signaling; Oxidative stress; Antioxidants; Redox therapeutics uuid:8e19e2e3-d67f-441f-8968-32a69c4dbbe4 uuid:61385ff3-5de2-4f6f-8a74-e725406de1a3 http://creativecommons.org/licenses/BY-NC-ND/4.0/ Pages: Page: Label: 94 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 322, 723, 369, 731 Annotation: Subtype: Link Rect: 274, 668, 404, 676 Annotation: Subtype: Link Rect: 37, 730, 37, 742 Annotation: Subtype: Link Rect: 90, 580, 94, 591 Destination: 6154 Annotation: Subtype: Link Rect: 96, 580, 101, 591 Destination: 5 Annotation: Subtype: Link Rect: 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57, 330, 288, 337 Annotation: Subtype: Link Rect: 57, 322, 144, 329 Annotation: Subtype: Link Rect: 57, 315, 288, 321 Annotation: Subtype: Link Rect: 57, 307, 285, 313 Annotation: Subtype: Link Rect: 57, 299, 287, 305 Annotation: Subtype: Link Rect: 57, 291, 288, 297 Annotation: Subtype: Link Rect: 57, 283, 260, 289 Annotation: Subtype: Link Rect: 57, 275, 91, 281 Annotation: Subtype: Link Rect: 57, 267, 288, 273 Annotation: Subtype: Link Rect: 57, 259, 227, 265 Annotation: Subtype: Link Rect: 57, 251, 288, 257 Annotation: Subtype: Link Rect: 57, 243, 288, 249 Annotation: Subtype: Link Rect: 57, 235, 277, 241 Annotation: Subtype: Link Rect: 57, 227, 223, 233 Annotation: Subtype: Link Rect: 57, 219, 257, 225 Annotation: Subtype: Link Rect: 57, 211, 277, 217 Annotation: Subtype: Link Rect: 57, 203, 284, 209 Annotation: Subtype: Link Rect: 57, 195, 282, 201 Annotation: Subtype: Link Rect: 57, 187, 146, 193 Annotation: Subtype: Link Rect: 57, 179, 288, 185 Annotation: Subtype: Link Rect: 57, 171, 278, 177 Annotation: Subtype: Link Rect: 57, 163, 276, 169 Annotation: Subtype: Link Rect: 57, 155, 270, 162 Annotation: Subtype: Link Rect: 57, 147, 286, 154 Annotation: Subtype: Link Rect: 57, 139, 288, 146 Annotation: Subtype: Link Rect: 57, 131, 84, 138 Annotation: Subtype: Link Rect: 57, 123, 288, 130 Annotation: Subtype: Link Rect: 57, 115, 288, 122 Annotation: Subtype: Link Rect: 57, 107, 114, 114 Annotation: Subtype: Link Rect: 57, 99, 276, 106 Annotation: Subtype: Link Rect: 57, 91, 153, 98 Annotation: Subtype: Link Rect: 57, 83, 287, 90 Annotation: Subtype: Link Rect: 57, 75, 286, 82 Annotation: Subtype: Link Rect: 57, 67, 105, 74 Annotation: Subtype: Link Rect: 57, 59, 268, 66 Annotation: Subtype: Link Rect: 57, 52, 222, 58 Annotation: Subtype: Link Rect: 326, 729, 557, 735 Annotation: Subtype: Link Rect: 326, 721, 507, 727 Annotation: Subtype: Link Rect: 326, 713, 554, 719 Annotation: Subtype: Link Rect: 326, 705, 553, 711 Annotation: Subtype: Link Rect: 326, 697, 424, 703 Annotation: Subtype: Link Rect: 326, 689, 549, 696 Annotation: Subtype: Link Rect: 326, 681, 459, 688 Annotation: Subtype: Link Rect: 326, 673, 557, 680 Annotation: Subtype: Link Rect: 326, 665, 413, 672 Annotation: Subtype: Link Rect: 326, 657, 547, 664 Annotation: Subtype: Link Rect: 326, 649, 533, 656 Annotation: Subtype: Link Rect: 326, 641, 540, 648 Annotation: Subtype: Link Rect: 326, 633, 546, 640 Annotation: Subtype: Link Rect: 326, 625, 557, 632 Annotation: Subtype: Link Rect: 326, 617, 381, 624 Annotation: Subtype: Link Rect: 326, 609, 556, 616 Annotation: Subtype: Link Rect: 326, 601, 557, 608 Annotation: Subtype: Link Rect: 326, 593, 527, 600 Annotation: Subtype: Link Rect: 326, 586, 557, 592 Annotation: Subtype: Link Rect: 326, 578, 541, 584 Annotation: Subtype: Link Rect: 326, 570, 543, 576 Annotation: Subtype: Link Rect: 326, 562, 381, 568 Annotation: Subtype: Link Rect: 326, 554, 555, 560 Annotation: Subtype: Link Rect: 326, 546, 555, 552 Annotation: Subtype: Link Rect: 326, 538, 540, 544 Annotation: Subtype: Link Rect: 326, 530, 553, 536 Annotation: Subtype: Link Rect: 326, 522, 550, 528 Annotation: Subtype: Link Rect: 326, 514, 408, 520 Annotation: Subtype: Link Rect: 326, 506, 549, 512 Annotation: Subtype: Link Rect: 326, 498, 557, 504 Annotation: Subtype: Link Rect: 326, 490, 507, 496 Annotation: Subtype: Link Rect: 326, 482, 553, 488 Annotation: Subtype: Link Rect: 326, 474, 548, 480 Annotation: Subtype: Link Rect: 326, 466, 525, 472 Annotation: Subtype: Link Rect: 326, 458, 367, 464 Annotation: Subtype: Link Rect: 326, 450, 557, 456 Annotation: Subtype: Link Rect: 326, 442, 557, 448 Annotation: Subtype: Link Rect: 326, 434, 416, 440 Annotation: Subtype: Link Rect: 326, 426, 543, 433 Annotation: Subtype: Link Rect: 326, 418, 523, 425 Annotation: Subtype: Link Rect: 326, 410, 542, 417 Annotation: Subtype: Link Rect: 326, 402, 557, 409 Annotation: Subtype: Link Rect: 326, 394, 542, 401 Annotation: Subtype: Link Rect: 326, 386, 557, 393 Annotation: Subtype: Link Rect: 326, 378, 547, 385 Annotation: Subtype: Link Rect: 326, 370, 548, 377 Annotation: Subtype: Link Rect: 326, 362, 551, 369 Annotation: Subtype: Link Rect: 326, 354, 548, 361 Annotation: Subtype: Link Rect: 326, 346, 410, 353 Annotation: Subtype: Link Rect: 326, 338, 557, 345 Annotation: Subtype: Link Rect: 326, 330, 540, 337 Annotation: Subtype: Link Rect: 326, 322, 549, 329 Annotation: Subtype: Link Rect: 326, 315, 482, 321 Annotation: Subtype: Link Rect: 326, 307, 552, 313 Annotation: Subtype: Link Rect: 326, 299, 555, 305 Annotation: Subtype: Link Rect: 326, 291, 381, 297 Annotation: Subtype: Link Rect: 326, 283, 550, 289 Annotation: Subtype: Link Rect: 326, 275, 508, 281 Annotation: Subtype: Link Rect: 326, 267, 543, 273 Annotation: Subtype: Link Rect: 326, 259, 557, 265 Annotation: Subtype: Link Rect: 326, 251, 557, 257 Annotation: Subtype: Link Rect: 326, 243, 557, 249 Annotation: Subtype: Link Rect: 326, 235, 548, 241 Annotation: Subtype: Link Rect: 326, 227, 374, 233 Annotation: Subtype: Link Rect: 326, 219, 548, 225 Annotation: Subtype: Link Rect: 326, 211, 542, 217 Annotation: Subtype: Link Rect: 326, 203, 518, 209 Annotation: Subtype: Link Rect: 326, 195, 555, 201 Annotation: Subtype: Link Rect: 326, 187, 551, 193 Annotation: Subtype: Link Rect: 326, 179, 397, 185 Annotation: Subtype: Link Rect: 326, 171, 557, 177 Annotation: Subtype: Link Rect: 326, 163, 542, 169 Annotation: Subtype: Link Rect: 326, 155, 527, 162 Annotation: Subtype: Link Rect: 326, 147, 548, 154 Annotation: Subtype: Link Rect: 326, 139, 545, 146 Annotation: Subtype: Link Rect: 326, 131, 547, 138 Annotation: Subtype: Link Rect: 326, 123, 541, 130 Annotation: Subtype: Link Rect: 326, 115, 557, 122 Annotation: Subtype: Link Rect: 326, 107, 374, 114 Annotation: Subtype: Link Rect: 326, 99, 548, 106 Annotation: Subtype: Link Rect: 326, 91, 492, 98 Annotation: Subtype: Link Rect: 326, 83, 554, 90 Annotation: Subtype: Link Rect: 326, 75, 514, 82 Annotation: Subtype: Link Rect: 326, 67, 557, 74 Annotation: Subtype: Link Rect: 326, 59, 557, 66 Annotation: Subtype: Link Rect: 326, 52, 468, 58 Page: Label: 149 Sequence: 56 Annotations: Annotation: Subtype: Link Rect: 57, 729, 285, 735 Annotation: Subtype: Link Rect: 57, 721, 281, 727 Annotation: Subtype: Link Rect: 57, 713, 279, 719 Annotation: Subtype: Link Rect: 57, 705, 112, 711 Annotation: Subtype: Link Rect: 57, 697, 288, 703 Annotation: Subtype: Link Rect: 57, 689, 288, 696 Annotation: Subtype: Link Rect: 57, 681, 84, 688 Annotation: Subtype: Link Rect: 57, 673, 287, 680 Annotation: Subtype: Link Rect: 57, 665, 273, 672 Annotation: Subtype: Link Rect: 57, 657, 275, 664 Annotation: Subtype: Link Rect: 57, 649, 152, 656 Annotation: Subtype: Link Rect: 57, 641, 288, 648 Annotation: Subtype: Link Rect: 57, 633, 288, 640 Annotation: Subtype: Link Rect: 57, 625, 287, 632 Annotation: Subtype: Link Rect: 57, 617, 203, 624 Annotation: Subtype: Link Rect: 57, 609, 288, 616 Annotation: Subtype: Link Rect: 57, 601, 288, 608 Annotation: Subtype: Link Rect: 57, 593, 221, 600 Annotation: Subtype: Link Rect: 57, 586, 284, 592 Annotation: Subtype: Link Rect: 57, 578, 278, 584 Annotation: Subtype: Link Rect: 57, 570, 261, 576 Annotation: Subtype: Link Rect: 57, 562, 231, 568 Annotation: Subtype: Link Rect: 57, 554, 275, 560 Annotation: Subtype: Link Rect: 57, 546, 286, 552 Annotation: Subtype: Link Rect: 57, 538, 185, 544 Annotation: Subtype: Link Rect: 57, 530, 280, 536 Annotation: Subtype: Link Rect: 57, 522, 278, 528 Annotation: Subtype: Link Rect: 57, 514, 244, 520 Annotation: Subtype: Link Rect: 57, 506, 282, 512 Annotation: Subtype: Link Rect: 57, 498, 283, 504 Annotation: Subtype: Link Rect: 57, 490, 219, 496 Annotation: Subtype: Link Rect: 57, 482, 258, 488 Annotation: Subtype: Link Rect: 57, 474, 270, 480 Annotation: Subtype: Link Rect: 57, 466, 271, 472 Annotation: Subtype: Link Rect: 57, 458, 268, 464 Annotation: Subtype: Link Rect: 57, 450, 266, 456 Annotation: Subtype: Link Rect: 57, 442, 274, 448 Annotation: Subtype: Link Rect: 57, 434, 286, 440 Annotation: Subtype: Link Rect: 57, 426, 170, 433 Annotation: Subtype: Link Rect: 57, 418, 288, 425 Annotation: Subtype: Link Rect: 57, 410, 288, 417 Annotation: Subtype: Link Rect: 57, 402, 278, 409 Annotation: Subtype: Link Rect: 57, 394, 241, 401 Annotation: Subtype: Link Rect: 57, 386, 278, 393 Annotation: Subtype: Link Rect: 57, 378, 112, 385 Annotation: Subtype: Link Rect: 57, 370, 279, 377 Annotation: Subtype: Link Rect: 57, 362, 211, 369 Annotation: Subtype: Link Rect: 57, 354, 282, 361 Annotation: Subtype: Link Rect: 57, 346, 280, 353 Annotation: Subtype: Link Rect: 57, 338, 112, 345 Annotation: Subtype: Link Rect: 57, 330, 274, 337 Annotation: Subtype: Link Rect: 57, 322, 259, 329 Annotation: Subtype: Link Rect: 57, 315, 286, 321 Annotation: Subtype: Link Rect: 57, 307, 232, 313 Annotation: Subtype: Link Rect: 57, 299, 288, 305 Annotation: Subtype: Link Rect: 57, 291, 284, 297 Annotation: Subtype: Link Rect: 57, 283, 281, 289 Annotation: Subtype: Link Rect: 57, 275, 266, 281 Annotation: Subtype: Link Rect: 57, 267, 84, 273 Annotation: Subtype: Link Rect: 57, 259, 276, 265 Annotation: Subtype: Link Rect: 57, 251, 288, 257 Annotation: Subtype: Link Rect: 57, 243, 288, 249 Annotation: Subtype: Link Rect: 57, 235, 233, 241 Annotation: Subtype: Link Rect: 57, 227, 285, 233 Annotation: Subtype: Link Rect: 57, 219, 271, 225 Annotation: Subtype: Link Rect: 57, 211, 283, 217 Annotation: Subtype: Link Rect: 57, 203, 98, 209 Annotation: Subtype: Link Rect: 57, 195, 288, 201 Annotation: Subtype: Link Rect: 57, 187, 288, 193 Annotation: Subtype: Link Rect: 57, 179, 165, 185 Annotation: Subtype: Link Rect: 57, 171, 279, 177 Annotation: Subtype: Link Rect: 57, 163, 193, 169 Annotation: Subtype: Link Rect: 57, 155, 288, 162 Annotation: Subtype: Link Rect: 57, 147, 288, 154 Annotation: Subtype: Link Rect: 57, 139, 268, 146 Annotation: Subtype: Link Rect: 57, 131, 139, 138 Annotation: Subtype: Link Rect: 57, 123, 277, 130 Annotation: Subtype: Link Rect: 57, 115, 284, 122 Annotation: Subtype: Link Rect: 57, 107, 288, 114 Annotation: Subtype: Link Rect: 57, 99, 269, 106 Annotation: Subtype: Link Rect: 57, 91, 288, 98 Annotation: Subtype: Link Rect: 57, 83, 271, 90 Annotation: Subtype: Link Rect: 57, 75, 84, 82 Annotation: Subtype: Link Rect: 57, 67, 266, 74 Annotation: Subtype: Link Rect: 57, 59, 288, 66 Annotation: Subtype: Link Rect: 57, 52, 91, 58 Annotation: Subtype: Link Rect: 326, 729, 523, 735 Annotation: Subtype: Link Rect: 326, 721, 367, 727 Annotation: Subtype: Link Rect: 326, 713, 536, 719 Annotation: Subtype: Link Rect: 326, 705, 557, 711 Annotation: Subtype: Link Rect: 326, 697, 491, 703 Annotation: Subtype: Link Rect: 326, 689, 551, 696 Annotation: Subtype: Link Rect: 326, 681, 496, 688 Annotation: Subtype: Link Rect: 326, 673, 557, 680 Annotation: Subtype: Link Rect: 326, 665, 555, 672 Annotation: Subtype: Link Rect: 326, 657, 556, 664 Annotation: Subtype: Link Rect: 326, 649, 557, 656 Annotation: Subtype: Link Rect: 326, 641, 383, 648 Annotation: Subtype: Link Rect: 326, 633, 550, 640 Annotation: Subtype: Link Rect: 326, 625, 548, 632 Annotation: Subtype: Link Rect: 326, 617, 535, 624 Annotation: Subtype: Link Rect: 326, 609, 545, 616 Annotation: Subtype: Link Rect: 326, 601, 557, 608 Annotation: Subtype: Link Rect: 326, 593, 452, 600 Annotation: Subtype: Link Rect: 326, 586, 557, 592 Annotation: Subtype: Link Rect: 326, 578, 557, 584 Annotation: Subtype: Link Rect: 326, 570, 476, 576 Annotation: Subtype: Link Rect: 326, 562, 536, 568 Annotation: Subtype: Link Rect: 326, 554, 553, 560 Annotation: Subtype: Link Rect: 326, 546, 553, 552 Annotation: Subtype: Link Rect: 326, 538, 485, 544 Annotation: Subtype: Link Rect: 326, 530, 555, 536 Annotation: Subtype: Link Rect: 326, 522, 484, 528 Annotation: Subtype: Link Rect: 326, 514, 557, 520 Annotation: Subtype: Link Rect: 326, 506, 540, 512 Annotation: Subtype: Link Rect: 326, 498, 554, 504 Annotation: Subtype: Link Rect: 326, 490, 399, 496 Annotation: Subtype: Link Rect: 326, 482, 551, 488 Annotation: Subtype: Link Rect: 326, 474, 538, 480 Annotation: Subtype: Link Rect: 326, 466, 489, 472 Annotation: Subtype: Link Rect: 326, 458, 557, 464 Annotation: Subtype: Link Rect: 326, 450, 542, 456 Annotation: Subtype: Link Rect: 326, 442, 549, 448 Annotation: Subtype: Link Rect: 326, 434, 556, 440 Annotation: Subtype: Link Rect: 326, 426, 493, 433 Annotation: Subtype: Link Rect: 326, 418, 552, 425 Annotation: Subtype: Link Rect: 326, 410, 496, 417 Annotation: Subtype: Link Rect: 326, 402, 544, 409 Annotation: Subtype: Link Rect: 326, 394, 554, 401 Annotation: Subtype: Link Rect: 326, 386, 552, 393 Annotation: Subtype: Link Rect: 326, 378, 473, 385 Annotation: Subtype: Link Rect: 326, 370, 557, 377 Annotation: Subtype: Link Rect: 326, 362, 547, 369 Annotation: Subtype: Link Rect: 326, 354, 470, 361 Annotation: Subtype: Link Rect: 326, 346, 557, 353 Annotation: Subtype: Link Rect: 326, 338, 472, 345 Annotation: Subtype: Link Rect: 326, 330, 548, 337 Annotation: Subtype: Link Rect: 326, 322, 528, 329 Annotation: Subtype: Link Rect: 326, 315, 553, 321 Annotation: Subtype: Link Rect: 326, 307, 530, 313 Annotation: Subtype: Link Rect: 326, 299, 536, 305 Annotation: Subtype: Link Rect: 326, 291, 556, 297 Annotation: Subtype: Link Rect: 326, 283, 346, 289 Annotation: Subtype: Link Rect: 326, 275, 541, 281 Annotation: Subtype: Link Rect: 326, 267, 544, 273 Annotation: Subtype: Link Rect: 326, 259, 552, 265 Annotation: Subtype: Link Rect: 326, 251, 394, 257 Annotation: Subtype: Link Rect: 326, 243, 554, 249 Annotation: Subtype: Link Rect: 326, 235, 554, 241 Annotation: Subtype: Link Rect: 326, 227, 552, 233 Annotation: Subtype: Link Rect: 326, 219, 461, 225 Annotation: Subtype: Link Rect: 326, 211, 557, 217 Annotation: Subtype: Link Rect: 326, 203, 374, 209 Annotation: Subtype: Link Rect: 326, 195, 554, 201 Annotation: Subtype: Link Rect: 326, 187, 540, 193 Annotation: Subtype: Link Rect: 326, 179, 557, 185 Annotation: Subtype: Link Rect: 326, 171, 376, 177 Annotation: Subtype: Link Rect: 326, 163, 557, 169 Annotation: Subtype: Link Rect: 326, 155, 556, 162 Annotation: Subtype: Link Rect: 326, 147, 401, 154 Annotation: Subtype: Link Rect: 326, 139, 545, 146 Annotation: Subtype: Link Rect: 326, 131, 551, 138 Annotation: Subtype: Link Rect: 326, 123, 428, 130 Annotation: Subtype: Link Rect: 326, 115, 557, 122 Annotation: Subtype: Link Rect: 326, 107, 551, 114 Annotation: Subtype: Link Rect: 326, 99, 549, 106 Annotation: Subtype: Link Rect: 326, 91, 459, 98 Annotation: Subtype: Link Rect: 326, 83, 517, 90 Annotation: Subtype: Link Rect: 326, 75, 538, 82 Annotation: Subtype: Link Rect: 326, 67, 528, 74 Annotation: Subtype: Link Rect: 326, 59, 360, 66 Annotation: Subtype: Link Rect: 326, 52, 549, 58 Page: Label: 150 Sequence: 57 Annotations: Annotation: Subtype: Link Rect: 57, 729, 284, 735 Annotation: Subtype: Link Rect: 57, 721, 275, 727 Annotation: Subtype: Link Rect: 57, 713, 112, 719 Annotation: Subtype: Link Rect: 57, 705, 275, 711 Annotation: Subtype: Link Rect: 57, 697, 286, 703 Annotation: Subtype: Link Rect: 57, 689, 284, 696 Annotation: Subtype: Link Rect: 57, 681, 180, 688 Annotation: Subtype: Link Rect: 57, 673, 288, 680 Annotation: Subtype: Link Rect: 57, 665, 288, 672 Annotation: Subtype: Link Rect: 57, 657, 288, 664 Annotation: Subtype: Link Rect: 57, 649, 112, 656 Annotation: Subtype: Link Rect: 57, 641, 280, 648 Annotation: Subtype: Link Rect: 57, 633, 288, 640 Annotation: Subtype: Link Rect: 57, 625, 271, 632 Annotation: Subtype: Link Rect: 57, 617, 232, 624 Annotation: Subtype: Link Rect: 57, 609, 288, 616 Annotation: Subtype: Link Rect: 57, 601, 283, 608 Annotation: Subtype: Link Rect: 57, 593, 288, 600 Annotation: Subtype: Link Rect: 57, 586, 164, 592 Annotation: Subtype: Link Rect: 57, 578, 279, 584 Annotation: Subtype: Link Rect: 57, 570, 284, 576 Annotation: Subtype: Link Rect: 57, 562, 256, 568 Annotation: Subtype: Link Rect: 57, 554, 288, 560 Annotation: Subtype: Link Rect: 57, 546, 288, 552 Annotation: Subtype: Link Rect: 57, 538, 268, 544 Annotation: Subtype: Link Rect: 57, 530, 84, 536 Annotation: Subtype: Link Rect: 57, 522, 283, 528 Annotation: Subtype: Link Rect: 57, 514, 84, 520 Annotation: Subtype: Link Rect: 57, 506, 285, 512 Annotation: Subtype: Link Rect: 57, 498, 288, 504 Annotation: Subtype: Link Rect: 57, 490, 112, 496 Annotation: Subtype: Link Rect: 57, 482, 279, 488 Annotation: Subtype: Link Rect: 57, 474, 286, 480 Annotation: Subtype: Link Rect: 57, 466, 257, 472 Annotation: Subtype: Link Rect: 57, 458, 288, 464 Annotation: Subtype: Link Rect: 57, 450, 288, 456 Annotation: Subtype: Link Rect: 57, 442, 119, 448 Annotation: Subtype: Link Rect: 57, 434, 269, 440 Annotation: Subtype: Link Rect: 57, 426, 284, 433 Annotation: Subtype: Link Rect: 57, 418, 288, 425 Annotation: Subtype: Link Rect: 57, 410, 98, 417 Annotation: Subtype: Link Rect: 57, 402, 277, 409 Annotation: Subtype: Link Rect: 57, 394, 288, 401 Annotation: Subtype: Link Rect: 57, 386, 264, 393 Annotation: Subtype: Link Rect: 57, 378, 273, 385 Annotation: Subtype: Link Rect: 57, 370, 288, 377 Annotation: Subtype: Link Rect: 57, 362, 288, 369 Annotation: Subtype: Link Rect: 57, 354, 183, 361 Annotation: Subtype: Link Rect: 57, 346, 284, 353 Annotation: Subtype: Link Rect: 57, 338, 287, 345 Annotation: Subtype: Link Rect: 57, 330, 288, 337 Annotation: Subtype: Link Rect: 57, 322, 132, 329 Annotation: Subtype: Link Rect: 57, 315, 288, 321 Annotation: Subtype: Link Rect: 57, 307, 278, 313 Annotation: Subtype: Link Rect: 57, 299, 268, 305 Annotation: Subtype: Link Rect: 57, 291, 288, 297 Annotation: Subtype: Link Rect: 57, 283, 218, 289 Annotation: Subtype: Link Rect: 57, 275, 271, 281 Annotation: Subtype: Link Rect: 57, 267, 270, 273 Annotation: Subtype: Link Rect: 57, 259, 288, 265 Annotation: Subtype: Link Rect: 57, 251, 138, 257 Annotation: Subtype: Link Rect: 57, 243, 264, 249 Annotation: Subtype: Link Rect: 57, 235, 273, 241 Annotation: Subtype: Link Rect: 57, 227, 281, 233 Annotation: Subtype: Link Rect: 57, 219, 105, 225 Annotation: Subtype: Link Rect: 57, 211, 266, 217 Annotation: Subtype: Link Rect: 57, 203, 286, 209 Annotation: Subtype: Link Rect: 57, 195, 287, 201 Annotation: Subtype: Link Rect: 57, 187, 91, 193 Annotation: Subtype: Link Rect: 57, 179, 282, 185 Annotation: Subtype: Link Rect: 57, 171, 279, 177 Annotation: Subtype: Link Rect: 57, 163, 281, 169 Annotation: Subtype: Link Rect: 57, 155, 177, 162 Annotation: Subtype: Link Rect: 57, 147, 288, 154 Annotation: Subtype: Link Rect: 57, 139, 269, 146 Annotation: Subtype: Link Rect: 57, 131, 285, 138 Annotation: Subtype: Link Rect: 57, 123, 105, 130 Annotation: Subtype: Link Rect: 57, 115, 288, 122 Annotation: Subtype: Link Rect: 57, 107, 84, 114 Annotation: Subtype: Link Rect: 57, 99, 288, 106 Annotation: Subtype: Link Rect: 57, 91, 185, 98 Annotation: Subtype: Link Rect: 57, 83, 288, 90 Annotation: Subtype: Link Rect: 57, 75, 144, 82 Annotation: Subtype: Link Rect: 57, 67, 277, 74 Annotation: Subtype: Link Rect: 57, 59, 173, 66 Annotation: Subtype: Link Rect: 57, 52, 284, 58 Annotation: Subtype: Link Rect: 326, 729, 542, 735 Annotation: Subtype: Link Rect: 326, 721, 554, 727 Annotation: Subtype: Link Rect: 326, 713, 465, 719 Annotation: Subtype: Link Rect: 326, 705, 557, 711 Annotation: Subtype: Link Rect: 326, 697, 538, 703 Annotation: Subtype: Link Rect: 326, 689, 528, 696 Annotation: Subtype: Link Rect: 326, 681, 557, 688 Annotation: Subtype: Link Rect: 326, 673, 557, 680 Annotation: Subtype: Link Rect: 326, 665, 360, 672 Annotation: Subtype: Link Rect: 326, 657, 552, 664 Annotation: Subtype: Link Rect: 326, 649, 557, 656 Annotation: Subtype: Link Rect: 326, 641, 534, 648 Annotation: Subtype: Link Rect: 326, 633, 557, 640 Annotation: Subtype: Link Rect: 326, 625, 552, 632 Annotation: Subtype: Link Rect: 326, 617, 454, 624 Annotation: Subtype: Link Rect: 326, 609, 536, 616 Annotation: Subtype: Link Rect: 326, 601, 554, 608 Annotation: Subtype: Link Rect: 326, 593, 544, 600 Annotation: Subtype: Link Rect: 326, 586, 539, 592 Annotation: Subtype: Link Rect: 326, 578, 544, 584 Annotation: Subtype: Link Rect: 326, 570, 349, 576 Annotation: Subtype: Link Rect: 326, 562, 552, 568 Annotation: Subtype: Link Rect: 326, 554, 545, 560 Annotation: Subtype: Link Rect: 326, 546, 360, 552 Annotation: Subtype: Link Rect: 326, 538, 542, 544 Annotation: Subtype: Link Rect: 326, 530, 453, 536 Annotation: Subtype: Link Rect: 326, 522, 557, 528 Annotation: Subtype: Link Rect: 326, 514, 498, 520 Annotation: Subtype: Link Rect: 326, 506, 533, 512 Annotation: Subtype: Link Rect: 326, 498, 553, 504 Annotation: Subtype: Link Rect: 326, 490, 374, 496 Annotation: Subtype: Link Rect: 326, 482, 557, 488 Annotation: Subtype: Link Rect: 326, 474, 557, 480 Annotation: Subtype: Link Rect: 326, 466, 350, 472 Annotation: Subtype: Link Rect: 326, 458, 542, 464 Annotation: Subtype: Link Rect: 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Annotation: Subtype: Link Rect: 326, 243, 531, 249 Annotation: Subtype: Link Rect: 326, 235, 555, 241 Annotation: Subtype: Link Rect: 326, 227, 467, 233 Annotation: Subtype: Link Rect: 326, 219, 550, 225 Annotation: Subtype: Link Rect: 326, 211, 555, 217 Annotation: Subtype: Link Rect: 326, 203, 551, 209 Annotation: Subtype: Link Rect: 326, 195, 552, 201 Annotation: Subtype: Link Rect: 326, 187, 360, 193 Annotation: Subtype: Link Rect: 326, 179, 557, 185 Annotation: Subtype: Link Rect: 326, 171, 552, 177 Annotation: Subtype: Link Rect: 326, 163, 399, 169 Annotation: Subtype: Link Rect: 326, 155, 534, 162 Annotation: Subtype: Link Rect: 326, 147, 557, 154 Annotation: Subtype: Link Rect: 326, 139, 557, 146 Annotation: Subtype: Link Rect: 326, 131, 349, 138 Annotation: Subtype: Link Rect: 326, 123, 555, 130 Annotation: Subtype: Link Rect: 326, 115, 544, 122 Annotation: Subtype: Link Rect: 326, 107, 550, 114 Annotation: Subtype: Link Rect: 326, 99, 557, 106 Annotation: Subtype: Link Rect: 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257 Annotation: Subtype: Link Rect: 57, 243, 266, 249 Annotation: Subtype: Link Rect: 57, 235, 184, 241 Annotation: Subtype: Link Rect: 57, 227, 288, 233 Annotation: Subtype: Link Rect: 57, 219, 279, 225 Annotation: Subtype: Link Rect: 57, 211, 168, 217 Annotation: Subtype: Link Rect: 57, 203, 288, 209 Annotation: Subtype: Link Rect: 57, 195, 187, 201 Annotation: Subtype: Link Rect: 57, 187, 274, 193 Annotation: Subtype: Link Rect: 57, 179, 272, 185 Annotation: Subtype: Link Rect: 57, 171, 84, 177 Annotation: Subtype: Link Rect: 57, 163, 275, 169 Annotation: Subtype: Link Rect: 57, 155, 170, 162 Annotation: Subtype: Link Rect: 57, 147, 286, 154 Annotation: Subtype: Link Rect: 57, 139, 214, 146 Annotation: Subtype: Link Rect: 57, 131, 288, 138 Annotation: Subtype: Link Rect: 57, 123, 126, 130 Annotation: Subtype: Link Rect: 57, 115, 281, 122 Annotation: Subtype: Link Rect: 57, 107, 288, 114 Annotation: Subtype: Link Rect: 57, 99, 288, 106 Annotation: Subtype: Link Rect: 57, 91, 114, 98 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326, 570, 557, 576 Annotation: Subtype: Link Rect: 326, 562, 504, 568 Annotation: Subtype: Link Rect: 326, 554, 557, 560 Annotation: Subtype: Link Rect: 326, 546, 557, 552 Annotation: Subtype: Link Rect: 326, 538, 543, 544 Annotation: Subtype: Link Rect: 326, 530, 479, 536 Annotation: Subtype: Link Rect: 326, 522, 531, 528 Annotation: Subtype: Link Rect: 326, 514, 551, 520 Annotation: Subtype: Link Rect: 326, 506, 549, 512 Annotation: Subtype: Link Rect: 326, 498, 360, 504 Annotation: Subtype: Link Rect: 326, 466, 549, 472 Annotation: Subtype: Link Rect: 326, 458, 557, 464 Annotation: Subtype: Link Rect: 326, 450, 545, 456 Annotation: Subtype: Link Rect: 326, 442, 543, 448 Annotation: Subtype: Link Rect: 326, 434, 557, 440 Annotation: Subtype: Link Rect: 326, 426, 423, 433 Annotation: Subtype: Link Rect: 326, 418, 551, 425 Annotation: Subtype: Link Rect: 326, 410, 541, 417 Annotation: Subtype: Link Rect: 326, 402, 557, 409 Annotation: Subtype: Link Rect: 326, 394, 434, 401 Annotation: Subtype: Link Rect: 326, 386, 553, 393 Annotation: Subtype: Link Rect: 326, 378, 555, 385 Annotation: Subtype: Link Rect: 326, 370, 422, 377 Annotation: Subtype: Link Rect: 326, 362, 533, 369 Annotation: Subtype: Link Rect: 326, 354, 550, 361 Annotation: Subtype: Link Rect: 326, 346, 367, 353 Annotation: Subtype: Link Rect: 326, 338, 557, 345 Annotation: Subtype: Link Rect: 326, 330, 553, 337 Annotation: Subtype: Link Rect: 326, 322, 521, 329 Annotation: Subtype: Link Rect: 326, 315, 557, 321 Annotation: Subtype: Link Rect: 326, 307, 539, 313 Annotation: Subtype: Link Rect: 326, 299, 539, 305 Annotation: Subtype: Link Rect: 326, 291, 553, 297 Annotation: Subtype: Link Rect: 326, 283, 548, 289 Annotation: Subtype: Link Rect: 326, 275, 553, 281 Annotation: Subtype: Link Rect: 326, 267, 530, 273 Annotation: Subtype: Link Rect: 459, 227, 550, 233 Annotation: Subtype: Link Rect: 326, 219, 346, 225 Annotation: Subtype: Link Rect: 326, 211, 542, 217 Annotation: Subtype: Link Rect: 326, 203, 553, 209 Annotation: Subtype: Link Rect: 326, 195, 513, 201 Annotation: Subtype: Link Rect: 326, 187, 543, 193 Annotation: Subtype: Link Rect: 326, 179, 551, 185 Annotation: Subtype: Link Rect: 326, 171, 538, 177 Annotation: Subtype: Link Rect: 326, 163, 557, 169 Annotation: Subtype: Link Rect: 326, 155, 390, 162 Annotation: Subtype: Link Rect: 326, 147, 556, 154 Annotation: Subtype: Link Rect: 326, 139, 380, 146 Annotation: Subtype: Link Rect: 326, 131, 554, 138 Annotation: Subtype: Link Rect: 326, 123, 469, 130 Annotation: Subtype: Link Rect: 326, 115, 550, 122 Annotation: Subtype: Link Rect: 326, 107, 553, 114 Annotation: Subtype: Link Rect: 326, 99, 455, 106 Annotation: Subtype: Link Rect: 326, 91, 557, 98 Annotation: Subtype: Link Rect: 326, 83, 553, 90 Annotation: Subtype: Link Rect: 326, 75, 403, 82 Annotation: Subtype: Link Rect: 326, 67, 557, 74 Annotation: Subtype: Link Rect: 326, 59, 549, 66 Annotation: Subtype: Link Rect: 326, 52, 550, 58 Page: Label: 154 Sequence: 61 Annotations: Annotation: Subtype: Link Rect: 57, 729, 179, 735 Annotation: Subtype: Link Rect: 57, 721, 288, 727 Annotation: Subtype: Link Rect: 57, 713, 269, 719 Annotation: Subtype: Link Rect: 57, 705, 187, 711 Annotation: Subtype: Link Rect: 57, 697, 274, 703 Annotation: Subtype: Link Rect: 57, 689, 282, 696 Annotation: Subtype: Link Rect: 57, 681, 176, 688 Annotation: Subtype: Link Rect: 57, 673, 288, 680 Annotation: Subtype: Link Rect: 57, 665, 276, 672 Annotation: Subtype: Link Rect: 57, 657, 112, 664 Annotation: Subtype: Link Rect: 57, 649, 276, 656 Annotation: Subtype: Link Rect: 57, 641, 285, 648 Annotation: Subtype: Link Rect: 57, 633, 204, 640 Annotation: Subtype: Link Rect: 57, 625, 288, 632 Annotation: Subtype: Link Rect: 57, 617, 279, 624 Annotation: Subtype: Link Rect: 57, 609, 241, 616 Annotation: Subtype: Link Rect: 57, 601, 255, 608 Annotation: Subtype: Link Rect: 57, 593, 216, 600 Annotation: Subtype: Link Rect: 57, 586, 274, 592 Annotation: Subtype: Link Rect: 57, 578, 288, 584 Annotation: Subtype: Link Rect: 57, 570, 105, 576 Annotation: Subtype: Link Rect: 57, 562, 265, 568 Annotation: Subtype: Link Rect: 57, 554, 288, 560 Annotation: Subtype: Link Rect: 57, 546, 288, 552 Annotation: Subtype: Link Rect: 57, 538, 260, 544 Annotation: Subtype: Link Rect: 57, 530, 272, 536 Annotation: Subtype: Link Rect: 57, 522, 288, 528 Annotation: Subtype: Link Rect: 57, 514, 281, 520 Annotation: Subtype: Link Rect: 57, 506, 260, 512 Annotation: Subtype: Link Rect: 57, 498, 288, 504 Annotation: Subtype: Link Rect: 57, 490, 287, 496 Annotation: Subtype: Link Rect: 57, 482, 288, 488 Annotation: Subtype: Link Rect: 57, 474, 283, 480 Annotation: Subtype: Link Rect: 57, 466, 73, 472 Annotation: Subtype: Link Rect: 57, 458, 269, 464 Annotation: Subtype: Link Rect: 57, 450, 285, 456 Annotation: Subtype: Link Rect: 57, 442, 283, 448 Annotation: Subtype: Link Rect: 57, 434, 84, 440 Annotation: Subtype: Link Rect: 57, 426, 288, 433 Annotation: Subtype: Link Rect: 57, 418, 288, 425 Annotation: Subtype: Link Rect: 57, 410, 281, 417 Annotation: Subtype: Link Rect: 57, 402, 84, 409 Annotation: Subtype: Link Rect: 57, 394, 256, 401 Annotation: Subtype: Link Rect: 57, 386, 288, 393 Annotation: Subtype: Link Rect: 57, 378, 274, 385 Annotation: Subtype: Link Rect: 57, 370, 279, 377 Annotation: Subtype: Link Rect: 57, 362, 266, 369 Annotation: Subtype: Link Rect: 57, 354, 278, 361 Annotation: Subtype: Link Rect: 57, 346, 288, 353 Annotation: Subtype: Link Rect: 57, 338, 288, 345 Annotation: Subtype: Link Rect: 57, 330, 113, 337 Annotation: Subtype: Link Rect: 57, 322, 251, 329 Annotation: Subtype: Link Rect: 57, 315, 286, 321 Annotation: Subtype: Link Rect: 57, 307, 260, 313 Annotation: Subtype: Link Rect: 57, 299, 284, 305 Annotation: Subtype: Link Rect: 57, 291, 284, 297 Annotation: Subtype: Link Rect: 57, 283, 231, 289 Annotation: Subtype: Link Rect: 57, 275, 283, 281 Annotation: Subtype: Link Rect: 57, 267, 280, 273 Annotation: Subtype: Link Rect: 57, 259, 195, 265 Annotation: Subtype: Link Rect: 57, 251, 262, 257 Annotation: Subtype: Link Rect: 57, 243, 281, 249 Annotation: Subtype: Link Rect: 57, 235, 288, 241 Annotation: Subtype: Link Rect: 57, 227, 288, 233 Annotation: Subtype: Link Rect: 57, 219, 129, 225 Annotation: Subtype: Link Rect: 57, 211, 279, 217 Annotation: Subtype: Link Rect: 57, 203, 274, 209 Annotation: Subtype: Link Rect: 57, 195, 98, 201 Annotation: Subtype: Link Rect: 57, 187, 288, 193 Annotation: Subtype: Link Rect: 57, 179, 267, 185 Annotation: Subtype: Link Rect: 57, 171, 187, 177 Annotation: Subtype: Link Rect: 57, 163, 265, 169 Annotation: Subtype: Link Rect: 57, 155, 219, 162 Annotation: Subtype: Link Rect: 57, 147, 274, 154 Annotation: Subtype: Link Rect: 57, 139, 278, 146 Annotation: Subtype: Link Rect: 57, 131, 119, 138 Annotation: Subtype: Link Rect: 57, 123, 278, 130 Annotation: Subtype: Link Rect: 57, 115, 287, 122 Annotation: Subtype: Link Rect: 57, 107, 202, 114 Annotation: Subtype: Link Rect: 57, 99, 269, 106 Annotation: Subtype: Link Rect: 57, 91, 282, 98 Annotation: Subtype: Link Rect: 57, 83, 239, 90 Annotation: Subtype: Link Rect: 57, 75, 288, 82 Annotation: Subtype: Link Rect: 57, 67, 282, 74 Annotation: Subtype: Link Rect: 57, 59, 280, 66 Annotation: Subtype: Link Rect: 57, 52, 277, 58 Annotation: Subtype: Link Rect: 326, 729, 557, 735 Annotation: Subtype: Link Rect: 326, 721, 540, 727 Annotation: Subtype: Link Rect: 326, 713, 353, 719 Annotation: Subtype: Link Rect: 326, 705, 552, 711 Annotation: Subtype: Link Rect: 326, 697, 557, 703 Annotation: Subtype: Link Rect: 326, 689, 557, 696 Annotation: Subtype: Link Rect: 326, 681, 503, 688 Annotation: Subtype: Link Rect: 326, 673, 557, 680 Annotation: Subtype: Link Rect: 326, 665, 550, 672 Annotation: Subtype: Link Rect: 326, 657, 556, 664 Annotation: Subtype: Link Rect: 326, 649, 394, 656 Annotation: Subtype: Link Rect: 326, 641, 557, 648 Annotation: Subtype: Link Rect: 326, 633, 557, 640 Annotation: Subtype: Link Rect: 326, 625, 449, 632 Annotation: Subtype: Link Rect: 326, 617, 557, 624 Annotation: Subtype: Link Rect: 326, 609, 556, 616 Annotation: Subtype: Link Rect: 326, 601, 425, 608 Annotation: Subtype: Link Rect: 326, 593, 557, 600 Annotation: Subtype: Link Rect: 326, 586, 551, 592 Annotation: Subtype: Link Rect: 326, 578, 554, 584 Annotation: Subtype: Link Rect: 326, 570, 360, 576 Annotation: Subtype: Link Rect: 326, 562, 552, 568 Annotation: Subtype: Link Rect: 326, 554, 551, 560 Annotation: Subtype: Link Rect: 326, 546, 557, 552 Annotation: Subtype: Link Rect: 326, 538, 416, 544 Annotation: Subtype: Link Rect: 326, 530, 543, 536 Annotation: Subtype: Link Rect: 326, 522, 557, 528 Annotation: Subtype: Link Rect: 326, 514, 518, 520 Annotation: Subtype: Link Rect: 326, 506, 555, 512 Annotation: Subtype: Link Rect: 326, 498, 557, 504 Annotation: Subtype: Link Rect: 326, 490, 360, 496 Annotation: Subtype: Link Rect: 326, 482, 542, 488 Annotation: Subtype: Link Rect: 326, 474, 557, 480 Annotation: Subtype: Link Rect: 326, 466, 510, 472 Annotation: Subtype: Link Rect: 326, 458, 536, 464 Annotation: Subtype: Link Rect: 326, 450, 557, 456 Annotation: Subtype: Link Rect: 326, 442, 374, 448 Annotation: Subtype: Link Rect: 326, 434, 549, 440 Annotation: Subtype: Link Rect: 326, 426, 551, 433 Annotation: Subtype: Link Rect: 326, 418, 553, 425 Annotation: Subtype: Link Rect: 326, 410, 456, 417 Annotation: Subtype: Link Rect: 326, 402, 556, 409 Annotation: Subtype: Link Rect: 326, 394, 557, 401 Annotation: Subtype: Link Rect: 326, 386, 557, 393 Annotation: Subtype: Link Rect: 326, 378, 423, 385 Annotation: Subtype: Link Rect: 326, 370, 556, 377 Annotation: Subtype: Link Rect: 326, 362, 543, 369 Annotation: Subtype: Link Rect: 326, 354, 556, 361 Annotation: Subtype: Link Rect: 326, 346, 360, 353 Annotation: Subtype: Link Rect: 326, 338, 542, 345 Annotation: Subtype: Link Rect: 326, 330, 553, 337 Annotation: Subtype: Link Rect: 326, 322, 547, 329 Annotation: Subtype: Link Rect: 326, 315, 447, 321 Annotation: Subtype: Link Rect: 326, 307, 528, 313 Annotation: Subtype: Link Rect: 326, 299, 551, 305 Annotation: Subtype: Link Rect: 326, 291, 532, 297 Annotation: Subtype: Link Rect: 326, 283, 553, 289 Annotation: Subtype: Link Rect: 326, 275, 543, 281 Annotation: Subtype: Link Rect: 326, 267, 541, 273 Annotation: Subtype: Link Rect: 326, 259, 556, 265 Annotation: Subtype: Link Rect: 326, 251, 398, 257 Annotation: Subtype: Link Rect: 326, 243, 550, 249 Annotation: Subtype: Link Rect: 326, 235, 557, 241 Annotation: Subtype: Link Rect: 326, 227, 557, 233 Annotation: Subtype: Link Rect: 326, 219, 543, 225 Annotation: Subtype: Link Rect: 326, 211, 548, 217 Annotation: Subtype: Link Rect: 326, 203, 551, 209 Annotation: Subtype: Link Rect: 326, 195, 460, 201 Annotation: Subtype: Link Rect: 326, 187, 543, 193 Annotation: Subtype: Link Rect: 326, 179, 557, 185 Annotation: Subtype: Link Rect: 326, 171, 557, 177 Annotation: Subtype: Link Rect: 326, 163, 408, 169 Annotation: Subtype: Link Rect: 326, 123, 533, 130 Annotation: Subtype: Link Rect: 326, 115, 542, 122 Annotation: Subtype: Link Rect: 326, 107, 545, 114 Annotation: Subtype: Link Rect: 326, 99, 557, 106 Annotation: Subtype: Link Rect: 326, 91, 414, 98 Annotation: Subtype: Link Rect: 326, 83, 540, 90 Annotation: Subtype: Link Rect: 326, 75, 555, 82 Annotation: Subtype: Link Rect: 326, 67, 541, 74 Annotation: Subtype: Link Rect: 326, 59, 460, 66 Annotation: Subtype: Link Rect: 326, 52, 549, 58 Page: Label: 155 Sequence: 62 Annotations: Annotation: Subtype: Link Rect: 57, 729, 276, 735 Annotation: Subtype: Link Rect: 57, 721, 286, 727 Annotation: Subtype: Link Rect: 57, 713, 255, 719 Annotation: Subtype: Link Rect: 57, 705, 271, 711 Annotation: Subtype: Link Rect: 57, 697, 288, 703 Annotation: Subtype: Link Rect: 57, 689, 274, 696 Annotation: Subtype: Link Rect: 57, 681, 244, 688 Annotation: Subtype: Link Rect: 57, 673, 267, 680 Annotation: Subtype: Link Rect: 57, 665, 288, 672 Annotation: Subtype: Link Rect: 57, 657, 135, 664 Annotation: Subtype: Link Rect: 57, 649, 288, 656 Annotation: Subtype: Link Rect: 57, 641, 288, 648 Annotation: Subtype: Link Rect: 57, 633, 183, 640 Annotation: Subtype: Link Rect: 57, 625, 274, 632 Annotation: Subtype: Link Rect: 57, 617, 282, 624 Annotation: Subtype: Link Rect: 57, 609, 105, 616 Annotation: Subtype: Link Rect: 57, 601, 288, 608 Annotation: Subtype: Link Rect: 57, 593, 112, 600 Annotation: Subtype: Link Rect: 57, 538, 283, 544 Annotation: Subtype: Link Rect: 57, 530, 254, 536 Annotation: Subtype: Link Rect: 57, 522, 288, 528 Annotation: Subtype: Link Rect: 57, 514, 288, 520 Annotation: Subtype: Link Rect: 57, 506, 105, 512 Annotation: Subtype: Link Rect: 57, 498, 258, 504 Annotation: Subtype: Link Rect: 57, 490, 288, 496 Annotation: Subtype: Link Rect: 57, 482, 276, 488 Annotation: Subtype: Link Rect: 57, 474, 185, 480 Annotation: Subtype: Link Rect: 57, 466, 288, 472 Annotation: Subtype: Link Rect: 57, 458, 288, 464 Annotation: Subtype: Link Rect: 57, 450, 217, 456 Annotation: Subtype: Link Rect: 57, 442, 285, 448 Annotation: Subtype: Link Rect: 57, 434, 283, 440 Annotation: Subtype: Link Rect: 57, 426, 105, 433 Annotation: Subtype: Link Rect: 57, 418, 265, 425 Annotation: Subtype: Link Rect: 57, 410, 266, 417 Annotation: Subtype: Link Rect: 57, 402, 100, 409 Annotation: Subtype: Link Rect: 57, 394, 272, 401 Annotation: Subtype: Link Rect: 57, 386, 273, 393 Annotation: Subtype: Link Rect: 57, 378, 258, 385 Annotation: Subtype: Link Rect: 57, 370, 288, 377 Annotation: Subtype: Link Rect: 57, 362, 278, 369 Annotation: Subtype: Link Rect: 57, 354, 198, 361 Annotation: Subtype: Link Rect: 57, 346, 288, 353 Annotation: Subtype: Link Rect: 57, 338, 288, 345 Annotation: Subtype: Link Rect: 57, 330, 268, 337 Annotation: Subtype: Link Rect: 57, 322, 288, 329 Annotation: Subtype: Link Rect: 57, 315, 270, 321 Annotation: Subtype: Link Rect: 57, 307, 288, 313 Annotation: Subtype: Link Rect: 57, 299, 275, 305 Annotation: Subtype: Link Rect: 57, 291, 274, 297 Annotation: Subtype: Link Rect: 57, 283, 274, 289 Annotation: Subtype: Link Rect: 57, 275, 285, 281 Annotation: Subtype: Link Rect: 57, 267, 288, 273 Annotation: Subtype: Link Rect: 57, 259, 284, 265 Annotation: Subtype: Link Rect: 57, 251, 270, 257 Annotation: Subtype: Link Rect: 57, 243, 281, 249 Annotation: Subtype: Link Rect: 57, 235, 84, 241 Annotation: Subtype: Link Rect: 57, 227, 278, 233 Annotation: Subtype: Link Rect: 57, 219, 278, 225 Annotation: Subtype: Link Rect: 57, 211, 162, 217 Annotation: Subtype: Link Rect: 57, 203, 268, 209 Annotation: Subtype: Link Rect: 57, 195, 286, 201 Annotation: Subtype: Link Rect: 57, 187, 278, 193 Annotation: Subtype: Link Rect: 57, 179, 288, 185 Annotation: Subtype: Link Rect: 57, 171, 144, 177 Annotation: Subtype: Link Rect: 57, 163, 288, 169 Annotation: Subtype: Link Rect: 57, 155, 288, 162 Annotation: Subtype: Link Rect: 57, 147, 264, 154 Annotation: Subtype: Link Rect: 57, 139, 288, 146 Annotation: Subtype: Link Rect: 57, 131, 262, 138 Annotation: Subtype: Link Rect: 57, 123, 91, 130 Annotation: Subtype: Link Rect: 57, 115, 280, 122 Annotation: Subtype: Link Rect: 57, 107, 288, 114 Annotation: Subtype: Link Rect: 57, 99, 91, 106 Annotation: Subtype: Link Rect: 57, 91, 275, 98 Annotation: Subtype: Link Rect: 57, 83, 275, 90 Annotation: Subtype: Link Rect: 57, 75, 163, 82 Annotation: Subtype: Link Rect: 57, 67, 267, 74 Annotation: Subtype: Link Rect: 57, 59, 253, 66 Annotation: Subtype: Link Rect: 57, 52, 270, 58 Annotation: Subtype: Link Rect: 326, 729, 547, 735 Annotation: Subtype: Link Rect: 326, 721, 550, 727 Annotation: Subtype: Link Rect: 326, 713, 353, 719 Annotation: Subtype: Link Rect: 326, 705, 548, 711 Annotation: Subtype: Link Rect: 326, 697, 538, 703 Annotation: Subtype: Link Rect: 326, 689, 542, 696 Annotation: Subtype: Link Rect: 326, 681, 486, 688 Annotation: Subtype: Link Rect: 326, 673, 517, 680 Annotation: Subtype: Link Rect: 326, 665, 544, 672 Annotation: Subtype: Link Rect: 326, 657, 549, 664 Annotation: Subtype: Link Rect: 326, 649, 391, 656 Annotation: Subtype: Link Rect: 326, 641, 537, 648 Annotation: Subtype: Link Rect: 326, 633, 538, 640 Annotation: Subtype: Link Rect: 326, 625, 554, 632 Annotation: Subtype: Link Rect: 326, 617, 550, 624 Annotation: Subtype: Link Rect: 326, 609, 482, 616 Annotation: Subtype: Link Rect: 326, 601, 553, 608 Annotation: Subtype: Link Rect: 326, 593, 544, 600 Annotation: Subtype: Link Rect: 326, 586, 535, 592 Annotation: Subtype: Link Rect: 326, 578, 532, 584 Annotation: Subtype: Link Rect: 326, 570, 360, 576 Annotation: Subtype: Link Rect: 326, 562, 557, 568 Annotation: Subtype: Link Rect: 326, 554, 557, 560 Annotation: Subtype: Link Rect: 326, 546, 540, 552 Annotation: Subtype: Link Rect: 326, 538, 533, 544 Annotation: Subtype: Link Rect: 326, 530, 546, 536 Annotation: Subtype: Link Rect: 326, 522, 555, 528 Annotation: Subtype: Link Rect: 326, 514, 484, 520 Annotation: Subtype: Link Rect: 326, 506, 557, 512 Annotation: Subtype: Link Rect: 326, 498, 552, 504 Annotation: Subtype: Link Rect: 326, 490, 536, 496 Annotation: Subtype: Link Rect: 326, 482, 536, 488 Annotation: Subtype: Link Rect: 326, 474, 459, 480 Annotation: Subtype: Link Rect: 326, 466, 549, 472 Annotation: Subtype: Link Rect: 326, 458, 544, 464 Annotation: Subtype: Link Rect: 326, 450, 418, 456 Annotation: Subtype: Link Rect: 326, 442, 557, 448 Annotation: Subtype: Link Rect: 326, 434, 557, 440 Annotation: Subtype: Link Rect: 326, 426, 550, 433 Annotation: Subtype: Link Rect: 326, 418, 533, 425 Annotation: Subtype: Link Rect: 326, 410, 516, 417 Annotation: Subtype: Link Rect: 326, 402, 552, 409 Annotation: Subtype: Link Rect: 326, 394, 460, 401 Annotation: Subtype: Link Rect: 326, 386, 557, 393 Annotation: Subtype: Link Rect: 326, 378, 551, 385 Annotation: Subtype: Link Rect: 326, 370, 557, 377 Annotation: Subtype: Link Rect: 326, 362, 533, 369 Annotation: Subtype: Link Rect: 326, 354, 555, 361 Annotation: Subtype: Link Rect: 326, 346, 552, 353 Annotation: Subtype: Link Rect: 326, 338, 552, 345 Annotation: Subtype: Link Rect: 326, 330, 412, 337 Annotation: Subtype: Link Rect: 326, 291, 542, 297 Annotation: Subtype: Link Rect: 326, 283, 534, 289 Annotation: Subtype: Link Rect: 326, 275, 557, 281 Annotation: Subtype: Link Rect: 326, 267, 549, 273 Annotation: Subtype: Link Rect: 326, 259, 554, 265 Annotation: Subtype: Link Rect: 326, 251, 422, 257 Annotation: Subtype: Link Rect: 326, 243, 540, 249 Annotation: Subtype: Link Rect: 326, 235, 477, 241 Annotation: Subtype: Link Rect: 326, 227, 545, 233 Annotation: Subtype: Link Rect: 326, 219, 527, 225 Annotation: Subtype: Link Rect: 326, 211, 557, 217 Annotation: Subtype: Link Rect: 326, 203, 544, 209 Annotation: Subtype: Link Rect: 326, 195, 557, 201 Annotation: Subtype: Link Rect: 326, 187, 353, 193 Annotation: Subtype: Link Rect: 326, 179, 555, 185 Annotation: Subtype: Link Rect: 326, 171, 514, 177 Annotation: Subtype: Link Rect: 326, 163, 549, 169 Annotation: Subtype: Link Rect: 326, 155, 427, 162 Annotation: Subtype: Link Rect: 326, 147, 557, 154 Annotation: Subtype: Link Rect: 326, 139, 550, 146 Annotation: Subtype: Link Rect: 326, 131, 557, 138 Annotation: Subtype: Link Rect: 326, 123, 557, 130 Annotation: Subtype: Link Rect: 326, 115, 391, 122 Annotation: Subtype: Link Rect: 326, 107, 555, 114 Annotation: Subtype: Link Rect: 326, 99, 545, 106 Annotation: Subtype: Link Rect: 326, 91, 553, 98 Annotation: Subtype: Link Rect: 326, 83, 556, 90 Annotation: Subtype: Link Rect: 326, 75, 552, 82 Annotation: Subtype: Link Rect: 326, 67, 406, 74 Annotation: Subtype: Link Rect: 326, 59, 557, 66 Annotation: Subtype: Link Rect: 326, 52, 511, 58 Page: Label: 156 Sequence: 63 Annotations: Annotation: Subtype: Link Rect: 57, 729, 284, 735 Annotation: Subtype: Link Rect: 57, 721, 284, 727 Annotation: Subtype: Link Rect: 57, 713, 209, 719 Annotation: Subtype: Link Rect: 57, 705, 288, 711 Annotation: Subtype: Link Rect: 57, 697, 288, 703 Annotation: Subtype: Link Rect: 57, 689, 285, 696 Annotation: Subtype: Link Rect: 57, 681, 165, 688 Annotation: Subtype: Link Rect: 57, 673, 288, 680 Annotation: Subtype: Link Rect: 57, 665, 288, 672 Annotation: Subtype: Link Rect: 57, 657, 147, 664 Annotation: Subtype: Link Rect: 57, 649, 268, 656 Annotation: Subtype: Link Rect: 57, 641, 270, 648 Annotation: Subtype: Link Rect: 57, 633, 288, 640 Annotation: Subtype: Link Rect: 57, 625, 279, 632 Annotation: Subtype: Link Rect: 57, 617, 285, 624 Annotation: Subtype: Link Rect: 57, 609, 264, 616 Annotation: Subtype: Link Rect: 57, 601, 152, 608 Annotation: Subtype: Link Rect: 57, 593, 248, 600 Annotation: Subtype: Link Rect: 57, 586, 283, 592 Annotation: Subtype: Link Rect: 57, 578, 280, 584 Annotation: Subtype: Link Rect: 57, 570, 112, 576 Annotation: Subtype: Link Rect: 57, 562, 258, 568 Annotation: Subtype: Link Rect: 57, 554, 281, 560 Annotation: Subtype: Link Rect: 57, 546, 288, 552 Annotation: Subtype: Link Rect: 57, 538, 281, 544 Annotation: Subtype: Link 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90 Annotation: Subtype: Link Rect: 57, 75, 273, 82 Annotation: Subtype: Link Rect: 57, 67, 288, 74 Annotation: Subtype: Link Rect: 57, 59, 281, 66 Annotation: Subtype: Link Rect: 57, 52, 91, 58 Annotation: Subtype: Link Rect: 326, 729, 536, 735 Annotation: Subtype: Link Rect: 326, 721, 556, 727 Annotation: Subtype: Link Rect: 326, 713, 403, 719 Annotation: Subtype: Link Rect: 326, 705, 554, 711 Annotation: Subtype: Link Rect: 326, 697, 546, 703 Annotation: Subtype: Link Rect: 326, 689, 557, 696 Annotation: Subtype: Link Rect: 326, 681, 397, 688 Annotation: Subtype: Link Rect: 326, 673, 554, 680 Annotation: Subtype: Link Rect: 326, 665, 557, 672 Annotation: Subtype: Link Rect: 326, 657, 412, 664 Annotation: Subtype: Link Rect: 326, 649, 525, 656 Annotation: Subtype: Link Rect: 326, 641, 557, 648 Annotation: Subtype: Link Rect: 326, 633, 549, 640 Annotation: Subtype: Link Rect: 326, 625, 432, 632 Annotation: Subtype: Link Rect: 326, 617, 557, 624 Annotation: Subtype: Link Rect: 326, 609, 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Link Rect: 326, 450, 557, 456 Annotation: Subtype: Link Rect: 326, 442, 552, 448 Annotation: Subtype: Link Rect: 326, 434, 550, 440 Annotation: Subtype: Link Rect: 326, 426, 474, 433 Annotation: Subtype: Link Rect: 326, 418, 551, 425 Annotation: Subtype: Link Rect: 326, 410, 501, 417 Annotation: Subtype: Link Rect: 326, 402, 540, 409 Annotation: Subtype: Link Rect: 326, 394, 537, 401 Annotation: Subtype: Link Rect: 326, 386, 557, 393 Annotation: Subtype: Link Rect: 326, 378, 432, 385 Annotation: Subtype: Link Rect: 326, 370, 557, 377 Annotation: Subtype: Link Rect: 326, 362, 477, 369 Annotation: Subtype: Link Rect: 326, 354, 557, 361 Annotation: Subtype: Link Rect: 326, 346, 557, 353 Annotation: Subtype: Link Rect: 326, 338, 556, 345 Annotation: Subtype: Link Rect: 326, 330, 534, 337 Annotation: Subtype: Link Rect: 326, 322, 557, 329 Annotation: Subtype: Link Rect: 326, 315, 542, 321 Annotation: Subtype: Link Rect: 326, 307, 555, 313 Annotation: Subtype: Link Rect: 326, 299, 555, 305 Annotation: Subtype: Link Rect: 326, 291, 510, 297 Annotation: Subtype: Link Rect: 326, 283, 556, 289 Annotation: Subtype: Link Rect: 326, 275, 545, 281 Annotation: Subtype: Link Rect: 326, 267, 420, 273 Annotation: Subtype: Link Rect: 326, 259, 550, 265 Annotation: Subtype: Link Rect: 326, 251, 551, 257 Annotation: Subtype: Link Rect: 326, 243, 454, 249 Annotation: Subtype: Link Rect: 326, 235, 557, 241 Annotation: Subtype: Link Rect: 326, 227, 557, 233 Annotation: Subtype: Link Rect: 326, 219, 534, 225 Annotation: Subtype: Link Rect: 326, 211, 525, 217 Annotation: Subtype: Link Rect: 326, 203, 536, 209 Annotation: Subtype: Link Rect: 326, 195, 530, 201 Annotation: Subtype: Link Rect: 326, 187, 546, 193 Annotation: Subtype: Link Rect: 326, 179, 557, 185 Annotation: Subtype: Link Rect: 326, 171, 502, 177 Annotation: Subtype: Link Rect: 326, 163, 545, 169 Annotation: Subtype: Link Rect: 326, 155, 535, 162 Annotation: Subtype: Link Rect: 326, 147, 557, 154 Annotation: Subtype: Link Rect: 326, 139, 554, 146 Annotation: Subtype: Link Rect: 326, 131, 353, 138 Annotation: Subtype: Link Rect: 326, 123, 554, 130 Annotation: Subtype: Link Rect: 326, 115, 551, 122 Annotation: Subtype: Link Rect: 326, 107, 353, 114 Annotation: Subtype: Link Rect: 326, 99, 542, 106 Annotation: Subtype: Link Rect: 326, 91, 555, 98 Annotation: Subtype: Link Rect: 326, 83, 490, 90 Annotation: Subtype: Link Rect: 326, 75, 557, 82 Annotation: Subtype: Link Rect: 326, 67, 557, 74 Annotation: Subtype: Link Rect: 326, 59, 541, 66 Annotation: Subtype: Link Rect: 326, 52, 495, 58 Page: Label: 162 Sequence: 69 Annotations: Annotation: Subtype: Link Rect: 57, 729, 288, 735 Annotation: Subtype: Link Rect: 57, 721, 288, 727 Annotation: Subtype: Link Rect: 57, 713, 286, 719 Annotation: Subtype: Link Rect: 57, 705, 134, 711 Annotation: Subtype: Link Rect: 57, 697, 288, 703 Annotation: Subtype: Link Rect: 57, 689, 279, 696 Annotation: Subtype: Link Rect: 57, 681, 280, 688 Annotation: Subtype: Link Rect: 57, 673, 175, 680 Annotation: Subtype: Link Rect: 57, 665, 285, 672 Annotation: Subtype: Link Rect: 57, 657, 136, 664 Annotation: Subtype: Link Rect: 57, 649, 288, 656 Annotation: Subtype: Link Rect: 57, 641, 200, 648 Annotation: Subtype: Link Rect: 57, 633, 265, 640 Annotation: Subtype: Link Rect: 57, 625, 274, 632 Annotation: Subtype: Link Rect: 57, 617, 288, 624 Annotation: Subtype: Link Rect: 57, 609, 144, 616 Annotation: Subtype: Link Rect: 57, 601, 277, 608 Annotation: Subtype: Link Rect: 57, 593, 287, 600 Annotation: Subtype: Link Rect: 57, 586, 288, 592 Annotation: Subtype: Link Rect: 57, 578, 184, 584 Annotation: Subtype: Link Rect: 57, 570, 287, 576 Annotation: Subtype: Link Rect: 57, 562, 202, 568 Annotation: Subtype: Link Rect: 57, 554, 274, 560 Annotation: Subtype: Link Rect: 57, 546, 267, 552 Annotation: Subtype: Link Rect: 57, 538, 91, 544 Annotation: Subtype: Link Rect: 57, 530, 288, 536 Annotation: Subtype: Link Rect: 57, 522, 218, 528 Annotation: Subtype: Link Rect: 57, 514, 268, 520 Annotation: Subtype: Link Rect: 57, 506, 288, 512 Annotation: Subtype: Link Rect: 57, 498, 288, 504 Annotation: Subtype: Link Rect: 57, 490, 105, 496 Annotation: Subtype: Link Rect: 57, 482, 286, 488 Annotation: Subtype: Link Rect: 57, 474, 274, 480 Annotation: Subtype: Link Rect: 57, 466, 210, 472 Annotation: Subtype: Link Rect: 57, 458, 273, 464 Annotation: Subtype: Link Rect: 57, 450, 270, 456 Annotation: Subtype: Link Rect: 57, 442, 288, 448 Annotation: Subtype: Link Rect: 57, 434, 242, 440 Annotation: Subtype: Link Rect: 326, 729, 557, 735 Annotation: Subtype: Link Rect: 326, 721, 395, 727 Annotation: Subtype: Link Rect: 326, 713, 545, 719 Annotation: Subtype: Link Rect: 326, 705, 541, 711 Annotation: Subtype: Link Rect: 326, 697, 557, 703 Annotation: Subtype: Link Rect: 326, 689, 540, 696 Annotation: Subtype: Link Rect: 326, 681, 548, 688 Annotation: Subtype: Link Rect: 326, 673, 545, 680 Annotation: Subtype: Link Rect: 326, 665, 374, 672 Annotation: Subtype: Link Rect: 326, 657, 550, 664 Annotation: Subtype: Link Rect: 326, 649, 557, 656 Annotation: Subtype: Link Rect: 326, 641, 381, 648 Annotation: Subtype: Link Rect: 326, 633, 555, 640 Annotation: Subtype: Link Rect: 326, 625, 557, 632 Annotation: Subtype: Link Rect: 326, 617, 546, 624 Annotation: Subtype: Link Rect: 326, 609, 432, 616 Annotation: Subtype: Link Rect: 326, 601, 539, 608 Annotation: Subtype: Link Rect: 326, 593, 544, 600 Annotation: Subtype: Link Rect: 326, 586, 554, 592 Annotation: Subtype: Link Rect: 326, 578, 557, 584 Annotation: Subtype: Link Rect: 326, 570, 411, 576 Annotation: Subtype: Link Rect: 326, 562, 557, 568 Annotation: Subtype: Link Rect: 326, 554, 556, 560 Annotation: Subtype: Link Rect: 326, 546, 532, 552 Annotation: Subtype: Link Rect: 326, 538, 533, 544 Annotation: Subtype: Link Rect: 326, 530, 549, 536 Annotation: Subtype: Link Rect: 326, 522, 557, 528 Annotation: Subtype: Link Rect: 326, 514, 358, 520 Annotation: Subtype: Link Rect: 326, 506, 557, 512 Annotation: Subtype: Link Rect: 326, 498, 530, 504 Annotation: Subtype: Link Rect: 326, 490, 537, 496 Annotation: Subtype: Link Rect: 326, 482, 557, 488 Annotation: Subtype: Link Rect: 326, 474, 557, 480 Annotation: Subtype: Link Rect: 326, 466, 557, 472 Annotation: Subtype: Link Rect: 326, 458, 547, 464 Annotation: Subtype: Link Rect: 326, 450, 510, 456 Annotation: Subtype: Link Rect: 538, 442, 557, 448 Annotation: Subtype: Link Rect: 326, 434, 483, 440 Checksum: 5e276b2f Type: CRC32 Checksum: 01ac264e7e0b65c968772fb37e83b039 Type: MD5 Checksum: 54007e22c56135c1230e8de827c5a99e18b2ba30 Type: SHA-1 Checksum: 6e3439327471e1d0aacb586b784503c6b3ba2003b4c8725002433cc9dce5990e Type: SHA-256