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Title:          Hif-1α Knockdown Reduces Glycolytic Metabolism and Induces Cell Death of Human Synovial Fibroblasts Under Normoxic Conditions
Subject:        Scientific Reports, doi:10.1038/s41598-017-03921-4
Keywords:       
Author:         Manuel J. Del Rey
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     Item: 
      Title: Hif-1α Knockdown Reduces Glycolytic Metabolism and Induces Cell Death of Human Synovial Fibroblasts Under Normoxic Conditio ...
      Children: 
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: HIF-1α regulates the expression of the glycolytic enzyme GAPDH in normoxic SF. 
         Item: 
          Title: The balance glycolysis/OXPHOS is shifted after HIF-1α silencing in SF. 
         Item: 
          Title: HIF-1α knockdown and glycolysis inhibition induce apoptotic cell death in fibroblasts. 
         Item: 
          Title: HIF-1α silencing decreases SF viability in vivo. 
       Item: 
        Title: Discussion
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Cells and reagents. 
         Item: 
          Title: Oligo- and Lentivirus-Mediated siRNA Knockdown. 
         Item: 
          Title: Quantitative Real Time-PCR (qRT-PCR) analyses. 
         Item: 
          Title: Protein expression analysis. 
         Item: 
          Title: Analysis of lactate production and cellular respiration. 
         Item: 
          Title: Analysis of cell viability in fibroblast cultures. 
         Item: 
          Title: Humanized air pouch model. 
         Item: 
          Title: Statistical analysis. 
       Item: 
        Title: Acknowledgements
       Item: 
        Title: Figure 1 Evaluation of HIF-1α function in SF under normoxic conditions.
       Item: 
        Title: Figure 2 Analysis of energy metabolism in SF.
       Item: 
        Title: Figure 3 HIF-1α knockdown and glycolysis inhibition induce apoptotic cell death in fibroblasts.
       Item: 
        Title: Figure 4 Viability of implanted RASF in the air pouch after HIF-1α siRNA injection.
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       Rect: 344, 400, 504, 388
     Thumb: true
  Checksum: 52fcf30c
   Type: CRC32
  Checksum: e864928741562eb2d9c59364bc261246
   Type: MD5
  Checksum: e4b93062ef6fe51c12619127dcb7d4012907a59b
   Type: SHA-1
  Checksum: d6fafec41d168d60b5638fa97b345f184398f30ec1e110818296247d5272ae66
   Type: SHA-256