54733b819e455426ae5d8cfd51d380e3 pmc_28818102.pdf bf20571bb83e6a1411a007c98597537464f6a7ef pmc_28818102.pdf 295653e8ec4cd1b54c59ec9198acc91f6156815e4467283ebee7d565c8bdcece pmc_28818102.pdf Title: Field evaluation of the efficacy of Mycobacterium bovis BCG vaccine against tuberculosis in goats Subject: BMC Veterinary Research, 2017, doi:10.1186/s12917-017-1182-5 Keywords: BCG,Efficacy,Field study,Goats,Tuberculosis,Vaccine Author: Enric Vidal Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Wed Aug 16 16:51:14 2017 CEST ModDate: Thu Aug 17 14:55:11 2017 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 6 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 784710 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AOEDMG+BknlgfAdvTTaf7f9f4f.B Type 1C WinAnsi yes yes no 8 0 AOEDPG+WhkjfdAdvTTe45e47d2 Type 1C WinAnsi yes yes no 9 0 AOEEAG+QjmkdqAdvTT7329fd89.I Type 1C WinAnsi yes yes no 10 0 AOEEAH+TkfbvpAdvTTb5929f4c Type 1C WinAnsi yes yes no 45 0 MyriadPro-Regular Type 1 Custom yes no no 13 0 AOEEDH+GtwfgnAdvTT99c4c969 Type 1C WinAnsi yes yes no 12 0 AOEEDI+TbmrxfAdvTT1b53b5fb.I Type 1C WinAnsi yes yes no 46 0 AOEEFL+TtpgrnAdvTT86d47313+20 Type 1C WinAnsi yes yes no 14 0 AOEEEK+JkqlgwAdvTT8861b38f.I Type 1C WinAnsi yes yes no 15 0 AOEEEJ+JyltrkAdvTT86d47313 Type 1C WinAnsi yes yes no 17 0 AOEFFH+VrrbvrAdvTT86d47313+03 Type 1C Custom yes yes yes 11 0 AOEFFI+DfqswtAdvTT86d47313+21 Type 1C WinAnsi yes yes no 16 0 AOEFFJ+NpjkfdAdvTT86d47313+22 Type 1C Custom yes yes no 18 0 AOEMGO+WpxcngAdvTTb5929f4c+20 Type 1C WinAnsi yes yes no 75 0 AOEMHP+TcfmktAdvTTb5929f4c+03 Type 1C Custom yes yes yes 82 0 AOEMIP+LxypwkAdvTT99c4c969+20 Type 1C WinAnsi yes yes no 83 0 AOEMJA+VyqqnhAdvTTaf7f9f4f.B+20 Type 1C WinAnsi yes yes no 84 0 YtfvmdOregonLDOBook Type 1C WinAnsi yes no no 109 0 PmcltsOpenSans-Extrabold Type 1C WinAnsi yes no no 110 0 QjfbvkOpenSans-Light Type 1C MacRoman yes no no 111 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-02-08 02:58:35 CET RepresentationInformation: pmc_28818102.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2018-02-08 07:51:57 CET Size: 784710 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 322 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Abstract Destination: sectionAbs1 Children: Item: Title: Background Destination: sectionASec1 Item: Title: Results Destination: sectionASec2 Item: Title: Conclusions Destination: sectionASec3 Item: Title: Background Destination: sectionSec1 Item: Title: Methods Destination: sectionSec2 Children: Item: Title: Herd and experimental schedule Destination: sectionSec3 Item: Title: Necropsy, tissue sampling and histopathology Destination: sectionSec4 Item: Title: MTBC culture Destination: sectionSec5 Item: Title: Direct DNA detection Destination: sectionSec6 Item: Title: Serology Destination: sectionSec7 Item: Title: Data analysis Destination: sectionSec8 Item: Title: Results Destination: sectionSec9 Item: Title: Discussion Destination: sectionSec10 Item: Title: Conclusion Destination: sectionSec11 Item: Title: Abbreviations Destination: sectionabr1 Item: Title: Funding Destination: sectionFPar1 Item: Title: Availability of data and materials Destination: sectionFPar2 Item: Title: Authors’ contributions Destination: sections12917-017-1182-5 Item: Title: Ethics approval Destination: sectionFPar3 Item: Title: Consent for publication Destination: sectionFPar4 Item: Title: Competing interests Destination: sectionFPar5 Item: Title: Publisher’s Note Destination: sectionFPar6 Item: Title: Author details Destination: sectionaunote1 Item: Title: References Destination: sectionBib1 Info: Title: Field evaluation of the efficacy of Mycobacterium bovis BCG vaccine against tuberculosis in goats Author: Enric Vidal Subject: BMC Veterinary Research, 2017, doi:10.1186/s12917-017-1182-5 Keywords: BCG,Efficacy,Field study,Goats,Tuberculosis,Vaccine Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Wed Aug 16 16:51:14 CEST 2017 ModDate: Thu Aug 17 14:55:11 CEST 2017 ID: 0xbebc222c4459dba05039cd5a5e385077, 0x9f803409c05e080459e64b2c8a04821a Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 95 ImageHeight: 91 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 688 ImageHeight: 126 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1183 ImageHeight: 862 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: AOEDMG+BknlgfAdvTTaf7f9f4f.B FontSubset: true FirstChar: 32 LastChar: 117 FontDescriptor: FontName: AOEDMG+BknlgfAdvTTaf7f9f4f.B Flags: Nonsymbolic FontBBox: -218, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AOEDPG+WhkjfdAdvTTe45e47d2 FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: AOEDPG+WhkjfdAdvTTe45e47d2 Flags: Nonsymbolic FontBBox: -218, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AOEEAG+QjmkdqAdvTT7329fd89.I FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: AOEEAG+QjmkdqAdvTT7329fd89.I Flags: Nonsymbolic FontBBox: -218, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AOEFFH+VrrbvrAdvTT86d47313+03 FontSubset: true FirstChar: 1 LastChar: 4 FontDescriptor: FontName: AOEFFH+VrrbvrAdvTT86d47313+03 Flags: Symbolic FontBBox: -281, -250, 906, 822 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: AOEMGO+WpxcngAdvTTb5929f4c+20 FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: AOEMGO+WpxcngAdvTTb5929f4c+20 Flags: Nonsymbolic FontBBox: -447, -208, 1375, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AOEEDH+GtwfgnAdvTT99c4c969 FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: AOEEDH+GtwfgnAdvTT99c4c969 Flags: Nonsymbolic FontBBox: -41, -250, 854, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MyriadPro-Regular FirstChar: 1 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -46, -250, 1126, 879 FontFile: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: AOEEAH+TkfbvpAdvTTb5929f4c FontSubset: true FirstChar: 32 LastChar: 250 FontDescriptor: FontName: AOEEAH+TkfbvpAdvTTb5929f4c Flags: Nonsymbolic FontBBox: -41, -250, 812, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: YtfvmdOregonLDOBook FirstChar: 0 LastChar: 255 FontDescriptor: FontName: YtfvmdOregonLDOBook Flags: Serif, Nonsymbolic FontBBox: 1, -308, 1045, 922 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AOEEDI+TbmrxfAdvTT1b53b5fb.I FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: AOEEDI+TbmrxfAdvTT1b53b5fb.I Flags: Nonsymbolic FontBBox: -114, -250, 864, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AOEEFL+TtpgrnAdvTT86d47313+20 FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: AOEEFL+TtpgrnAdvTT86d47313+20 Flags: Nonsymbolic FontBBox: -218, -218, 1291, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PmcltsOpenSans-Extrabold FirstChar: 32 LastChar: 149 FontDescriptor: FontName: PmcltsOpenSans-Extrabold Flags: Nonsymbolic FontBBox: -728, -293, 1407, 1124 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AOEEEK+JkqlgwAdvTT8861b38f.I FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: AOEEEK+JkqlgwAdvTT8861b38f.I Flags: Serif, Nonsymbolic FontBBox: -187, -239, 1062, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: QjfbvkOpenSans-Light FirstChar: 32 LastChar: 222 FontDescriptor: FontName: QjfbvkOpenSans-Light Flags: Nonsymbolic FontBBox: -521, -269, 1140, 1048 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: AOEFFI+DfqswtAdvTT86d47313+21 FontSubset: true FirstChar: 32 LastChar: 153 FontDescriptor: FontName: AOEFFI+DfqswtAdvTT86d47313+21 Flags: Nonsymbolic FontBBox: -20, -208, 1208, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AOEEEJ+JyltrkAdvTT86d47313 FontSubset: true FirstChar: 32 LastChar: 233 FontDescriptor: FontName: AOEEEJ+JyltrkAdvTT86d47313 Flags: Serif, Nonsymbolic FontBBox: -218, -239, 1020, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AOEFFJ+NpjkfdAdvTT86d47313+22 FontSubset: true FirstChar: 21 LastChar: 22 FontDescriptor: FontName: AOEFFJ+NpjkfdAdvTT86d47313+22 Flags: Nonsymbolic FontBBox: -166, -260, 1031, 906 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: AOEMHP+TcfmktAdvTTb5929f4c+03 FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: AOEMHP+TcfmktAdvTTb5929f4c+03 Flags: Symbolic FontBBox: -531, -260, 802, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: AOEMIP+LxypwkAdvTT99c4c969+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: AOEMIP+LxypwkAdvTT99c4c969+20 Flags: Nonsymbolic FontBBox: -447, -197, 1583, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AOEMJA+VyqqnhAdvTTaf7f9f4f.B+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: AOEMJA+VyqqnhAdvTTaf7f9f4f.B+20 Flags: Nonsymbolic FontBBox: -468, -197, 1656, 864 FontFile3: true Encoding: WinAnsiEncoding XMP: BCG,Efficacy,Field study,Goats,Tuberculosis,Vaccine Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) application/pdf 10.1186/s12917-017-1182-5 BMC Veterinary Research BMC Veterinary Research, 2017, doi:10.1186/s12917-017-1182-5 BCG Efficacy Field study Goats Tuberculosis Vaccine Field evaluation of the efficacy of Mycobacterium bovis BCG vaccine against tuberculosis in goats Enric Vidal Claudia Arrieta-Villegas Miriam Grasa Irene Mercader Mariano Domingo Bernat Pérez de Val 2017-08-17T14:55:11+02:00 2017-08-16T22:51:14+08:00 Arbortext Advanced Print Publisher 9.1.440/W Unicode 2017-08-17T14:55:11+02:00 uuid:1d87e680-d842-4fdc-8dd4-d075a85eebb3 uuid:d9a06d4d-2234-4d4d-8623-cacd3121aea2 default 1 converted uuid:0d079403-5f59-43f0-89d7-07aa9cd5c45c converted to PDF/A-2b pdfToolbox 2017-08-16T22:57:48+08:00 2 B Enric Vidal http://orcid.org/0000-0002-4965-3286 Springer Nature ORCID Schema http://springernature.com/ns/xmpExtensions/2.0/ sn authorInfo Bag AuthorInformation external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. editorInfo Bag EditorInformation external Editor information: contains the name of each editor and his/her ORCID identifier. seriesEditorInfo Bag SeriesEditorInformation external Series editor information: contains the name of each series editor and his/her ORCID identifier. AuthorInformation http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author Specifies the types of author information: name and ORCID of an author. name Text Gives the name of an author. orcid URI Gives the ORCID of an author. EditorInformation http://springernature.com/ns/xmpExtensions/2.0/editorInfo/ editor Specifies the types of editor information: name and ORCID of an editor. name Text Gives the name of an editor. orcid URI Gives the ORCID of an editor. SeriesEditorInformation http://springernature.com/ns/xmpExtensions/2.0/seriesEditorInfo/ seriesEditor Specifies the types of series editor information: name and ORCID of a series editor. name Text Gives the name of a series editor. orcid URI Gives the ORCID of a series editor. http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal A structure containing the characteristics of a font used in a document Fonts Bag Font internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text A structure containing the characteristics of a font used in a document. http://ns.adobe.com/xap/1.0/sType/Font# stFnt Font http://ns.adobe.com/pdfx/1.3/ pdfx PDF/X ID Schema internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 484, 657, 538, 679 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 105, 573, 114, 582 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 175, 258, 180, 268 Flags: Print AppearanceDictionary: true Destination: 79 Annotation: Subtype: Link Rect: 187, 258, 192, 268 Flags: Print AppearanceDictionary: true Destination: 79 Annotation: Subtype: Link Rect: 214, 222, 218, 232 Flags: Print AppearanceDictionary: true Destination: 79 Annotation: Subtype: Link Rect: 224, 222, 229, 232 Flags: Print AppearanceDictionary: true Destination: 79 Annotation: Subtype: Link Rect: 448, 330, 453, 340 Flags: Print AppearanceDictionary: true Destination: 79 Annotation: Subtype: Link Rect: 458, 330, 463, 340 Flags: Print AppearanceDictionary: true Destination: 79 Annotation: Subtype: Link Rect: 385, 294, 390, 304 Flags: Print AppearanceDictionary: true Destination: 79 Annotation: Subtype: Link Rect: 396, 294, 401, 304 Flags: Print AppearanceDictionary: true Destination: 79 Annotation: Subtype: Link Rect: 468, 246, 478, 256 Flags: Print AppearanceDictionary: true Destination: 79 Annotation: Subtype: Link Rect: 498, 234, 502, 244 Flags: Print AppearanceDictionary: true Destination: 79 Annotation: Subtype: Link Rect: 507, 234, 517, 244 Flags: Print AppearanceDictionary: true Destination: 79 Annotation: Subtype: Link Rect: 508, 222, 518, 232 Flags: Print AppearanceDictionary: true Destination: 79 Annotation: Subtype: Link Rect: 523, 222, 533, 232 Flags: Print AppearanceDictionary: true Destination: 79 Annotation: Subtype: Link Rect: 351, 174, 361, 184 Flags: Print AppearanceDictionary: true Destination: 79 Annotation: Subtype: Link Rect: 366, 174, 375, 184 Flags: Print AppearanceDictionary: true Destination: 79 Annotation: Subtype: Link Rect: 114, 126, 169, 134 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 239, 65, 357, 72 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 182, 41, 321, 48 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 86, 501, 149, 510 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 146, 417, 156, 426 Flags: Print AppearanceDictionary: true Destination: 99 Annotation: Subtype: Link Rect: 149, 201, 158, 210 Flags: Print AppearanceDictionary: true Destination: 99 Annotation: Subtype: Link Rect: 429, 363, 439, 372 Flags: Print AppearanceDictionary: true Destination: 99 Annotation: Subtype: Link Rect: 383, 255, 392, 264 Flags: Print AppearanceDictionary: true Destination: 99 Annotation: Subtype: Link Rect: 493, 243, 503, 252 Flags: Print AppearanceDictionary: true Destination: 99 Annotation: Subtype: Link Rect: 438, 69, 448, 78 Flags: Print AppearanceDictionary: true Destination: 99 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 187, 609, 197, 618 Flags: Print AppearanceDictionary: true Destination: 99 Annotation: Subtype: Link Rect: 227, 369, 232, 378 Flags: Print AppearanceDictionary: true Destination: 43 Annotation: Subtype: Link Rect: 157, 345, 175, 354 Flags: Print AppearanceDictionary: true Destination: 71 Annotation: Subtype: Link Rect: 206, 345, 211, 354 Flags: Print AppearanceDictionary: true Destination: 43 Annotation: Subtype: Link Rect: 99, 297, 168, 306 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 78, 273, 95, 282 Flags: Print AppearanceDictionary: true Destination: 71 Annotation: Subtype: Link Rect: 126, 273, 131, 282 Flags: Print AppearanceDictionary: true Destination: 43 Annotation: Subtype: Link Rect: 343, 597, 348, 606 Flags: Print AppearanceDictionary: true Destination: 71 Annotation: Subtype: Link Rect: 329, 321, 334, 330 Flags: Print AppearanceDictionary: true Destination: 79 Annotation: Subtype: Link Rect: 339, 321, 349, 330 Flags: Print AppearanceDictionary: true Destination: 79 Annotation: Subtype: Link Rect: 452, 285, 462, 294 Flags: Print AppearanceDictionary: true Destination: 79 Annotation: Subtype: Link Rect: 468, 285, 478, 294 Flags: Print AppearanceDictionary: true Destination: 79 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 528, 129, 533, 138 Flags: Print AppearanceDictionary: true Destination: 79 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 183, 597, 193, 606 Flags: Print AppearanceDictionary: true Destination: 79 Annotation: Subtype: Link Rect: 198, 597, 208, 606 Flags: Print AppearanceDictionary: true Destination: 99 Thumb: true Page: Sequence: 6 Thumb: true Checksum: 98f72608 Type: CRC32 Checksum: 54733b819e455426ae5d8cfd51d380e3 Type: MD5 Checksum: bf20571bb83e6a1411a007c98597537464f6a7ef Type: SHA-1 Checksum: 295653e8ec4cd1b54c59ec9198acc91f6156815e4467283ebee7d565c8bdcece Type: SHA-256