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Title:          Cytoplasmic cyclin D1 controls the migration and invasiveness of mantle lymphoma cells
Subject:        Scientific Reports, doi:10.1038/s41598-017-14222-1
Keywords:       
Author:         Simon Body
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     Item: 
      Title: Cytoplasmic cyclin D1 controls the migration and invasiveness of mantle lymphoma cells
      Children: 
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Cyclin D1 accumulates in the cytoplasm in a subset of MCL lines and primary tumours. 
         Item: 
          Title: Cytoplasmic cyclin D1 is a marker of MCL aggressiveness. 
         Item: 
          Title: A proteomic-based interactome analysis reveals an extensive network of cyclin D1-interacting proteins. 
         Item: 
          Title: The set of cytosolic partners of cyclin D1 is enriched in structural proteins. 
         Item: 
          Title: Cytoplasmic cyclin D1 controls MCL migration and invasion, but not adhesion. 
         Item: 
          Title: MCL cell lines have different engraftment kinetics in xenograft models. 
         Item: 
          Title: The nuclear retention of cyclin D1 alters the invasiveness/migratory properties of MCL cells in vitro. 
         Item: 
          Title: The nuclear relocalisation of cyclin D1 alters the invasiveness/migratory properties of MCL cells in vivo. 
       Item: 
        Title: Discussion
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Antibodies. 
         Item: 
          Title: MCL patients and analysis of cyclin D1 localization. 
         Item: 
          Title: Cells culture and transfection. 
         Item: 
          Title: Transwell migration and invasion assays. 
         Item: 
          Title: Indirect immunofluorescence, F-actin staining and confocal microscopy analysis. 
         Item: 
          Title: Immunoprecipitation and immunoblotting. 
         Item: 
          Title: Affinity purification, mass spectrometry, protein characterization. 
         Item: 
          Title: Engraftment of GFP/mCherry-Luc expressing MCL cells in immunocompromised mice. 
         Item: 
          Title: Statistical analyses. 
       Item: 
        Title: Acknowledgements
       Item: 
        Title: Figure 1 Cyclin D1 may be preferentially distributed in the cytoplasm.
       Item: 
        Title: Figure 2 Cytoskeleton-associated proteins interact with cyclin D1 in JeKo1 cells.
       Item: 
        Title: Figure 3 Cytoplasmic cyclin D1 controls the invasion and migration of MCL cells in vitro.
       Item: 
        Title: Figure 4 MCL cells display variable engraftment properties.
       Item: 
        Title: Figure 5 The inhibition of cyclin D1 export impairs both the migration and invasion of MCL cells in vitro.
       Item: 
        Title: Figure 6 The inhibition of cyclin D1 export impairs MCL engraftment in vivo.
       Item: 
        Title: Table 1 Correlation between clinical/histological features and cyclin D1 localization for MCL patients.
       Item: 
        Title: Table 2 Percentage of tumour cells in various organs from control (C1-5) and KPT-330 treated (K1-5) SCID mice.
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   Type: CRC32
  Checksum: 0725fb709795381b1c6a4a1fec546a61
   Type: MD5
  Checksum: 6e19c4caf722c328dad358153ae6616f55a7588f
   Type: SHA-1
  Checksum: 780d07fd400d79a4672e48d106363db4319271fb9608ba892fe72c711ccbad65
   Type: SHA-256