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Title:          Genetic correlation between amyotrophic lateral sclerosis and schizophrenia
Subject:        Nature Communications 8,  (2017). doi:10.1038/ncomms14774
Author:         Dick Schijven
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        Title: Results
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          Title: Genetic correlation between ALS and schizophrenia
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          Title: Polygenic risk score analysis
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        Title: Figure™1Genetic correlation between ALS and eight secondary traits.Error bars indicating 95percnt confidence intervals and P-values were calculated by the LD score regression software using a block jackknife procedure. Secondary traits are: AD, AlzheimerC
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          Title: Modelling misdiagnosis and comorbidity
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        Title: Figure™2Analysis of PRS for schizophrenia in a target sample of 10,032 ALS cases and 16,627 healthy controls.P-value thresholds (PT) for schizophrenia SNPs are shown on the x axis, where the number of SNPs increases with a more lenient PT. Delta Explained
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        Title: Figure™3Odds ratio for ALS by PRS deciles for schizophrenia.The figure applies to schizophrenia P-value threshold (PT)=0.2. The PRS for this threshold were converted to ten deciles containing near identical numbers of individuals. Decile 1 contained the l
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          Title: Pleiotropic risk loci
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        Title: Discussion
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        Title: Figure™4Pleiotropy-informed ALS risk loci determined by analysis of cFDR in ALS GWAS P-values given schizophrenia GWAS P-values (cFDRALS|SCZ).Each point denotes a SNP; its x axis position corresponds to its chromosomal location and its height indicates th
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          Title: LD score regression
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          Title: Polygenic risk score analysis
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          Title: Diagnostic misclassification
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          Title: Expected comorbidity
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          Title: Pleiotropy-informed risk loci for ALS
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          Title: Data availability
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       Item: 
        Title: PhukanJ.The syndrome of cognitive impairment in amyotrophic lateral sclerosis: a population-based studyJ. Neurol. Neurosurg. Psychiatry831021082012ByrneS.Aggregation of neurologic and neuropsychiatric disease in amyotrophic lateral sclerosis kindreds: a p
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        Title: We acknowledge helpful contributions from Mr Gert Jan van de Vendel in the design and execution of PRS analyses. This study received support from the ALS Association; Fondation Thierry Latran; the Motor Neurone Disease Association of England, Wales and No
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   Type: CRC32
  Checksum: 451895eec18d2df90c8aa0d9c939dc1d
   Type: MD5
  Checksum: e5cd07f9acf3c7ec4d786f449fef9ea62efa5095
   Type: SHA-1
  Checksum: 28ad073fceafd6b2f6fe5e0817e169e40c6df52076731a506187025556d1e1d4
   Type: SHA-256