26a21e6d740f536a890782a9ab704264 289124.pdf ae51f8dab1e3095be81f62ff850895fb1c239bad 289124.pdf 3e97b290a158cda2b355655605b21899ef465479dba3089567e546134a424c60 289124.pdf Title: The Geography of the Alzheimer’s Disease Mortality in Spain: Should We Focus on Industrial Pollutants Prevention? Subject: Alzheimer’s disease (AD) has a high worldwide prevalence but little is known about its aetiology and risk factors. Recent research suggests environmental factors might increase AD risk. We aim to describe the association between AD mortality and the presence of highly polluting industry in small areas in Spain between 1999 and 2010. We calculated AD age-adjusted Standardized Mortality Ratio (SMR), stratified by sex, grouped by industrial pollution density, compared for each small area of Spain. In the small areas with the highest mortality, the SMR among women was at least 25% greater than the national average (18% in men). The distribution of AD mortality was generally similar to that of high industrial pollution (higher mortality in the north, the Mediterranean coast and in some southern areas). The risk of AD mortality among women was 140% higher (123% among men) in areas with the highest industrial density in comparison to areas without polluting industries. This study has identified a geographical pattern of small areas with higher AD mortality risk and an ecological positive association with the density of highly polluting industry. Further research is needed on the potential impact of this type of industry pollution on AD aetiology and mortality. Keywords: Alzheimer’s disease; mortality; industry Author: Èrica Martínez-Solanas, Montse Vergara-Duarte, Miquel Ortega Cerdà, Juan Carlos Martín-Sánchez, Maria Buxó, Eduard Rodríguez-Farré, Joan Benach and Glòria Pérez Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.17 CreationDate: Mon Dec 11 07:02:07 2017 CET ModDate: Mon Dec 11 07:02:07 2017 CET Custom Metadata: yes Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 5 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 425509 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JGKWBK+URWPalladioL-Ital Type 1 Custom yes yes no 48 0 BRFFUC+URWPalladioL-Bold Type 1 Custom yes yes no 49 0 IBJPOT+VnURWPalladioL-Bold Type 1 Custom yes yes no 50 0 OXBKYU+TeXGyreAdventor-Bold Type 1 Custom yes yes no 51 0 GZYJGB+URWPalladioL-Roma Type 1 Custom yes yes no 52 0 ACKGZT+VnURWPalladioL Type 1 Custom yes yes no 53 0 XAOEUN+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 58 0 ABCDEE+Palatino Linotype TrueType WinAnsi yes yes no 103 0 Times New Roman TrueType WinAnsi no no no 104 0 MBGPCK+VnURWPalladioL-Italic Type 1 Custom yes yes no 152 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-03-23 02:50:36 CET RepresentationInformation: 289124.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-03-22 12:41:17 CET Size: 425509 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはの〠 Item: Title: ごとづ〠ぇづはでひちばとどっちぬ〠いどびぴひどぢふぴどはの〠はて〠ぁぬぺとづどねづひ〙び〠いどびづちびづ〠きはひぴちぬどぴべ〠ちのつ〠ぉのつふびぴひどちぬ〠ぐはぬぬふぴどはの〠 Item: Title: ごとづ〠ぁびびはっどちぴどはの〠ぢづぴぷづづの〠ぁぬぺとづどねづひ〙び〠いどびづちびづ〠きはひぴちぬどぴべ〠ちのつ〠ぉのつふびぴひどちぬ〠ぐはぬぬふぴどはの〠ぅへばはびふひづ〠 Item: Title: ぉねばぬどっちぴどはのび〠てはひ〠うふひぴとづひ〠げづびづちひっと〠 Item: Title: ぐふぢぬどっ〠えづちぬぴと〠ぐはぬどっどづび〠げづっはねねづのつちぴどはのび〠 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: JGKWBK+URWPalladioL-Ital FontSubset: true FirstChar: 2 LastChar: 241 FontDescriptor: FontName: JGKWBK+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: BRFFUC+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 122 FontDescriptor: FontName: BRFFUC+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: IBJPOT+VnURWPalladioL-Bold FontSubset: true FirstChar: 145 LastChar: 226 FontDescriptor: FontName: IBJPOT+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: OXBKYU+TeXGyreAdventor-Bold FontSubset: true FirstChar: 68 LastChar: 73 FontDescriptor: FontName: OXBKYU+TeXGyreAdventor-Bold Flags: Symbolic FontBBox: -679, -304, 1661, 1236 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: GZYJGB+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 241 FontDescriptor: FontName: GZYJGB+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: ACKGZT+VnURWPalladioL FontSubset: true FirstChar: 160 LastChar: 243 FontDescriptor: FontName: ACKGZT+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: MBGPCK+VnURWPalladioL-Italic FontSubset: true FirstChar: 129 LastChar: 226 FontDescriptor: FontName: MBGPCK+VnURWPalladioL-Italic Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 75, 757, 216, 793 Annotation: Subtype: Link Rect: 474, 757, 519, 793 Annotation: Subtype: Link Rect: 197, 641, 209, 656 Annotation: Subtype: Link Rect: 328, 641, 341, 656 Annotation: Subtype: Link Rect: 212, 628, 225, 643 Annotation: Subtype: Link Rect: 493, 628, 506, 643 Annotation: Subtype: Link Rect: 390, 92, 397, 101 ActionDest: 149 Annotation: Subtype: Link Rect: 165, 38, 262, 50 Annotation: Subtype: Link Rect: 389, 38, 519, 50 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 168, 729, 175, 738 ActionDest: 149 Annotation: Subtype: Link Rect: 175, 729, 182, 738 ActionDest: 149 Annotation: Subtype: Link Rect: 98, 715, 105, 724 ActionDest: 149 Annotation: Subtype: Link Rect: 105, 715, 112, 724 ActionDest: 149 Annotation: Subtype: Link Rect: 410, 702, 417, 711 ActionDest: 149 Annotation: Subtype: Link Rect: 417, 702, 424, 711 ActionDest: 149 Annotation: Subtype: Link Rect: 453, 634, 460, 643 ActionDest: 149 Annotation: Subtype: Link Rect: 493, 580, 500, 589 ActionDest: 149 Annotation: Subtype: Link Rect: 235, 499, 242, 508 ActionDest: 149 Annotation: Subtype: Link Rect: 313, 359, 320, 371 ActionDest: 97 Annotation: Subtype: Link Rect: 109, 170, 116, 182 ActionDest: 97 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 127, 324, 134, 336 ActionDest: 97 Annotation: Subtype: Link Rect: 119, 81, 126, 90 ActionDest: 149 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 283, 729, 295, 738 ActionDest: 149 Annotation: Subtype: Link Rect: 485, 715, 497, 724 ActionDest: 149 Annotation: Subtype: Link Rect: 168, 702, 180, 711 ActionDest: 149 Annotation: Subtype: Link Rect: 273, 688, 285, 697 ActionDest: 149 Annotation: Subtype: Link Rect: 186, 594, 198, 603 ActionDest: 149 Annotation: Subtype: Link Rect: 133, 526, 145, 535 ActionDest: 149 Annotation: Subtype: Link Rect: 456, 351, 468, 360 ActionDest: 149 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 172, 657, 209, 667 Annotation: Subtype: Link Rect: 304, 618, 342, 629 Annotation: Subtype: Link Rect: 348, 618, 384, 629 Annotation: Subtype: Link Rect: 100, 593, 137, 603 Annotation: Subtype: Link Rect: 143, 593, 179, 603 Annotation: Subtype: Link Rect: 100, 554, 137, 564 Annotation: Subtype: Link Rect: 143, 554, 179, 564 Annotation: Subtype: Link Rect: 248, 514, 346, 525 Annotation: Subtype: Link Rect: 172, 451, 209, 461 Annotation: Subtype: Link Rect: 216, 451, 252, 461 Annotation: Subtype: Link Rect: 234, 398, 271, 409 Annotation: Subtype: Link Rect: 278, 398, 314, 409 Annotation: Subtype: Link Rect: 430, 372, 467, 383 Annotation: Subtype: Link Rect: 474, 372, 510, 383 Annotation: Subtype: Link Rect: 311, 347, 349, 358 Annotation: Subtype: Link Rect: 355, 347, 391, 358 Annotation: Subtype: Link Rect: 100, 309, 137, 319 Annotation: Subtype: Link Rect: 143, 309, 179, 319 Annotation: Subtype: Link Rect: 378, 282, 416, 293 Annotation: Subtype: Link Rect: 422, 282, 458, 293 Annotation: Subtype: Link Rect: 76, 240, 166, 271 Annotation: Subtype: Link Rect: 234, 234, 424, 245 Checksum: ddffd31b Type: CRC32 Checksum: 26a21e6d740f536a890782a9ab704264 Type: MD5 Checksum: ae51f8dab1e3095be81f62ff850895fb1c239bad Type: SHA-1 Checksum: 3e97b290a158cda2b355655605b21899ef465479dba3089567e546134a424c60 Type: SHA-256