ebd59c20b6fca47db59a635f8aa7e1da pmc_28914822.pdf f8f024ece829e015cb63d23570b943b81df26551 pmc_28914822.pdf 8cd70d560da79c90f2b78e9fcb0df76f4dc4c5aed62778fd8fea4c827021962f pmc_28914822.pdf Title: Cytotoxic Evaluation of (2S)-5,7-Dihydroxy-6-prenylflavanone Derivatives Loaded PLGA Nanoparticles against MiaPaCa-2 Cells Subject: The search for new alternatives for the prevention and treatment of cancer is extremely important to minimize human mortality. Natural products are an alternative to chemical drugs, since they are a source of many potential compounds with anticancer properties. In the present study, the (2S)-5,7-dihydroxy-6-prenylflavanone (semi-systematic name), also called (2S)-5,7-dihydroxy-6-(3-methyl-2-buten-1-yl)-2-phenyl-2,3-dihydro-4H-1-Benzopyran-4-one (CAS Name registered) (1) was isolated from Eysenhardtia platycarpa leaves. This flavanone 1 was considered as the lead compound to generate new cytotoxic derivatives 1a, 1b, 1c and 1d. These compounds 1, 1a, 1b, 1c, and 1d were then loaded in nanosized drug delivery systems such as polymeric nanoparticles (NPs). Small homogeneous spherical shaped NPs were obtained. Cytotoxic activity of free compounds 1, 1a, 1b, 1c, and 1d and encapsulated in polymeric NPs (NPs1, NPs1a, NPs1b, NPs1c and NPs1d) were evaluated against the pancreatic cancer cell line MiaPaCa-2. The obtained results demonstrated that NPs1a and NPs1b exhibited optimal cytotoxicity, and an even higher improvement of the cytotoxic efficacy was exhibited with the encapsulation of 1a. Based on these results, NPs1a were proposed as promising anticancer agent candidates. Keywords: flavanone; Eysenhardtia; cytotoxic activity; MiaPaCa-2 Author: Berenice Andrade-Carrera, Beatriz Clares, Véronique Noé, Mireia Mallandrich, Ana C. Calpena, María Luisa García and María Luisa Garduño-Ramírez Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.17 CreationDate: Wed Sep 20 07:55:49 2017 CEST ModDate: Wed Sep 20 07:55:49 2017 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 21 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 4984564 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OOZPZQ+URWPalladioL-Ital Type 1 Custom yes yes no 145 0 KNNUVC+URWPalladioL-Bold Type 1 Custom yes yes no 146 0 RBBFCD+URWPalladioL-BoldItal Type 1 Custom yes yes no 147 0 OXBKYU+TeXGyreAdventor-Bold Type 1 Custom yes yes no 148 0 YSPQJI+VnURWPalladioL-Bold Type 1 Custom yes yes no 149 0 VNGAJG+URWPalladioL-Roma Type 1 Custom yes yes no 150 0 EIFDAO+VnURWPalladioL Type 1 Custom yes yes no 151 0 PUSVWS+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 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yes no 872 0 MPUDFL+PazoMath Type 1 Builtin yes yes no 906 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-02-08 02:57:51 CET RepresentationInformation: pmc_28914822.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2018-12-31 03:36:59 CET Size: 4984564 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはの〠 Item: Title: げづびふぬぴび〠ちのつ〠いどびっふびびどはの〠 Children: Item: Title: ぃとづねどっちぬ〠ぃとちひちっぴづひどぺちぴどはの〠 Item: Title: ぐとちひねちっはねはつふぬちぴどはの〠 Children: Item: Title: ぅびぴづひどてどっちぴどはの〠 Item: Title: きづぴとべぬちぴどはの〠 Item: Title: ぃべっぬどぺちぴどはの〠 Item: Title: ざどのべぬはではふび〭ぃべっぬどぺちぴどはの〠 Item: Title: ぃべぴはぴはへどっ〠ぁびびちべ〠はて〠うひづづ〠ぃはねばはふのつび〠 Children: Item: Title: あひどのづ〠ことひどねば〠〨ぁひぴづねどち〠びちぬどのち〩〠 Item: Title: ぃづぬぬ〠ざどちぢどぬどぴべ〠きどちぐちぃち〭〲〠ぃづぬぬび〠 Item: Title: ぐがぇぁ〠ぎぐび〠 Item: Title: ぃべぴはぴはへどっ〠ぁっぴどぶどぴべ〠はて〠ぎぐび〠 Item: Title: きちぴづひどちぬび〠ちのつ〠きづぴとはつび〠 Children: Item: Title: ぐぬちのぴ〠きちぴづひどちぬ〠 Item: Title: きちぴづひどちぬび〠ちのつ〠ぉのびぴひふねづのぴちぴどはの〠 Item: Title: ぐひづばちひちぴどはの〠はて〠きづぴとちのはぬどっ〠ぅへぴひちっぴ〠 Item: Title: ぉびはぬちぴどはの〠はて〠ぃはねばはふのつ〠〨〲こ〩〭〵〬〷〭いどとべつひはへべ〭〶〭〨〳〭ねづぴとべぬ〭〲〭ぢふぴづの〭〱〭べぬ〩〭〲〭ばとづのべぬ〭〲〬〳〭つどとべつひは〭〴え〭〱〭〠ぢづのぺはばべひちの〭〴〭はのづ〠〨〱〩〠 Item: Title: ぐひづばちひちぴどはの〠はて〠いづひどぶちぴどぶづび〠 Item: Title: ぐひづばちひちぴどはのび〠ぐがぇぁ〠ぎぐび〠 Children: Item: Title: ぐちひぴどっぬづ〠こどぺづ〠ぁのちぬべびどび〠 Item: Title: ずづぴち〠ぐはぴづのぴどちぬ〠きづちびふひづねづのぴび〠 Item: Title: きはひばとはぬはでどっちぬ〠こぴふつどづび〠 Item: Title: ぅのぴひちばねづのぴ〠ぅててどっどづのっべ〠〨ぅぅ〠〥〩〠 Item: Title: ぃべぴはぴはへどっ〠ぁびびちべび〠 Children: Item: Title: あひどのづ〠ことひどねば〬〠ぁひぴづねどち〠びちぬどのち〠ぁびびちべ〠 Item: Title: ぃづぬぬ〠ぃふぬぴふひづ〠 Item: Title: ぃづぬぬ〠ざどちぢどぬどぴべ〠こぴふつどづび〠 Item: Title: いちぴち〠ぁのちぬべびどび〠 Item: Title: ぃはのっぬふびどはのび〠 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