b3f96bf42774dcfc7e8744c2fa30de25 289152.pdf 0decc3732865a4b3ffd2a25568c80c72d2505a83 289152.pdf d8c1307e6480255c24ec1b80f6176541c4b82e85b4faff19cce5207e358df208 289152.pdf Title: A Novel Role For Nanog As An Early Cancer Risk Marker In Patients With Laryngeal Precancerous Lesions Subject: Scientific Reports, doi:10.1038/s41598-017-11709-9 Keywords: Author: Juan P. Rodrigo Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Sat Sep 2 00:56:44 2017 CEST ModDate: Tue Sep 5 12:53:23 2017 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 7 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1556462 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- TXNZVB+Corbel CID TrueType Identity-H yes yes yes 244 0 YHMUUL+Corbel-BoldItalic Type 1C WinAnsi yes yes yes 245 0 MinionPro-Regular Type 1C Custom yes no yes 23 0 BLOKUG+Corbel-Bold2 Type 1C WinAnsi yes yes yes 20 0 MinionPro-It Type 1C Custom yes no yes 19 0 NITFAW+Corbel2 Type 1C WinAnsi yes yes yes 22 0 IUZGXX+Corbel-Bold CID TrueType Identity-H yes yes yes 246 0 EuclidSymbol-Bold Type 1C Custom yes no yes 247 0 LNYZNR+TimesNewRomanPSMT Type 1C WinAnsi yes yes yes 248 0 BLOKUG+Corbel-Bold2 Type 1C WinAnsi yes yes yes 172 0 NITFAW+Corbel2 Type 1C WinAnsi yes yes yes 173 0 TXNZVB+Corbel CID TrueType Identity-H yes yes yes 286 0 MyriadPro-It Type 1C WinAnsi yes no yes 175 0 MinionPro-Bold Type 1C WinAnsi yes no yes 18 0 EuclidSymbol Type 1C Custom yes no yes 21 0 BLOKUG+Corbel-Bold2 Type 1C WinAnsi yes yes yes 161 0 NITFAW+Corbel2 Type 1C WinAnsi yes yes yes 152 0 TXNZVB+Corbel CID TrueType Identity-H yes yes yes 146 0 MyriadPro-It Type 1C WinAnsi yes no yes 158 0 MinionPro-BoldIt Type 1C WinAnsi yes no yes 51 0 TXNZVB+Corbel CID TrueType Identity-H yes yes yes 174 0 QNNKFH+STIXGeneral-Regular Type 1C WinAnsi yes yes yes 127 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-02-22 02:47:58 CET RepresentationInformation: 289152.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-02-21 11:32:09 CET Size: 1556462 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 322 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: A Novel Role For Nanog As An Early Cancer Risk Marker In Patients With Laryngeal Precancerous Lesions Children: Item: Title: Results Children: Item: Title: NANOG protein expression in the early stages of laryngeal tumorigenesis. Item: Title: Associations with laryngeal cancer risk. Item: Title: Multicenter validation of NANOG as cancer risk marker. Item: Title: Discussion Item: Title: Methods Children: Item: Title: Patients and tissue specimens. Item: Title: Immunohistochemistry. Item: Title: Statistical analysis. Item: Title: Acknowledgements Item: Title: Figure 1 Immunohistochemical analysis of NANOG expression in laryngeal dysplasias. Item: Title: Figure 2 Kaplan-Meier cancer-free survival curves in the exploratory series of 82 patients with laryngeal dysplasias categorized by NANOG protein scores (A) or NANOG protein expression dichotomized as strong (score 2) versus negative to moderate expressio Item: Title: Table 1 Evolution of the premalignant lesions in relation to histopathological diagnosis and NANOG protein expression. Item: Title: Table 2 Univariate Cox Proportional Hazards Model to Estimate Laryngeal Cancer Risk in the exploratory cohort. Item: Title: Table 3 Univariate Cox Proportional Hazards Model to Estimate Laryngeal Cancer Risk in the validation cohort. Info: Title: A Novel Role For Nanog As An Early Cancer Risk Marker In Patients With Laryngeal Precancerous Lesions Author: Juan P. 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Rodrigo M. amp#x000C1;ngeles Villaronga Sofamp#x000ED;a T. Menamp#x000E9;ndez Francisco Hermida-Prado Miquel Quer Isabel Vilaseca Eva Allonca Daniel Pedregal Mallo Aurora Astudillo Juana M. Garcamp#x000ED;a-Pedrero 10.1038/s41598-017-11709-9 http://dx.doi.org/10.1038/s41598-017-11709-9 journal Scientific Reports © 0, The Author(s) 2045-2322 10.1038/s41598-017-11709-9 Springer 2017-09-05T12:53:23+02:00 2017-09-02T04:26:44+05:30 2017-09-05T12:53:23+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) VoR uuid:fd07caad-73ca-451f-a184-2c7d1596140b uuid:c2c23085-a56b-4eba-94b6-461caafeb2d6 default 1 converted uuid:4dae679e-0375-437c-aa2f-ef1674130a99 converted to PDF/A-2b pdfToolbox 2017-09-02T04:27:20+05:30 2 B http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. 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