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Title:          Hyperspectral Raman imaging of neuritic plaques and neurofibrillary tangles in brain tissue from Alzheimer’s disease patients
Subject:        Scientific Reports, doi:10.1038/s41598-017-16002-3
Keywords:       
Author:         Ralph Michael
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     Item: 
      Title: Hyperspectral Raman imaging of neuritic plaques and neurofibrillary tangles in brain tissue from Alzheimer’s disease patien ...
      Children: 
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Comparison with histology. 
         Item: 
          Title: Tissue component distribution. 
         Item: 
          Title: Cluster analysis. 
       Item: 
        Title: Discussion
       Item: 
        Title: Conclusion
       Item: 
        Title: Materials and Methods
        Children: 
         Item: 
          Title: Brain donor information. 
         Item: 
          Title: Tissue preparation. 
         Item: 
          Title: Raman spectroscopy. 
         Item: 
          Title: Tissue component analysis. 
         Item: 
          Title: Cluster analysis. 
         Item: 
          Title: Data Availability. 
       Item: 
        Title: Acknowledgements
       Item: 
        Title: Figure 1 Comparison of the Raman microscopy results with conventionally stained brain sections.
       Item: 
        Title: Figure 2 White light images and spatial intensity distributions of Raman signals for β-sheets, proteins, lipids, water, broad-band autofluorescence and protein-to-lipid ratio, β-sheet-to lipid ratio and β-sheets-to-protein ratio.
       Item: 
        Title: Figure 3 Intensity profiles of different tissue components from two samples shown in Fig.
       Item: 
        Title: Figure 4 Raman scatter plots showing the spatial correlation of proteins, β-sheets, lipids and autofluorescence.
       Item: 
        Title: Figure 5 Hierarchical 2, 4 and 8 cluster analysis in the fingerprint Raman shift region (700–1800 cm−1) of one tissue sample (29F3).
       Item: 
        Title: Figure 6 Combined hierarchical 4 cluster analysis of all 12 samples together.
       Item: 
        Title: Figure 7 Detailed view of the Raman spectral regions between 650 and 750 cm−1 and between fingerprint region between 950 and 1500 cm−1 of the combined hierarchical 4 cluster analysis shown in Fig.
       Item: 
        Title: Table 1 Raman intensities in photons per wavenumber for β-sheets, proteins, lipids, water, broad-band autofluorescence and protein-to-lipid ratio, β-sheet-to lipid ratio and β-sheets-to-protein ratio.
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The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
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                  </pdfaSchema:property>
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