5fccafae159cf24fd9799d8272e8bb2c  pmc_29326609.pdf
6b0dacb1ee26ccbd6a604c051475ea8fac518398  pmc_29326609.pdf
2cdac4a58374ef9bea979c4bdc67b91c8354260c85d54501ae2d761e04da7fce  pmc_29326609.pdf

Title:          A Biomarker to Differentiate between Primary and Cocaine-Induced Major Depression in Cocaine Use Disorder: The Role of Platelet IRAS/Nischarin (I1-Imidazoline Receptor)
Subject:        The association of cocaine use disorder (CUD) and comorbid major depressive disorder (MDD; CUD/MDD) is characterized by high prevalence and poor treatment outcomes.
Keywords:       platelet biomarker, IRAS/nischarin, cocaine use disorder, major depressive disorder, cocaine-induced depression, acute tryptophan depletion, antidepressant drugs
Author:         Jesús A. García-Sevilla and Marta Torrens
Creator:        Adobe InDesign CS6 (Windows)
Producer:       Adobe PDF Library 10.0.1
CreationDate:   Wed Nov 29 09:05:53 2017 CET
ModDate:        Wed Nov 29 10:05:05 2017 CET
Tagged:         yes
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          9
Encrypted:      no
Page size:      595.276 x 779.528 pts
Page rot:       0
File size:      853253 bytes
Optimized:      yes
PDF version:    1.6


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
TZRSCC+HelveticaNeueLTStd-Lt         Type 1C           Custom           yes yes yes    466  0
NQUIWO+HelveticaNeueLTStd-Bd         Type 1C           Custom           yes yes yes    469  0
GDDSCC+HelveticaNeueLTStd-BdIt       Type 1C           WinAnsi          yes yes yes    471  0
CXFUYK+HelveticaNeueLTStd-LtIt       Type 1C           Custom           yes yes yes    474  0
THPSCC+HelveticaNeueLTStd-MdIt       Type 1C           WinAnsi          yes yes yes    476  0
LVTRUS+STIXGeneral-Regular           Type 1C           Custom           yes yes yes    479  0
UTCTQA+MinionPro-Regular             Type 1C           Custom           yes yes yes    482  0
BORJKM+STIXGeneral-Bold              Type 1C           WinAnsi          yes yes yes    382  0
ZLNXIQ+MinionPro-Bold                Type 1C           Custom           yes yes yes    379  0
TZRSCC+HelveticaNeueLTStd-Lt         Type 1C           WinAnsi          yes yes yes    378  0
VAPZEY+MinionPro-It                  Type 1C           Custom           yes yes yes    384  0
TZRSCC+HelveticaNeueLTStd-Lt         Type 1C           WinAnsi          yes yes yes    383  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-05-30 02:37:11 CEST
 RepresentationInformation: pmc_29326609.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2018-03-05 03:51:04 CET
  Size: 853253
  Format: PDF
  Version: 1.6
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF, Tagged PDF
  PDFMetadata: 
   Objects: 0
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Outlines: 
     Item: 
      Title: A Biomarker to Differentiate between Primary and Cocaine-Induced Major Depression in Cocaine Use Disorder: The Role of Platele琀 䤀刀䄀匀⼀一椀猀挀栀愀爀椀渀 䤀㄀ⴀ䤀洀椀搀愀稀漀氀椀渀攀 刀攀挀攀瀀琀漀爀㸾㰼⽄⡦灳祴ⴰ㠭〰㈵㠮楮摤㨮㐱㈸〺㜲ㄩ⽓⽇潔漾㸼㰯䄠㔵㠠〠刯乥硴‵㌵‰⁒⽐慲敮琠㔱㔠〠刯呩瑬攨䥮瑲潤畣瑩潮
      Children: 
       Item: 
        Title: Introduction
       Item: 
        Title: Materials and Methods
        Children: 
         Item: 
          Title: Subjects and Recruitment
         Item: 
          Title: Clinical Assessments
         Item: 
          Title: Psychiatric Research Interview for Substance Use and Mental Disorders (PRISM)
         Item: 
          Title: Acute Tryptophan Depletion Test
         Item: 
          Title: Blood/Platelet Samples
         Item: 
          Title: Platelet Membrane Preparation
         Item: 
          Title: Immunoblot Assays and Quantification 
of Target Protein Contents
         Item: 
          Title: Data and Statistical Analysis
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Sociodemographic, Clinical Characteristics, and the Acute Trp Depletion Test
         Item: 
          Title: Platelet 5-HT2A Receptor in CUD/MDD Patients: Basal Receptor Contents and Effects of ATD and AD
         Item: 
          Title: Platelet IRAS/Nischarin in CUD/MDD Patients: Basal Protein Content and Effects of ATD and AD
       Item: 
        Title: Discussion
        Children: 
         Item: 
          Title: Limitations
       Item: 
        Title: Conclusion
       Item: 
        Title: Ethics Statement
       Item: 
        Title: Author Contributions
       Item: 
        Title: Acknowledgments
       Item: 
        Title: References
   Filters: 
    FilterPipeline: FlateDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1415
      ImageHeight: 1610
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1654
      ImageHeight: 1180
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: VAPZEY+MinionPro-It
      FontSubset: true
      FirstChar: 29
      LastChar: 237
      FontDescriptor: 
       FontName: VAPZEY+MinionPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -201, -360, 1684, 1002
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: UTCTQA+MinionPro-Regular
      FontSubset: true
      FirstChar: 21
      LastChar: 243
      FontDescriptor: 
       FontName: UTCTQA+MinionPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -290, -360, 1684, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: TZRSCC+HelveticaNeueLTStd-Lt
      FontSubset: true
      FirstChar: 30
      LastChar: 150
      FontDescriptor: 
       FontName: TZRSCC+HelveticaNeueLTStd-Lt
       Flags: Nonsymbolic
       FontBBox: -166, -214, 1050, 967
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: NQUIWO+HelveticaNeueLTStd-Bd
      FontSubset: true
      FirstChar: 30
      LastChar: 122
      FontDescriptor: 
       FontName: NQUIWO+HelveticaNeueLTStd-Bd
       Flags: Nonsymbolic
       FontBBox: -166, -218, 1078, 975
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GDDSCC+HelveticaNeueLTStd-BdIt
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: GDDSCC+HelveticaNeueLTStd-BdIt
       Flags: Nonsymbolic, Italic
       FontBBox: -166, -218, 1129, 975
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: CXFUYK+HelveticaNeueLTStd-LtIt
      FontSubset: true
      FirstChar: 30
      LastChar: 250
      FontDescriptor: 
       FontName: CXFUYK+HelveticaNeueLTStd-LtIt
       Flags: Nonsymbolic, Italic
       FontBBox: -165, -214, 1099, 951
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ZLNXIQ+MinionPro-Bold
      FontSubset: true
      FirstChar: 30
      LastChar: 117
      FontDescriptor: 
       FontName: ZLNXIQ+MinionPro-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -319, -360, 1684, 1024
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: THPSCC+HelveticaNeueLTStd-MdIt
      FontSubset: true
      FirstChar: 32
      LastChar: 250
      FontDescriptor: 
       FontName: THPSCC+HelveticaNeueLTStd-MdIt
       Flags: Nonsymbolic, Italic
       FontBBox: -165, -218, 1125, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: BORJKM+STIXGeneral-Bold
      FontSubset: true
      FirstChar: 61
      LastChar: 61
      FontDescriptor: 
       FontName: BORJKM+STIXGeneral-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -998, -455, 2000, 1055
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: LVTRUS+STIXGeneral-Regular
      FontSubset: true
      FirstChar: 28
      LastChar: 215
      FontDescriptor: 
       FontName: LVTRUS+STIXGeneral-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -443, 2000, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 4.2.1-c043 52.372728, 2009/01/18-15:08:04        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
            xmlns:stRef="http://ns.adobe.com/xap/1.0/sType/ResourceRef#"
            xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#">
         <xmpMM:InstanceID>uuid:39ebd7fd-8de9-49e5-b0bb-17c4d8d0e01a</xmpMM:InstanceID>
         <xmpMM:OriginalDocumentID>adobe:docid:indd:7b7f4af8-a1e4-11dd-855d-ca4c1b90e82f</xmpMM:OriginalDocumentID>
         <xmpMM:DocumentID>xmp.id:B5123C1BDCD4E71197C6C98D3578F5BC</xmpMM:DocumentID>
         <xmpMM:RenditionClass>proof:pdf</xmpMM:RenditionClass>
         <xmpMM:DerivedFrom rdf:parseType="Resource">
            <stRef:instanceID>xmp.iid:B4123C1BDCD4E71197C6C98D3578F5BC</stRef:instanceID>
            <stRef:documentID>xmp.did:010E567DA297E7119799D464E3002523</stRef:documentID>
            <stRef:originalDocumentID>adobe:docid:indd:7b7f4af8-a1e4-11dd-855d-ca4c1b90e82f</stRef:originalDocumentID>
            <stRef:renditionClass>default</stRef:renditionClass>
         </xmpMM:DerivedFrom>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:parameters>from application/x-indesign to application/pdf</stEvt:parameters>
                  <stEvt:softwareAgent>Adobe InDesign CS6 (Windows)</stEvt:softwareAgent>
                  <stEvt:changed>/</stEvt:changed>
                  <stEvt:when>2017-11-29T13:35:53+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreateDate>2017-11-29T13:35:53+05:30</xmp:CreateDate>
         <xmp:ModifyDate>2017-11-29T14:35:05+05:30</xmp:ModifyDate>
         <xmp:MetadataDate>2017-11-29T14:35:05+05:30</xmp:MetadataDate>
         <xmp:CreatorTool>Adobe InDesign CS6 (Windows)</xmp:CreatorTool>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">A Biomarker to Differentiate between Primary and Cocaine-Induced Major Depression in Cocaine Use Disorder: The Role of Platelet IRAS/Nischarin (I1-Imidazoline Receptor)</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">The association of cocaine use disorder (CUD) and comorbid major depressive disorder (MDD; CUD/MDD) is characterized by high prevalence and poor treatment outcomes.</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Jesús A. García-Sevilla and Marta Torrens</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>platelet biomarker</rdf:li>
               <rdf:li>IRAS/nischarin</rdf:li>
               <rdf:li>cocaine use disorder</rdf:li>
               <rdf:li>major depressive disorder</rdf:li>
               <rdf:li>cocaine-induced depression</rdf:li>
               <rdf:li>acute tryptophan depletion</rdf:li>
               <rdf:li>antidepressant drugs</rdf:li>
            </rdf:Bag>
         </dc:subject>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>Adobe PDF Library 10.0.1</pdf:Producer>
         <pdf:Trapped>False</pdf:Trapped>
         <pdf:Keywords>platelet biomarker, IRAS/nischarin, cocaine use disorder, major depressive disorder, cocaine-induced depression, acute tryptophan depletion, antidepressant drugs</pdf:Keywords>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 43, 755, 146, 717
      Annotation: 
       Subtype: Link
       Rect: 519, 708, 551, 676
      Annotation: 
       Subtype: Link
       Rect: 424, 38, 549, 30
      Annotation: 
       Subtype: Link
       Rect: 474, 744, 549, 736
      Annotation: 
       Subtype: Link
       Rect: 458, 736, 549, 728
      Annotation: 
       Subtype: Link
       Rect: 455, 728, 549, 720
      Annotation: 
       Subtype: Link
       Rect: 45, 38, 108, 30
      Annotation: 
       Subtype: Link
       Rect: 116, 38, 173, 30
      Annotation: 
       Subtype: Link
       Rect: 87, 552, 158, 543
      Annotation: 
       Subtype: Link
       Rect: 77, 403, 156, 395
      Annotation: 
       Subtype: Link
       Rect: 68, 383, 158, 375
      Annotation: 
       Subtype: Link
       Rect: 77, 73, 158, 65
      Annotation: 
       Subtype: Link
       Rect: 175, 661, 549, 636
      Annotation: 
       Subtype: Link
       Rect: 175, 638, 543, 613
      Annotation: 
       Subtype: Link
       Rect: 175, 615, 549, 590
      Annotation: 
       Subtype: Link
       Rect: 175, 592, 535, 567
      Annotation: 
       Subtype: Link
       Rect: 175, 569, 422, 544
      Annotation: 
       Subtype: Link
       Rect: 175, 531, 241, 521
      Annotation: 
       Subtype: Link
       Rect: 253, 531, 358, 521
      Annotation: 
       Subtype: Link
       Rect: 363, 520, 455, 509
      Annotation: 
       Subtype: Link
       Rect: 175, 508, 271, 498
      Annotation: 
       Subtype: Link
       Rect: 289, 508, 348, 498
      Annotation: 
       Subtype: Link
       Rect: 351, 98, 355, 86
       ActionDest: 22
      Annotation: 
       Subtype: Link
       Rect: 367, 87, 372, 74
       ActionDest: 22
      Annotation: 
       Subtype: Link
       Rect: 322, 75, 327, 63
       ActionDest: 22
      Annotation: 
       Subtype: Link
       Rect: 331, 75, 336, 63
       ActionDest: 25
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 45, 38, 108, 30
      Annotation: 
       Subtype: Link
       Rect: 116, 38, 173, 30
      Annotation: 
       Subtype: Link
       Rect: 424, 38, 549, 30
      Annotation: 
       Subtype: Link
       Rect: 266, 685, 270, 672
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 48, 662, 53, 649
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 104, 662, 108, 649
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 150, 581, 154, 569
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 159, 581, 168, 569
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 209, 558, 219, 546
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 226, 558, 235, 546
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 118, 535, 128, 523
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 133, 535, 142, 523
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 247, 489, 256, 477
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 108, 443, 117, 431
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 84, 432, 93, 419
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 98, 432, 107, 419
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 165, 397, 174, 385
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 223, 294, 232, 281
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 237, 294, 246, 281
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 251, 248, 260, 235
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 309, 697, 338, 684
       ActionDest: 1
      Annotation: 
       Subtype: Link
       Rect: 329, 685, 339, 672
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 437, 639, 446, 626
       ActionDest: 25
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 45, 38, 108, 30
      Annotation: 
       Subtype: Link
       Rect: 116, 38, 173, 30
      Annotation: 
       Subtype: Link
       Rect: 424, 38, 549, 30
      Annotation: 
       Subtype: Link
       Rect: 129, 614, 138, 601
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 176, 539, 185, 526
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 115, 527, 124, 514
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 146, 470, 156, 457
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 160, 470, 169, 457
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 274, 434, 283, 421
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 82, 296, 91, 283
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 194, 181, 204, 168
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 175, 123, 184, 110
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 517, 720, 546, 706
       ActionDest: 1
      Annotation: 
       Subtype: Link
       Rect: 413, 685, 443, 672
       ActionDest: 1
      Annotation: 
       Subtype: Link
       Rect: 309, 473, 318, 460
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 323, 473, 333, 460
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 497, 213, 506, 201
       ActionDest: 25
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 45, 38, 108, 30
      Annotation: 
       Subtype: Link
       Rect: 116, 38, 173, 30
      Annotation: 
       Subtype: Link
       Rect: 424, 38, 549, 30
      Annotation: 
       Subtype: Link
       Rect: 184, 685, 193, 672
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 48, 639, 58, 626
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 64, 639, 73, 626
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 45, 628, 80, 614
       ActionDest: 9
      Annotation: 
       Subtype: Link
       Rect: 126, 616, 136, 603
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 141, 616, 150, 603
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 309, 708, 318, 695
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 323, 708, 333, 695
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 392, 696, 402, 684
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 408, 696, 418, 684
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 338, 605, 368, 592
       ActionDest: 1
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 45, 38, 108, 30
      Annotation: 
       Subtype: Link
       Rect: 116, 38, 173, 30
      Annotation: 
       Subtype: Link
       Rect: 424, 38, 549, 30
      Annotation: 
       Subtype: Link
       Rect: 229, 570, 289, 556
      Annotation: 
       Subtype: Link
       Rect: 45, 558, 154, 546
      Annotation: 
       Subtype: Link
       Rect: 238, 490, 266, 477
       ActionDest: 1
      Annotation: 
       Subtype: Link
       Rect: 161, 409, 170, 396
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 141, 276, 170, 263
       ActionDest: 1
      Annotation: 
       Subtype: Link
       Rect: 104, 242, 132, 229
       ActionDest: 1
      Annotation: 
       Subtype: Link
       Rect: 144, 122, 184, 108
       ActionDest: 9
      Annotation: 
       Subtype: Link
       Rect: 247, 87, 286, 74
       ActionDest: 9
      Annotation: 
       Subtype: Link
       Rect: 306, 685, 346, 672
       ActionDest: 9
      Annotation: 
       Subtype: Link
       Rect: 485, 662, 523, 648
       ActionDest: 9
      Annotation: 
       Subtype: Link
       Rect: 377, 628, 416, 615
       ActionDest: 9
      Annotation: 
       Subtype: Link
       Rect: 482, 605, 522, 592
       ActionDest: 9
      Annotation: 
       Subtype: Link
       Rect: 509, 570, 547, 556
       ActionDest: 9
      Annotation: 
       Subtype: Link
       Rect: 429, 536, 468, 523
       ActionDest: 9
      Annotation: 
       Subtype: Link
       Rect: 339, 390, 372, 376
       ActionDest: 17
      Annotation: 
       Subtype: Link
       Rect: 491, 367, 532, 353
       ActionDest: 17
      Annotation: 
       Subtype: Link
       Rect: 503, 344, 544, 330
       ActionDest: 17
      Annotation: 
       Subtype: Link
       Rect: 430, 298, 470, 284
       ActionDest: 17
      Annotation: 
       Subtype: Link
       Rect: 504, 275, 544, 261
       ActionDest: 17
      Annotation: 
       Subtype: Link
       Rect: 369, 229, 409, 215
       ActionDest: 17
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 45, 38, 108, 30
      Annotation: 
       Subtype: Link
       Rect: 116, 38, 173, 30
      Annotation: 
       Subtype: Link
       Rect: 424, 38, 549, 30
      Annotation: 
       Subtype: Link
       Rect: 192, 294, 201, 281
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 206, 294, 215, 281
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 80, 260, 89, 247
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 94, 260, 103, 247
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 165, 191, 205, 178
       ActionDest: 9
      Annotation: 
       Subtype: Link
       Rect: 508, 260, 517, 247
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 389, 87, 398, 74
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 391, 76, 400, 63
       ActionDest: 25
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 45, 38, 108, 30
      Annotation: 
       Subtype: Link
       Rect: 116, 38, 173, 30
      Annotation: 
       Subtype: Link
       Rect: 424, 38, 549, 30
      Annotation: 
       Subtype: Link
       Rect: 48, 708, 57, 695
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 197, 696, 206, 684
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 255, 696, 264, 684
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 171, 616, 180, 603
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 276, 466, 285, 454
       ActionDest: 28
      Annotation: 
       Subtype: Link
       Rect: 276, 443, 285, 431
       ActionDest: 28
      Annotation: 
       Subtype: Link
       Rect: 48, 374, 57, 362
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 63, 374, 73, 362
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 194, 271, 203, 258
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 207, 271, 216, 258
       ActionDest: 25
      Annotation: 
       Subtype: Link
       Rect: 66, 74, 160, 63
      Annotation: 
       Subtype: Link
       Rect: 361, 102, 457, 92
      Annotation: 
       Subtype: Link
       Rect: 447, 74, 545, 63
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 45, 38, 108, 30
      Annotation: 
       Subtype: Link
       Rect: 116, 38, 173, 30
      Annotation: 
       Subtype: Link
       Rect: 424, 38, 549, 30
      Annotation: 
       Subtype: Link
       Rect: 259, 690, 289, 680
      Annotation: 
       Subtype: Link
       Rect: 59, 681, 122, 671
      Annotation: 
       Subtype: Link
       Rect: 70, 652, 144, 642
      Annotation: 
       Subtype: Link
       Rect: 233, 576, 289, 566
      Annotation: 
       Subtype: Link
       Rect: 180, 538, 237, 528
      Annotation: 
       Subtype: Link
       Rect: 263, 500, 289, 490
      Annotation: 
       Subtype: Link
       Rect: 59, 491, 124, 481
      Annotation: 
       Subtype: Link
       Rect: 70, 443, 146, 433
      Annotation: 
       Subtype: Link
       Rect: 70, 405, 164, 395
      Annotation: 
       Subtype: Link
       Rect: 112, 377, 180, 367
      Annotation: 
       Subtype: Link
       Rect: 193, 348, 280, 338
      Annotation: 
       Subtype: Link
       Rect: 151, 310, 227, 300
      Annotation: 
       Subtype: Link
       Rect: 190, 272, 273, 262
      Annotation: 
       Subtype: Link
       Rect: 70, 244, 164, 234
      Annotation: 
       Subtype: Link
       Rect: 263, 225, 289, 215
      Annotation: 
       Subtype: Link
       Rect: 59, 215, 107, 205
      Annotation: 
       Subtype: Link
       Rect: 259, 196, 289, 186
      Annotation: 
       Subtype: Link
       Rect: 59, 187, 126, 177
      Annotation: 
       Subtype: Link
       Rect: 263, 158, 289, 148
      Annotation: 
       Subtype: Link
       Rect: 59, 149, 127, 139
      Annotation: 
       Subtype: Link
       Rect: 219, 111, 289, 101
      Annotation: 
       Subtype: Link
       Rect: 59, 101, 109, 91
      Annotation: 
       Subtype: Link
       Rect: 70, 73, 129, 63
      Annotation: 
       Subtype: Link
       Rect: 383, 681, 446, 671
      Annotation: 
       Subtype: Link
       Rect: 331, 643, 429, 633
      Annotation: 
       Subtype: Link
       Rect: 426, 595, 509, 585
      Annotation: 
       Subtype: Link
       Rect: 467, 557, 548, 547
      Annotation: 
       Subtype: Link
       Rect: 365, 510, 463, 500
      Annotation: 
       Subtype: Link
       Rect: 464, 472, 534, 462
      Annotation: 
       Subtype: Link
       Rect: 453, 443, 504, 433
      Annotation: 
       Subtype: Link
       Rect: 331, 405, 420, 395
      Annotation: 
       Subtype: Link
       Rect: 428, 367, 513, 357
      Annotation: 
       Subtype: Link
       Rect: 428, 329, 513, 319
      Annotation: 
       Subtype: Link
       Rect: 520, 301, 549, 291
      Annotation: 
       Subtype: Link
       Rect: 320, 291, 376, 281
      Annotation: 
       Subtype: Link
       Rect: 365, 244, 471, 234
      Annotation: 
       Subtype: Link
       Rect: 365, 187, 461, 177
      Annotation: 
       Subtype: Link
       Rect: 511, 168, 549, 158
      Annotation: 
       Subtype: Link
       Rect: 320, 158, 347, 148
      Annotation: 
       Subtype: Link
       Rect: 524, 139, 549, 129
      Annotation: 
       Subtype: Link
       Rect: 320, 130, 366, 120
      Annotation: 
       Subtype: Link
       Rect: 398, 111, 495, 101
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 45, 38, 108, 30
      Annotation: 
       Subtype: Link
       Rect: 116, 38, 173, 30
      Annotation: 
       Subtype: Link
       Rect: 424, 38, 549, 30
      Annotation: 
       Subtype: Link
       Rect: 259, 719, 289, 709
      Annotation: 
       Subtype: Link
       Rect: 59, 709, 130, 699
      Annotation: 
       Subtype: Link
       Rect: 108, 671, 210, 661
      Annotation: 
       Subtype: Link
       Rect: 230, 633, 289, 623
      Annotation: 
       Subtype: Link
       Rect: 59, 624, 77, 614
      Annotation: 
       Subtype: Link
       Rect: 406, 662, 548, 652
  Checksum: e03d3085
   Type: CRC32
  Checksum: 5fccafae159cf24fd9799d8272e8bb2c
   Type: MD5
  Checksum: 6b0dacb1ee26ccbd6a604c051475ea8fac518398
   Type: SHA-1