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Title:          Overlapping Effects of New Monoclonal Antibodies for Severe Asthma
Subject:        Drugs, doi:10.1007/s40265-017-0810-5
Author:         Christian Domingo
Creator:        Springer
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      Title: Overlapping Effects of New Monoclonal Antibodies for Severe Asthma
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        Title: Abstract
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       Item: 
        Title: A Brief History of Recent Developments in Severe Asthma Treatment
        Destination: Sec1
       Item: 
        Title: Pathophysiological Pathways of Asthma Susceptible to Blocking
        Destination: Sec2
        Children: 
         Item: 
          Title: The Allergic Cascade or Adaptive Immunity
          Destination: Sec3
         Item: 
          Title: Innate Immunity
          Destination: Sec4
       Item: 
        Title: The Mediators: The Interleukins
        Destination: Sec5
        Children: 
         Item: 
          Title: Interleukin 5 (IL-5)
          Destination: Sec6
         Item: 
          Title: Interleukin 33 (IL-33)
          Destination: Sec7
         Item: 
          Title: Interleukins 4 and 13 (IL-4 and IL-13)
          Destination: Sec8
       Item: 
        Title: Effector Cells
        Destination: Sec9
        Children: 
         Item: 
          Title: Classical Effector Cells: Mast Cells and Basophils
          Destination: Sec10
         Item: 
          Title: Cells with a Recently Identified Effector Role: Eosinophils and Natural Killer T Cells
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          Children: 
           Item: 
            Title: Eosinophils
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           Item: 
            Title: Natural Killer Cells
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       Item: 
        Title: The Relationship between Adaptive and Innate Immunity
        Destination: Sec14
       Item: 
        Title: Pharmacological Effects of Monoclonal Antibodies for Asthma
        Destination: Sec15
        Children: 
         Item: 
          Title: Omalizumab
          Destination: Sec16
         Item: 
          Title: Anti-IL-5: Mepolizumab and Reslizumab
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         Item: 
          Title: Agents in Late Stage of Clinical Evaluation: Benralizumab and Dupilumab
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        Title: Conclusions
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        Title: Acknowledgements
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        Title: References
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                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
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                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
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                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                           <pdfaProperty:description>Starting page</pdfaProperty:description>
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                           <pdfaProperty:description>Ending page</pdfaProperty:description>
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                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
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                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
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                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
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                           <pdfaProperty:name>Trapped</pdfaProperty:name>
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                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
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                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
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                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
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                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
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                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
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                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
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                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
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                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
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