74389d44e5d376d24fe85b48b9b5f249 PIIS2211124717309798.pdf ae091a06228f58d4007fcceadc2d0cd9ca6c4927 PIIS2211124717309798.pdf 553f2bd176eb75325ca69766da50d8d5d105b8be2708531c5dc416d7240131c2 PIIS2211124717309798.pdf Title: BMP4 Gene Therapy in Mature Mice Reduces BAT Activation but Protects from Obesity by Browning Subcutaneous Adipose Tissue Subject: CellReports, 20 (2017) 1038-1049. doi:10.1016/j.celrep.2017.07.020 Author: Jenny M. Hoffmann Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Fri Jul 28 20:56:11 2017 CEST ModDate: Sat Jul 29 07:38:19 2017 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 602.986 x 782.986 pts Page rot: 0 File size: 4869268 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KBJFOM+AdvPSHEL-B Type 1C WinAnsi yes yes no 833 0 KBJFPN+AdvPSHN-H Type 1C WinAnsi yes yes no 837 0 KBJFPO+AdvPSHN-M Type 1C MacRoman yes yes no 840 0 KBJFPP+AdvPSMPi6 Type 1C WinAnsi yes yes no 842 0 KBJGAA+AdvP4C4E59 Type 1C WinAnsi yes yes no 844 0 KBJHEI+AdvPSHN-MI Type 1C WinAnsi yes yes no 847 0 KBJHEJ+AdvPSSym Type 1C WinAnsi yes yes no 849 0 KBJFPO+AdvPSHN-M Type 1C MacRoman yes yes no 654 0 KBJFPN+AdvPSHN-H Type 1C WinAnsi yes yes no 665 0 JONJPP+AdvPSA189 Type 1C WinAnsi yes yes no 663 0 KBJGAA+AdvP4C4E59 Type 1C WinAnsi yes yes no 653 0 JONKAB+AdvPSA183 Type 1C Custom yes yes no 659 0 JONKAC+Advhelvneue-italic Type 1C WinAnsi yes yes no 668 0 JONKAD+AdvPS3F4C13 Type 1C WinAnsi yes yes no 671 0 KBJHEJ+AdvPSSym Type 1C WinAnsi yes yes no 667 0 JONKEE+AdvP4C4E74 Type 1C Custom yes yes no 691 0 JONLHN+Helvetica-Bold Type 1C WinAnsi yes yes no 703 0 JONLHO+AdvHelN-L Type 1C WinAnsi yes yes no 698 0 JONOJO+Helvetica-Bold Type 1C WinAnsi yes yes no 709 0 JONOJL+ArialMT TrueType WinAnsi yes yes no 707 0 JONOJN+Calibri TrueType WinAnsi yes yes no 716 0 JOOCCI+AdvPS4721B4 Type 1C WinAnsi yes yes no 738 0 JOOCCJ+AdvPSHN-HI Type 1C WinAnsi yes yes no 739 0 JOOFCG+AdvP7DED Type 1C WinAnsi yes yes no 775 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-01-21 02:46:56 CET RepresentationInformation: PIIS2211124717309798.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-01-18 23:45:37 CET Size: 4869268 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'mmc1' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found ID: PDF-HUL-122 Offset: 4843943 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 904 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: BMP4 Gene Therapy in Mature Mice Reduces BAT Activation but Protects from Obesity by Browning Subcutaneous Adipose Tissue Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Results Destination: flink2 Children: Item: Title: Increased Circulating BMP4 Levels in AAV-BMP4-Treated Mice Destination: slink3 Item: Title: BMP4 Prevents Obesity in High-Fat-Diet-Fed Mice and Increases Energy Expenditure Destination: slink4 Item: Title: AAV BMP4 Mice Have Improved Glucose Tolerance and Insulin Sensitivity Destination: slink5 Item: Title: Elevated BMP4 Is Associated with Increased Lipid Accumulation in BAT Destination: slink6 Item: Title: Elevated BMP4 Induces Browning of SubQ Adipose Tissue Destination: slink7 Item: Title: BMP4 Drives Browning of Differentiating Preadipocytes Destination: slink8 Item: Title: SubQ WAT of HFD-Fed BMP4 Mice Also Shows Increased Browning Destination: slink9 Children: Item: Title: BMP4-Induced Browning of the SubQ WAT in Mature Mice—a Consequence of Transdifferentiation? Destination: tlink1 Item: Title: Hypertrophic Obesity in Mice Is Characterized by Cellular BMP4 Resistance and Increased Noggin Destination: slink10 Item: Title: Discussion Destination: flink11 Item: Title: Experimental Procedures Destination: flink12 Children: Item: Title: Animals Destination: slink13 Item: Title: Recombinant AAV Vectors and In Vivo Administration Destination: slink14 Item: Title: Figures and Statistical Calculations Destination: slink15 Item: Title: Supplemental Information Destination: falink16 Item: Title: Author Contributions Destination: flink17 Item: Title: Acknowledgments Destination: acklink1 Item: Title: References Destination: blink1 Info: Title: BMP4 Gene Therapy in Mature Mice Reduces BAT Activation but Protects from Obesity by Browning Subcutaneous Adipose Tissue Author: Jenny M. 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-291, 875, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JONLHN+Helvetica-Bold FontSubset: true FirstChar: 65 LastChar: 73 FontDescriptor: FontName: JONLHN+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding TrueType: Font: BaseFont: JONOJL+ArialMT FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: JONOJL+ArialMT Flags: Nonsymbolic FontBBox: -665, -325, 2000, 1006 FontFile2: true Encoding: WinAnsiEncoding Font: BaseFont: JONOJN+Calibri FontSubset: true FirstChar: 42 LastChar: 54 FontDescriptor: FontName: JONOJN+Calibri Flags: Nonsymbolic FontBBox: -503, -307, 1240, 964 FontFile2: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.celrep.2017.07.020 BMP4 Gene Therapy in Mature Mice Reduces BAT Activation but Protects from Obesity by Browning Subcutaneous Adipose Tissue Jenny M. Hoffmann John R. Grünberg Christopher Church Ivet Elias Vilborg Palsdottir John-Olov Jansson Fatima Bosch Ann Hammarstedt Shahram Hedjazifar Ulf Smith BMP4 white adipose tissue brown adipose tissue obesity insulin resistance glucose tolerance energy expenditure CellReports, 20 (2017) 1038-1049. doi:10.1016/j.celrep.2017.07.020 ElsevierCompany. journal CellReports © 2017 The Author(s). 2211-1247 20 5 1 August 2017 2017-08-01 1038-1049 1038 1049 10.1016/j.celrep.2017.07.020 http://dx.doi.org/10.1016/j.celrep.2017.07.020 2010-04-23 true 10.1016/j.celrep.2017.07.020 elsevier.com sciencedirect.com VoR 6.5 10.1016/j.celrep.2017.07.020 noindex true 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2017-07-29T00:26:11+05:30 2017-07-29T11:08:19+05:30 2017-07-29T11:08:19+05:30 True Acrobat Distiller 8.1.0 (Windows) uuid:759450f3-33d7-457b-8cb8-b95f67478635 uuid:9bec0e93-64d4-4262-8e0b-09f8ca3d7169 http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 1038 Sequence: 1 Annotations: 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