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Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2a33fae0 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@707f7052 Children: Item: Title: Participants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11028347 Item: Title: Experimental design and procedures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@14899482 Children: Item: Title: mRNA and miRNA profiling Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@21588809 Item: Title: Pathway analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2aae9190 Item: Title: Validation of profiling results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2f333739 Item: Title: Functional analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77468bd9 Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12bb4df8 Children: Item: Title: Statistical analysis of miRNA profiling data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4cc77c2e Item: Title: Statistical analysis for mRNA profiling data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a7b0070 Item: Title: Statistical analysis for qPCR, western blot, ICW and immunofluorescence data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@39a054a5 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@71bc1ae4 Children: Item: Title: Study population Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6ed3ef1 Item: Title: Specific genes are differentially expressed in the jejunal mucosa of patients with IBS-D Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2437c6dc Item: Title: The jejunal mucosa of patients with IBS-D shows a distinctive miRNA expression signature Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1f89ab83 Item: Title: miRNA-mRNA pairing analysis identified intestinal epithelial-related functions and humoral immune response as potentially dysregulated in the jejunal mucosa of patients with IBS-D Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e73f9ac Item: Title: CGN and CLDN2 are targets of hsa-miR-125b-5p and hsa-miR-16 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@61064425 Item: Title: hsa-miR-125b-5p and hsa-miR-16 are involved in the impairment of TJ structure and epithelial barrier function by modulating CGN and CLDN2 expression Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b1d7fff Item: Title: Major clinical and histopathological features of patients with IBS-D correlate with hsa-miR-125b-5p and hsa-miR-16 and their target genes, CGN and CLDN2 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@299a06ac Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@383534aa Item: Title: 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