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Title:          Centrality in the host–pathogen interactome is associated with pathogen fitness during infection
Subject:        Nature Communications 8,  (2017). doi:10.1038/ncomms14092
Author:         Núria Crua Asensio
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        Title: Results
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         Item: 
          Title: Hubs in the interactome are central for pathogen fitness
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         Item: 
          Title: Connectivity explains in™vivo and in™vitro fitness changes
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          Title: Pathogens target but not disrupt host networks
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        Title: Discussion
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        Title: Figure™1Analysis of the centrality-lethality rule in Yersinia pestis.The percentage of essential proteins both in™vivo (during infection) and in™vitro (growth in culture medium) was plotted against its degree in (a) the pathogen (green) and (b) the host-p
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          Title: Databases
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         Item: 
          Title: Statistical analyses
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       Item: 
        Title: Figure™2Analysis of fitness shifting during Y. pestis infection.(a) Representation of in™vivo against in™vitro fitness z-scores (calculated according to z =( x  ) / ). Proteins that rank 2.5 times higher in™vivo than in™vitro are coloured red while those 
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         Item: 
          Title: Calculation of network parameters
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         Item: 
          Title: Function enrichment
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        Title: Figure™3Simulation of the host network attack by the pathogen Y. pestis.In a we present an exemplar of the three attack strategies used, in this case for the endocytosis pathway. The endocytosis network (a) was subjected to successive node removal accordi
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          Title: Data availability
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a7b0070
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        Title: YangH.Insight into bacterial virulence mechanisms against host immune response via the Yersinia pestis-human protein-protein interaction networkInfect. Immun.79441344242011DyerM. D.MuraliT. M.SobralB. W.The landscape of human proteins interacting with vir
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       Item: 
        Title: M.T.B. would like to acknowledge support from the Programa Ramón y Cajal (RYC-2012-09999). This study has been funded by the Ministerio de Economía y Competitividad (SAF2014-56568-R) and a Research Grant 2016 by the European Society of Clinical Microbiolo
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        Title: ACKNOWLEDGEMENTS
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        Title: Additional information
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   Type: CRC32
  Checksum: 406b1fe34f10f9fef100faf361a7f4ab
   Type: MD5
  Checksum: 8e5bb1572936786ea2ad87b09de3708a56c59980
   Type: SHA-1