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sectionSec2 Children: Item: Title: Animals and sampling Destination: sectionSec3 Item: Title: Group allocation Destination: sectionSec4 Item: Title: Urine biomarkers analysis Destination: sectionSec5 Item: Title: Statistical analysis Destination: sectionSec6 Item: Title: Results Destination: sectionSec7 Item: Title: Discussion Destination: sectionSec8 Item: Title: Conclusions Destination: sectionSec9 Item: Title: Abbreviations Destination: sectionabr1 Item: Title: Acknowledgment Destination: sections12917-017-0956-0 Item: Title: Funding Destination: sectionFPar1 Item: Title: Availability of data and materials Destination: sectionFPar2 Item: Title: Authors’ contributions Destination: sectionFPar3 Item: Title: Competing interests Destination: sectionFPar4 Item: Title: Consent for publication Destination: sectionFPar5 Item: Title: Ethics approval and consent to participate Destination: sectionFPar6 Item: Title: Author details Destination: sectionaunote1 Item: Title: References 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