d09790691df68ee77db499949513b53c  pmc_28158993.pdf
e19952037aaed9b7eaea437c81aa9d04668a215b  pmc_28158993.pdf
846919721048ddc317ade8ae7df27e9f47c4e4db0a0f2430e09e17d90fd52e04  pmc_28158993.pdf

Title:          Comparative differential proteomic analysis of minimal change disease and focal segmental glomerulosclerosis
Subject:        BMC Nephrology, 2017, doi:10.1186/s12882-017-0452-6
Keywords:       Focal segmental glomerulosclerosis,Glomerular disease,Mass spectrometry,Minimal change disease,Proteomics,Urine,2D-DIGE
Author:         Vanessa Pérez
Creator:        Arbortext Advanced Print Publisher 9.1.440/W Unicode
Producer:       Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
CreationDate:   Thu Feb  2 14:58:00 2017 CET
ModDate:        Fri Feb  3 15:01:05 2017 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          9
Encrypted:      no
Page size:      595.276 x 790.866 pts
Page rot:       0
File size:      974590 bytes
Optimized:      no
PDF version:    1.4

name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-Regular                    Type 1            Custom           yes no  no       8  0
MMDGON+VqgcqbAdvTT99c4c969           Type 1C           WinAnsi          yes yes no       9  0
MMDGOL+HflxwrAdvTTe45e47d2           Type 1C           WinAnsi          yes yes no      13  0
MMDGOO+WfmgttAdvTTb5929f4c+20        Type 1C           WinAnsi          yes yes no      40  0
MMDGOM+VrjjwxAdvTTb5929f4c           Type 1C           WinAnsi          yes yes no      38  0
MMDGPO+QhhjxyAdvTT86d47313           Type 1C           WinAnsi          yes yes no      15  0
MMDGPP+HxkjpxAdvTT86d47313+20        Type 1C           WinAnsi          yes yes no      10  0
MMDGKL+QvnjqvAdvTTaf7f9f4f.B         Type 1C           WinAnsi          yes yes no      12  0
MMDHLM+XtxxxnAdvTT7329fd89.I         Type 1C           WinAnsi          yes yes no      14  0
MMDHNN+GlnndsAdvTT8861b38f.I         Type 1C           WinAnsi          yes yes no      11  0
MMDIBO+QcdfqbAdvTT86d47313+03        Type 1C           Custom           yes yes yes     36  0
MMDIBN+HhqjwyAdvTT86d47313+22        Type 1C           Custom           yes yes no      37  0
MMDICO+RgpplcAdvTT1b53b5fb.I         Type 1C           WinAnsi          yes yes no      39  0
MMDIHN+QdhymkAdvTTb5929f4c+03        Type 1C           Custom           yes yes yes     56  0
MMEOMG+LbyddvAdvTT99c4c969+20        Type 1C           WinAnsi          yes yes no      96  0
MMEOPF+QgrkbrAdvTTb5929f4c+01        Type 1C           Custom           yes yes yes    127  0
RgxqgxOpenSans-Extrabold             Type 1C           WinAnsi          yes no  no     128  0
WhcgcbOpenSans-Light                 Type 1C           MacRoman         yes no  no     129  0
HfltccOregonLDOBook                  Type 1C           WinAnsi          yes no  no     130  0

Jhove (Rel. 1.6, 2011-01-04)
 Date: 2018-11-23 11:59:14 CET
 RepresentationInformation: pmc_28158993.pdf
  ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22)
  LastModified: 2018-02-08 08:12:57 CET
  Size: 974590
  Format: PDF
  Version: 1.4
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  ErrorMessage: Invalid destination object
   Offset: 746577
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 380
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: Abstract
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7c53a9eb
      Children: 
       Item: 
        Title: Background
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed17bee
       Item: 
        Title: Methods
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2a33fae0
       Item: 
        Title: Results
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@707f7052
       Item: 
        Title: Conclusions
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11028347
     Item: 
      Title: Background
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@14899482
     Item: 
      Title: Methods
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@21588809
      Children: 
       Item: 
        Title: Patients
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2aae9190
       Item: 
        Title: Study design
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2f333739
       Item: 
        Title: Renal biopsy
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77468bd9
       Item: 
        Title: Anthropometric and biochemical parameters
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12bb4df8
       Item: 
        Title: Urine collection
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4cc77c2e
       Item: 
        Title: Sample labeling and two-dimensional gel electrophoresis
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a7b0070
       Item: 
        Title: Spot picking and mass spectrometric protein identification
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@39a054a5
       Item: 
        Title: Enzyme-linked Immunosorbent assay (ELISA)
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@71bc1ae4
       Item: 
        Title: Statistical analyses
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6ed3ef1
     Item: 
      Title: Results
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2437c6dc
      Children: 
       Item: 
        Title: 2D-DIGE MS
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1f89ab83
       Item: 
        Title: Validation by ELISA
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e73f9ac
       Item: 
        Title: Decision tree analysis
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@61064425
     Item: 
      Title: Discussion
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b1d7fff
     Item: 
      Title: Conclusions
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@299a06ac
     Item: 
      Title: Additional files
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@383534aa
     Item: 
      Title: Abbreviations
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6bc168e5
     Item: 
      Title: Acknowledgements
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b3300e5
     Item: 
      Title: Funding
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2e5c649
     Item: 
      Title: Availability of data and materials
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@136432db
     Item: 
      Title: Authors’ contributions
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7382f612
     Item: 
      Title: Competing interests
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1055e4af
     Item: 
      Title: Consent for publication
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3caeaf62
     Item: 
      Title: Ethics approval and consent to participate
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e6ea0c6
     Item: 
      Title: Author details
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a38e57f
     Item: 
      Title: References
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5577140b
   Info: 
    Title: Comparative differential proteomic analysis of minimal change disease and focal segmental glomerulosclerosis
    Author: Vanessa Pérez
    Subject: BMC Nephrology, 2017, doi:10.1186/s12882-017-0452-6
    Keywords: Focal segmental glomerulosclerosis,Glomerular disease,Mass spectrometry,Minimal change disease,Proteomics,Urine,2D-DIGE
    Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode
    Producer: Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
    CreationDate: Thu Feb 02 14:58:00 CET 2017
    ModDate: Fri Feb 03 15:01:05 CET 2017
   ID: 0x596cd40a97941aad64e35304d4c2ab5b, 0x3f486712202f978a7f4753cf0d705ed5
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      ImageWidth: 688
      ImageHeight: 126
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 95
      ImageHeight: 91
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      ImageWidth: 1183
      ImageHeight: 2274
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      ImageWidth: 1183
      ImageHeight: 628
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
   Fonts: 
    Type1: 
     Font: 
      BaseFont: MMEOMG+LbyddvAdvTT99c4c969+20
      FontSubset: true
      FirstChar: 32
      LastChar: 146
      FontDescriptor: 
       FontName: MMEOMG+LbyddvAdvTT99c4c969+20
       Flags: Nonsymbolic
       FontBBox: -447, -197, 1583, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: RgxqgxOpenSans-Extrabold
      FirstChar: 32
      LastChar: 149
      FontDescriptor: 
       FontName: RgxqgxOpenSans-Extrabold
       Flags: Nonsymbolic
       FontBBox: -728, -293, 1407, 1124
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: WhcgcbOpenSans-Light
      FirstChar: 32
      LastChar: 222
      FontDescriptor: 
       FontName: WhcgcbOpenSans-Light
       Flags: Nonsymbolic
       FontBBox: -521, -269, 1140, 1048
       FontFile3: true
      Encoding: MacRomanEncoding
     Font: 
      BaseFont: HfltccOregonLDOBook
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HfltccOregonLDOBook
       Flags: Serif, Nonsymbolic
       FontBBox: 1, -308, 1045, 922
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MMDIBO+QcdfqbAdvTT86d47313+03
      FontSubset: true
      FirstChar: 1
      LastChar: 4
      FontDescriptor: 
       FontName: MMDIBO+QcdfqbAdvTT86d47313+03
       Flags: Symbolic
       FontBBox: -135, -250, 906, 822
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MMDIBN+HhqjwyAdvTT86d47313+22
      FontSubset: true
      FirstChar: 21
      LastChar: 22
      FontDescriptor: 
       FontName: MMDIBN+HhqjwyAdvTT86d47313+22
       Flags: Nonsymbolic
       FontBBox: -166, -270, 1031, 906
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: MMDGOM+VrjjwxAdvTTb5929f4c
      FontSubset: true
      FirstChar: 32
      LastChar: 252
      FontDescriptor: 
       FontName: MMDGOM+VrjjwxAdvTTb5929f4c
       Flags: Nonsymbolic
       FontBBox: -41, -250, 812, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MMDICO+RgpplcAdvTT1b53b5fb.I
      FontSubset: true
      FirstChar: 32
      LastChar: 118
      FontDescriptor: 
       FontName: MMDICO+RgpplcAdvTT1b53b5fb.I
       Flags: Nonsymbolic
       FontBBox: -114, -250, 864, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MMDGOO+WfmgttAdvTTb5929f4c+20
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: MMDGOO+WfmgttAdvTTb5929f4c+20
       Flags: Nonsymbolic
       FontBBox: -447, -208, 1375, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 1
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -46, -250, 1126, 879
       FontFile: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: MMDGON+VqgcqbAdvTT99c4c969
      FontSubset: true
      FirstChar: 32
      LastChar: 122
      FontDescriptor: 
       FontName: MMDGON+VqgcqbAdvTT99c4c969
       Flags: Nonsymbolic
       FontBBox: -41, -250, 854, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MMDGPP+HxkjpxAdvTT86d47313+20
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: MMDGPP+HxkjpxAdvTT86d47313+20
       Flags: Nonsymbolic
       FontBBox: -218, -218, 1291, 812
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MMDHNN+GlnndsAdvTT8861b38f.I
      FontSubset: true
      FirstChar: 32
      LastChar: 110
      FontDescriptor: 
       FontName: MMDHNN+GlnndsAdvTT8861b38f.I
       Flags: Nonsymbolic
       FontBBox: -187, -239, 1062, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MMDGKL+QvnjqvAdvTTaf7f9f4f.B
      FontSubset: true
      FirstChar: 32
      LastChar: 117
      FontDescriptor: 
       FontName: MMDGKL+QvnjqvAdvTTaf7f9f4f.B
       Flags: Nonsymbolic
       FontBBox: -218, -250, 875, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MMDGOL+HflxwrAdvTTe45e47d2
      FontSubset: true
      FirstChar: 32
      LastChar: 233
      FontDescriptor: 
       FontName: MMDGOL+HflxwrAdvTTe45e47d2
       Flags: Nonsymbolic
       FontBBox: -218, -250, 833, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MMDHLM+XtxxxnAdvTT7329fd89.I
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: MMDHLM+XtxxxnAdvTT7329fd89.I
       Flags: Nonsymbolic
       FontBBox: -218, -250, 885, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MMDGPO+QhhjxyAdvTT86d47313
      FontSubset: true
      FirstChar: 32
      LastChar: 246
      FontDescriptor: 
       FontName: MMDGPO+QhhjxyAdvTT86d47313
       Flags: Serif, Nonsymbolic
       FontBBox: -218, -239, 1020, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MMDIHN+QdhymkAdvTTb5929f4c+03
      FontSubset: true
      FirstChar: 1
      LastChar: 4
      FontDescriptor: 
       FontName: MMDIHN+QdhymkAdvTTb5929f4c+03
       Flags: Symbolic
       FontBBox: -531, -260, 802, 968
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MMEOPF+QgrkbrAdvTTb5929f4c+01
      FontSubset: true
      FirstChar: 2
      LastChar: 21
      FontDescriptor: 
       FontName: MMEOPF+QgrkbrAdvTTb5929f4c+01
       Flags: Symbolic
       FontBBox: -41, -218, 1114, 1062
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 4.2.1-c041 52.342996, 2008/05/07-20:48:00        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Keywords>Focal segmental glomerulosclerosis,Glomerular disease,Mass spectrometry,Minimal change disease,Proteomics,Urine,2D-DIGE</pdf:Keywords>
         <pdf:Producer>Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>10.1186/s12882-017-0452-6</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>BMC Nephrology</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">BMC Nephrology, 2017, doi:10.1186/s12882-017-0452-6</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Focal segmental glomerulosclerosis</rdf:li>
               <rdf:li>Glomerular disease</rdf:li>
               <rdf:li>Mass spectrometry</rdf:li>
               <rdf:li>Minimal change disease</rdf:li>
               <rdf:li>Proteomics</rdf:li>
               <rdf:li>Urine</rdf:li>
               <rdf:li>2D-DIGE</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Comparative differential proteomic analysis of minimal change disease and focal segmental glomerulosclerosis</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Vanessa Pérez</rdf:li>
               <rdf:li>Dolores López</rdf:li>
               <rdf:li>Ester Boixadera</rdf:li>
               <rdf:li>Meritxell Ibernón</rdf:li>
               <rdf:li>Anna Espinal</rdf:li>
               <rdf:li>Josep Bonet</rdf:li>
               <rdf:li>Ramón Romero</rdf:li>
            </rdf:Seq>
         </dc:creator>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:MetadataDate>2017-02-03T15:01:05+01:00</xmp:MetadataDate>
         <xmp:CreateDate>2017-02-02T21:58+08:00</xmp:CreateDate>
         <xmp:CreatorTool>Arbortext Advanced Print Publisher 9.1.440/W Unicode</xmp:CreatorTool>
         <xmp:ModifyDate>2017-02-03T15:01:05+01:00</xmp:ModifyDate>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:a4049263-88b9-492c-850b-4faf10967a95</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:e37d31a6-2787-480d-948a-68ccc689018b</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:026d028c-eccb-4d9a-ba7a-b39b0544b0e8</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2017-02-02T22:51:31+08:00</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/">
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#">
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>editorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag EditorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Editor information: contains the name of each editor and his/her ORCID identifier.</pdfaProperty:description>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>seriesEditorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag SeriesEditorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Series editor information: contains the name of each series editor and his/her ORCID identifier.</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>EditorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/editorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>editor</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of editor information: name and ORCID of an editor.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an editor.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an editor.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>SeriesEditorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/seriesEditorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>seriesEditor</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of series editor information: name and ORCID of a series editor.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of a series editor.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of a series editor.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/t/pg/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpTPg</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Paged-Text</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A structure containing the characteristics of a font used in a document</pdfaProperty:description>
                           <pdfaProperty:name>Fonts</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag Font</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).</pdfaProperty:description>
                           <pdfaProperty:name>PlateNames</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>A structure containing the characteristics of a font used in a document.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Font#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stFnt</pdfaType:prefix>
                           <pdfaType:type>Font</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/X ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 484, 657, 538, 679
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 411, 229, 416, 239
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 424, 229, 429, 239
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 493, 157, 498, 167
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 504, 157, 508, 167
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 510, 109, 515, 119
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 521, 109, 526, 119
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 114, 153, 177, 161
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 180, 153, 234, 161
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 239, 65, 357, 72
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 182, 41, 321, 48
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 173, 633, 178, 642
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 184, 633, 194, 642
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 280, 597, 285, 606
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 140, 537, 149, 546
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 156, 537, 166, 546
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 136, 309, 146, 318
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 171, 225, 181, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 187, 225, 197, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 344, 153, 353, 162
       Flags: Print
       AppearanceDictionary: true
       Destination: null
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 183, 285, 193, 294
       Flags: Print
       AppearanceDictionary: true
       Destination: null
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 530, 621, 535, 630
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 389, 83, 392, 90
       Flags: Print
       AppearanceDictionary: true
       Destination: null
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 132, 537, 142, 546
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 91, 393, 96, 402
       Flags: Print
       AppearanceDictionary: true
       Destination: 34
      Annotation: 
       Subtype: Link
       Rect: 195, 333, 199, 342
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 82, 213, 87, 222
       Flags: Print
       AppearanceDictionary: true
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 285, 153, 290, 162
       Flags: Print
       AppearanceDictionary: true
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 94, 141, 99, 150
       Flags: Print
       AppearanceDictionary: true
       Destination: null
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 326, 93, 331, 102
       Flags: Print
       AppearanceDictionary: true
       Destination: null
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 130, 225, 135, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 245, 141, 254, 150
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 259, 141, 269, 150
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 348, 165, 357, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 363, 165, 372, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 391, 93, 400, 102
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 406, 93, 415, 102
       Flags: Print
       AppearanceDictionary: true
       Destination: null
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 98, 657, 108, 666
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 116, 657, 126, 666
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 224, 621, 234, 630
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 160, 537, 169, 546
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 142, 501, 152, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 202, 309, 212, 318
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 218, 309, 228, 318
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 61, 139, 118, 147
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 61, 118, 118, 126
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 9
     Thumb: true
  Checksum: 4b78e392
   Type: CRC32
  Checksum: d09790691df68ee77db499949513b53c
   Type: MD5
  Checksum: e19952037aaed9b7eaea437c81aa9d04668a215b
   Type: SHA-1