239eccb64f474aa7a4e8f4cda861f74f pmc_28170003.pdf 79ceef9fc644148133f64f4410af7c446ac58114 pmc_28170003.pdf 8c63067cb4f1238cee62e25f3061d17f759cec3c4e1e7c01b9401bca6a6a7121 pmc_28170003.pdf Title: Brain volumetric and metabolic correlates of electroconvulsive therapy for treatment-resistant depression: a longitudinal neuroimaging study Subject: Translational Psychiatry 7, e1023 (2017). doi:10.1038/tp.2016.267 Author: M Cano Creator: Arbortext Advanced Print Publisher 10.0.1465/W Unicode Producer: Acrobat Distiller 8.0.0 (Windows) CreationDate: Fri Jan 27 08:50:01 2017 CET ModDate: Fri Jan 27 18:33:43 2017 CET Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 864960 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DHJKOM+Arial-BoldMT Type 1C WinAnsi yes yes no 308 0 DHJKPM+AdvTT5afe5d37.B Type 1C WinAnsi yes yes no 309 0 DHJKPN+AdvOTa20b42a7 Type 1C WinAnsi yes yes no 310 0 DHJKPO+AdvTT6780a46b Type 1C WinAnsi yes yes no 311 0 DHJKPP+AdvOT46dcae81 Type 1C WinAnsi yes yes no 312 0 DHJLAA+AdvOT46dcae81+fb Type 1C Custom yes yes yes 313 0 DHJLAB+AdvOT65f8a23b.I Type 1C WinAnsi yes yes no 322 0 DHJLAC+AdvOT3b30f6db.B Type 1C WinAnsi yes yes no 323 0 DHJLBD+AdvOT46dcae81+20 Type 1C WinAnsi yes yes no 327 0 DHJLFE+AdvEls-ent4 Type 1C WinAnsi yes yes no 99 0 DHJLFF+AdvOT7d2ebc01 Type 1C WinAnsi yes yes no 100 0 DHJLED+AdvOT46dcae81+22 Type 1C Custom yes yes no 103 0 DHJLFD+AdvPi1 Type 1C WinAnsi yes yes no 105 0 DHJLGG+AdvOT65f8a23b.I+03 Type 1C Custom yes yes yes 113 0 DHJLHH+AdvOT919a0533.B Type 1C WinAnsi yes yes no 106 0 DHJLHI+AdvTT6780a46b+22 Type 1C Custom yes yes no 108 0 DHJLII+AdvTT6780a46b+fb Type 1C Custom yes yes yes 107 0 DHJLIJ+AdvTT6780a46b+20 Type 1C WinAnsi yes yes no 110 0 DIEJMM+AdvOT65f8a23b.I+20 Type 1C WinAnsi yes yes no 125 0 Jhove (Rel. 1.6, 2011-01-04) Date: 2019-02-14 18:12:45 CET RepresentationInformation: pmc_28170003.pdf ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22) LastModified: 2018-02-08 08:12:43 CET Size: 864960 Format: PDF Version: 1.6 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 847344 ErrorMessage: Invalid destination object Offset: 847344 ErrorMessage: Invalid destination object Offset: 847344 ErrorMessage: Invalid destination object Offset: 847344 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 847344 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 847344 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 847344 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 846491 ErrorMessage: Invalid destination object Offset: 847344 ErrorMessage: Invalid destination object Offset: 847344 ErrorMessage: Invalid destination object Offset: 847344 ErrorMessage: Invalid destination object Offset: 847344 ErrorMessage: Invalid destination object Offset: 847344 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 347 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7c53a9eb Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed17bee Item: Title: Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2a33fae0 Children: Item: Title: Participants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@707f7052 Item: Title: Electroconvulsive therapy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11028347 Item: Title: Study protocol Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@14899482 Item: Title: MRI and MRS acquisition and preprocessing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@21588809 Children: Item: Title: Three-dimensional anatomical images Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2aae9190 Item: Title: 1H MR spectroscopy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2f333739 Item: Title: Statistical analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77468bd9 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12bb4df8 Children: Item: Title: Sociodemographic and clinical characteristics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4cc77c2e Item: Title: Neuroimaging analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a7b0070 Children: Item: Title: Structural MRI Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@39a054a5 Item: Title: Table 1 Sociodemographic and clinical characteristics of the study samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@71bc1ae4 Item: Title: Table 2 Brain areas showing gray matter volume increases in patients with treatment-resistant depression Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6ed3ef1 Item: Title: Outline placeholder Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2437c6dc Children: Item: Title: Outline placeholder Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1f89ab83 Children: Item: Title: Structural covariance Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e73f9ac Item: Title: 1H MR spectroscopy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@61064425 Item: Title: Relationship with clinical change Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b1d7fff Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@299a06ac Item: Title: Figure 2 (a) Individual hippocampal NAA/Cr ratio change between MRI1 and MRI3 in patients with TRD. Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@383534aa Item: Title: Figure 2 (a) Individual hippocampal NAA/Cr ratio change between MRI1 and MRI3 in patients with TRD. Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6bc168e5 Item: Title: Figure 2 (a) Individual hippocampal NAA/Cr ratio change between MRI1 and MRI3 in patients with TRD. Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b3300e5 Item: Title: Figure 2 (a) Individual hippocampal NAA/Cr ratio change between MRI1 and MRI3 in patients with TRD. Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2e5c649 Item: Title: ACKNOWLEDGEMENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@136432db Item: Title: REFERENCES Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7382f612 Info: Title: Brain volumetric and metabolic correlates of electroconvulsive therapy for treatment-resistant depression: a longitudinal neuroimaging study Author: M Cano Subject: Translational Psychiatry 7, e1023 (2017). doi:10.1038/tp.2016.267 Creator: Arbortext Advanced Print Publisher 10.0.1465/W Unicode Producer: Acrobat Distiller 8.0.0 (Windows) CreationDate: Fri Jan 27 09:20:01 CET 2017 ModDate: Fri Jan 27 19:03:43 CET 2017 ID: 0xe529eb76c8725081bbf8989d6c6e13a1, 0xc5244393934fd44994fe3b91449691cf Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 2251 ImageHeight: 2257 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 2571 ImageHeight: 765 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 2832 ImageHeight: 1808 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: DHJLAB+AdvOT65f8a23b.I FontSubset: true FirstChar: 37 LastChar: 122 FontDescriptor: FontName: DHJLAB+AdvOT65f8a23b.I Flags: Nonsymbolic FontBBox: -104, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DHJLAC+AdvOT3b30f6db.B FontSubset: true FirstChar: 44 LastChar: 119 FontDescriptor: FontName: DHJLAC+AdvOT3b30f6db.B Flags: Nonsymbolic FontBBox: -31, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DHJLFE+AdvEls-ent4 FontSubset: true FirstChar: 111 LastChar: 111 FontDescriptor: FontName: DHJLFE+AdvEls-ent4 Flags: Nonsymbolic FontBBox: 0, -343, 1166, 1218 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DHJLFF+AdvOT7d2ebc01 FontSubset: true FirstChar: 50 LastChar: 56 FontDescriptor: FontName: DHJLFF+AdvOT7d2ebc01 Flags: Nonsymbolic FontBBox: -31, -208, 958, 916 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DHJLBD+AdvOT46dcae81+20 FontSubset: true FirstChar: 145 LastChar: 151 FontDescriptor: FontName: DHJLBD+AdvOT46dcae81+20 Flags: Nonsymbolic FontBBox: 0, -197, 1125, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DHJLED+AdvOT46dcae81+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: DHJLED+AdvOT46dcae81+22 Flags: Nonsymbolic FontBBox: 0, -145, 687, 822 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: DHJLFD+AdvPi1 FontSubset: true FirstChar: 52 LastChar: 52 FontDescriptor: FontName: DHJLFD+AdvPi1 Flags: Nonsymbolic FontBBox: 13, -323, 958, 824 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DHJLHH+AdvOT919a0533.B FontSubset: true FirstChar: 46 LastChar: 117 FontDescriptor: FontName: DHJLHH+AdvOT919a0533.B Flags: Nonsymbolic FontBBox: -31, -250, 656, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DHJLII+AdvTT6780a46b+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DHJLII+AdvTT6780a46b+fb Flags: Symbolic FontBBox: 9, 0, 875, 750 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DHJLHI+AdvTT6780a46b+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: DHJLHI+AdvTT6780a46b+22 Flags: Nonsymbolic FontBBox: 0, -250, 875, 791 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: DHJLIJ+AdvTT6780a46b+20 FontSubset: true FirstChar: 150 LastChar: 151 FontDescriptor: FontName: DHJLIJ+AdvTT6780a46b+20 Flags: Nonsymbolic FontBBox: 0, -114, 1156, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DHJLGG+AdvOT65f8a23b.I+03 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: DHJLGG+AdvOT65f8a23b.I+03 Flags: Symbolic FontBBox: -72, -208, 760, 802 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DHJKOM+Arial-BoldMT FontSubset: true FirstChar: 69 LastChar: 80 FontDescriptor: FontName: DHJKOM+Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DHJKPM+AdvTT5afe5d37.B FontSubset: true FirstChar: 65 LastChar: 98 FontDescriptor: FontName: DHJKPM+AdvTT5afe5d37.B Flags: Nonsymbolic FontBBox: -31, -250, 895, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DHJKPN+AdvOTa20b42a7 FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: DHJKPN+AdvOTa20b42a7 Flags: Serif, Nonsymbolic FontBBox: -72, -239, 979, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DHJKPO+AdvTT6780a46b FontSubset: true FirstChar: 37 LastChar: 243 FontDescriptor: FontName: DHJKPO+AdvTT6780a46b Flags: Nonsymbolic FontBBox: -41, -250, 875, 843 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DHJKPP+AdvOT46dcae81 FontSubset: true FirstChar: 37 LastChar: 252 FontDescriptor: FontName: DHJKPP+AdvOT46dcae81 Flags: Nonsymbolic FontBBox: -41, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DHJLAA+AdvOT46dcae81+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: DHJLAA+AdvOT46dcae81+fb Flags: Symbolic FontBBox: 0, 0, 739, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DIEJMM+AdvOT65f8a23b.I+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: DIEJMM+AdvOT65f8a23b.I+20 Flags: Nonsymbolic FontBBox: -177, -197, 1083, 822 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1038/tp.2016.267 M Cano I Martínez-Zalacaín Á Bernabéu-Sanz O Contreras-Rodríguez R Hernández-Ribas E Via A de Arriba-Arnau V Gálvez M Urretavizcaya J Pujol J M Menchón N Cardoner C Soriano-Mas Translational Psychiatry 7, e1023 (2017). doi:10.1038/tp.2016.267 Nature Publishing Group © 2017 Nature Publishing Group Brain volumetric and metabolic correlates of electroconvulsive therapy for treatment-resistant depression: a longitudinal neuroimaging study Acrobat Distiller 8.0.0 (Windows) © 2017 Nature Publishing Group 10.1038/tp.2016.267 2158-3188 8 2 Nature Publishing Group permissions@nature.com e1023 7 2017-02-01 http://dx.doi.org/10.1038/tp.2016.267 2017-01-27T13:20:01+05:30 Arbortext Advanced Print Publisher 10.0.1465/W Unicode Translational Psychiatry 7, e1023 (2017). doi:10.1038/tp.2016.267 2017-01-27T23:03:43+05:30 2017-01-27T23:03:43+05:30 doi:10.1038/tp.2016.267 True uuid:f7840ee3-afe5-48e0-b5ea-15617f05f2ad uuid:d6596d98-953a-441d-ab31-640f187d0160 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 215, 410, 290, 419 Annotation: Subtype: Link Rect: 177, 351, 181, 360 Destination: 75 Annotation: Subtype: Link Rect: 58, 290, 72, 299 Destination: 75 Annotation: Subtype: Link Rect: 203, 260, 209, 269 Destination: null Annotation: Subtype: Link Rect: 63, 240, 70, 249 Destination: null Annotation: Subtype: Link Rect: 86, 200, 93, 208 Destination: null Annotation: Subtype: Link Rect: 132, 179, 135, 188 Destination: 75 Annotation: Subtype: Link Rect: 137, 179, 143, 188 Destination: null Annotation: Subtype: Link Rect: 242, 169, 249, 178 Destination: null Annotation: Subtype: Link Rect: 106, 149, 113, 158 Destination: null Annotation: Subtype: Link Rect: 492, 322, 509, 331 Destination: null Annotation: Subtype: Link Rect: 354, 302, 358, 311 Destination: 75 Annotation: Subtype: Link Rect: 359, 302, 376, 311 Destination: null Annotation: Subtype: Link Rect: 449, 302, 456, 311 Destination: null Annotation: Subtype: Link Rect: 518, 302, 521, 311 Destination: 75 Annotation: Subtype: Link Rect: 523, 302, 530, 311 Destination: null Annotation: Subtype: Link Rect: 531, 302, 538, 311 Destination: null Annotation: Subtype: Link Rect: 330, 271, 336, 280 Destination: null Annotation: Subtype: Link Rect: 338, 271, 345, 280 Destination: null Annotation: Subtype: Link Rect: 353, 251, 360, 259 Destination: null Annotation: Subtype: Link Rect: 543, 220, 549, 229 Destination: null Annotation: Subtype: Link Rect: 340, 189, 347, 198 Destination: null Annotation: Subtype: Link Rect: 348, 189, 355, 198 Destination: null Annotation: Subtype: Link Rect: 356, 189, 363, 198 Destination: null Annotation: Subtype: Link Rect: 364, 189, 371, 198 Destination: null Annotation: Subtype: Link Rect: 57, 65, 119, 72 Annotation: Subtype: Link Rect: 130, 65, 188, 72 Annotation: Subtype: Link Rect: 435, 749, 502, 757 Annotation: Subtype: Link Rect: 278, 734, 348, 742 Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 254, 717, 261, 726 Destination: null Annotation: Subtype: Link Rect: 81, 707, 85, 716 Destination: 75 Annotation: Subtype: Link Rect: 86, 707, 93, 716 Destination: null Annotation: Subtype: Link Rect: 125, 667, 132, 676 Destination: null Annotation: Subtype: Link Rect: 84, 420, 90, 428 Destination: null Annotation: Subtype: Link Rect: 165, 402, 171, 410 Destination: null Annotation: Subtype: Link Rect: 278, 328, 284, 336 Destination: null Annotation: Subtype: Link Rect: 79, 194, 94, 202 Destination: null Annotation: Subtype: Link Rect: 114, 139, 120, 147 Destination: null Annotation: Subtype: Link Rect: 529, 708, 535, 716 Destination: null Annotation: Subtype: Link Rect: 343, 464, 349, 472 Destination: null Annotation: Subtype: Link Rect: 453, 445, 459, 453 Destination: null Annotation: Subtype: Link Rect: 504, 408, 510, 416 Destination: null Annotation: Subtype: Link Rect: 473, 353, 479, 361 Destination: null Annotation: Subtype: Link Rect: 481, 353, 487, 361 Destination: null Annotation: Subtype: Link Rect: 464, 157, 542, 165 Annotation: Subtype: Link Rect: 546, 160, 552, 168 Destination: null Annotation: Subtype: Link Rect: 553, 160, 559, 168 Destination: null Annotation: Subtype: Link Rect: 477, 133, 483, 141 Destination: null Annotation: Subtype: Link Rect: 377, 96, 383, 104 Destination: null Thumb: true Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 479, 191, 507, 200 Destination: 24 Annotation: Subtype: Link Rect: 401, 76, 429, 84 Destination: 30 Annotation: Subtype: Link Rect: 449, 76, 479, 84 Destination: 30 Thumb: true Page: Label: 4 Thumb: true Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 248, 318, 279, 327 Destination: 34 Annotation: Subtype: Link Rect: 103, 193, 139, 202 Destination: 50 Annotation: Subtype: Link Rect: 317, 403, 331, 412 Destination: 75 Annotation: Subtype: Link Rect: 344, 372, 351, 381 Destination: null Annotation: Subtype: Link Rect: 352, 372, 359, 381 Destination: null Annotation: Subtype: Link Rect: 454, 302, 461, 311 Destination: null Annotation: Subtype: Link Rect: 462, 302, 469, 311 Destination: null Annotation: Subtype: Link Rect: 524, 191, 542, 200 Destination: null Annotation: Subtype: Link Rect: 334, 140, 351, 149 Destination: null Annotation: Subtype: Link Rect: 486, 130, 493, 139 Destination: null Annotation: Subtype: Link Rect: 495, 130, 501, 139 Destination: null Annotation: Subtype: Link Rect: 334, 90, 341, 99 Destination: null Thumb: true Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 85, 342, 92, 351 Destination: null Annotation: Subtype: Link Rect: 102, 302, 109, 310 Destination: null Annotation: Subtype: Link Rect: 110, 302, 117, 310 Destination: null Annotation: Subtype: Link Rect: 126, 291, 129, 300 Destination: 75 Annotation: Subtype: Link Rect: 176, 221, 183, 230 Destination: null Annotation: Subtype: Link Rect: 184, 221, 191, 230 Destination: null Annotation: Subtype: Link Rect: 192, 221, 199, 230 Destination: null Annotation: Subtype: Link Rect: 201, 221, 208, 230 Destination: null Annotation: Subtype: Link Rect: 150, 160, 154, 169 Destination: 75 Annotation: Subtype: Link Rect: 155, 160, 162, 169 Destination: null Annotation: Subtype: Link Rect: 235, 140, 242, 149 Destination: null Annotation: Subtype: Link Rect: 143, 120, 150, 129 Destination: null Annotation: Subtype: Link Rect: 137, 59, 144, 68 Destination: null Annotation: Subtype: Link Rect: 410, 312, 417, 321 Destination: null Annotation: Subtype: Link Rect: 552, 271, 559, 280 Destination: null Annotation: Subtype: Link Rect: 552, 201, 559, 210 Destination: null Annotation: Subtype: Link Rect: 552, 190, 559, 199 Destination: null Annotation: Subtype: Link Rect: 482, 160, 489, 169 Destination: null Annotation: Subtype: Link Rect: 496, 150, 503, 159 Destination: null Annotation: Subtype: Link Rect: 504, 150, 511, 159 Destination: null Annotation: Subtype: Link Rect: 382, 100, 389, 109 Destination: null Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 198, 665, 205, 674 Destination: null Annotation: Subtype: Link Rect: 228, 552, 245, 561 Destination: null Annotation: Subtype: Link Rect: 70, 347, 77, 356 Destination: null Annotation: Subtype: Link Rect: 74, 326, 81, 335 Destination: null Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 450, 248, 559, 255 Annotation: Subtype: Link Rect: 311, 239, 331, 246 Thumb: true Checksum: e2ed7b12 Type: CRC32 Checksum: 239eccb64f474aa7a4e8f4cda861f74f Type: MD5 Checksum: 79ceef9fc644148133f64f4410af7c446ac58114 Type: SHA-1