83a0d4f1d6fd9ab3d4bdf20ca731b783 pmc_28239501.pdf dbd3c359709aefd3c51b820943d2c442aa54d41e pmc_28239501.pdf 529287f3af61fb9e9866661da697483ee619668c70a942b8e3536501e6c37ab4 pmc_28239501.pdf Title: 4047392.dvi Keywords: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 15.0 (Windows); modified using iTextSharp™ 5.4.0 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Sun Jan 22 14:52:01 2017 CET ModDate: Mon Feb 6 08:14:33 2017 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 600.05 x 800 pts Page rot: 0 File size: 531442 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- BAOGFO+MinionPro-It Type 1C Custom yes yes yes 13 0 BAOGFP+Minion-Black Type 1C WinAnsi yes yes no 14 0 BAOGHA+MinionPro-Regular Type 1C Custom yes yes yes 15 0 YIWTOV+MinionPro-Regular CID TrueType Identity-H yes yes yes 1 0 BAOGIA+MinionMath-Regular Type 1C Custom yes yes yes 62 0 BAOGMA+MinionMath-Capt Type 1C Custom yes yes yes 114 0 BAOGNA+MinionPro-Capt Type 1C WinAnsi yes yes no 144 0 Jhove (Rel. 1.6, 2011-01-04) Date: 2019-02-14 18:11:29 CET RepresentationInformation: pmc_28239501.pdf ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22) LastModified: 2018-02-08 08:11:07 CET Size: 531442 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 181 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Info: Title: 4047392.dvi Keywords: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 15.0 (Windows); modified using iTextSharp™ 5.4.0 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Sun Jan 22 14:52:01 CET 2017 ModDate: Mon Feb 06 08:14:33 CET 2017 ID: 0x07b683195f95ce0509ec2b0952680ccd, 0x9f9c3568e71a27c106daf67f8cb52cdf Filters: FilterPipeline: FlateDecode Fonts: Type0: Font: BaseFont: YIWTOV+MinionPro-Regular Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: BAOGNA+MinionPro-Capt FontSubset: true FirstChar: 97 LastChar: 97 FontDescriptor: FontName: BAOGNA+MinionPro-Capt Flags: Nonsymbolic FontBBox: -304, -369, 1712, 1007 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BAOGMA+MinionMath-Capt FontSubset: true FirstChar: 2 LastChar: 2 FontDescriptor: FontName: BAOGMA+MinionMath-Capt Flags: Symbolic FontBBox: 124, 53, 486, 470 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BAOGFO+MinionPro-It FontSubset: true FirstChar: 2 LastChar: 180 FontDescriptor: FontName: BAOGFO+MinionPro-It Flags: Serif, Symbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BAOGFP+Minion-Black FontSubset: true FirstChar: 40 LastChar: 146 FontDescriptor: FontName: BAOGFP+Minion-Black Flags: Serif, Nonsymbolic, ForceBold FontBBox: -133, -250, 1120, 827 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BAOGIA+MinionMath-Regular FontSubset: true FirstChar: 2 LastChar: 177 FontDescriptor: FontName: BAOGIA+MinionMath-Regular Flags: Symbolic FontBBox: 12, -257, 699, 666 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BAOGHA+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 180 FontDescriptor: FontName: BAOGHA+MinionPro-Regular Flags: Serif, Symbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: YIWTOV+MinionPro-Regular CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: YIWTOV+MinionPro-Regular Flags: Nonsymbolic FontBBox: -289, -360, 1684, 917 FontFile2: true XMP: application/pdfConsensus on the Definition of Advanced Parkinson’s Disease: A Neurologists-Based Delphi Study (CEPA Study)Luquin, Maria-RosarioKulisevsky, JaimeMartinez-Martin, PabloMir, PabloTolosa, Eduardo S.To date, no consensus exists on the key factors for diagnosing advanced Parkinson disease (APD). To obtain consensus on the definition of APD, we performed a prospective, multicenter, Spanish nationwide, 3-round Delphi study (CEPA study). An ad hoc questionnaire was designed with 33 questions concerning the relevance of several clinical features for APD diagnosis. In the first-round, 240 neurologists of the Spanish Movement Disorders Group participated in the study. The results obtained were incorporated into the questionnaire and both, results and questionnaire, were sent out to and fulfilled by 26 experts in Movement Disorders. Review of results from the second-round led to a classification of symptoms as indicative of “definitive,” “probable,” and “possible” APD. This classification was confirmed by 149 previous participating neurologists in a third-round, where 92% completely or very much agreed with the classification. Definitive symptoms of APD included disability requiring help for the activities of daily living, presence of motor fluctuations with limitations to perform basic activities of daily living without help, severe dysphagia, recurrent falls, and dementia. These results will help neurologists to identify some key factors in APD diagnosis, thus allowing users to categorize the patients for a homogeneous recognition of this condition.Parkinson’s DiseaseHindawi Publishing Corporation2017/01/23Research articledoi:10.1155/2017/4047392en Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 155, 126, 160, 136 Flags: Print, NoZoom, NoRotate Destination: 41 Annotation: Subtype: Link Rect: 163, 126, 169, 136 Flags: Print, NoZoom, NoRotate Destination: 41 Annotation: Subtype: Link Rect: 124, 115, 129, 125 Flags: Print, NoZoom, NoRotate Destination: 41 Annotation: Subtype: Link Rect: 342, 159, 348, 170 Flags: Print, NoZoom, NoRotate Destination: 41 Annotation: Subtype: Link Rect: 352, 159, 358, 170 Flags: Print, NoZoom, NoRotate Destination: 41 Annotation: Subtype: Link Rect: 489, 91, 495, 102 Flags: Print, NoZoom, NoRotate Destination: 41 Annotation: Subtype: Link Rect: 500, 91, 505, 102 Flags: Print, NoZoom, NoRotate Destination: 41 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