18eac89fe192aa64a5b560672cd6e070  pmc_28287086.pdf
575e62afcb01950916224dc3ae212feda9c9314c  pmc_28287086.pdf

Title:          Pre-plaque conformational changes in Alzheimer’s disease-linked Aβ and APP
Subject:        Nature Communications 8, (2017). doi:10.1038/ncomms14726
Author:         O. Klementieva
Creator:        Arbortext Advanced Print Publisher 9.0.226/W
Producer:       Acrobat Distiller 8.1.0 (Windows)
CreationDate:   Sat Mar  4 06:16:23 2017 CET
ModDate:        Tue Mar  7 07:43:34 2017 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           AcroForm
JavaScript:     no
Pages:          9
Encrypted:      no
Page size:      595.276 x 782.362 pts
Page rot:       0
File size:      2536934 bytes
Optimized:      yes
PDF version:    1.6

name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
IGHGGB+AdvOTea1a7398                 Type 1C           Custom           yes yes yes    355  0
IGHGGC+AdvPi1                        Type 1C           WinAnsi          yes yes no     356  0
IGHGHD+AdvOTcb88df00                 Type 1C           Custom           yes yes yes    365  0
IGHGMC+Arial-BoldMT                  Type 1C           WinAnsi          yes yes no     366  0
IGHGOC+AdvOTf23bb480                 Type 1C           Custom           yes yes yes    367  0
IGHHGA+AdvTTda6f6cb8.B               Type 1C           Custom           yes yes yes    377  0
IGHHNE+AdvGreek_B                    Type 1C           WinAnsi          yes yes no     175  0
IGHHKA+AdvOT125c650c                 Type 1C           Custom           yes yes yes    166  0
IGHHLB+AdvOT1ef757c0                 Type 1C           Custom           yes yes yes    168  0
IGHHLC+AdvP4C4E74                    Type 1C           Custom           yes yes yes    153  0
IGHHMC+AdvOT7d6df7ab.I               Type 1C           Custom           yes yes yes    154  0
IGHHND+AdvOTb65e897d.B               Type 1C           Custom           yes yes yes    169  0
IGIJPF+Helvetica                     Type 1C           WinAnsi          yes yes no     198  0
IGIKLC+Symbol                        Type 1C           Custom           yes yes yes    199  0
IGIKNC+Helvetica-Oblique             Type 1C           WinAnsi          yes yes no     181  0
IGIKOD+MathPackTen                   Type 1C           Custom           yes yes no     200  0
IGIKOE+Helvetica-Bold                Type 1C           WinAnsi          yes yes no     201  0
IGILMA+AdvOT9bd21c25.I               Type 1C           Custom           yes yes yes    205  0
IGILOA+AdvEls-ent4                   Type 1C           WinAnsi          yes yes no     206  0
IGILOB+AdvItcSymbol-M                Type 1C           WinAnsi          yes yes no     187  0
IGLHFH+Advsymbol                     Type 1C           Custom           yes yes no     211  0
IGMFEC+MyriadPro-Regular             Type 1C           WinAnsi          yes yes no     214  0
IGPCMM+Helvetica                     Type 1C           WinAnsi          yes yes no     219  0
IGPJID+AdvEls-ent3                   Type 1C           WinAnsi          yes yes no     223  0

Jhove (Rel. 1.6, 2011-01-04)
 Date: 2019-02-14 18:09:55 CET
 RepresentationInformation: pmc_28287086.pdf
  ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22)
  LastModified: 2018-02-08 08:09:09 CET
  Size: 2536934
  Format: PDF
  Version: 1.6
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 401
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseNone
    Outlines: 
     Item: 
      Title: title_link
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7c53a9eb
      Children: 
       Item: 
        Title: Results
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed17bee
        Children: 
         Item: 
          Title: Pre-plaque beta-sheet transition in transgenic AD models
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2a33fae0
         Item: 
          Title: Early changes in AbetasolAPP complexes in AD transgenic mice
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@707f7052
       Item: 
        Title: Figure™1Early beta-structural transition in transgenic AD mouse brains.(a) FTIR maps were integrated for the beta-sheet spectral region at 1,635-1,620thinspcm-1 to visualize absorption intensities for the beta-sheet content in brain sections of Tg19959 (u
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11028347
       Item: 
        Title: Figure™2Non-fibrillar Abeta1-40 oligomers with beta-sheet quaternary structure.(a) Left panel: normalized FTIR spectra of Abeta1-40 monomers (M) in 10thinspmM HepessolD2O pD11, fibrils (F) after 24thinsph incubation in 10thinspmM Hepes pD7.4 and Abeta1-40
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@14899482
        Children: 
         Item: 
          Title: Abeta aggregation and synapse pathology
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@21588809
       Item: 
        Title: Figure™3beta-sheet aggregation in cultured AD transgenic primary neurons.(a) Bright field image (upper panel) and FTIR map (lower panel) of AD neurons cultured for 19 DIV on a FTIR sample support. Scale bar, 50thinspmgrm. (b) Averaged and normalized secon
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2aae9190
       Item: 
        Title: Discussion
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2f333739
       Item: 
        Title: Figure™4Native Abeta and APP complexes in Tg19959 mouse brains change with age.(a) Blue native polyacrylamide gel electrophoresis (BN-PAGE) and subsequent Western blot of membrane-associated TBST fractions of mouse brain homogenates at 1 and 2 months of a
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77468bd9
       Item: 
        Title: Methods
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12bb4df8
        Children: 
         Item: 
          Title: Animals
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4cc77c2e
          Children: 
           Item: 
            Title: Experimental design
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a7b0070
       Item: 
        Title: Figure™5Abeta42 disrupts the cytoarchitecture of dendritic terminals in Tg19959 mouse brains with age.(a) High-resolution confocal microscopy images™of immunofluorescently labelled Abeta42 (red), the post-synaptic protein drebrin (green) and the pre-synap
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@39a054a5
        Children: 
         Item: 
          Title: Outline placeholder
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@71bc1ae4
          Children: 
           Item: 
            Title: Experimental procedures
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6ed3ef1
         Item: 
          Title: Abeta1-40 and Abeta1-42 peptides
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2437c6dc
         Item: 
          Title: Synchrotron-based mgrFTIR
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1f89ab83
         Item: 
          Title: FTIR spectral analysis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e73f9ac
         Item: 
          Title: Immunohistochemistry
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@61064425
         Item: 
          Title: Confocal microscopy
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b1d7fff
         Item: 
          Title: Biochemical analysis of mouse brain tissue
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@299a06ac
         Item: 
          Title: Statistical analysis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@383534aa
         Item: 
          Title: Data availability
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6bc168e5
       Item: 
        Title: MarshallK. E.MarchanteR.XueW.-F.SerpellL. C.The relationship between amyloid structure and cytotoxicityPrion81921962014BakerM. J.Using Fourier transform IR spectroscopy to analyze biological materialsNat. Protoc.9177117912014MillerL. M.DumasP.From structu
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b3300e5
       Item: 
        Title: We thank Vladimir Denisov and Sara Linse for critical input to this manuscript. We™thank Per Persson for the access to FTIR equipment. This work was funded by grants from Alzheimerfonden, Interreg Öresund-Kattegat-Skagerrak (EU), the Swedish Research Coun
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2e5c649
       Item: 
        Title: ACKNOWLEDGEMENTS
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@136432db
       Item: 
        Title: Author contributions
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7382f612
       Item: 
        Title: Additional information
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1055e4af
   Info: 
    Title: Pre-plaque conformational changes in Alzheimer’s disease-linked Aβ and APP
    Author: O. Klementieva
    Subject: Nature Communications 8, (2017). doi:10.1038/ncomms14726
    Creator: Arbortext Advanced Print Publisher 9.0.226/W
    Producer: Acrobat Distiller 8.1.0 (Windows)
    CreationDate: Sat Mar 04 06:46:23 CET 2017
    ModDate: Tue Mar 07 08:13:34 CET 2017
   ID: 0xd814b35aa17d7fa4cb05b5927b44c43a, 0x86018530e76ff7478e72ddf83ecc3f59
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      ImageWidth: 478
      ImageHeight: 593
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 2095
      ImageHeight: 681
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 1368
      ImageHeight: 526
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 2010
      ImageHeight: 512
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 905
      ImageHeight: 645
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 1940
      ImageHeight: 621
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 893
      ImageHeight: 659
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 741
      ImageHeight: 568
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      ImageWidth: 1120
      ImageHeight: 600
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 650
      ImageHeight: 744
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 2173
      ImageHeight: 619
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 777
      ImageHeight: 578
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      ImageWidth: 423
      ImageHeight: 683
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 931
      ImageHeight: 820
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      ImageWidth: 260
      ImageHeight: 509
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      ImageWidth: 281
      ImageHeight: 416
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      ImageWidth: 2046
      ImageHeight: 629
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      ImageWidth: 229
      ImageHeight: 316
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      ImageWidth: 537
      ImageHeight: 490
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      ImageWidth: 538
      ImageHeight: 490
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      ImageWidth: 537
      ImageHeight: 492
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 1558
      ImageHeight: 2076
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: IGHGGB+AdvOTea1a7398
      FontSubset: true
      FirstChar: 31
      LastChar: 180
      FontDescriptor: 
       FontName: IGHGGB+AdvOTea1a7398
       Flags: Symbolic
       FontBBox: -31, -197, 979, 822
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IGHGGC+AdvPi1
      FontSubset: true
      FirstChar: 97
      LastChar: 109
      FontDescriptor: 
       FontName: IGHGGC+AdvPi1
       Flags: Serif, Nonsymbolic
       FontBBox: 13, -323, 958, 824
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IGHHKA+AdvOT125c650c
      FontSubset: true
      FirstChar: 83
      LastChar: 83
      FontDescriptor: 
       FontName: IGHHKA+AdvOT125c650c
       Flags: Symbolic
       FontBBox: -31, -197, 979, 822
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IGIJPF+Helvetica
      FontSubset: true
      FirstChar: 32
      LastChar: 213
      FontDescriptor: 
       FontName: IGIJPF+Helvetica
       Flags: Nonsymbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IGIKLC+Symbol
      FontSubset: true
      FirstChar: 2
      LastChar: 181
      FontDescriptor: 
       FontName: IGIKLC+Symbol
       Flags: Symbolic
       FontBBox: -180, -293, 1090, 1010
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IGHHLB+AdvOT1ef757c0
      FontSubset: true
      FirstChar: 31
      LastChar: 197
      FontDescriptor: 
       FontName: IGHHLB+AdvOT1ef757c0
       Flags: Serif, Symbolic
       FontBBox: -135, -250, 1010, 854
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IGIKOD+MathPackTen
      FontSubset: true
      FirstChar: 2
      LastChar: 2
      FontDescriptor: 
       FontName: IGIKOD+MathPackTen
       Flags: Symbolic, Italic
       FontBBox: 22, -307, 996, 808
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: IGHHND+AdvOTb65e897d.B
      FontSubset: true
      FirstChar: 44
      LastChar: 147
      FontDescriptor: 
       FontName: IGHHND+AdvOTb65e897d.B
       Flags: Serif, Symbolic
       FontBBox: -125, -250, 1052, 854
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IGIKOE+Helvetica-Bold
      FontSubset: true
      FirstChar: 97
      LastChar: 103
      FontDescriptor: 
       FontName: IGIKOE+Helvetica-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IGHGHD+AdvOTcb88df00
      FontSubset: true
      FirstChar: 45
      LastChar: 147
      FontDescriptor: 
       FontName: IGHGHD+AdvOTcb88df00
       Flags: Symbolic
       FontBBox: -31, -197, 968, 833
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IGILMA+AdvOT9bd21c25.I
      FontSubset: true
      FirstChar: 45
      LastChar: 121
      FontDescriptor: 
       FontName: IGILMA+AdvOT9bd21c25.I
       Flags: Symbolic
       FontBBox: -83, -197, 1010, 822
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IGHGMC+Arial-BoldMT
      FontSubset: true
      FirstChar: 69
      LastChar: 80
      FontDescriptor: 
       FontName: IGHGMC+Arial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IGILOA+AdvEls-ent4
      FontSubset: true
      FirstChar: 111
      LastChar: 111
      FontDescriptor: 
       FontName: IGILOA+AdvEls-ent4
       Flags: Nonsymbolic
       FontBBox: 0, -343, 1166, 1218
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IGHGOC+AdvOTf23bb480
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: IGHGOC+AdvOTf23bb480
       Flags: Symbolic
       FontBBox: -31, -187, 968, 822
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IGHHNE+AdvGreek_B
      FontSubset: true
      FirstChar: 98
      LastChar: 108
      FontDescriptor: 
       FontName: IGHHNE+AdvGreek_B
       Flags: Serif, Nonsymbolic
       FontBBox: 0, -302, 989, 812
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IGLHFH+Advsymbol
      FontSubset: true
      FirstChar: 2
      LastChar: 2
      FontDescriptor: 
       FontName: IGLHFH+Advsymbol
       Flags: Serif, Symbolic
       FontBBox: -177, -291, 1083, 1010
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: IGIKNC+Helvetica-Oblique
      FontSubset: true
      FirstChar: 40
      LastChar: 115
      FontDescriptor: 
       FontName: IGIKNC+Helvetica-Oblique
       Flags: Nonsymbolic, Italic
       FontBBox: -170, -225, 1116, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IGMFEC+MyriadPro-Regular
      FontSubset: true
      FirstChar: 150
      LastChar: 150
      FontDescriptor: 
       FontName: IGMFEC+MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IGHHGA+AdvTTda6f6cb8.B
      FontSubset: true
      FirstChar: 49
      LastChar: 57
      FontDescriptor: 
       FontName: IGHHGA+AdvTTda6f6cb8.B
       Flags: Serif, Symbolic
       FontBBox: -93, -218, 1000, 875
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IGHHLC+AdvP4C4E74
      FontSubset: true
      FirstChar: 2
      LastChar: 188
      FontDescriptor: 
       FontName: IGHHLC+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IGHHMC+AdvOT7d6df7ab.I
      FontSubset: true
      FirstChar: 45
      LastChar: 133
      FontDescriptor: 
       FontName: IGHHMC+AdvOT7d6df7ab.I
       Flags: Serif, Symbolic
       FontBBox: -156, -250, 1000, 854
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IGILOB+AdvItcSymbol-M
      FontSubset: true
      FirstChar: 177
      LastChar: 177
      FontDescriptor: 
       FontName: IGILOB+AdvItcSymbol-M
       Flags: Nonsymbolic
       FontBBox: -62, -229, 1208, 833
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IGPCMM+Helvetica
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: IGPCMM+Helvetica
       Flags: Nonsymbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IGPJID+AdvEls-ent3
      FontSubset: true
      FirstChar: 114
      LastChar: 114
      FontDescriptor: 
       FontName: IGPJID+AdvEls-ent3
       Flags: Nonsymbolic
       FontBBox: 0, -208, 1083, 739
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 4.0-c316 44.253921, Sun Oct 01 2006 17:14:39">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="doi:10.1038/ncomms14726"
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1038/ncomms14726</dc:identifier>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>O. Klementieva</rdf:li>
               <rdf:li>K. Willén</rdf:li>
               <rdf:li>I. Martinsson</rdf:li>
               <rdf:li>B. Israelsson</rdf:li>
               <rdf:li>A. Engdahl</rdf:li>
               <rdf:li>J. Cladera</rdf:li>
               <rdf:li>P. Uvdal</rdf:li>
               <rdf:li>G. K. Gouras</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Nature Communications 8, (2017). doi:10.1038/ncomms14726</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Nature Publishing Group</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:rights>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">&#xA;        © 2017 Nature Publishing Group</rdf:li>
            </rdf:Alt>
         </dc:rights>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Pre-plaque conformational changes in Alzheimer’s disease-linked Aβ and APP</rdf:li>
            </rdf:Alt>
         </dc:title>
      </rdf:Description>
      <rdf:Description rdf:about="doi:10.1038/ncomms14726"
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>Acrobat Distiller 8.1.0 (Windows)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about="doi:10.1038/ncomms14726"
            xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/">
         <prism:copyright>© 2017 Nature Publishing Group</prism:copyright>
         <prism:doi>10.1038/ncomms14726</prism:doi>
         <prism:eIssn>2041-1723</prism:eIssn>
         <prism:endingPage>9</prism:endingPage>
         <prism:issn/>
         <prism:number/>
         <prism:publicationName>Nature Publishing Group</prism:publicationName>
         <prism:rightsAgent>permissions@nature.com</prism:rightsAgent>
         <prism:startingPage>1</prism:startingPage>
         <prism:volume>8</prism:volume>
         <prism:publicationDate>
            <rdf:Bag>
               <rdf:li>--01</rdf:li>
            </rdf:Bag>
         </prism:publicationDate>
         <prism:url>
            <rdf:Bag>
               <rdf:li>http://dx.doi.org/10.1038/ncomms14726</rdf:li>
            </rdf:Bag>
         </prism:url>
      </rdf:Description>
      <rdf:Description rdf:about="doi:10.1038/ncomms14726"
            xmlns:xap="http://ns.adobe.com/xap/1.0/">
         <xap:CreateDate>2017-03-04T10:46:23+05:30</xap:CreateDate>
         <xap:CreatorTool>Arbortext Advanced Print Publisher 9.0.226/W</xap:CreatorTool>
         <xap:Label>Nature Communications 8, (2017). doi:10.1038/ncomms14726</xap:Label>
         <xap:MetadataDate>2017-03-07T12:13:34+05:30</xap:MetadataDate>
         <xap:ModifyDate>2017-03-07T12:13:34+05:30</xap:ModifyDate>
         <xap:Identifier>
            <rdf:Bag>
               <rdf:li>doi:10.1038/ncomms14726</rdf:li>
            </rdf:Bag>
         </xap:Identifier>
      </rdf:Description>
      <rdf:Description rdf:about="doi:10.1038/ncomms14726"
            xmlns:xapRights="http://ns.adobe.com/xap/1.0/rights/">
         <xapRights:Marked>True</xapRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about="doi:10.1038/ncomms14726"
            xmlns:xapMM="http://ns.adobe.com/xap/1.0/mm/">
         <xapMM:DocumentID>uuid:b61803ab-e3e1-475f-90ce-ca97bc7e4942</xapMM:DocumentID>
         <xapMM:InstanceID>uuid:c0684275-75a2-407d-bcb3-bb7a1f5f5bc0</xapMM:InstanceID>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 68, 43, 165, 51
      Annotation: 
       Subtype: Link
       Rect: 238, 43, 321, 51
      Annotation: 
       Subtype: Link
       Rect: 245, 23, 360, 30
     Thumb: true
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 158, 622, 162, 629
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 215, 360, 218, 368
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 200, 350, 204, 357
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 219, 318, 231, 326
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 46, 293, 68, 303
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 209, 276, 218, 284
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 146, 255, 149, 263
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 285, 214, 289, 221
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 143, 172, 159, 179
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 514, 705, 522, 713
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 321, 670, 342, 679
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 329, 607, 356, 617
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 372, 538, 388, 545
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 409, 496, 425, 504
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 473, 450, 508, 460
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 510, 429, 546, 439
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 522, 304, 548, 313
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 533, 234, 549, 242
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 518, 199, 546, 209
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 449, 182, 456, 190
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 456, 140, 463, 148
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 472, 99, 480, 106
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 486, 95, 521, 104
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 525, 88, 533, 96
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
     Thumb: true
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 109, 78, 116, 85
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 214, 53, 248, 62
       Destination: 63
      Annotation: 
       Subtype: Link
       Rect: 141, 46, 149, 54
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 245, 23, 360, 30
     Thumb: true
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 256, 116, 289, 126
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 150, 74, 174, 84
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 306, 231, 323, 239
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 296, 210, 314, 218
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
     Thumb: true
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 91, 304, 119, 314
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 69, 235, 76, 242
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 262, 158, 286, 167
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 223, 141, 230, 148
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 463, 126, 489, 135
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 381, 67, 388, 75
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 245, 23, 360, 30
     Thumb: true
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 260, 42, 289, 52
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 379, 199, 406, 209
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 542, 193, 549, 200
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 417, 178, 442, 188
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
     Thumb: true
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 273, 120, 289, 128
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 408, 267, 427, 274
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 463, 246, 470, 253
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 331, 122, 337, 128
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 397, 97, 403, 103
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 245, 23, 360, 30
     Thumb: true
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 173, 594, 179, 600
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 165, 531, 185, 539
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 133, 514, 152, 522
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 230, 450, 236, 456
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 80, 290, 83, 296
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 159, 205, 171, 211
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 262, 129, 265, 135
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 385, 650, 412, 656
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 455, 630, 474, 637
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 381, 564, 400, 571
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 539, 482, 544, 488
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 374, 308, 380, 314
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
     Thumb: true
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 219, 697, 239, 705
       Destination: 63
      Annotation: 
       Subtype: Link
       Rect: 464, 227, 531, 234
      Annotation: 
       Subtype: Link
       Rect: 303, 218, 368, 225
      Annotation: 
       Subtype: Link
       Rect: 475, 189, 538, 196
      Annotation: 
       Subtype: Link
       Rect: 303, 180, 371, 187
      Annotation: 
       Subtype: Link
       Rect: 406, 62, 528, 69
      Annotation: 
       Subtype: Link
       Rect: 245, 23, 360, 30
     Thumb: true
  Checksum: 4dc0140e
   Type: CRC32
  Checksum: 18eac89fe192aa64a5b560672cd6e070
   Type: MD5
  Checksum: 575e62afcb01950916224dc3ae212feda9c9314c
   Type: SHA-1