9535fc4cbccfe22fa5ed2e426c86d751 pmc_28398265.pdf 641cf00e964ae6b3a5e18291e02cec91d1b69f39 pmc_28398265.pdf Title: A Waist-Worn Inertial Measurement Unit for Long- Term Monitoring of Parkinson’s Disease Patients Subject: Inertial measurement units (IMUs) are devices used, among other fields, in health applications, since they are light, small and effective. More concretely, IMUs have been demonstrated to be useful in the monitoring of motor symptoms of Parkinson’s disease (PD). In this sense, most of previous works have attempted to assess PD symptoms in controlled environments or short tests. This paper presents the design of an IMU, called 9 3, that aims to assess PD symptoms, enabling the possibility to perform a map of patients’ symptoms at their homes during long periods. The device is able to acquire and store raw inertial data for artificial intelligence algorithmic training purposes. Furthermore, the presented IMU enables the real-time execution of the developed and embedded learning models. Results show the great flexibility of the 9 3, storing inertial information and algorithm outputs, sending messages to external devices and being able to detect freezing of gait and bradykinetic gait. Results obtained in 12 patients exhibit a sensitivity and specificity over 80%. Additionally, the system enables working 23 days (at waking hours) with a 1200 mAh battery and a sampling rate of 50 Hz, opening up the possibility to be used for other applications like wellbeing and sports. Keywords: inertial measurement unit; Parkinson’s disease; monitoring; inertial data capture; algorithm Author: Daniel Rodríguez-Martín, Carlos Pérez-López, Albert Samà, Andreu Català, Joan Manuel Moreno Arostegui, Joan Cabestany, Berta Mestre, Sheila Alcaine, Anna Prats, María de la Cruz Crespo and Àngels Bayés Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Tue Apr 11 08:54:27 2017 CEST ModDate: Tue Apr 11 08:54:27 2017 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 28 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 4293804 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GJMTQA+URWPalladioL-Ital Type 1 Custom yes yes no 140 0 MWYIRX+URWPalladioL-Bold Type 1 Custom yes yes no 141 0 RBYNXT+VnURWPalladioL-Bold Type 1 Custom yes yes no 142 0 QCLODT+URWPalladioL-Roma Type 1 Custom yes yes no 143 0 YPOTRE+VnURWPalladioL Type 1 Custom yes yes no 144 0 EXROKO+CMSY10 Type 1 Builtin yes yes no 145 0 RVSEMT+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 149 0 IYLPED+CMBSY10 Type 1 Builtin yes yes no 325 0 DDFOFH+PalatinoLinotype TrueType WinAnsi yes yes no 350 0 DDFPBF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 351 0 DDFPBH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 352 0 DDFPGH+TimesNewRoman TrueType WinAnsi yes yes no 353 0 DDFOFH+PalatinoLinotype TrueType WinAnsi yes yes no 376 0 DDFPBF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 377 0 DDFPBH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 378 0 RHFKGB+EURM10 Type 1 Builtin yes yes no 401 0 DDLCPH+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 418 0 DDFOFH+PalatinoLinotype TrueType WinAnsi yes yes no 419 0 DDFPBF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 420 0 DDFPBH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 421 0 DDFOFH+PalatinoLinotype TrueType WinAnsi yes yes no 446 0 DDFPBF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 447 0 DDFPBH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 448 0 DDFOFH+PalatinoLinotype TrueType WinAnsi yes yes no 541 0 DDFPBF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 542 0 DDFPBH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 543 0 QDTWCG+MSBM10 Type 1 Builtin yes yes no 600 0 DDLFBK+CambriaMath CID TrueType Identity-H yes yes yes 605 0 DDFOFH+PalatinoLinotype TrueType WinAnsi yes yes no 606 0 DDFPBF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 607 0 DDFPBH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 608 0 SOSTRQ+CMR10 Type 1 Builtin yes yes no 639 0 QQXUPP+PazoMath Type 1 Builtin yes yes no 640 0 QHUCUA+PazoMath-Italic Type 1 Builtin yes yes no 641 0 GUMJGR+CMEX10 Type 1 Builtin yes yes no 642 0 DDLFBK+CambriaMath CID TrueType Identity-H yes yes yes 650 0 DDFOFH+PalatinoLinotype TrueType WinAnsi yes yes no 651 0 DDFPBF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 652 0 DDFPBH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 653 0 DDFOFG+PalatinoLinotype CID TrueType Identity-H yes yes yes 720 0 DDFOFH+PalatinoLinotype TrueType WinAnsi yes yes no 721 0 DDFPBF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 722 0 DDFPBH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 723 0 DDLCPH+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 753 0 DDFOFH+PalatinoLinotype TrueType WinAnsi yes yes no 754 0 DDFPBF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 755 0 DDFPBH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 756 0 DDLCPH+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 783 0 DDFOFH+PalatinoLinotype TrueType WinAnsi yes yes no 784 0 DDFPBF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 785 0 DDFPBH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 786 0 java.lang.ClassCastException: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject cannot be cast to edu.harvard.hul.ois.jhove.module.pdf.PdfDictionary at edu.harvard.hul.ois.jhove.module.PdfModule.readDocCatalogDict(PdfModule.java:1284) at edu.harvard.hul.ois.jhove.module.PdfModule.parse(PdfModule.java:525) at edu.harvard.hul.ois.jhove.JhoveBase.processFile(JhoveBase.java:825) at edu.harvard.hul.ois.jhove.JhoveBase.process(JhoveBase.java:614) at edu.harvard.hul.ois.jhove.JhoveBase.dispatch(JhoveBase.java:465) at Jhove.main(Jhove.java:296) Jhove (Rel. 1.6, 2011-01-04) Date: 2019-02-14 18:07:05 CET RepresentationInformation: pmc_28398265.pdf ReportingModule: BYTESTREAM, Rel. 1.3 (2007-04-10) LastModified: 2018-02-08 08:05:51 CET Size: 4293804 Format: bytestream Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/octet-stream Checksum: 6250cc4c Type: CRC32 Checksum: 9535fc4cbccfe22fa5ed2e426c86d751 Type: MD5 Checksum: 641cf00e964ae6b3a5e18291e02cec91d1b69f39 Type: SHA-1