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Title:          Angiotensin II type 1/adenosine A2A receptor oligomers: a novel target for tardive dyskinesia
Subject:        Scientific Reports, doi:10.1038/s41598-017-02037-z
Keywords:       
Author:         Paulo A. de Oliveira
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     Item: 
      Title: Angiotensin II type 1/adenosine A2A receptor oligomers: a novel target for tardive dyskinesia
      Children: 
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: AT1R and A2AR form heteromers in cultured cells. 
         Item: 
          Title: Structure of AT1R/A2AR heteromer. 
         Item: 
          Title: Functional consequences of the AT1R and A2AR oligomerization. 
         Item: 
          Title: AT1R and A2AR heteromers are expressed in mouse striatum. 
         Item: 
          Title: Functional interplay between AT1R and A2AR in an animal model of TD. 
       Item: 
        Title: Discussion
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Reagents. 
         Item: 
          Title: Plasmid constructs. 
         Item: 
          Title: Animals. 
         Item: 
          Title: Cell culture. 
         Item: 
          Title: Fixed brain tissue preparation. 
         Item: 
          Title: Bioluminescence resonance energy transfer measurements. 
         Item: 
          Title: Intracellular calcium determination. 
         Item: 
          Title: Immunohistochemistry. 
         Item: 
          Title: Proximity ligation in situ assay. 
         Item: 
          Title: Computational modeling. 
          Children: 
           Item: 
            Title: Ligand docking. 
           Item: 
            Title: Protein-protein docking. 
           Item: 
            Title: Molecular dynamics system setup. 
           Item: 
            Title: Molecular dynamics simulations. 
         Item: 
          Title: Reserpine-induced vacuous chewing movements. 
         Item: 
          Title: Statistics. 
       Item: 
        Title: Acknowledgements
       Item: 
        Title: Figure 1 AT1R and A2AR physically interact in HEK-293T cells.
       Item: 
        Title: Figure 2 Conformational arrangement of AT1R/A2AR heterotetramer.
       Item: 
        Title: Figure 3 A2AR expression potentiates AT1R functioning.
       Item: 
        Title: Figure 4 Detection of AT1R and A2AR proximity in mice striatal sections.
       Item: 
        Title: Figure 5 Effect of AT1R and A2AR blocking in the TD animal model.
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