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Title:          Ligand chain length drives activation of lipid G protein-coupled receptors
Subject:        Scientific Reports, doi:10.1038/s41598-017-02104-5
Keywords:       
Author:         Anastassia Troupiotis-Tsaamp#x000EF;laki
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     Item: 
      Title: Ligand chain length drives activation of lipid G protein-coupled receptors
      Children: 
       Item: 
        Title: Results and Discussion
        Children: 
         Item: 
          Title: Molecular dynamics simulations of S1P1 in complex with the natural S1P agonist. 
         Item: 
          Title: Mechanism of S1P-induced activation of S1P1. 
         Item: 
          Title: Synthesis of S1P analogs. 
         Item: 
          Title: Functional characterization of S1P analogs at S1P receptors. 
         Item: 
          Title: Structure-activity relationships at the sphingosine receptor family. 
       Item: 
        Title: Conclusions
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Molecular dynamics simulations of sphingosine-1-phosphate receptors in complex with ligands. 
         Item: 
          Title: Chemistry. 
         Item: 
          Title: Functional characterization of S1P analogs at S1P receptors. 
          Children: 
           Item: 
            Title: Cell lines. 
           Item: 
            Title: Cell culture. 
           Item: 
            Title: Transient transfection for S1P1 expression. 
           Item: 
            Title: Aequorin-based calcium mobilization assay. 
           Item: 
            Title: NF-κB luciferase reporter assay. 
           Item: 
            Title: Statistical analysis. 
       Item: 
        Title: Acknowledgements
       Item: 
        Title: Figure 1 Structure of ML056, Fingolimod-phosphate, S1P and synthetic derivatives 1–4 of variable chain length.
       Item: 
        Title: Figure 2 Mechanism of S1P-induced activation of S1P1.
       Item: 
        Title: Figure 3 Functional response of S1P receptors to S1P synthetic analogs.
       Item: 
        Title: Figure 4 NF-κB activation via S1P2 in response to S1P analogs.
       Item: 
        Title: Figure 5 Molecular dynamics simulations of sphingosine-1-phosphate receptors.
       Item: 
        Title: Table 1 Emax values of S1P derivatives at S1P receptors.
       Item: 
        Title: Table 2 pEC50 values of S1P derivatives at S1P receptors.
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