13e6d0de77a3e95127769045155aa611  pmc_28526017.pdf
fd73c28484c9501a7939bcb2e32748d9d57c8e4f  pmc_28526017.pdf
f5e155365a2d48e48f7a6520289a8e72013544f4e9d319a0a2b3262fb9ecade6  pmc_28526017.pdf

Title:          The effect of hypoxia on the lipidome of recombinant Pichia pastoris
Subject:        Microbial Cell Factories, doi:10.1186/s12934-017-0699-4
Keywords:       Lipidomics,Pichia pastoris,Hypoxia,Recombinant protein production,Antibody fragment,Protein secretion,Unfolded protein response
Author:         Núria Adelantado
Creator:        Springer
Producer:       Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
CreationDate:   Tue May 16 12:42:42 2017 CEST
ModDate:        Fri May 19 08:36:04 2017 CEST
Tagged:         no
UserProperties: no
Suspects:       no
Form:           AcroForm
JavaScript:     no
Pages:          15
Encrypted:      no
Page size:      595.276 x 790.866 pts
Page rot:       0
File size:      2056596 bytes
Optimized:      no
PDF version:    1.6

name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-Light                      Type 1C           Custom           yes no  yes    126  0
MyriadPro-It                         Type 1C           WinAnsi          yes no  yes     79  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes    113  0
MyriadPro-Bold                       Type 1C           Custom           yes no  yes    114  0
MyriadPro-LightIt                    Type 1C           WinAnsi          yes no  yes    194  0
WarnockPro-Regular                   Type 1C           Custom           yes no  yes     80  0
MyriadPro-Regular                    Type 1C           Custom           yes no  yes     81  0
WarnockPro-It                        Type 1C           Custom           yes no  yes     78  0
JPGKFF+OpenSans                      Type 1C           WinAnsi          yes yes no    1281  0
FJQTGU+MTSY                          Type 1C           Custom           yes yes yes    115  0
MyriadPro-SemiboldIt                 Type 1C           Custom           yes no  yes    116  0
JPVVCD+SPSMTSYBBold                  Type 1C           Custom           yes yes yes    122  0
ACPYEX+MyriadPro-Semibold3           Type 1C           Custom           yes yes no     123  0
ZYFSQZ+MTSYB                         Type 1C           Custom           yes yes no     124  0
ACPYEX+MyriadPro-Semibold2           Type 1C           Custom           yes yes no     125  0
ZYFSQZ+MTSYB                         Type 1C           Custom           yes yes no     127  0
UTSOYJ+Helvetica-Oblique             Type 1C           WinAnsi          yes yes no     188  0
WWRAAF+Helvetica                     Type 1C           WinAnsi          yes yes no     189  0
WWRAAF+Helvetica-BoldOblique         Type 1C           WinAnsi          yes yes no     190  0
UTSOYJ+Helvetica-Oblique             Type 1C           WinAnsi          yes yes no     191  0
WWRAAF+Helvetica                     Type 1C           WinAnsi          yes yes no     192  0
WWRAAF+Helvetica                     Type 1C           WinAnsi          yes yes no     193  0
TPDIKL+Helvetica-Bold                Type 1C           WinAnsi          yes yes no     299  0
TPDIKL+WarnockPro-Regular2           Type 1C           Custom           yes yes no     352  0
RMEWIP+MTSYN                         Type 1C           Custom           yes yes no     353  0
RMEWIP+STIXMath-Regular              Type 1C           WinAnsi          yes yes yes    354  0
IXZHRH+OpenSans-Light                Type 1C           Custom           yes yes no     396  0
HYKBDJ+OregonLDOBook                 Type 1C           WinAnsi          yes yes no     399  0
IXZHRH+OpenSans-Extrabold            Type 1C           WinAnsi          yes yes no     392  0

Jhove (Rel. 1.6, 2011-01-04)
 Date: 2019-02-06 04:47:28 CET
 RepresentationInformation: pmc_28526017.pdf
  ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22)
  LastModified: 2018-02-08 08:01:01 CET
  Size: 2056596
  Format: PDF
  Version: 1.6
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 1534
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: The effect of hypoxia on the lipidome of recombinant Pichia pastoris
      Children: 
       Item: 
        Title: Abstract 
        Children: 
         Item: 
          Title: Background: 
         Item: 
          Title: Results: 
         Item: 
          Title: Conclusions: 
       Item: 
        Title: Background
       Item: 
        Title: Results and discussion
        Children: 
         Item: 
          Title: Hypoxia and fluconazole treatment do not exert synergistic effects on protein secretion
         Item: 
          Title: High Fab secretion yield is observed in all tested culture conditions
         Item: 
          Title: Integrated transcriptomic-lipidomic analysis of the hypoxia effect
          Children: 
           Item: 
            Title: Changes in fatty acid unsaturation were correlated with transcriptional changes of OLE1 encoding fatty acid desaturase
           Item: 
            Title: Changes in the phospholipid pattern correlate with the presenceabsence of intracellular levels of free inositol and UPR upregulation under hypoxia
           Item: 
            Title: Ergosterol content is reduced due to hypoxic conditions
           Item: 
            Title: Non-polar lipids accumulate under hypoxic conditions due to inositol depletion
           Item: 
            Title: Sphingolipids with long fatty acyl moieties increase upon hypoxia
         Item: 
          Title: Fluconazole treatment reduces the ergosterol content but results in a lipid profile different from the hypoxic condition
       Item: 
        Title: Conclusions
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Strain
         Item: 
          Title: Chemostat cultivation
         Item: 
          Title: Hypoxic conditions
         Item: 
          Title: Fluconazole treatment
         Item: 
          Title: Analytical methods
         Item: 
          Title: Cell disruption and protein extraction
         Item: 
          Title: Lipid analysis
         Item: 
          Title: Transcriptional analysis by droplet digital PCR (ddPCR)
         Item: 
          Title: Statistical analysis
       Item: 
        Title: Authors’ contributions
       Item: 
        Title: References
   Info: 
    Title: The effect of hypoxia on the lipidome of recombinant Pichia pastoris
    Author: Núria Adelantado
    Subject: Microbial Cell Factories, doi:10.1186/s12934-017-0699-4
    Keywords: Lipidomics,Pichia pastoris,Hypoxia,Recombinant protein production,Antibody fragment,Protein secretion,Unfolded protein response
    Creator: Springer
    Producer: Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
    CreationDate: Tue May 16 13:12:42 CEST 2017
    ModDate: Fri May 19 08:36:04 CEST 2017
   ID: 0x558db2c02121569e072e31be650a6462, 0x56ac551d7cbfe7454e52881b60ba986e
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 2
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 46
      ImageHeight: 6
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 96
      ImageHeight: 90
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 46
      ImageHeight: 15
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 46
      ImageHeight: 7
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 46
      ImageHeight: 66
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 46
      ImageHeight: 12
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 46
      ImageHeight: 8
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 46
      ImageHeight: 13
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 22
      ImageHeight: 8
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 4
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 4
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 4
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 4
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 5
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 1962
      ImageHeight: 1915
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 1474
      ImageHeight: 936
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 1470
      ImageHeight: 904
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 1878
      ImageHeight: 1020
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 1474
      ImageHeight: 1193
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: WWRAAF+Helvetica
      FontSubset: true
      FirstChar: 32
      LastChar: 122
      FontDescriptor: 
       FontName: WWRAAF+Helvetica
       Flags: Nonsymbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JPGKFF+OpenSans
      FontSubset: true
      FirstChar: 32
      LastChar: 116
      FontDescriptor: 
       FontName: JPGKFF+OpenSans
       Flags: Nonsymbolic
       FontBBox: -550, -271, 1204, 1048
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: WWRAAF+Helvetica
      FontSubset: true
      FirstChar: 32
      LastChar: 122
      FontDescriptor: 
       FontName: WWRAAF+Helvetica
       Flags: Nonsymbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MyriadPro-LightIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-LightIt
       Flags: Nonsymbolic, Italic
       FontBBox: -121, -250, 1007, 863
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -221, -533, 1474, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-It
       Flags: Nonsymbolic, Italic
       FontBBox: -185, -250, 1090, 953
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -177, -533, 1474, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: TPDIKL+WarnockPro-Regular2
      FontSubset: true
      FirstChar: 27
      LastChar: 33
      FontDescriptor: 
       FontName: TPDIKL+WarnockPro-Regular2
       Flags: Symbolic, SmallCap
       FontBBox: 0, -243, 1026, 700
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: RMEWIP+MTSYN
      FontSubset: true
      FirstChar: 31
      LastChar: 33
      FontDescriptor: 
       FontName: RMEWIP+MTSYN
       Flags: Symbolic
       FontBBox: 0, 0, 696, 275
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: RMEWIP+STIXMath-Regular
      FontSubset: true
      FirstChar: 32
      LastChar: 174
      FontDescriptor: 
       FontName: RMEWIP+STIXMath-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -524, 3238, 2566
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: TPDIKL+Helvetica-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 89
      FontDescriptor: 
       FontName: TPDIKL+Helvetica-Bold
       Flags: Nonsymbolic
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: FJQTGU+MTSY
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: FJQTGU+MTSY
       Flags: Symbolic
       FontBBox: 0, -954, 1043, 796
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-SemiboldIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiboldIt
       Flags: Nonsymbolic, Italic
       FontBBox: -193, -250, 1164, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JPVVCD+SPSMTSYBBold
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: JPVVCD+SPSMTSYBBold
       Flags: Symbolic
       FontBBox: -16, -935, 987, 896
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ACPYEX+MyriadPro-Semibold3
      FontSubset: true
      FirstChar: 28
      LastChar: 33
      FontDescriptor: 
       FontName: ACPYEX+MyriadPro-Semibold3
       Flags: Symbolic
       FontBBox: 0, -209, 858, 710
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: ZYFSQZ+MTSYB
      FontSubset: true
      FirstChar: 31
      LastChar: 31
      FontDescriptor: 
       FontName: ZYFSQZ+MTSYB
       Flags: Symbolic
       FontBBox: 0, 0, 696, 297
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: UTSOYJ+Helvetica-Oblique
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: UTSOYJ+Helvetica-Oblique
       Flags: Nonsymbolic, Italic
       FontBBox: -214, -225, 1198, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ACPYEX+MyriadPro-Semibold2
      FontSubset: true
      FirstChar: 27
      LastChar: 32
      FontDescriptor: 
       FontName: ACPYEX+MyriadPro-Semibold2
       Flags: Symbolic
       FontBBox: 0, -209, 858, 710
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: WWRAAF+Helvetica
      FontSubset: true
      FirstChar: 32
      LastChar: 122
      FontDescriptor: 
       FontName: WWRAAF+Helvetica
       Flags: Nonsymbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MyriadPro-Light
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Light
       Flags: Nonsymbolic
       FontBBox: -49, -250, 1046, 883
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WWRAAF+Helvetica-BoldOblique
      FontSubset: true
      FirstChar: 32
      LastChar: 88
      FontDescriptor: 
       FontName: WWRAAF+Helvetica-BoldOblique
       Flags: Nonsymbolic, Italic
       FontBBox: -218, -228, 1207, 962
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ZYFSQZ+MTSYB
      FontSubset: true
      FirstChar: 31
      LastChar: 31
      FontDescriptor: 
       FontName: ZYFSQZ+MTSYB
       Flags: Symbolic
       FontBBox: 0, 0, 696, 297
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: UTSOYJ+Helvetica-Oblique
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: UTSOYJ+Helvetica-Oblique
       Flags: Nonsymbolic, Italic
       FontBBox: -214, -225, 1198, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c015 81.159809, 2016/11/11-01:42:16        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:author="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:jav="http://www.niso.org/schemas/jav/1.0/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmp:CreateDate>2017-05-16T16:12:42+05:30</xmp:CreateDate>
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2017-05-19T08:36:04+02:00</xmp:ModifyDate>
         <xmp:MetadataDate>2017-05-19T08:36:04+02:00</xmp:MetadataDate>
         <pdf:Producer>Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)</pdf:Producer>
         <pdf:Keywords>Lipidomics,Pichia pastoris,Hypoxia,Recombinant protein production,Antibody fragment,Protein secretion,Unfolded protein response</pdf:Keywords>
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1186/s12934-017-0699-4</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>BioMed Central</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Microbial Cell Factories, doi:10.1186/s12934-017-0699-4</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Lipidomics</rdf:li>
               <rdf:li>Pichia pastoris</rdf:li>
               <rdf:li>Hypoxia</rdf:li>
               <rdf:li>Recombinant protein production</rdf:li>
               <rdf:li>Antibody fragment</rdf:li>
               <rdf:li>Protein secretion</rdf:li>
               <rdf:li>Unfolded protein response</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">The effect of hypoxia on the lipidome of recombinant Pichia pastoris</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Núria Adelantado</rdf:li>
               <rdf:li>Pablo Tarazona</rdf:li>
               <rdf:li>Karlheinz Grillitsch</rdf:li>
               <rdf:li>Xavier García-Ortega</rdf:li>
               <rdf:li>Sergi Monforte</rdf:li>
               <rdf:li>Francisco Valero</rdf:li>
               <rdf:li>Ivo Feussner</rdf:li>
               <rdf:li>Günther Daum</rdf:li>
               <rdf:li>Pau Ferrer</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <crossmark:DOI>10.1186/s12934-017-0699-4</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <prism:url>"http://dx.doi.org/10.1186/s12934-017-0699-4</prism:url>
         <prism:doi>10.1186/s12934-017-0699-4</prism:doi>
         <prism:issn>1475-2859</prism:issn>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Microbial Cell Factories</prism:publicationName>
         <prism:copyright>The Author(s)</prism:copyright>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1186/s12934-017-0699-4</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <jav:journal_article_version>VoR</jav:journal_article_version>
         <xmpMM:DocumentID>uuid:552f7b22-340c-4930-a74b-d54f5fe4901b</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:44d39a8a-0efe-4d3d-aceb-93330d1c7aac</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:d09c8305-2a31-4b30-8a82-5bbae38d7bf8</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2017-05-16T16:13:45+05:30</stEvt:when>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:9fa97e70-2a70-45f0-b863-8e6a46575346</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2017-05-16T16:14:21+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <sn:authorInfo>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Pau Ferrer</author:name>
                  <author:orcid>http://orcid.org/0000-0002-5287-4127</author:orcid>
               </rdf:li>
            </rdf:Bag>
         </sn:authorInfo>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>robots</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>Crossmark Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was publishe.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Starting page</pdfaProperty:description>
                           <pdfaProperty:name>startingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 347, 598, 359, 586
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 182, 80, 307, 72
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 443, 64, 525, 56
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 180, 56, 247, 48
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 201, 226, 206, 214
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 212, 226, 217, 214
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 358, 215, 363, 202
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 369, 215, 374, 202
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 366, 191, 371, 178
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 377, 191, 382, 178
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 307, 143, 312, 130
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 484, 683, 541, 658
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 137, 692, 142, 680
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 138, 656, 148, 644
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 153, 656, 163, 644
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 97, 620, 107, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 113, 620, 123, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 232, 620, 242, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 96, 596, 106, 584
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 112, 596, 122, 584
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 261, 596, 271, 584
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 277, 596, 287, 584
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 206, 524, 216, 512
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 169, 500, 179, 488
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 205, 404, 215, 392
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 210, 368, 220, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 193, 332, 203, 320
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 160, 260, 170, 248
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 177, 260, 187, 248
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 121, 200, 131, 188
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 137, 200, 147, 188
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 204, 116, 214, 104
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 404, 680, 414, 668
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 420, 680, 430, 668
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 334, 668, 345, 656
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 351, 668, 361, 656
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 308, 620, 318, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 522, 596, 533, 584
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 387, 476, 397, 464
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 464, 476, 473, 464
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 307, 464, 317, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 390, 464, 400, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 525, 464, 535, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 366, 428, 376, 416
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 407, 284, 416, 272
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 178, 643, 188, 631
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 183, 499, 220, 487
       Flags: Print
       AppearanceDictionary: true
       Destination: 302
      Annotation: 
       Subtype: Link
       Rect: 215, 379, 225, 367
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 224, 343, 260, 331
       Flags: Print
       AppearanceDictionary: true
       Destination: 302
      Annotation: 
       Subtype: Link
       Rect: 154, 319, 159, 307
       Flags: Print
       AppearanceDictionary: true
       Destination: 117
      Annotation: 
       Subtype: Link
       Rect: 164, 247, 174, 235
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 187, 163, 197, 151
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 205, 163, 214, 151
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 333, 512, 338, 500
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 352, 380, 362, 368
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 453, 356, 458, 344
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 407, 200, 412, 188
       Flags: Print
       AppearanceDictionary: true
       Destination: 171
      Annotation: 
       Subtype: Link
       Rect: 421, 200, 431, 188
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
     Thumb: true
    Page: 
     Sequence: 4
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 77, 495, 82, 483
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 126, 459, 131, 447
       Flags: Print
       AppearanceDictionary: true
       Destination: 171
      Annotation: 
       Subtype: Link
       Rect: 278, 387, 288, 375
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 56, 375, 66, 363
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 275, 279, 285, 267
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 186, 111, 190, 99
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 139, 75, 149, 63
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 413, 519, 418, 507
       Flags: Print
       AppearanceDictionary: true
       Destination: 171
      Annotation: 
       Subtype: Link
       Rect: 523, 459, 533, 447
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 355, 411, 365, 399
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 433, 363, 443, 351
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 430, 315, 440, 303
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 503, 267, 513, 255
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 528, 231, 533, 219
       Flags: Print
       AppearanceDictionary: true
       Destination: 171
      Annotation: 
       Subtype: Link
       Rect: 351, 159, 361, 147
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 483, 135, 493, 123
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 523, 111, 533, 99
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 147, 118, 152, 106
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 457, 154, 467, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 382, 106, 392, 94
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 457, 94, 467, 82
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 328, 203, 335, 194
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
     Thumb: true
    Page: 
     Sequence: 7
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 275, 668, 285, 656
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 103, 632, 113, 620
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 97, 608, 102, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 107, 608, 117, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 123, 608, 133, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 188, 584, 198, 572
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 277, 548, 287, 536
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 59, 524, 69, 512
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 242, 512, 252, 500
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 275, 380, 285, 368
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 210, 356, 215, 344
       Flags: Print
       AppearanceDictionary: true
       Destination: 171
      Annotation: 
       Subtype: Link
       Rect: 280, 344, 285, 332
       Flags: Print
       AppearanceDictionary: true
       Destination: 206
      Annotation: 
       Subtype: Link
       Rect: 201, 260, 211, 248
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 257, 260, 267, 248
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 488, 656, 498, 644
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 502, 656, 512, 644
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 425, 536, 434, 524
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 440, 536, 449, 524
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 511, 524, 516, 512
       Flags: Print
       AppearanceDictionary: true
       Destination: 259
      Annotation: 
       Subtype: Link
       Rect: 423, 488, 433, 476
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 504, 440, 514, 428
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 348, 380, 358, 368
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 359, 272, 369, 260
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 427, 248, 432, 236
       Flags: Print
       AppearanceDictionary: true
       Destination: 171
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 127, 493, 132, 481
       Flags: Print
       AppearanceDictionary: true
       Destination: 259
      Annotation: 
       Subtype: Link
       Rect: 523, 668, 533, 656
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 526, 536, 536, 524
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 304, 524, 314, 512
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
     Thumb: true
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 234, 704, 244, 692
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 124, 668, 134, 656
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 163, 644, 168, 632
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 77, 620, 81, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 227, 608, 232, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 206
      Annotation: 
       Subtype: Link
       Rect: 212, 560, 221, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 227, 560, 237, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 194, 500, 199, 488
       Flags: Print
       AppearanceDictionary: true
       Destination: 259
      Annotation: 
       Subtype: Link
       Rect: 118, 488, 123, 476
       Flags: Print
       AppearanceDictionary: true
       Destination: 259
      Annotation: 
       Subtype: Link
       Rect: 486, 572, 491, 560
       Flags: Print
       AppearanceDictionary: true
       Destination: 273
     Thumb: true
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 147, 404, 157, 392
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 232, 320, 242, 308
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 159, 284, 169, 272
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 100, 212, 110, 200
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 471, 607, 481, 595
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 307, 451, 317, 439
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 345, 427, 355, 415
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 308, 187, 538, 175
       Flags: Print
       AppearanceDictionary: true
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 304, 175, 347, 163
       Flags: Print
       AppearanceDictionary: true
       Destination: 82
     Thumb: true
    Page: 
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 103, 296, 113, 284
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 207, 248, 217, 236
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 186, 212, 196, 200
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 171, 140, 181, 128
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 361, 644, 371, 632
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 462, 560, 472, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 398, 512, 408, 500
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 523, 440, 533, 428
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 499, 380, 508, 368
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 350, 332, 360, 320
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 428, 188, 433, 176
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
     Thumb: true
    Page: 
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 117, 428, 122, 416
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 147, 368, 157, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 163, 368, 173, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 385
      Annotation: 
       Subtype: Link
       Rect: 206, 296, 215, 284
       Flags: Print
       AppearanceDictionary: true
       Destination: 381
      Annotation: 
       Subtype: Link
       Rect: 62, 189, 148, 180
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 14
     Thumb: true
    Page: 
     Sequence: 15
     Thumb: true
  Checksum: bd56ff8a
   Type: CRC32
  Checksum: 13e6d0de77a3e95127769045155aa611
   Type: MD5
  Checksum: fd73c28484c9501a7939bcb2e32748d9d57c8e4f
   Type: SHA-1