b5be2b1669950d2bc272323cf80dd552 pmc_28566750.pdf ee7841d8a0e9ba8a843624ef15db08af4a1905fa pmc_28566750.pdf Title: Mutation Spectrum in the CACNA1A Gene in 49 Patients with Episodic Ataxia Subject: Scientific Reports, doi:10.1038/s41598-017-02554-x Keywords: Author: Camp#x000E8;lia Sintas Creator: Springer Producer: iTextSharp™ 5.5.1 ©2000-2014 iText Group NV (AGPL-version); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Fri May 19 15:08:55 2017 CEST ModDate: Wed May 24 11:46:04 2017 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 2511824 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MDPUJA+Corbel-Bold CID TrueType Identity-H yes yes yes 17 0 FAHJPO+Corbel CID TrueType Identity-H yes yes yes 439 0 EuclidSymbol Type 1C Custom yes no yes 15 0 MinionPro-Regular Type 1C Custom yes no yes 19 0 Corbel-BoldItalic TrueType WinAnsi yes no yes 440 0 MinionPro-It Type 1C Custom yes no yes 14 0 Corbel-Bold TrueType WinAnsi yes no yes 441 0 RDDTBQ+Corbel-BoldItalic CID TrueType Identity-H yes yes yes 120 0 Corbel TrueType WinAnsi yes no yes 18 0 EuclidSymbol-Bold Type 1C Custom yes no yes 442 0 BQZDLW+TimesNewRomanPSMT TrueType WinAnsi yes yes yes 443 0 Corbel-Bold TrueType WinAnsi yes no yes 463 0 FLWUEO+Corbel CID TrueType Identity-H yes yes yes 464 0 Corbel TrueType WinAnsi yes no yes 465 0 MyriadPro-It Type 1C WinAnsi yes no yes 466 0 MADXJA+STIXGeneral-Regular Type 1C Custom yes yes yes 13 0 MinionPro-Bold Type 1C WinAnsi yes no yes 16 0 Corbel TrueType WinAnsi yes no yes 55 0 Corbel-Bold TrueType WinAnsi yes no yes 56 0 DDZUCS+Corbel CID TrueType Identity-H yes yes yes 57 0 Corbel TrueType WinAnsi yes no yes 58 0 MyriadPro-It Type 1C WinAnsi yes no yes 59 0 Corbel TrueType WinAnsi yes no yes 141 0 Corbel-Bold TrueType WinAnsi yes no yes 142 0 GFPTSM+Corbel CID TrueType Identity-H yes yes yes 143 0 Corbel TrueType WinAnsi yes no yes 144 0 MyriadPro-It Type 1C WinAnsi yes no yes 145 0 Corbel-Bold TrueType WinAnsi yes no yes 187 0 LDHXFC+Corbel CID TrueType Identity-H yes yes yes 188 0 Corbel TrueType WinAnsi yes no yes 189 0 MyriadPro-It Type 1C WinAnsi yes no yes 190 0 Corbel-Bold TrueType WinAnsi yes no yes 215 0 WVLYDG+Corbel CID TrueType Identity-H yes yes yes 216 0 Corbel TrueType WinAnsi yes no yes 217 0 MyriadPro-It Type 1C WinAnsi yes no yes 218 0 EuclidSymbol-Italic Type 1C Custom yes no yes 323 0 Jhove (Rel. 1.6, 2011-01-04) Date: 2019-02-14 18:02:36 CET RepresentationInformation: pmc_28566750.pdf ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22) LastModified: 2018-02-08 08:00:21 CET Size: 2511824 Format: PDF Version: 1.6 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid destination object Offset: 1697970 ErrorMessage: Invalid destination object Offset: 1697970 ErrorMessage: Invalid destination object Offset: 1670666 ErrorMessage: Invalid destination object Offset: 1670666 ErrorMessage: Invalid destination object Offset: 1670666 ErrorMessage: Invalid destination object Offset: 1697970 ErrorMessage: Invalid destination object Offset: 1697970 ErrorMessage: Invalid destination object Offset: 1670666 ErrorMessage: Invalid destination object Offset: 1697970 ErrorMessage: Invalid destination object Offset: 1697970 ErrorMessage: Invalid destination object Offset: 1697970 ErrorMessage: Invalid destination object Offset: 1697970 ErrorMessage: Invalid destination object Offset: 1697970 MIMEtype: application/pdf PDFMetadata: Objects: 546 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Mutation Spectrum in the CACNA1A Gene in 49 Patients with Episodic Ataxia Children: Item: Title: Results Children: Item: Title: Patients. Item: Title: Sequencing analysis of CACNA1A. Item: Title: CNV analysis of CACNA1A. Item: Title: Nonsense mediated mRNA decay (NMD) assay. Item: Title: Discussion Item: Title: Methods Children: Item: Title: Patients. Item: Title: Sampling and mutation screening. Item: Title: CNV analysis. Item: Title: Nonsense-mediated mRNA decay (NMD) assay. Item: Title: Acknowledgements Item: Title: Figure 1 CACNA1A gene and protein structure with the identified pathogenic variants. Item: Title: Figure 2 Pedigrees from individuals with identified changes. Item: Title: Figure 3 CNV studies in the CACNA1A gene of patient 474. Item: Title: Table 1 Clinical information and results from the CACNA1A mutational screening in episodic ataxia patients with identified variants. Info: Title: Mutation Spectrum in the CACNA1A Gene in 49 Patients with Episodic Ataxia Author: Camp#x000E8;lia Sintas Subject: Scientific Reports, doi:10.1038/s41598-017-02554-x Keywords: Creator: Springer Producer: iTextSharp™ 5.5.1 ©2000-2014 iText Group NV (AGPL-version); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Fri May 19 15:38:55 CEST 2017 ModDate: Wed May 24 11:46:04 CEST 2017 ID: 0xb3fcc2b1bbe18c02817f470e6ac1fe20, 0xf028b845f7a064cd1be5915f4405622a Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: ImageWidth: 1650 ImageHeight: 820 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: ImageWidth: 1650 ImageHeight: 1152 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: ImageWidth: 1650 ImageHeight: 1884 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: MDPUJA+Corbel-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: FAHJPO+Corbel Encoding: Identity-H ToUnicode: true Font: BaseFont: RDDTBQ+Corbel-BoldItalic Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: EuclidSymbol-Italic FirstChar: 0 LastChar: 255 FontDescriptor: FontName: EuclidSymbol-Italic Flags: Symbolic, Italic FontBBox: -166, -276, 1162, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: EuclidSymbol-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: EuclidSymbol-Bold Flags: Symbolic FontBBox: -186, -308, 1101, 960 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MADXJA+STIXGeneral-Regular FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: MADXJA+STIXGeneral-Regular Flags: Serif, Symbolic FontBBox: -995, -455, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: EuclidSymbol FirstChar: 0 LastChar: 255 FontDescriptor: FontName: EuclidSymbol Flags: Symbolic FontBBox: -166, -253, 1090, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true TrueType: Font: BaseFont: Corbel FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Corbel Flags: Nonsymbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: Corbel-BoldItalic FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Corbel-BoldItalic Flags: Nonsymbolic, Italic FontBBox: -494, -239, 1194, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: Corbel-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Corbel-Bold Flags: Nonsymbolic FontBBox: -556, -239, 1155, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: BQZDLW+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 120 FontDescriptor: FontName: BQZDLW+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: FLWUEO+Corbel CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: FLWUEO+Corbel Flags: Symbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Font: BaseFont: RDDTBQ+Corbel-BoldItalic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: RDDTBQ+Corbel-BoldItalic Flags: Symbolic, Italic FontBBox: -494, -239, 1194, 952 FontFile2: true Font: BaseFont: MDPUJA+Corbel-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: MDPUJA+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true XMP: Mutation Spectrum in the CACNA1A Gene in 49 Patients with Episodic Ataxia Camp#x000E8;lia Sintas Oriel Carreamp#x000F1;o Noamp#x000E8;lia Fernamp#x000E0;ndez-Castillo Roser Corominas Marta Vila-Pueyo Claudio Toma Ester Cuenca-Leamp#x000F3;n Isabel Barroeta Carles Roig Vamp#x000ED;ctor Volpini Alfons Macaya Bru Cormand Springer US Scientific Reports, doi:10.1038/s41598-017-02554-x Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 296, 526, 305, 514 Annotation: Subtype: Link Rect: 397, 514, 406, 502 Annotation: Subtype: Link Rect: 299, 288, 302, 276 ActionDest: 51 Annotation: Subtype: Link Rect: 549, 288, 552, 276 ActionDest: 51 Annotation: Subtype: Link Rect: 523, 268, 526, 256 ActionDest: 51 Annotation: Subtype: Link Rect: 544, 248, 547, 236 ActionDest: 51 Annotation: Subtype: Link Rect: 549, 248, 552, 236 ActionDest: 51 Annotation: Subtype: Link Rect: 484, 238, 487, 226 ActionDest: 51 Annotation: Subtype: Link Rect: 313, 53, 382, 43 Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 314, 284, 316, 272 ActionDest: 51 Annotation: Subtype: Link Rect: 181, 274, 184, 262 ActionDest: 51 Annotation: Subtype: Link Rect: 397, 274, 399, 262 ActionDest: 51 Annotation: Subtype: Link Rect: 465, 244, 468, 232 ActionDest: 51 Annotation: Subtype: Link Rect: 549, 244, 552, 232 ActionDest: 51 Annotation: Subtype: Link Rect: 288, 234, 294, 222 ActionDest: 51 Annotation: Subtype: Link Rect: 396, 234, 402, 222 ActionDest: 51 Annotation: Subtype: Link Rect: 405, 204, 408, 192 ActionDest: null Annotation: Subtype: Link Rect: 411, 204, 414, 192 ActionDest: 51 Annotation: Subtype: Link Rect: 416, 204, 422, 192 ActionDest: 51 Annotation: Subtype: Link Rect: 425, 204, 431, 192 ActionDest: 51 Annotation: Subtype: Link Rect: 305, 184, 311, 172 ActionDest: 51 Annotation: Subtype: Link Rect: 314, 184, 320, 172 ActionDest: 52 Annotation: Subtype: Link Rect: 190, 174, 196, 162 ActionDest: 52 Annotation: Subtype: Link Rect: 540, 164, 546, 152 ActionDest: 52 Annotation: Subtype: Link Rect: 549, 164, 554, 152 ActionDest: 52 Annotation: Subtype: Link Rect: 230, 154, 235, 142 ActionDest: 52 Annotation: Subtype: Link Rect: 196, 85, 200, 73 ActionDest: 3 Annotation: Subtype: Link Rect: 524, 652, 530, 643 ActionDest: null Annotation: Subtype: Link Rect: 524, 627, 527, 618 ActionDest: 51 Annotation: Subtype: Link Rect: 524, 605, 530, 597 ActionDest: 52 Annotation: Subtype: Link Rect: 534, 605, 540, 597 ActionDest: 52 Annotation: Subtype: Link Rect: 524, 537, 530, 528 ActionDest: 52 Annotation: Subtype: Link Rect: 524, 505, 530, 496 ActionDest: 52 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 224, 420, 228, 408 ActionDest: null Annotation: Subtype: Link Rect: 246, 420, 250, 408 ActionDest: null Annotation: Subtype: Link Rect: 532, 410, 536, 398 ActionDest: 3 Annotation: Subtype: Link Rect: 353, 400, 357, 388 ActionDest: 3 Annotation: Subtype: Link Rect: 480, 380, 554, 368 Annotation: Subtype: Link Rect: 155, 370, 179, 358 Annotation: Subtype: Link Rect: 358, 370, 464, 358 Annotation: Subtype: Link Rect: 236, 330, 240, 318 ActionDest: 48 Annotation: Subtype: Link Rect: 284, 271, 288, 257 ActionDest: null Annotation: Subtype: Link Rect: 387, 260, 392, 248 ActionDest: null Annotation: Subtype: Link Rect: 350, 251, 356, 237 ActionDest: null Annotation: Subtype: Link Rect: 290, 200, 295, 188 ActionDest: 52 Annotation: Subtype: Link Rect: 298, 200, 304, 188 ActionDest: 52 Annotation: Subtype: Link Rect: 224, 170, 227, 158 ActionDest: 51 Annotation: Subtype: Link Rect: 180, 160, 186, 148 ActionDest: 52 Annotation: Subtype: Link Rect: 398, 122, 403, 110 ActionDest: null Annotation: Subtype: Link Rect: 396, 82, 400, 70 ActionDest: 49 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 393, 285, 401, 273 Annotation: Subtype: Link Rect: 487, 234, 491, 222 ActionDest: 3 Annotation: Subtype: Link Rect: 508, 224, 511, 212 ActionDest: 51 Annotation: Subtype: Link Rect: 513, 224, 519, 212 ActionDest: 52 Annotation: Subtype: Link Rect: 178, 194, 280, 182 Annotation: Subtype: Link Rect: 408, 194, 513, 182 Annotation: Subtype: Link Rect: 380, 174, 386, 162 ActionDest: 51 Annotation: Subtype: Link Rect: 389, 174, 395, 162 ActionDest: 52 Annotation: Subtype: Link Rect: 397, 174, 403, 162 ActionDest: 52 Annotation: Subtype: Link Rect: 508, 144, 517, 132 Annotation: Subtype: Link Rect: 491, 64, 497, 52 ActionDest: 52 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 515, 178, 521, 166 ActionDest: 52 Annotation: Subtype: Link Rect: 524, 178, 530, 166 ActionDest: 52 Annotation: Subtype: Link Rect: 204, 138, 210, 126 ActionDest: 52 Annotation: Subtype: Link Rect: 212, 138, 218, 126 ActionDest: 52 Annotation: Subtype: Link Rect: 220, 138, 226, 126 ActionDest: 52 Annotation: Subtype: Link Rect: 313, 118, 319, 106 ActionDest: 52 Annotation: Subtype: Link Rect: 454, 78, 462, 66 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 215, 704, 218, 692 ActionDest: null Annotation: Subtype: Link Rect: 221, 704, 226, 692 ActionDest: 52 Annotation: Subtype: Link Rect: 288, 684, 293, 672 ActionDest: 52 Annotation: Subtype: Link Rect: 192, 654, 198, 642 ActionDest: 52 Annotation: Subtype: Link Rect: 279, 654, 285, 642 ActionDest: 52 Annotation: Subtype: Link Rect: 528, 644, 533, 632 ActionDest: null Annotation: Subtype: Link Rect: 189, 634, 195, 622 ActionDest: 52 Annotation: Subtype: Link Rect: 253, 634, 259, 622 ActionDest: 52 Annotation: Subtype: Link Rect: 420, 634, 426, 622 ActionDest: 52 Annotation: Subtype: Link Rect: 239, 624, 245, 612 ActionDest: 52 Annotation: Subtype: Link Rect: 365, 624, 369, 612 ActionDest: 3 Annotation: Subtype: Link Rect: 498, 534, 504, 522 ActionDest: null Annotation: Subtype: Link Rect: 544, 524, 549, 512 ActionDest: null Annotation: Subtype: Link Rect: 193, 484, 199, 472 ActionDest: 52 Annotation: Subtype: Link Rect: 197, 464, 202, 452 ActionDest: 52 Annotation: Subtype: Link Rect: 392, 434, 398, 422 ActionDest: null Annotation: Subtype: Link Rect: 510, 404, 516, 392 ActionDest: 52 Annotation: Subtype: Link Rect: 518, 404, 524, 392 ActionDest: 52 Annotation: Subtype: Link Rect: 350, 284, 355, 272 ActionDest: 52 Annotation: Subtype: Link Rect: 417, 284, 422, 272 ActionDest: 52 Annotation: Subtype: Link Rect: 493, 284, 499, 272 ActionDest: 52 Annotation: Subtype: Link Rect: 381, 274, 387, 262 ActionDest: 52 Annotation: Subtype: Link Rect: 415, 274, 420, 262 ActionDest: 52 Annotation: Subtype: Link Rect: 467, 274, 473, 262 ActionDest: 52 Annotation: Subtype: Link Rect: 388, 140, 394, 128 ActionDest: 52 Annotation: Subtype: Link Rect: 473, 120, 479, 108 ActionDest: 52 Annotation: Subtype: Link Rect: 482, 120, 487, 108 ActionDest: 52 Annotation: Subtype: Link Rect: 447, 90, 551, 78 Annotation: Subtype: Link Rect: 316, 80, 412, 68 Annotation: Subtype: Link Rect: 475, 60, 554, 48 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 155, 734, 256, 722 Annotation: Subtype: Link Rect: 270, 536, 279, 524 Annotation: Subtype: Link Rect: 251, 348, 337, 336 Annotation: Subtype: Link Rect: 269, 271, 357, 261 Annotation: Subtype: Link Rect: 372, 254, 451, 244 Annotation: Subtype: Link Rect: 290, 237, 371, 227 Annotation: Subtype: Link Rect: 317, 220, 393, 210 Annotation: Subtype: Link Rect: 461, 203, 554, 193 Annotation: Subtype: Link Rect: 207, 161, 309, 151 Annotation: Subtype: Link Rect: 179, 144, 280, 134 Annotation: Subtype: Link Rect: 363, 127, 471, 117 Annotation: Subtype: Link Rect: 179, 110, 284, 100 Annotation: Subtype: Link Rect: 359, 93, 415, 83 Annotation: Subtype: Link Rect: 403, 76, 458, 66 Annotation: Subtype: Link Rect: 353, 59, 429, 49 Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 528, 735, 554, 724 Annotation: Subtype: Link Rect: 167, 726, 219, 716 Annotation: Subtype: Link Rect: 179, 709, 262, 699 Annotation: Subtype: Link Rect: 466, 692, 521, 682 Annotation: Subtype: Link Rect: 364, 675, 441, 665 Annotation: Subtype: Link Rect: 405, 658, 480, 648 Annotation: Subtype: Link Rect: 240, 641, 319, 631 Annotation: Subtype: Link Rect: 343, 607, 426, 597 Annotation: Subtype: Link Rect: 320, 590, 395, 580 Annotation: Subtype: Link Rect: 317, 573, 393, 563 Annotation: Subtype: Link Rect: 336, 556, 387, 546 Annotation: Subtype: Link Rect: 282, 539, 359, 529 Annotation: Subtype: Link Rect: 282, 522, 361, 512 Annotation: Subtype: Link Rect: 294, 505, 369, 495 Annotation: Subtype: Link Rect: 388, 488, 495, 478 Annotation: Subtype: Link Rect: 379, 471, 486, 461 Annotation: Subtype: Link Rect: 405, 454, 452, 444 Annotation: Subtype: Link Rect: 304, 437, 371, 427 Annotation: Subtype: Link Rect: 458, 420, 554, 410 Annotation: Subtype: Link Rect: 269, 395, 337, 384 Annotation: Subtype: Link Rect: 179, 377, 237, 367 Annotation: Subtype: Link Rect: 504, 369, 554, 359 Annotation: Subtype: Link Rect: 167, 360, 209, 350 Annotation: Subtype: Link Rect: 527, 327, 554, 316 Annotation: Subtype: Link Rect: 167, 318, 210, 308 Annotation: Subtype: Link Rect: 287, 301, 349, 291 Annotation: Subtype: Link Rect: 484, 284, 531, 274 Annotation: Subtype: Link Rect: 326, 267, 438, 257 Annotation: Subtype: Link Rect: 252, 250, 336, 240 Annotation: Subtype: Link Rect: 260, 233, 344, 223 Annotation: Subtype: Link Rect: 399, 216, 507, 206 Annotation: Subtype: Link Rect: 324, 182, 426, 172 Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 370, 657, 474, 644 Annotation: Subtype: Link Rect: 344, 533, 504, 521 Thumb: true Checksum: c09394ae Type: CRC32 Checksum: b5be2b1669950d2bc272323cf80dd552 Type: MD5 Checksum: ee7841d8a0e9ba8a843624ef15db08af4a1905fa Type: SHA-1