5b040cfa5c8277bb1eaafada7226b1bf pmc_28620295.pdf 7482f34cf6c3982afc39f3d0013eae60e2c3dac6 pmc_28620295.pdf 8860001fe649cd437e7f1f8c9ebbb53144045ac1154a524640ff06921e77742a pmc_28620295.pdf Title: Slow and Fast Neocortical Oscillations in the Senescence-Accelerated Mouse Model SAMP8 Subject: The senescence-accelerated mouse prone 8 (SAMP8) model is characterized by accelerated, progressive cognitive decline as well as Alzheimer's disease (AD)-like neurodegenerative changes, and resembles the etiology of multicausal, sporadic late-onset/age-related AD in humans. Keywords: slow waves, slow oscillations, aging, gamma, cerebral cortex, Up states, Alzheimer, brain rhythms Author: Maria V. Sanchez-Vives Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.12 CreationDate: Fri May 19 09:31:25 2017 CEST ModDate: Fri May 19 12:59:33 2017 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 3569965 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ULIVVW+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 698 0 ICFDFN+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 699 0 DFPFGV+HelveticaNeueLTStd-MdIt Type 1 Custom yes yes no 700 0 QUIJHV+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 701 0 MZIEKT+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 702 0 IMLXCB+MinionPro-It Type 1 Custom yes yes no 476 0 EALSYZ+MTGU Type 1 Builtin yes yes no 477 0 RCECTW+MinionPro-Regular Type 1 Custom yes yes no 484 0 PROYOR+MTSYN Type 1 Builtin yes yes no 475 0 PIOQSV+MinionPro-Bold Type 1 Custom yes yes no 495 0 WTUXLH+RMTMI Type 1 Builtin yes yes no 493 0 TNCNDS+MTSY Type 1 Builtin yes yes no 502 0 Jhove (Rel. 1.6, 2011-01-04) Date: 2019-02-14 18:00:57 CET RepresentationInformation: pmc_28620295.pdf ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22) LastModified: 2018-02-08 07:58:31 CET Size: 3569965 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 812 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Slow and Fast Neocortical Oscillations in the Senescence-Accelerated Mouse Model SAMP8 Children: Item: Title: INTRODUCTION Item: Title: MATERIALS AND METHODS Children: Item: Title: Animals Item: Title: In Vivo Extracellular Recordings Item: Title: Data Analysis Item: Title: Statistical Analysis Item: Title: RESULTS Children: Item: Title: Parameters of the Slow Oscillation in Anesthetized SAMP8 Mice Item: Title: Fast Components of SAMP8 Cortical Slow Oscillations Item: Title: DISCUSSION Item: Title: AUTHOR CONTRIBUTIONS Item: Title: ACKNOWLEDGMENTS Item: Title: REFERENCES Info: Title: Slow and Fast Neocortical Oscillations in the Senescence-Accelerated Mouse Model SAMP8 Author: Maria V. Sanchez-Vives Subject: The senescence-accelerated mouse prone 8 (SAMP8) model is characterized by accelerated, progressive cognitive decline as well as Alzheimer's disease (AD)-like neurodegenerative changes, and resembles the etiology of multicausal, sporadic late-onset/age-related AD in humans. Keywords: slow waves, slow oscillations, aging, gamma, cerebral cortex, Up states, Alzheimer, brain rhythms Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.12 CreationDate: Fri May 19 10:01:25 CEST 2017 ModDate: Fri May 19 13:29:33 CEST 2017 ID: 0xc79f6afa2d6f713f6a9db61298715a63, 0xc261a5beb4360a4ca52f7a13f9a2958a Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: RCECTW+MinionPro-Regular FontSubset: true FirstChar: 37 LastChar: 252 FontDescriptor: FontName: RCECTW+MinionPro-Regular Flags: Symbolic FontBBox: -288, -358, 1684, 989 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: TNCNDS+MTSY FontSubset: true FirstChar: 3 LastChar: 3 FontDescriptor: FontName: TNCNDS+MTSY Flags: Symbolic FontBBox: 0, -954, 1043, 796 FontFile: true Font: BaseFont: ULIVVW+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 2 LastChar: 124 FontDescriptor: FontName: ULIVVW+HelveticaNeueLTStd-Bd Flags: Symbolic FontBBox: -164, -216, 1078, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: ICFDFN+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 2 LastChar: 150 FontDescriptor: FontName: ICFDFN+HelveticaNeueLTStd-Lt Flags: Symbolic FontBBox: -164, -212, 1050, 967 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: PROYOR+MTSYN FontSubset: true FirstChar: 0 LastChar: 67 FontDescriptor: FontName: PROYOR+MTSYN Flags: Symbolic FontBBox: 0, -954, 1043, 900 FontFile: true Font: BaseFont: DFPFGV+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 122 FontDescriptor: FontName: DFPFGV+HelveticaNeueLTStd-MdIt Flags: Symbolic FontBBox: -163, -216, 1125, 947 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: IMLXCB+MinionPro-It FontSubset: true FirstChar: 40 LastChar: 169 FontDescriptor: FontName: IMLXCB+MinionPro-It Flags: Symbolic FontBBox: -199, -358, 1684, 1002 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: QUIJHV+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 39 LastChar: 250 FontDescriptor: FontName: QUIJHV+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -163, -212, 1099, 951 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: EALSYZ+MTGU FontSubset: true FirstChar: 50 LastChar: 109 FontDescriptor: FontName: EALSYZ+MTGU Flags: Symbolic FontBBox: 25, -213, 839, 683 FontFile: true Font: BaseFont: WTUXLH+RMTMI FontSubset: true FirstChar: 60 LastChar: 60 FontDescriptor: FontName: WTUXLH+RMTMI Flags: Symbolic FontBBox: 0, -213, 987, 680 FontFile: true Font: BaseFont: MZIEKT+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: MZIEKT+HelveticaNeueLTStd-BdIt Flags: Symbolic FontBBox: -164, -216, 1129, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: PIOQSV+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 117 FontDescriptor: FontName: PIOQSV+MinionPro-Bold Flags: Symbolic FontBBox: -317, -358, 1684, 1024 FontFile: true EncodingDictionary: Differences: true XMP: 2017-05-19T13:01:25+05:30 LaTeX with hyperref package 2017-05-19T16:29:33+05:30 2017-05-19T16:29:33+05:30 application/pdf The senescence-accelerated mouse prone 8 (SAMP8) model is characterized by accelerated, progressive cognitive decline as well as Alzheimer's disease (AD)-like neurodegenerative changes, and resembles the etiology of multicausal, sporadic late-onset/age-related AD in humans. Maria V. 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