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Title:          Gag-protease coevolution analyses define novel structural surfaces in the HIV-1 matrix and capsid involved in resistance to Protease Inhibitors
Subject:        Scientific Reports, doi:10.1038/s41598-017-03260-4
Keywords:       
Author:         Francisco M Codoamp#x000F1;er
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     Item: 
      Title: Gag-protease coevolution analyses define novel structural surfaces in the HIV-1 matrix and capsid involved in resistance to ...
      Children: 
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: HIV-1 mutations at Gag cleavage and non-cleavage sites emerge concomitantly in vivo during resistance to PIs. 
         Item: 
          Title: HIV-1 Gag coevolving residues identify the matrix protein as the major contributor to protease evolution under selective pr ...
         Item: 
          Title: HIV-1 Gag coevolving residues define specific protein surfaces in the matrix and capsid. 
         Item: 
          Title: Gag-protease coevolution during treatment with PIs is independent of HIV-1-specific CD8+T-cell immune pressure. 
       Item: 
        Title: Discussion
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Study subjects. 
         Item: 
          Title: Ethics Statement. 
         Item: 
          Title: Bulk amplification of the HIV-1 Gag-protease coding region. 
         Item: 
          Title: Single genome amplification (SGA) of the HIV-1 Gag -protease coding region. 
         Item: 
          Title: Sequence analyses. 
         Item: 
          Title: Gag-protease coevolutionary analysis for protein sequences: CAPS. 
         Item: 
          Title: Molecular modelling. 
         Item: 
          Title: HLA typing and assessment of HIV-1–specific CD8 + T-cell responses. 
       Item: 
        Title: Acknowledgements
       Item: 
        Title: Figure 1 Gag cleavage sites and protease mutations in long-term PI-experienced HIV-1–infected patients.
       Item: 
        Title: Figure 2 HIV-1 Gag correlated residues with protease.
       Item: 
        Title: Figure 3 Coevolving groups of Gag-protease residues and protein structural mapping.
       Item: 
        Title: Figure 4 Mapping of coevolving HIV-1 p17 and p24 sites at the quaternary protein structural level.
       Item: 
        Title: Figure 5 Correlated Gag resides and HIV-1 Gag-specific CD8+ T-cell responses.
       Item: 
        Title: Table 1 Amino acid variation in Gag proteins.
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  Checksum: a67fec57
   Type: CRC32
  Checksum: c5961774417b7ed23d21537a017aaeaf
   Type: MD5
  Checksum: 25fbb251f4771c87f7f432d99b25fe59e100a002
   Type: SHA-1