77961563ac6c5d72736aaa3866b45be9 pmc_28630427.pdf 7aa232df4abca08c047db83d4bfd94c1f6cd8145 pmc_28630427.pdf 597fd65aabd081a33350d595621b00150bded93b87bebecd727fd9de9260b90a pmc_28630427.pdf Title: Insulin use and Excess Fracture Risk in Patients with Type 2 Diabetes: A Propensity-Matched cohort analysis Subject: Scientific Reports, doi:10.1038/s41598-017-03748-z Keywords: Author: Eladio Losada-Grande Creator: Springer Producer: iTextSharp™ 5.5.1 ©2000-2014 iText Group NV (AGPL-version); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Sat Jun 10 04:23:43 2017 CEST ModDate: Tue Jun 13 12:42:11 2017 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1369146 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GOQESC+Corbel CID TrueType Identity-H yes yes yes 286 0 GQCASC+TimesNewRomanPSMT TrueType WinAnsi yes yes yes 287 0 Corbel-Bold TrueType WinAnsi yes no yes 71 0 GERZSC+Corbel-Bold CID TrueType Identity-H yes yes yes 105 0 Corbel TrueType WinAnsi yes no yes 18 0 MinionPro-Regular Type 1C Custom yes no yes 13 0 Corbel-Bold TrueType WinAnsi yes no yes 329 0 DYNHMI+Corbel CID TrueType Identity-H yes yes yes 330 0 Corbel TrueType WinAnsi yes no yes 331 0 MyriadPro-It Type 1C WinAnsi yes no yes 332 0 EuclidSymbol-Bold Type 1C Custom yes no yes 14 0 EuclidSymbol Type 1C Custom yes no yes 15 0 STIXGeneral-Bold Type 1C Custom yes no yes 16 0 JEBTIW+STIXGeneral-Regular Type 1C Custom yes yes yes 17 0 MinionPro-Bold Type 1C Custom yes no yes 19 0 Corbel TrueType WinAnsi yes no yes 30 0 Corbel-Bold TrueType WinAnsi yes no yes 31 0 GXJQCC+Corbel CID TrueType Identity-H yes yes yes 32 0 Corbel TrueType WinAnsi yes no yes 33 0 MyriadPro-It Type 1C WinAnsi yes no yes 34 0 Corbel TrueType WinAnsi yes no yes 83 0 Corbel-Bold TrueType WinAnsi yes no yes 84 0 HXOTLA+Corbel CID TrueType Identity-H yes yes yes 85 0 Corbel TrueType WinAnsi yes no yes 86 0 MyriadPro-It Type 1C WinAnsi yes no yes 87 0 Corbel-Bold TrueType WinAnsi yes no yes 135 0 KEIXBU+Corbel CID TrueType Identity-H yes yes yes 136 0 Corbel TrueType WinAnsi yes no yes 137 0 MyriadPro-It Type 1C WinAnsi yes no yes 138 0 MinionPro-It Type 1C Custom yes no yes 171 0 Corbel-Bold TrueType WinAnsi yes no yes 192 0 JXBINW+Corbel CID TrueType Identity-H yes yes yes 193 0 Corbel TrueType WinAnsi yes no yes 194 0 MyriadPro-It Type 1C WinAnsi yes no yes 195 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-02-08 02:51:10 CET RepresentationInformation: pmc_28630427.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2018-02-08 07:58:04 CET Size: 1369146 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 417 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Insulin use and Excess Fracture Risk in Patients with Type 2 Diabetes: A Propensity-Matched cohort analysis Children: Item: Title: Results Item: Title: Discussion Item: Title: Research Design and Methods Children: Item: Title: Data collection. Item: Title: Patient involvement. Item: Title: Outcomes. Item: Title: Exposures. Item: Title: Confounders. Item: Title: Statistical analysis. Item: Title: Sensitivity analysis. Item: Title: Acknowledgements Item: Title: Figure 1 Cumulative incidence function plot of bone fracture after type 2 diabetes mellitus diagnosis between non-insulin and insulin users accounting for time-varying exposure. Item: Title: Table 1 Baseline characteristics of patients with incident T2DM stratified by insulin use vs non-insulin use during follow-up. Item: Title: Table 2 Fracture incidence among matched users of any insulin (N = 2,979) and non-users of insulin (N = 14,895). Item: Title: Table 3 Fracture incidence among users of any insulin (N = 2,980) vs matched non-users (N = 24,900), stratified by quartiles of insulin medication possession ratio (MPR) within first year of first insulin use. 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