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Title:          Plasticity in the Oxidative Folding Pathway of the High Affinity Nerita Versicolor Carboxypeptidase Inhibitor (NvCI)
Subject:        Scientific Reports, doi:10.1038/s41598-017-05657-7
Keywords:       
Author:         Sebastiamp#x000E1;n A. Esperante
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     Item: 
      Title: Plasticity in the Oxidative Folding Pathway of the High Affinity Nerita Versicolor Carboxypeptidase Inhibitor (NvCI)
      Children: 
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Oxidative folding of NvCI. 
         Item: 
          Title: Reductive unfolding of NvCI. 
         Item: 
          Title: Disulfide-pairing analysis of the major folding intermediates. 
         Item: 
          Title: Stop-go folding of the major intermediates of NvCI. 
         Item: 
          Title: Conformational Stability of NvCI. 
         Item: 
          Title: Functional and conformational characterization of des(15–51) NvCI. 
       Item: 
        Title: Discussion
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Protein expression and purification. 
         Item: 
          Title: Oxidative Folding and Reductive Unfolding Experiments. 
         Item: 
          Title: Disulfide-bond content and disulfide pairing analysis of the major intermediates of oxidative folding and reductive unfoldi ...
         Item: 
          Title: Stop/Go folding. 
         Item: 
          Title: Disulfide scrambling. 
         Item: 
          Title: Circular Dichroism, Fluorescence and NMR spectroscopy. 
         Item: 
          Title: MALDI-TOF analyses. 
         Item: 
          Title: Determination of MCPs inhibitory activities of native NvCI and des(15–51) intermediate. 
       Item: 
        Title: Acknowledgements
       Item: 
        Title: Figure 1 Schematic view of the native three-dimensional structure of NvCI and the NvCI-hCPA4 complex.
       Item: 
        Title: Figure 2 RP-HPLC analysis of the folding intermediates and quantitative analysis of disulfide species along the oxidative folding pathway of NvCI.
       Item: 
        Title: Figure 3 Secondary and tertiary structural changes upon oxidative folding of NvCI.
       Item: 
        Title: Figure 4 Reductive unfolding of native NvCI.
       Item: 
        Title: Figure 5 Disulfide-pairing determination of the major oxidative folding intermediates of NvCI.
       Item: 
        Title: Figure 6 Derivatization and HPLC isolation of two 2 S-S folding intermediates of NvCI.
       Item: 
        Title: Figure 7 Stop/go folding of the major folding/unfolding intermediates of NvCI.
       Item: 
        Title: Figure 8 Oxidative folding of NvCI in the presence of high denaturing conditions.
       Item: 
        Title: Figure 9 Disulfide scrambling of NvCI under different concentrations of denaturants.
       Item: 
        Title: Figure 10 Schematic representation of the disulfide oxidative folding pathway of NvCI.
       Item: 
        Title: Table 1 Summary of Ki values of native and des(15–51) intermediate against various carboxypeptidases.
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   Type: CRC32
  Checksum: 54d1cb989e26c41e69fb5bbfde866a50
   Type: MD5
  Checksum: 9ccab2cc433e19ad648d84ff2e12efb602f259f6
   Type: SHA-1
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   Type: SHA-256