6f31c27aad7e133673250bbd61287ef3 pmc_28738907.pdf 7549fe1907830f5fc93416155caa823b662f6a2c pmc_28738907.pdf Title: RIG-I expression in perifascicular myofibers is a reliable biomarker of dermatomyositis Subject: Arthritis Research & Therapy, 2017, doi:10.1186/s13075-017-1383-0 Keywords: Inflammatory myopathies,Dermatomyositis,Biomarker,Muscle biopsy,Perifascicular atrophy Author: Xavier Suárez-Calvet Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Mon Jul 17 15:22:51 2017 CEST ModDate: Mon Jul 24 15:22:35 2017 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 7 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 730502 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-Regular Type 1 Custom yes no no 8 0 DPGDFB+KjflsmAdvTTb5929f4c+20 Type 1C WinAnsi yes yes no 106 0 DPGDEP+QxtkvfAdvTTe45e47d2 Type 1C WinAnsi yes yes no 14 0 DPGDFC+RfgxdnAdvTT99c4c969 Type 1C WinAnsi yes yes no 11 0 DPGDFA+DwkjblAdvTTb5929f4c Type 1C WinAnsi yes yes no 49 0 DPGDGD+PyqnxgAdvTT1b53b5fb.I Type 1C WinAnsi yes yes no 66 0 DPGDGE+CwcqrbAdvTTb5929f4c+03 Type 1C Custom yes yes yes 67 0 DPGDBA+BhsybtAdvTTaf7f9f4f.B Type 1C WinAnsi yes yes no 9 0 DPGDHE+BtymwbAdvTT86d47313 Type 1C WinAnsi yes yes no 15 0 DPGECB+LmfxrrAdvTT7329fd89.I Type 1C WinAnsi yes yes no 16 0 DPGEED+VmpyvbAdvTT8861b38f.I Type 1C WinAnsi yes yes no 10 0 DPGEEE+SxptttAdvTT86d47313+20 Type 1C Custom yes yes yes 12 0 DPGEFE+HjxgqfAdvTT86d47313+03 Type 1C Custom yes yes yes 13 0 DPGEKE+DkjywvAdvTTe45e47d2+03 Type 1C Custom yes yes yes 65 0 DPGEKD+WbyhsjAdvTTe45e47d2+20 Type 1C WinAnsi yes yes no 68 0 DPGLGM+XgnbrqAdvTT99c4c969+20 Type 1C WinAnsi yes yes no 107 0 DPGLHM+JlxykpAdvTTaf7f9f4f.B+20 Type 1C WinAnsi yes yes no 108 0 FrlxrpOpenSans-Light Type 1C MacRoman yes no no 131 0 NjdmrgOregonLDOBook Type 1C WinAnsi yes no no 132 0 VsnkrjOpenSans-Extrabold Type 1C WinAnsi yes no no 133 0 Jhove (Rel. 1.6, 2011-01-04) Date: 2019-02-14 17:58:04 CET RepresentationInformation: pmc_28738907.pdf ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22) LastModified: 2018-02-08 07:54:46 CET Size: 730502 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 ErrorMessage: Invalid destination object Offset: 499005 MIMEtype: application/pdf PDFMetadata: Objects: 356 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7c53a9eb Children: Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed17bee Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2a33fae0 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@707f7052 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11028347 Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@14899482 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@21588809 Children: Item: Title: Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2aae9190 Item: Title: Serum autoantibodies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2f333739 Item: Title: Immunohistochemical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77468bd9 Item: Title: Analysis of perifascicular atrophy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12bb4df8 Item: Title: Statistics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4cc77c2e Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a7b0070 Children: Item: Title: Clinical data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@39a054a5 Item: Title: Perifascicular atrophy affecting two rows of muscle fibers is more frequently associated with DM Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@71bc1ae4 Item: Title: Perifascicular RIG-I expression is associated with DM Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6ed3ef1 Item: Title: Value of combined analysis of perifascicular atrophy and RIG-I for the diagnosis of DM Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2437c6dc Item: Title: Comparison of RIG-I and MxA staining Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1f89ab83 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e73f9ac Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@61064425 Item: Title: Additional files Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b1d7fff Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@299a06ac Item: Title: Availability of data and materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@383534aa Item: Title: Ethics approval and consent to participate Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6bc168e5 Item: Title: Consent for publication Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b3300e5 Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2e5c649 Item: Title: Publisher’s Note Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@136432db Item: Title: Author details Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7382f612 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1055e4af Info: Title: RIG-I expression in perifascicular myofibers is a reliable biomarker of dermatomyositis Author: Xavier Suárez-Calvet Subject: Arthritis Research & Therapy, 2017, doi:10.1186/s13075-017-1383-0 Keywords: Inflammatory myopathies,Dermatomyositis,Biomarker,Muscle biopsy,Perifascicular atrophy Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Mon Jul 17 15:22:51 CEST 2017 ModDate: Mon Jul 24 15:22:35 CEST 2017 ID: 0x4916dcbab29a684bf5b371f8690371ea, 0xfb89a449bff2357239087d0388a75b51 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: ImageWidth: 688 ImageHeight: 126 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 95 ImageHeight: 91 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 1183 ImageHeight: 880 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: DPGEKE+DkjywvAdvTTe45e47d2+03 FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: DPGEKE+DkjywvAdvTTe45e47d2+03 Flags: Symbolic FontBBox: -531, -250, 791, 947 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DPGDGD+PyqnxgAdvTT1b53b5fb.I FontSubset: true FirstChar: 32 LastChar: 119 FontDescriptor: FontName: DPGDGD+PyqnxgAdvTT1b53b5fb.I Flags: Nonsymbolic FontBBox: -114, -250, 864, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DPGDGE+CwcqrbAdvTTb5929f4c+03 FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: DPGDGE+CwcqrbAdvTTb5929f4c+03 Flags: Symbolic FontBBox: -531, -260, 802, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FrlxrpOpenSans-Light FirstChar: 32 LastChar: 222 FontDescriptor: FontName: FrlxrpOpenSans-Light Flags: Nonsymbolic FontBBox: -521, -269, 1140, 1048 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: DPGEKD+WbyhsjAdvTTe45e47d2+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: DPGEKD+WbyhsjAdvTTe45e47d2+20 Flags: Nonsymbolic FontBBox: -447, -197, 1302, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NjdmrgOregonLDOBook FirstChar: 0 LastChar: 255 FontDescriptor: FontName: NjdmrgOregonLDOBook Flags: Serif, Nonsymbolic FontBBox: 1, -308, 1045, 922 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: VsnkrjOpenSans-Extrabold FirstChar: 32 LastChar: 149 FontDescriptor: FontName: VsnkrjOpenSans-Extrabold Flags: Nonsymbolic FontBBox: -728, -293, 1407, 1124 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MyriadPro-Regular FirstChar: 1 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -46, -250, 1126, 879 FontFile: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: DPGDBA+BhsybtAdvTTaf7f9f4f.B FontSubset: true FirstChar: 32 LastChar: 117 FontDescriptor: FontName: DPGDBA+BhsybtAdvTTaf7f9f4f.B Flags: Nonsymbolic FontBBox: -218, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DPGDFB+KjflsmAdvTTb5929f4c+20 FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: DPGDFB+KjflsmAdvTTb5929f4c+20 Flags: Nonsymbolic FontBBox: -447, -208, 1375, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DPGEED+VmpyvbAdvTT8861b38f.I FontSubset: true FirstChar: 32 LastChar: 112 FontDescriptor: FontName: DPGEED+VmpyvbAdvTT8861b38f.I Flags: Nonsymbolic FontBBox: -187, -239, 1062, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DPGDFC+RfgxdnAdvTT99c4c969 FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: DPGDFC+RfgxdnAdvTT99c4c969 Flags: Nonsymbolic FontBBox: -41, -250, 854, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DPGLGM+XgnbrqAdvTT99c4c969+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: DPGLGM+XgnbrqAdvTT99c4c969+20 Flags: Nonsymbolic FontBBox: -447, -197, 1583, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DPGEEE+SxptttAdvTT86d47313+20 FontSubset: true FirstChar: 1 LastChar: 145 FontDescriptor: FontName: DPGEEE+SxptttAdvTT86d47313+20 Flags: Symbolic FontBBox: -218, -218, 1291, 812 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DPGLHM+JlxykpAdvTTaf7f9f4f.B+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: DPGLHM+JlxykpAdvTTaf7f9f4f.B+20 Flags: Nonsymbolic FontBBox: -468, -197, 1656, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DPGEFE+HjxgqfAdvTT86d47313+03 FontSubset: true FirstChar: 1 LastChar: 5 FontDescriptor: FontName: DPGEFE+HjxgqfAdvTT86d47313+03 Flags: Symbolic FontBBox: -281, -250, 906, 822 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DPGDEP+QxtkvfAdvTTe45e47d2 FontSubset: true FirstChar: 32 LastChar: 225 FontDescriptor: FontName: DPGDEP+QxtkvfAdvTTe45e47d2 Flags: Nonsymbolic FontBBox: -218, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DPGDHE+BtymwbAdvTT86d47313 FontSubset: true FirstChar: 32 LastChar: 246 FontDescriptor: FontName: DPGDHE+BtymwbAdvTT86d47313 Flags: Serif, Nonsymbolic FontBBox: -218, -239, 1020, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DPGECB+LmfxrrAdvTT7329fd89.I FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: DPGECB+LmfxrrAdvTT7329fd89.I Flags: Nonsymbolic FontBBox: -218, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DPGDFA+DwkjblAdvTTb5929f4c FontSubset: true FirstChar: 32 LastChar: 246 FontDescriptor: FontName: DPGDFA+DwkjblAdvTTb5929f4c Flags: Nonsymbolic FontBBox: -41, -250, 812, 864 FontFile3: true Encoding: WinAnsiEncoding XMP: Inflammatory myopathies,Dermatomyositis,Biomarker,Muscle biopsy,Perifascicular atrophy Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) application/pdf 10.1186/s13075-017-1383-0 Arthritis Research & Therapy Arthritis Research & Therapy, 2017, doi:10.1186/s13075-017-1383-0 Inflammatory myopathies Dermatomyositis Biomarker Muscle biopsy Perifascicular atrophy RIG-I expression in perifascicular myofibers is a reliable biomarker of dermatomyositis Xavier Suárez-Calvet Eduard Gallardo Iago Pinal-Fernandez Noemi De Luna Cinta Lleixà Jordi Díaz-Manera Ricardo Rojas-García Ivan Castellví M. Angeles Martínez Josep M. Grau Albert Selva-O’Callaghan Isabel Illa 2017-07-24T15:22:35+02:00 2017-07-17T21:22:51+08:00 Arbortext Advanced Print Publisher 9.1.440/W Unicode 2017-07-24T15:22:35+02:00 uuid:ba7bee5a-e6af-4902-8c1d-e9fd313851d0 uuid:8f350566-8978-4aab-a074-3c4ebe2077f0 default 1 converted uuid:04042d84-8ab0-42fe-89cf-f97c165d3cc6 converted to PDF/A-2b pdfToolbox 2017-07-17T21:34:10+08:00 2 B Springer Nature ORCID Schema http://springernature.com/ns/xmpExtensions/2.0/ sn authorInfo Bag AuthorInformation external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. editorInfo Bag EditorInformation external Editor information: contains the name of each editor and his/her ORCID identifier. seriesEditorInfo Bag SeriesEditorInformation external Series editor information: contains the name of each series editor and his/her ORCID identifier. AuthorInformation http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author Specifies the types of author information: name and ORCID of an author. name Text Gives the name of an author. orcid URI Gives the ORCID of an author. EditorInformation http://springernature.com/ns/xmpExtensions/2.0/editorInfo/ editor Specifies the types of editor information: name and ORCID of an editor. name Text Gives the name of an editor. orcid URI Gives the ORCID of an editor. SeriesEditorInformation http://springernature.com/ns/xmpExtensions/2.0/seriesEditorInfo/ seriesEditor Specifies the types of series editor information: name and ORCID of a series editor. name Text Gives the name of a series editor. orcid URI Gives the ORCID of a series editor. http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal A structure containing the characteristics of a font used in a document Fonts Bag Font internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text A structure containing the characteristics of a font used in a document. http://ns.adobe.com/xap/1.0/sType/Font# stFnt Font http://ns.adobe.com/pdfx/1.3/ pdfx PDF/X ID Schema internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 484, 657, 538, 679 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 141, 169, 146, 179 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 376, 253, 381, 263 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 390, 253, 395, 263 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 517, 241, 522, 251 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 528, 241, 533, 251 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 466, 205, 471, 215 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 465, 145, 469, 155 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 476, 145, 481, 155 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 307, 121, 312, 131 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 326, 97, 331, 107 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 114, 126, 181, 134 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 185, 126, 233, 134 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 239, 65, 357, 72 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 182, 41, 321, 48 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 78, 681, 83, 690 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 280, 645, 285, 654 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 59, 609, 69, 618 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 136, 573, 140, 582 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 99, 549, 108, 558 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 267, 417, 271, 426 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 277, 417, 287, 426 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 264, 273, 269, 282 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 275, 273, 285, 282 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 155, 165, 165, 174 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 81, 141, 91, 150 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 177, 69, 187, 78 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 194, 69, 204, 78 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 438, 249, 443, 258 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 351, 153, 356, 162 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 427, 567, 432, 577 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 476, 531, 481, 541 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 500, 459, 505, 469 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 509, 411, 513, 421 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 365, 357, 374, 367 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 325, 333, 335, 343 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 84, 464, 89, 474 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 167, 404, 172, 414 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 77, 368, 87, 378 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 215, 368, 225, 378 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 528, 404, 533, 414 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 85, 693, 90, 702 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 280, 585, 285, 594 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 136, 441, 141, 450 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 125, 237, 129, 246 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 343, 465, 347, 474 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 389, 465, 393, 474 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 429, 381, 434, 390 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 368, 357, 373, 366 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 307, 309, 312, 318 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 387, 57, 391, 66 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 61, 585, 153, 592 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 61, 528, 153, 535 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 61, 435, 153, 442 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 7 Thumb: true Checksum: ecc5b4e1 Type: CRC32 Checksum: 6f31c27aad7e133673250bbd61287ef3 Type: MD5 Checksum: 7549fe1907830f5fc93416155caa823b662f6a2c Type: SHA-1