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Item: Title: Sample preparation. Item: Title: Next Generation Sequencing panel-based analyses. Item: Title: Variant calling and allele quantification. Item: Title: Validation of the sample pooling results. Item: Title: Classification of variants. Item: Title: Disease association studies. Item: Title: Sanger sequencing verification of novel variants. Item: Title: Data Availability. Item: Title: Ethical use of human participants statement. Item: Title: Results Item: Title: Discussion Item: Title: Acknowledgements Item: Title: Figure 1 Graphical representation of the number of alleles (y-axis) of each variant detected (listed in x-axis and ordered according to the number of alleles found) in our Behçet disease patient cohort. Item: Title: Table 1 Classification of the variants found in the present study in BD patients. Item: Title: Table 2 Analysis of the association with BD of rare variants in seven genes related to AIDs. Item: Title: Table 3 Number of alleles of the different variants found in our BD patients reported in clinical database and/or pathogenic according to PolyPhen2 and/or SIFT. 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