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Title:          The inhibitory mechanism of Hal3 on the yeast Ppz1 phosphatase: A mutagenesis analysis
Subject:        Scientific Reports, doi:10.1038/s41598-017-09360-5
Keywords:       
Author:         Cristina Molero
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     Item: 
      Title: The inhibitory mechanism of Hal3 on the yeast Ppz1 phosphatase: A mutagenesis analysis
      Children: 
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Screen of a random-mutagenesis library for deregulated versions of Ppz1. 
          Children: 
           Item: 
            Title: Phenotypic analysis of mutated alleles of PPZ1. 
           Item: 
            Title: Determination of the capacity Hal3 to inhibit the Ppz1 variants. 
           Item: 
            Title: Ppz1 variants retain the ability to bind Hal3. 
           Item: 
            Title: Characterization of additional PPZ1 alleles. 
           Item: 
            Title: Mapping the mutations in Ppz1 and PP1c sequences. 
       Item: 
        Title: Discussion
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Yeast strains and growth conditions. 
         Item: 
          Title: Recombinant DNA techniques and plasmids. 
         Item: 
          Title: Random PCR Mutagenesis and screen for Ppz1 deregulated versions. 
         Item: 
          Title: Yeast protein extraction and immunoblot analysis. 
         Item: 
          Title: Expression of Ppz1 mutated versions in E. coli. 
         Item: 
          Title: Assay of protein phosphatase activity. 
         Item: 
          Title: Detection of protein-protein interactions. 
         Item: 
          Title: Phenotypic analysis of yeast cells. 
         Item: 
          Title: Data availability. 
       Item: 
        Title: Acknowledgements
       Item: 
        Title: Figure 1 Growth on caffeine plates of selected Ppz1 clones carrying single amino acid mutations.
       Item: 
        Title: Figure 2 Tolerance to Li+ cations conferred by the diverse variants of the Ppz1 phosphatase.
       Item: 
        Title: Figure 3 Ppz1 variants show differences in the pattern of in vitro inhibition by Hal3.
       Item: 
        Title: Figure 4 Interaction of Hal3 with the different Ppz1 variants.
       Item: 
        Title: Figure 5 Phenotypic analysis and expression levels of selected Ppz1 versions carrying two amino acid changes.
       Item: 
        Title: Figure 6 Hal3 binding capacity and inhibition profile of Ppz1 variants carrying two aminoacid mutations.
       Item: 
        Title: Figure 7 Alignment of the catalytic domains of Ppz1 from S.
       Item: 
        Title: Figure 8 Mapping mutations and functional elements on a structural model of the C-terminal catalytic moiety of ScPpz1.
       Item: 
        Title: Table 1 Mutations affecting the catalytic domain of Ppz1 that result in single amino acid change.
       Item: 
        Title: Table 2 Mutations affecting the catalytic domain of Ppz1 that result in changes in two amino acids.
       Item: 
        Title: Table 3 Yeast strains used in this work.
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                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. 
Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

</pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright </pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
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               </rdf:li>
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                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
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