5d3a7572351997e69817d95119e6b7df pmc_28871256.pdf 0981adaec2d4c094fedb521ad0e628f1f19c7b08 pmc_28871256.pdf ac100347176571c44f40883f1dbc2284e7044dba546ef65be80eb78551ff118d pmc_28871256.pdf Title: Human Leukocyte Antigen (HLA)-DRB1*15:01 and HLA-DRB5*01:01 Present Complementary Peptide Repertoires Subject: Human leukocyte antigen (HLA)-DR15 is a haplotype associated with multiple sclerosis. Keywords: human leukocyte antigen-DR, binding motif, mass spectrometry, peptidome, multiple sclerosis Author: Iñaki Alvarez Creator: Adobe InDesign CS6 (Windows) Producer: Adobe PDF Library 10.0.1 CreationDate: Thu Aug 17 10:54:14 2017 CEST ModDate: Thu Aug 17 11:28:27 2017 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 1061321 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HTXMSU+HelveticaNeueLTStd-Lt Type 1C Custom yes yes yes 424 0 RVAUCA+HelveticaNeueLTStd-Bd Type 1C Custom yes yes yes 425 0 RVAUCA+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes yes 433 0 CWIDAE+HelveticaNeueLTStd-LtIt Type 1C Custom yes yes yes 434 0 CWIDAE+HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes yes yes 435 0 CWIDAE+MinionPro-Regular Type 1C Custom yes yes yes 441 0 MTLLKK+STIXGeneral-Regular Type 1C Custom yes yes yes 442 0 MTLLKK+MinionPro-It Type 1C Custom yes yes yes 443 0 HTXMSU+HelveticaNeueLTStd-Lt Type 1C WinAnsi yes yes yes 356 0 HTXMSU+HelveticaNeueLTStd-Lt Type 1C WinAnsi yes yes yes 360 0 MTLLKK+MinionPro-Bold Type 1C Custom yes yes yes 370 0 XUYZIO+CourierNewPSMT TrueType WinAnsi yes yes yes 376 0 XUYZIO+STIXGeneral-Bold Type 1C Custom yes yes yes 377 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-02-08 02:45:58 CET RepresentationInformation: pmc_28871256.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2020-08-10 03:40:08 CEST Size: 1061321 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 546 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Human Leukocyte Antigen (HLA)-DRB1*15:01 and HLA-DRB5*01:01 Present Complementary Peptide Repertoires Children: Item: Title: Introduction Item: Title: Materials and Methods Children: Item: Title: Cell Lines and Antibodies Item: Title: Purification of the HLA-DR-Associated Peptide Pools Item: Title: LC–MS/MS Analysis Item: Title: MS/MS Ion Search and Peptide Identification Item: Title: Identification of the Peptide-Binding Core Item: Title: Modeling of the Peptide–HLA-DR Interaction Item: Title: Binding Assays Item: Title: Results Children: Item: Title: Characterization of the Peptide Repertoires Bound to DR2a and DR2b Molecules Item: Title: Refinement of the HLA-DRB1*15:01 and HLA-DRB5*01:01 Binding Motifs Item: Title: Low Similarity of the Peptide Repertoires Associated with DR2a and DR2b Item: Title: Contribution of HLA-DRB1*15:01 and HLA-DRB5*01:01 to the Repertoire of HLA-DR15 Item: Title: Binding Assay to HLA-DR Molecules Item: Title: Modeling of MHC–Peptide Complexes Item: Title: Discussion Item: Title: Author Contributions Item: Title: Acknowledgments Item: Title: Funding Item: Title: Supplementary Material Item: Title: References Info: Title: Human Leukocyte Antigen (HLA)-DRB1*15:01 and HLA-DRB5*01:01 Present Complementary Peptide Repertoires Author: Iñaki Alvarez Subject: Human leukocyte antigen (HLA)-DR15 is a haplotype associated with multiple sclerosis. Keywords: human leukocyte antigen-DR, binding motif, mass spectrometry, peptidome, multiple sclerosis Creator: Adobe InDesign CS6 (Windows) Producer: Adobe PDF Library 10.0.1 CreationDate: Thu Aug 17 11:24:14 CEST 2017 ModDate: Thu Aug 17 11:58:27 CEST 2017 ID: 0x2c69763a24cc224fabbacc1784441cb3, 0x4052b157eb713e48ac72353d6013974b Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 839 ImageHeight: 1208 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 839 ImageHeight: 1375 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 839 ImageHeight: 1208 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 839 ImageHeight: 1208 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1245 ImageHeight: 2426 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1245 ImageHeight: 2426 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1245 ImageHeight: 2426 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 958 ImageHeight: 993 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1418 ImageHeight: 1075 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Fonts: Type1: Font: BaseFont: RVAUCA+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: RVAUCA+HelveticaNeueLTStd-BdIt Flags: Nonsymbolic, Italic FontBBox: -166, -218, 1129, 975 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: CWIDAE+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 30 LastChar: 242 FontDescriptor: FontName: CWIDAE+HelveticaNeueLTStd-LtIt Flags: Nonsymbolic, Italic FontBBox: -165, -214, 1099, 951 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MTLLKK+MinionPro-Bold FontSubset: true FirstChar: 30 LastChar: 117 FontDescriptor: FontName: MTLLKK+MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: CWIDAE+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 32 LastChar: 241 FontDescriptor: FontName: CWIDAE+HelveticaNeueLTStd-MdIt Flags: Nonsymbolic, Italic FontBBox: -165, -218, 1125, 947 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: HTXMSU+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 30 LastChar: 181 FontDescriptor: FontName: HTXMSU+HelveticaNeueLTStd-Lt Flags: Nonsymbolic FontBBox: -166, -214, 1050, 967 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: CWIDAE+MinionPro-Regular FontSubset: true FirstChar: 25 LastChar: 237 FontDescriptor: FontName: CWIDAE+MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: RVAUCA+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 31 LastChar: 150 FontDescriptor: FontName: RVAUCA+HelveticaNeueLTStd-Bd Flags: Nonsymbolic FontBBox: -166, -218, 1078, 975 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: XUYZIO+STIXGeneral-Bold FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: XUYZIO+STIXGeneral-Bold Flags: Serif, Nonsymbolic FontBBox: -998, -455, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MTLLKK+STIXGeneral-Regular FontSubset: true FirstChar: 28 LastChar: 215 FontDescriptor: FontName: MTLLKK+STIXGeneral-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -443, 2000, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MTLLKK+MinionPro-It FontSubset: true FirstChar: 29 LastChar: 169 FontDescriptor: FontName: MTLLKK+MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true TrueType: Font: BaseFont: XUYZIO+CourierNewPSMT FontSubset: true FirstChar: 65 LastChar: 89 FontDescriptor: FontName: XUYZIO+CourierNewPSMT Flags: Serif, Nonsymbolic FontBBox: -122, -680, 623, 1021 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true XMP: uuid:16599b67-9a12-431e-8956-16aa9658c49e adobe:docid:indd:7b7f4af8-a1e4-11dd-855d-ca4c1b90e82f xmp.id:8C58DD9C2983E711BE1BD720B09CF530 proof:pdf xmp.iid:8B58DD9C2983E711BE1BD720B09CF530 xmp.did:F22FBC7FF162E71189BCDA94CA248EAE adobe:docid:indd:7b7f4af8-a1e4-11dd-855d-ca4c1b90e82f default converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2017-08-17T14:24:14+05:30 2017-08-17T14:24:14+05:30 2017-08-17T14:58:27+05:30 2017-08-17T14:58:27+05:30 Adobe InDesign CS6 (Windows) application/pdf Human Leukocyte Antigen (HLA)-DRB1*15:01 and HLA-DRB5*01:01 Present Complementary Peptide Repertoires Human leukocyte antigen (HLA)-DR15 is a haplotype associated with multiple sclerosis. Iñaki Alvarez human leukocyte antigen-DR binding motif mass spectrometry peptidome multiple sclerosis Adobe PDF Library 10.0.1 False human leukocyte antigen-DR, binding motif, mass spectrometry, peptidome, multiple sclerosis Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 43, 755, 162, 717 Annotation: Subtype: Link Rect: 519, 708, 551, 676 Annotation: Subtype: Link Rect: 434, 38, 549, 30 Annotation: Subtype: Link Rect: 474, 744, 549, 736 Annotation: Subtype: Link Rect: 468, 736, 549, 728 Annotation: Subtype: Link Rect: 451, 728, 549, 720 Annotation: Subtype: Link Rect: 45, 38, 114, 30 Annotation: Subtype: Link Rect: 122, 38, 179, 30 Annotation: Subtype: Link Rect: 87, 444, 158, 435 Annotation: Subtype: Link Rect: 96, 275, 158, 267 Annotation: Subtype: Link Rect: 73, 73, 158, 65 Annotation: Subtype: Link Rect: 175, 650, 509, 625 Annotation: Subtype: Link Rect: 175, 627, 518, 602 Annotation: Subtype: Link Rect: 175, 604, 506, 579 Annotation: Subtype: Link Rect: 175, 581, 292, 556 Annotation: Subtype: Link Rect: 175, 544, 267, 533 Annotation: Subtype: Link Rect: 279, 544, 342, 533 Annotation: Subtype: Link Rect: 350, 544, 404, 533 Annotation: Subtype: Link Rect: 416, 544, 504, 533 Annotation: Subtype: Link Rect: 175, 532, 240, 522 Annotation: Subtype: Link Rect: 264, 532, 316, 522 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 45, 38, 114, 30 Annotation: Subtype: Link Rect: 122, 38, 179, 30 Annotation: Subtype: Link Rect: 434, 38, 549, 30 Annotation: Subtype: Link Rect: 196, 593, 201, 580 ActionDest: 252 Annotation: Subtype: Link Rect: 206, 593, 215, 580 ActionDest: 252 Annotation: Subtype: Link Rect: 257, 524, 266, 511 ActionDest: 252 Annotation: Subtype: Link Rect: 214, 455, 223, 442 ActionDest: 252 Annotation: Subtype: Link Rect: 101, 432, 110, 419 ActionDest: 252 Annotation: Subtype: Link Rect: 101, 386, 111, 373 ActionDest: 252 Annotation: Subtype: Link Rect: 114, 340, 123, 327 ActionDest: 252 Annotation: Subtype: Link Rect: 128, 340, 137, 327 ActionDest: 252 Annotation: Subtype: Link Rect: 213, 294, 222, 281 ActionDest: 252 Annotation: Subtype: Link Rect: 246, 282, 255, 270 ActionDest: 252 Annotation: Subtype: Link Rect: 264, 282, 289, 270 Annotation: Subtype: Link Rect: 45, 271, 101, 258 Annotation: Subtype: Link Rect: 70, 167, 79, 155 ActionDest: 252 Annotation: Subtype: Link Rect: 508, 403, 517, 390 ActionDest: 252 Annotation: Subtype: Link Rect: 521, 403, 530, 390 ActionDest: 252 Annotation: Subtype: Link Rect: 493, 351, 502, 339 ActionDest: 299 Annotation: Subtype: Link Rect: 508, 351, 517, 339 ActionDest: 299 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 45, 38, 114, 30 Annotation: Subtype: Link Rect: 122, 38, 179, 30 Annotation: Subtype: Link Rect: 434, 38, 549, 30 Annotation: Subtype: Link Rect: 90, 466, 99, 453 ActionDest: 299 Annotation: Subtype: Link Rect: 274, 275, 283, 262 ActionDest: 299 Annotation: Subtype: Link Rect: 183, 213, 192, 201 ActionDest: 299 Annotation: Subtype: Link Rect: 144, 179, 153, 166 ActionDest: 299 Annotation: Subtype: Link Rect: 159, 179, 168, 166 ActionDest: 299 Annotation: Subtype: Link Rect: 415, 669, 424, 656 ActionDest: 252 Annotation: Subtype: Link Rect: 428, 669, 437, 656 ActionDest: 299 Annotation: Subtype: Link Rect: 534, 595, 544, 582 ActionDest: 299 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 45, 38, 114, 30 Annotation: Subtype: Link Rect: 122, 38, 179, 30 Annotation: Subtype: Link Rect: 434, 38, 549, 30 Annotation: Subtype: Link Rect: 271, 685, 280, 672 ActionDest: 299 Annotation: Subtype: Link Rect: 220, 605, 261, 592 ActionDest: 69 Annotation: Subtype: Link Rect: 48, 582, 87, 569 ActionDest: 69 Annotation: Subtype: Link Rect: 118, 501, 158, 488 ActionDest: 69 Annotation: Subtype: Link Rect: 480, 708, 520, 695 ActionDest: 69 Annotation: Subtype: Link Rect: 416, 615, 425, 602 ActionDest: 252 Annotation: Subtype: Link Rect: 432, 615, 442, 602 ActionDest: 252 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 45, 38, 114, 30 Annotation: Subtype: Link Rect: 122, 38, 179, 30 Annotation: Subtype: Link Rect: 434, 38, 549, 30 Annotation: Subtype: Link Rect: 227, 719, 236, 707 ActionDest: 299 Annotation: Subtype: Link Rect: 184, 662, 217, 649 ActionDest: 135 Annotation: Subtype: Link Rect: 213, 513, 246, 500 ActionDest: 135 Annotation: Subtype: Link Rect: 90, 416, 119, 403 ActionDest: 151 Annotation: Subtype: Link Rect: 116, 324, 125, 311 ActionDest: 252 Annotation: Subtype: Link Rect: 91, 290, 119, 277 ActionDest: 184 Annotation: Subtype: Link Rect: 274, 167, 283, 155 ActionDest: 252 Annotation: Subtype: Link Rect: 458, 398, 467, 385 ActionDest: 252 Annotation: Subtype: Link Rect: 476, 398, 505, 385 ActionDest: 184 Annotation: Subtype: Link Rect: 348, 283, 378, 270 ActionDest: 184 Annotation: Subtype: Link Rect: 446, 225, 475, 212 ActionDest: 184 Annotation: Subtype: Link Rect: 346, 99, 387, 86 ActionDest: 200 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 45, 38, 114, 30 Annotation: Subtype: Link Rect: 122, 38, 179, 30 Annotation: Subtype: Link Rect: 434, 38, 549, 30 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 45, 38, 114, 30 Annotation: Subtype: Link Rect: 122, 38, 179, 30 Annotation: Subtype: Link Rect: 434, 38, 549, 30 Annotation: Subtype: Link Rect: 48, 497, 88, 484 ActionDest: 200 Annotation: Subtype: Link Rect: 257, 351, 266, 339 ActionDest: 252 Annotation: Subtype: Link Rect: 270, 351, 279, 339 ActionDest: 299 Annotation: Subtype: Link Rect: 56, 340, 86, 327 ActionDest: 184 Annotation: Subtype: Link Rect: 56, 248, 91, 235 ActionDest: 230 Annotation: Subtype: Link Rect: 45, 191, 78, 178 ActionDest: 230 Annotation: Subtype: Link Rect: 309, 720, 342, 707 ActionDest: 230 Annotation: Subtype: Link Rect: 388, 282, 397, 270 ActionDest: 252 Annotation: Subtype: Link Rect: 401, 282, 410, 270 ActionDest: 252 Annotation: Subtype: Link Rect: 414, 282, 424, 270 ActionDest: 299 Annotation: Subtype: Link Rect: 519, 213, 529, 201 ActionDest: 252 Annotation: Subtype: Link Rect: 535, 213, 544, 201 ActionDest: 252 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 45, 38, 114, 30 Annotation: Subtype: Link Rect: 122, 38, 179, 30 Annotation: Subtype: Link Rect: 434, 38, 549, 30 Rotate: 90 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 45, 38, 114, 30 Annotation: Subtype: Link Rect: 122, 38, 179, 30 Annotation: Subtype: Link Rect: 434, 38, 549, 30 Annotation: Subtype: Link Rect: 48, 259, 57, 247 ActionDest: 299 Annotation: Subtype: Link Rect: 63, 259, 72, 247 ActionDest: 299 Annotation: Subtype: Link Rect: 126, 259, 135, 247 ActionDest: 299 Annotation: Subtype: Link Rect: 141, 259, 150, 247 ActionDest: 299 Annotation: Subtype: Link Rect: 127, 236, 136, 224 ActionDest: 299 Annotation: Subtype: Link Rect: 174, 190, 183, 178 ActionDest: 252 Annotation: Subtype: Link Rect: 417, 627, 426, 615 ActionDest: 252 Annotation: Subtype: Link Rect: 474, 317, 484, 304 ActionDest: 299 Annotation: Subtype: Link Rect: 379, 87, 414, 74 ActionDest: 135 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 45, 38, 114, 30 Annotation: Subtype: Link Rect: 122, 38, 179, 30 Annotation: Subtype: Link Rect: 434, 38, 549, 30 Annotation: Subtype: Link Rect: 154, 386, 190, 373 ActionDest: 230 Annotation: Subtype: Link Rect: 135, 271, 144, 258 ActionDest: 252 Annotation: Subtype: Link Rect: 148, 271, 157, 258 ActionDest: 299 Annotation: Subtype: Link Rect: 161, 271, 170, 258 ActionDest: 299 Annotation: Subtype: Link Rect: 88, 213, 98, 200 ActionDest: 299 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 45, 38, 114, 30 Annotation: Subtype: Link Rect: 122, 38, 179, 30 Annotation: Subtype: Link Rect: 434, 38, 549, 30 Annotation: Subtype: Link Rect: 90, 501, 289, 488 Annotation: Subtype: Link Rect: 45, 489, 200, 477 Annotation: Subtype: Link Rect: 131, 416, 203, 406 Annotation: Subtype: Link Rect: 160, 378, 248, 368 Annotation: Subtype: Link Rect: 70, 302, 143, 292 Annotation: Subtype: Link Rect: 187, 169, 241, 159 Annotation: Subtype: Link Rect: 70, 112, 125, 102 Annotation: Subtype: Link Rect: 259, 83, 289, 73 Annotation: Subtype: Link Rect: 59, 74, 131, 64 Annotation: Subtype: Link Rect: 436, 425, 490, 415 Annotation: Subtype: Link Rect: 331, 397, 434, 387 Annotation: Subtype: Link Rect: 390, 378, 525, 368 Annotation: Subtype: Link Rect: 331, 330, 396, 320 Annotation: Subtype: Link Rect: 524, 292, 549, 282 Annotation: Subtype: Link Rect: 320, 283, 361, 273 Annotation: Subtype: Link Rect: 331, 216, 397, 206 Annotation: Subtype: Link Rect: 354, 188, 435, 178 Annotation: Subtype: Link Rect: 331, 150, 426, 140 Annotation: Subtype: Link Rect: 370, 112, 441, 102 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 45, 38, 114, 30 Annotation: Subtype: Link Rect: 122, 38, 179, 30 Annotation: Subtype: Link Rect: 434, 38, 549, 30 Annotation: Subtype: Link Rect: 113, 700, 184, 690 Annotation: Subtype: Link Rect: 183, 671, 250, 661 Annotation: Subtype: Link Rect: 113, 633, 178, 623 Annotation: Subtype: Link Rect: 70, 595, 133, 585 Annotation: Subtype: Link Rect: 131, 567, 191, 557 Annotation: Subtype: Link Rect: 121, 529, 204, 519 Annotation: Subtype: Link Rect: 162, 500, 264, 490 Annotation: Subtype: Link Rect: 263, 462, 289, 452 Annotation: Subtype: Link Rect: 59, 453, 127, 443 Annotation: Subtype: Link Rect: 231, 424, 289, 414 Annotation: Subtype: Link Rect: 59, 415, 87, 405 Annotation: Subtype: Link Rect: 263, 386, 289, 376 Annotation: Subtype: Link Rect: 59, 377, 111, 367 Annotation: Subtype: Link Rect: 186, 348, 267, 338 Annotation: Subtype: Link Rect: 399, 700, 471, 690 Annotation: Subtype: Link Rect: 331, 662, 404, 652 Annotation: Subtype: Link Rect: 461, 633, 504, 623 Annotation: Subtype: Link Rect: 331, 595, 409, 585 Annotation: Subtype: Link Rect: 524, 567, 549, 557 Annotation: Subtype: Link Rect: 320, 557, 366, 547 Annotation: Subtype: Link Rect: 486, 491, 539, 481 Annotation: Subtype: Link Rect: 480, 462, 547, 452 Annotation: Subtype: Link Rect: 493, 396, 549, 386 Annotation: Subtype: Link Rect: 306, 386, 390, 376 Checksum: 89b9f556 Type: CRC32 Checksum: 5d3a7572351997e69817d95119e6b7df Type: MD5 Checksum: 0981adaec2d4c094fedb521ad0e628f1f19c7b08 Type: SHA-1 Checksum: ac100347176571c44f40883f1dbc2284e7044dba546ef65be80eb78551ff118d Type: SHA-256