5de5d0d694611b0b1c82a446fa629265 pmc_29260317.pdf bdf27302261b7ee6607fc49ed8e9c92123b8bed8 pmc_29260317.pdf 64b7f9ac6f952493302890974493747f23424cc9f58acf9997b8de1b5113b049 pmc_29260317.pdf Title: Effects of long-term cysteamine treatment in patients with cystinosis Subject: Pediatr Nephrol, doi:10.1007/s00467-017-3856-4 Keywords: CTNS gene mutations,Cystine-depleting therapy,End-stage renal disease,Extrarenal complications,Lysosomal cystine accumulation,Renal Fanconi syndrome Author: Gema Ariceta Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 9.0.0 (Windows) CreationDate: Fri Feb 15 11:08:23 2019 CET ModDate: Sat Feb 16 03:56:50 2019 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 761871 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- 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GHLNKG+YxqlhvAdvP0004 Type 1C WinAnsi yes yes no 302 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2019-11-27 05:12:33 CET RepresentationInformation: pmc_29260317.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2019-03-25 03:36:57 CET Size: 761871 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR13' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR14' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR15' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR16' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR47' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR19' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR48' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR49' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR50' cannot be 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edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR16' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR47' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR46' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR50' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR51' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR46' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR50' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR50' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR46' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR51' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR51' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect 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edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR16' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR16' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR16' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR45' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR46' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR16' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR46' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR45' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR18' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR19' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR19' cannot be found Offset: 725048 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'CR18' cannot be found Offset: 725048 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1210 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Effects of long-term cysteamine treatment in patients with cystinosis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7d4793a8 Children: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@449b2d27 Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5479e3f Item: Title: Pathogenesis of cystinosis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@27082746 Item: Title: Cysteamine therapy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66133adc Item: Title: Long-term effects of cysteamine therapy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7bfcd12c Item: Title: Renal outcomes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42f30e0a Item: Title: Extrarenal complications Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@24273305 Children: Item: Title: Eye disorders Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5b1d2887 Item: Title: Endocrine disorders Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46f5f779 Item: Title: Neurocognitive disorders Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1c2c22f3 Item: Title: Muscular disorders Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@18e8568 Item: Title: Pulmonary disorders Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33e5ccce Item: Title: Mortality Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5a42bbf4 Item: Title: Treatment adherence Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@270421f5 Item: Title: Conclusions Destination: 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