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Title:           CRTC1 mediates preferential transcription at neuronal activity-regulated CRE/TATA promoters
Subject:         Scientific Reports, doi:10.1038/s41598-017-18215-y
Keywords:        
Author:          Arnaldo Parra-Damas
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     Item: 
      Title: CRTC1 mediates preferential transcription at neuronal activity-regulated CRE/TATA promoters
      Children: 
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Time-dependent activation of CREB-dependent transcription in neurons. 
         Item: 
          Title: Activity-dependent CRTC1 activation in neurons. 
         Item: 
          Title: Activity-dependent recruitment of CRTC1 to target gene promoters. 
         Item: 
          Title: Neuronal activity induces binding of CRTC1 to the CREB transcriptional complex. 
       Item: 
        Title: Discussion
       Item: 
        Title: Materials and Methods
        Children: 
         Item: 
          Title: Generation of short hairpin RNA (shRNA). 
         Item: 
          Title: Primary neuronal culture. 
         Item: 
          Title: Gene expression analysis. 
         Item: 
          Title: Biochemical analysis. 
         Item: 
          Title: ChIP-qPCR analysis. 
         Item: 
          Title: Statistical analysis. 
         Item: 
          Title: Ethical experimental statement. 
         Item: 
          Title: Data availability statement. 
       Item: 
        Title: Acknowledgements
       Item: 
        Title: Figure 1 Neuronal activity induces CREB-dependent gene expression in primary cortical neurons.
       Item: 
        Title: Figure 2 Activity-dependent CRTC1 activation in cultured neurons.
       Item: 
        Title: Figure 3 Differential recruitment of CRTC1 and CREB to target gene promoters upon neuronal activity.
       Item: 
        Title: Figure 4 Deficient binding of CRTC1 and CREB to Psen1 and Psen2 promoters.
       Item: 
        Title: Figure 5 CREB silencing does not affect basal PS1 protein levels.
       Item: 
        Title: Figure 6 Activity-dependent binding of CRTC1 to CREB in neurons.
       Item: 
        Title: Table 1 Consensus CRE sites in the promoter regions of CREB target genes in Mus musculus.
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                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. 
Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

</pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright </pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
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       AppearanceDictionary: true
      Annotation: 
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       Rect: 226, 616, 364, 605
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
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      Annotation: 
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     Thumb: true
  Checksum: 1b2422b1
   Type: CRC32
  Checksum: 28cd19a01d82677876a90a376963ece9
   Type: MD5
  Checksum: f63a5ddf250a6ab2384d64c52b34f308221e32fa
   Type: SHA-1
  Checksum: c271bcc845a10d238876baf01602bb140f68282342cbe6cdc513e6cba8eeda6b
   Type: SHA-256