7757aa2e0b19fd726b0e78a3be63342f  pmc_29289645.pdf
e08675f6736c1c1dce62abece2379fc0ad96a5e3  pmc_29289645.pdf
9c3831a36eb9e8349045defe160a47c2cb4e3f062d1d115b9b5c39dda4f2d947  pmc_29289645.pdf

Title:          Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease
Subject:        Molecular Metabolism, 8 (2018) 117-131. doi:10.1016/j.molmet.2017.12.008
Author:         Mohammad Zarei
Creator:        Elsevier
Producer:       Acrobat Distiller 8.1.0 (Windows)
CreationDate:   Wed Feb  7 15:01:22 2018 CET
ModDate:        Wed Feb  7 15:02:19 2018 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          15
Encrypted:      no
Page size:      595.276 x 793.701 pts
Page rot:       0
File size:      4810189 bytes
Optimized:      yes
PDF version:    1.7

name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
HMOMAH+AdvPS44A44B                   Type 1C           WinAnsi          yes yes no    1092  0
HMOLKO+AdvOTad521943                 Type 1C           WinAnsi          yes yes no    1055  0
HMOLLO+AdvPS3F4C13                   Type 1C           WinAnsi          yes yes no    1058  0
HMOLLP+AdvP4C4E59                    Type 1C           WinAnsi          yes yes no    1060  0
HMOLMA+AdvOT9d0303c0.B               Type 1C           WinAnsi          yes yes no    1062  0
HMOLMB+AdvOT8e81dcaa                 Type 1C           WinAnsi          yes yes no    1064  0
HMOLMC+AdvOT8e81dcaa+fb              Type 1C           Custom           yes yes yes   1076  0
HMOLMD+AdvOTa4800bed.I               Type 1C           WinAnsi          yes yes no    1066  0
HMOLME+AdvPS4721B4                   Type 1C           WinAnsi          yes yes no    1069  0
HMOLMF+AdvPSSym                      Type 1C           Custom           yes yes no    1071  0
HMOLNG+AdvOT8e81dcaa+20              Type 1C           WinAnsi          yes yes no    1080  0
HMOLNH+AdvP4C4E74                    Type 1C           Custom           yes yes yes   1084  0
HMOMBH+AdvP4C4E51                    Type 1C           WinAnsi          yes yes no     765  0
HMPALK+AdvOT1ae6bdaa.BI              Type 1C           WinAnsi          yes yes no     772  0
HMPALL+AdvPS3ECA66                   Type 1C           WinAnsi          yes yes no     770  0
HMPGKF+AdvOT9d0303c0.B+fb            Type 1C           Custom           yes yes yes    781  0
HNAGBB+AdvPS4BD310                   Type 1C           WinAnsi          yes yes no     789  0
HNAGCC+AdvOTad521943+20              Type 1C           WinAnsi          yes yes no     793  0

Jhove (Rel. 1.6, 2011-01-04)
 Date: 2019-02-01 04:46:15 CET
 RepresentationInformation: pmc_29289645.pdf
  ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22)
  LastModified: 2018-06-11 03:40:36 CEST
  Size: 4810189
  Format: PDF
  Version: 1.7
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ErrorMessage: Invalid destination object
   Offset: 4774634
  ErrorMessage: Invalid destination object
   Offset: 4774634
  ErrorMessage: Invalid destination object
   Offset: 4774634
  ErrorMessage: Invalid destination object
   Offset: 4774634
  ErrorMessage: Invalid destination object
   Offset: 4774634
  ErrorMessage: Invalid destination object
   Offset: 4774634
  ErrorMessage: Invalid destination object
   Offset: 4774634
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  ErrorMessage: Invalid destination object
   Offset: 4772928
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 1166
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Outlines: 
     Item: 
      Title: Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7c53a9eb
      Children: 
       Item: 
        Title: 1. Introduction
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed17bee
       Item: 
        Title: 2. Research design and methods
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2a33fae0
        Children: 
         Item: 
          Title: 2.1. Reagents
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@707f7052
         Item: 
          Title: 2.2. Mice
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11028347
         Item: 
          Title: 2.3. Cell culture
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@14899482
         Item: 
          Title: 2.4. Human samples
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@21588809
         Item: 
          Title: 2.5. RNA preparation and quantitative RT-PCR
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2aae9190
         Item: 
          Title: 2.6. Immunoblotting
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2f333739
         Item: 
          Title: 2.7. Electrophoretic mobility shift assay
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77468bd9
         Item: 
          Title: 2.8. Hematoxylin-eosin and Oil Red and staining
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12bb4df8
         Item: 
          Title: 2.9. Statistical analyses
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4cc77c2e
       Item: 
        Title: 3. Results
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a7b0070
        Children: 
         Item: 
          Title: 3.1. Pparβ/δ−/– mice show increased hepatic VLDLR levels
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@39a054a5
         Item: 
          Title: 3.2. Pparβ/δ deficiency exacerbates hepatic steatosis and VLDLR upregulation caused by ER stress
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@71bc1ae4
         Item: 
          Title: 3.3. FGF21 protects against hepatic steatosis and the upregulation of VLDLR levels caused by ER stress
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6ed3ef1
         Item: 
          Title: 3.4. VLDLR upregulation is intensified by fructose feeding in the liver of Pparβ/δ-null mice
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2437c6dc
         Item: 
          Title: 3.5. VLDLR content is increased in the liver of patients with steatosis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1f89ab83
       Item: 
        Title: 4. Discussion
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e73f9ac
       Item: 
        Title: 5. Conclusions
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@61064425
       Item: 
        Title: Author's contribution
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b1d7fff
       Item: 
        Title: Financial support
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@299a06ac
       Item: 
        Title: Conflict of interest
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@383534aa
       Item: 
        Title: Appendix A. Supplementary data
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6bc168e5
       Item: 
        Title: References
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b3300e5
   Info: 
    Title: Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease
    Author: Mohammad Zarei
    Subject: Molecular Metabolism, 8 (2018) 117-131. doi:10.1016/j.molmet.2017.12.008
    Creator: Elsevier
    Producer: Acrobat Distiller 8.1.0 (Windows)
    CreationDate: Wed Feb 07 15:31:22 CET 2018
    ModDate: Wed Feb 07 15:32:19 CET 2018
   ID: 0x53c4b480a3b0f2c7093b678dd1b118e0, 0x0f29be8621396348b26ce14de20e107f
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      ImageWidth: 103
      ImageHeight: 102
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 2046
      ImageHeight: 2332
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 2060
      ImageHeight: 2523
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 1512
      ImageHeight: 2486
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 1586
      ImageHeight: 2486
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 2060
      ImageHeight: 1907
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 1603
      ImageHeight: 2367
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 1805
      ImageHeight: 2486
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 1595
      ImageHeight: 1015
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: HMOLLO+AdvPS3F4C13
      FontSubset: true
      FirstChar: 97
      LastChar: 109
      FontDescriptor: 
       FontName: HMOLLO+AdvPS3F4C13
       Flags: Nonsymbolic
       FontBBox: 0, -291, 875, 697
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HMPALL+AdvPS3ECA66
      FontSubset: true
      FirstChar: 98
      LastChar: 100
      FontDescriptor: 
       FontName: HMPALL+AdvPS3ECA66
       Flags: Nonsymbolic
       FontBBox: 0, -208, 927, 697
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HMOMAH+AdvPS44A44B
      FontSubset: true
      FirstChar: 101
      LastChar: 101
      FontDescriptor: 
       FontName: HMOMAH+AdvPS44A44B
       Flags: Nonsymbolic
       FontBBox: 0, -197, 1000, 802
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HMOLLP+AdvP4C4E59
      FontSubset: true
      FirstChar: 42
      LastChar: 42
      FontDescriptor: 
       FontName: HMOLLP+AdvP4C4E59
       Flags: Nonsymbolic
       FontBBox: -31, -250, 1000, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HMPALK+AdvOT1ae6bdaa.BI
      FontSubset: true
      FirstChar: 45
      LastChar: 114
      FontDescriptor: 
       FontName: HMPALK+AdvOT1ae6bdaa.BI
       Flags: Nonsymbolic
       FontBBox: -52, -270, 895, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HMOLMA+AdvOT9d0303c0.B
      FontSubset: true
      FirstChar: 46
      LastChar: 121
      FontDescriptor: 
       FontName: HMOLMA+AdvOT9d0303c0.B
       Flags: Nonsymbolic
       FontBBox: -31, -218, 770, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HMOLMB+AdvOT8e81dcaa
      FontSubset: true
      FirstChar: 35
      LastChar: 246
      FontDescriptor: 
       FontName: HMOLMB+AdvOT8e81dcaa
       Flags: Nonsymbolic
       FontBBox: -31, -208, 770, 927
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HMOLMD+AdvOTa4800bed.I
      FontSubset: true
      FirstChar: 44
      LastChar: 118
      FontDescriptor: 
       FontName: HMOLMD+AdvOTa4800bed.I
       Flags: Nonsymbolic
       FontBBox: -52, -270, 895, 927
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HMOLME+AdvPS4721B4
      FontSubset: true
      FirstChar: 97
      LastChar: 100
      FontDescriptor: 
       FontName: HMOLME+AdvPS4721B4
       Flags: Nonsymbolic
       FontBBox: 0, -208, 843, 697
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HMPGKF+AdvOT9d0303c0.B+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: HMPGKF+AdvOT9d0303c0.B+fb
       Flags: Symbolic
       FontBBox: 0, 0, 500, 718
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HMOLMF+AdvPSSym
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: HMOLMF+AdvPSSym
       Flags: Symbolic
       FontBBox: -177, -291, 1083, 1010
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: HMOLMC+AdvOT8e81dcaa+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: HMOLMC+AdvOT8e81dcaa+fb
       Flags: Symbolic
       FontBBox: 0, 0, 500, 718
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HNAGBB+AdvPS4BD310
      FontSubset: true
      FirstChar: 98
      LastChar: 100
      FontDescriptor: 
       FontName: HNAGBB+AdvPS4BD310
       Flags: Nonsymbolic
       FontBBox: 0, -208, 989, 697
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HMOLNG+AdvOT8e81dcaa+20
      FontSubset: true
      FirstChar: 145
      LastChar: 146
      FontDescriptor: 
       FontName: HMOLNG+AdvOT8e81dcaa+20
       Flags: Nonsymbolic
       FontBBox: -156, -145, 1000, 718
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HNAGCC+AdvOTad521943+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: HNAGCC+AdvOTad521943+20
       Flags: Nonsymbolic
       FontBBox: -156, -166, 1093, 718
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HMOLNH+AdvP4C4E74
      FontSubset: true
      FirstChar: 2
      LastChar: 254
      FontDescriptor: 
       FontName: HMOLNH+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HMOMBH+AdvP4C4E51
      FontSubset: true
      FirstChar: 60
      LastChar: 62
      FontDescriptor: 
       FontName: HMOMBH+AdvP4C4E51
       Flags: Nonsymbolic
       FontBBox: -31, -239, 1041, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HMOLKO+AdvOTad521943
      FontSubset: true
      FirstChar: 40
      LastChar: 243
      FontDescriptor: 
       FontName: HMOLKO+AdvOTad521943
       Flags: Nonsymbolic
       FontBBox: -31, -229, 802, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 4.0-c316 44.253921, Sun Oct 01 2006 17:14:39">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1016/j.molmet.2017.12.008</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Hepatic regulation of VLDL receptor by PPAR&amp;beta;/&amp;delta; and FGF21 modulates non-alcoholic fatty liver disease</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Mohammad Zarei</rdf:li>
               <rdf:li>Emma Barroso</rdf:li>
               <rdf:li>Xavier Palomer</rdf:li>
               <rdf:li>Jianli Dai</rdf:li>
               <rdf:li>Patricia Rada</rdf:li>
               <rdf:li>Tania Quesada-López</rdf:li>
               <rdf:li>Joan Carles Escolà-Gil</rdf:li>
               <rdf:li>Lidia Cedó</rdf:li>
               <rdf:li>Mohammad Reza Zali</rdf:li>
               <rdf:li>Mahsa Molaei</rdf:li>
               <rdf:li>Reza Dabiri</rdf:li>
               <rdf:li>Santiago Vázquez</rdf:li>
               <rdf:li>Eugènia Pujol</rdf:li>
               <rdf:li>Ángela M. Valverde</rdf:li>
               <rdf:li>Francesc Villarroya</rdf:li>
               <rdf:li>Yong Liu</rdf:li>
               <rdf:li>Walter Wahli</rdf:li>
               <rdf:li>Manuel Vázquez-Carrera</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>VLDLR</rdf:li>
               <rdf:li>PPAR</rdf:li>
               <rdf:li>FGF21</rdf:li>
               <rdf:li>ATF4</rdf:li>
               <rdf:li>ER stress</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Molecular Metabolism, 8 (2018) 117-131. doi:10.1016/j.molmet.2017.12.008</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Elsevier GmbH</rdf:li>
            </rdf:Bag>
         </dc:publisher>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Molecular Metabolism</prism:publicationName>
         <prism:copyright>© 2017 The Authors. Published by Elsevier GmbH.</prism:copyright>
         <prism:issn>2212-8778</prism:issn>
         <prism:volume>8</prism:volume>
         <prism:coverDisplayDate>February 2018</prism:coverDisplayDate>
         <prism:pageRange>117-131</prism:pageRange>
         <prism:startingPage>117</prism:startingPage>
         <prism:endingPage>131</prism:endingPage>
         <prism:doi>10.1016/j.molmet.2017.12.008</prism:doi>
         <prism:url>https://doi.org/10.1016/j.molmet.2017.12.008</prism:url>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1016/j.molmet.2017.12.008</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:ElsevierWebPDFSpecifications>6.5</pdfx:ElsevierWebPDFSpecifications>
         <pdfx:doi>10.1016/j.molmet.2017.12.008</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xap="http://ns.adobe.com/xap/1.0/">
         <xap:CreatorTool>Elsevier</xap:CreatorTool>
         <xap:CreateDate>2018-02-07T19:31:22+05:30</xap:CreateDate>
         <xap:ModifyDate>2018-02-07T19:32:19+05:30</xap:ModifyDate>
         <xap:MetadataDate>2018-02-07T19:32:19+05:30</xap:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapRights="http://ns.adobe.com/xap/1.0/rights/">
         <xapRights:Marked>True</xapRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>Acrobat Distiller 8.1.0 (Windows)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapMM="http://ns.adobe.com/xap/1.0/mm/">
         <xapMM:DocumentID>uuid:4ddf25b1-da3f-44fd-9434-87682c7ef2b4</xapMM:DocumentID>
         <xapMM:InstanceID>uuid:67cd2829-6438-4b22-9d0b-747f55952efa</xapMM:InstanceID>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
         <ali:license_ref>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <ali:uri>http://creativecommons.org/licenses/by-nc-nd/4.0/</ali:uri>
               </rdf:li>
            </rdf:Bag>
         </ali:license_ref>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 117
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 42, 565, 42, 566
      Annotation: 
       Subtype: Link
       Rect: 111, 567, 114, 576
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 117, 567, 120, 576
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 122, 567, 126, 576
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 131, 565, 131, 566
      Annotation: 
       Subtype: Link
       Rect: 190, 567, 193, 576
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 196, 567, 199, 576
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 202, 567, 205, 576
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 211, 565, 211, 566
      Annotation: 
       Subtype: Link
       Rect: 271, 567, 274, 576
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 277, 567, 280, 576
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 282, 567, 286, 576
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 291, 565, 291, 566
      Annotation: 
       Subtype: Link
       Rect: 329, 567, 333, 576
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 338, 565, 338, 566
      Annotation: 
       Subtype: Link
       Rect: 392, 567, 396, 576
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 398, 567, 401, 576
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 42, 554, 42, 556
      Annotation: 
       Subtype: Link
       Rect: 126, 556, 129, 565
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 132, 556, 135, 565
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 137, 556, 141, 565
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 147, 554, 147, 556
      Annotation: 
       Subtype: Link
       Rect: 235, 556, 239, 565
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 241, 556, 244, 565
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 247, 556, 250, 565
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 256, 554, 256, 556
      Annotation: 
       Subtype: Link
       Rect: 298, 556, 301, 565
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 304, 556, 307, 565
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 313, 554, 313, 556
      Annotation: 
       Subtype: Link
       Rect: 398, 556, 405, 565
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 42, 543, 42, 545
      Annotation: 
       Subtype: Link
       Rect: 97, 545, 105, 554
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 110, 543, 110, 545
      Annotation: 
       Subtype: Link
       Rect: 156, 545, 163, 554
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 169, 543, 169, 545
      Annotation: 
       Subtype: Link
       Rect: 238, 545, 242, 554
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 247, 543, 247, 545
      Annotation: 
       Subtype: Link
       Rect: 302, 545, 305, 554
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 311, 543, 311, 545
      Annotation: 
       Subtype: Link
       Rect: 387, 545, 390, 554
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 393, 545, 396, 554
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 42, 532, 42, 534
      Annotation: 
       Subtype: Link
       Rect: 118, 534, 121, 543
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 124, 534, 127, 543
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 130, 534, 133, 543
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 139, 532, 139, 534
      Annotation: 
       Subtype: Link
       Rect: 174, 534, 181, 543
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 186, 532, 186, 534
      Annotation: 
       Subtype: Link
       Rect: 237, 534, 244, 543
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 246, 534, 254, 543
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 256, 534, 263, 543
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 268, 532, 268, 534
      Annotation: 
       Subtype: Link
       Rect: 364, 534, 368, 543
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 370, 534, 374, 543
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 376, 534, 380, 543
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 382, 534, 386, 543
       Destination: 961
      Annotation: 
       Subtype: Link
       Rect: 413, 335, 529, 341
      Annotation: 
       Subtype: Link
       Rect: 405, 286, 414, 295
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 95, 104, 170, 112
      Annotation: 
       Subtype: Link
       Rect: 42, 48, 174, 56
      Annotation: 
       Subtype: Link
       Rect: 467, 647, 491, 671
      Annotation: 
       Subtype: Link
       Rect: 397, 19, 505, 25
      Annotation: 
       Subtype: Link
       Rect: 42, 13, 111, 19
    Page: 
     Label: 118
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 162, 681, 171, 690
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 80, 637, 87, 646
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 94, 637, 101, 646
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 152, 615, 161, 624
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 215, 582, 231, 591
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 179, 538, 186, 547
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 193, 538, 204, 547
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 285, 527, 299, 536
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 258, 516, 272, 525
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 62, 494, 75, 503
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 210, 483, 234, 492
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 122, 451, 136, 460
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 82, 440, 96, 449
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 204, 407, 217, 416
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 216, 374, 226, 383
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 224, 352, 238, 361
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 223, 319, 236, 328
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 88, 297, 101, 306
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 90, 264, 103, 273
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 379, 703, 393, 712
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 536, 692, 550, 701
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 452, 637, 466, 646
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 389, 593, 402, 602
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 536, 319, 550, 328
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 518, 231, 550, 240
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 467, 177, 480, 186
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 440, 19, 549, 25
      Annotation: 
       Subtype: Link
       Rect: 483, 13, 552, 19
    Page: 
     Label: 119
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 163, 615, 177, 624
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 166, 604, 197, 613
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 79, 560, 92, 569
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 124, 374, 137, 383
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 73, 133, 87, 142
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 458, 648, 485, 657
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 386, 604, 415, 613
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 295, 560, 333, 569
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 500, 560, 528, 569
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 295, 527, 325, 536
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 459, 527, 488, 536
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 469, 451, 483, 460
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 407, 429, 420, 438
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 295, 407, 335, 416
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 384, 396, 413, 405
       Destination: 87
      Annotation: 
       Subtype: Link
       Rect: 329, 385, 342, 394
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 448, 374, 477, 383
       Destination: 87
      Annotation: 
       Subtype: Link
       Rect: 334, 352, 362, 361
       Destination: 87
      Annotation: 
       Subtype: Link
       Rect: 495, 330, 508, 339
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 414, 286, 427, 295
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 329, 275, 357, 284
       Destination: 87
      Annotation: 
       Subtype: Link
       Rect: 400, 253, 429, 262
       Destination: 87
      Annotation: 
       Subtype: Link
       Rect: 409, 199, 438, 208
       Destination: 87
      Annotation: 
       Subtype: Link
       Rect: 312, 188, 325, 197
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 367, 188, 380, 197
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 295, 166, 356, 175
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 479, 144, 516, 153
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 523, 144, 528, 153
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 407, 67, 416, 76
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 397, 19, 505, 25
      Annotation: 
       Subtype: Link
       Rect: 42, 13, 111, 19
    Page: 
     Label: 120
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 440, 19, 549, 25
      Annotation: 
       Subtype: Link
       Rect: 483, 13, 552, 19
    Page: 
     Label: 121
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 397, 19, 505, 25
      Annotation: 
       Subtype: Link
       Rect: 42, 13, 111, 19
    Page: 
     Label: 122
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 64, 637, 92, 646
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 232, 571, 261, 580
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 212, 549, 241, 558
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 130, 505, 160, 514
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 192, 462, 205, 471
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 230, 407, 261, 416
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 96, 319, 110, 328
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 186, 308, 200, 317
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 269, 253, 296, 262
       Destination: 158
      Annotation: 
       Subtype: Link
       Rect: 253, 220, 281, 229
       Destination: 158
      Annotation: 
       Subtype: Link
       Rect: 167, 199, 226, 208
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 253, 177, 283, 186
       Destination: 158
      Annotation: 
       Subtype: Link
       Rect: 253, 166, 266, 175
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 88, 155, 117, 164
       Destination: 158
      Annotation: 
       Subtype: Link
       Rect: 229, 144, 258, 153
       Destination: 158
      Annotation: 
       Subtype: Link
       Rect: 83, 111, 145, 120
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 124, 89, 155, 98
       Destination: 158
      Annotation: 
       Subtype: Link
       Rect: 124, 45, 152, 54
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 474, 692, 506, 701
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 315, 659, 345, 668
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 470, 593, 484, 602
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 509, 571, 523, 580
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 432, 549, 460, 558
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 408, 505, 437, 514
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 313, 494, 327, 503
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 335, 483, 372, 492
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 465, 440, 504, 449
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 315, 385, 344, 394
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 427, 363, 457, 372
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 345, 286, 373, 295
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 347, 264, 378, 273
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 347, 220, 384, 229
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 419, 45, 450, 54
       Destination: 201
      Annotation: 
       Subtype: Link
       Rect: 440, 19, 549, 25
      Annotation: 
       Subtype: Link
       Rect: 483, 13, 552, 19
    Page: 
     Label: 123
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 397, 19, 505, 25
      Annotation: 
       Subtype: Link
       Rect: 42, 13, 111, 19
    Page: 
     Label: 124
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 440, 19, 549, 25
      Annotation: 
       Subtype: Link
       Rect: 483, 13, 552, 19
    Page: 
     Label: 125
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 44, 176, 73, 185
       Destination: 201
      Annotation: 
       Subtype: Link
       Rect: 150, 176, 179, 185
       Destination: 201
      Annotation: 
       Subtype: Link
       Rect: 78, 132, 108, 141
       Destination: 201
      Annotation: 
       Subtype: Link
       Rect: 165, 110, 196, 119
       Destination: 201
      Annotation: 
       Subtype: Link
       Rect: 44, 66, 73, 75
       Destination: 201
      Annotation: 
       Subtype: Link
       Rect: 173, 44, 202, 53
       Destination: 201
      Annotation: 
       Subtype: Link
       Rect: 351, 132, 382, 141
       Destination: 201
      Annotation: 
       Subtype: Link
       Rect: 401, 99, 429, 108
       Destination: 201
      Annotation: 
       Subtype: Link
       Rect: 397, 19, 505, 25
      Annotation: 
       Subtype: Link
       Rect: 42, 13, 111, 19
    Page: 
     Label: 126
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 440, 19, 549, 25
      Annotation: 
       Subtype: Link
       Rect: 483, 13, 552, 19
    Page: 
     Label: 127
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 397, 19, 505, 25
      Annotation: 
       Subtype: Link
       Rect: 42, 13, 111, 19
    Page: 
     Label: 128
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 62, 373, 75, 382
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 116, 329, 145, 338
       Destination: 216
      Annotation: 
       Subtype: Link
       Rect: 285, 296, 299, 305
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 62, 263, 75, 272
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 242, 241, 251, 250
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 122, 176, 136, 185
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 208, 132, 222, 141
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 285, 66, 299, 75
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 143, 44, 157, 53
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 390, 351, 415, 360
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 447, 285, 460, 294
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 514, 187, 528, 195
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 347, 439, 358, 447
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 274, 411, 285, 418
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 440, 19, 549, 25
      Annotation: 
       Subtype: Link
       Rect: 483, 13, 552, 19
    Page: 
     Label: 129
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 254, 670, 279, 679
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 188, 648, 213, 657
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 223, 637, 236, 646
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 254, 615, 279, 624
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 254, 593, 279, 602
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 251, 516, 264, 525
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 166, 462, 179, 471
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 258, 440, 272, 449
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 42, 407, 56, 416
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 77, 396, 90, 405
       Destination: 691
      Annotation: 
       Subtype: Link
       Rect: 460, 547, 532, 554
      Annotation: 
       Subtype: Link
       Rect: 293, 536, 354, 543
      Annotation: 
       Subtype: Link
       Rect: 308, 487, 532, 495
      Annotation: 
       Subtype: Link
       Rect: 308, 476, 500, 484
      Annotation: 
       Subtype: Link
       Rect: 506, 476, 517, 484
      Annotation: 
       Subtype: Link
       Rect: 308, 465, 532, 473
      Annotation: 
       Subtype: Link
       Rect: 308, 454, 445, 462
      Annotation: 
       Subtype: Link
       Rect: 451, 454, 466, 462
      Annotation: 
       Subtype: Link
       Rect: 308, 444, 532, 451
      Annotation: 
       Subtype: Link
       Rect: 308, 433, 532, 440
      Annotation: 
       Subtype: Link
       Rect: 308, 422, 350, 429
      Annotation: 
       Subtype: Link
       Rect: 356, 422, 363, 429
      Annotation: 
       Subtype: Link
       Rect: 308, 411, 532, 418
      Annotation: 
       Subtype: Link
       Rect: 308, 400, 532, 407
      Annotation: 
       Subtype: Link
       Rect: 308, 389, 443, 396
      Annotation: 
       Subtype: Link
       Rect: 449, 389, 460, 396
      Annotation: 
       Subtype: Link
       Rect: 308, 378, 532, 385
      Annotation: 
       Subtype: Link
       Rect: 308, 367, 513, 374
      Annotation: 
       Subtype: Link
       Rect: 518, 367, 530, 374
      Annotation: 
       Subtype: Link
       Rect: 308, 356, 532, 363
      Annotation: 
       Subtype: Link
       Rect: 308, 345, 532, 352
      Annotation: 
       Subtype: Link
       Rect: 308, 334, 532, 341
      Annotation: 
       Subtype: Link
       Rect: 308, 323, 323, 330
      Annotation: 
       Subtype: Link
       Rect: 329, 323, 344, 330
      Annotation: 
       Subtype: Link
       Rect: 308, 312, 532, 319
      Annotation: 
       Subtype: Link
       Rect: 308, 301, 532, 309
      Annotation: 
       Subtype: Link
       Rect: 308, 290, 509, 298
      Annotation: 
       Subtype: Link
       Rect: 514, 290, 526, 298
      Annotation: 
       Subtype: Link
       Rect: 308, 279, 532, 287
      Annotation: 
       Subtype: Link
       Rect: 308, 268, 532, 276
      Annotation: 
       Subtype: Link
       Rect: 308, 257, 532, 265
      Annotation: 
       Subtype: Link
       Rect: 308, 246, 493, 254
      Annotation: 
       Subtype: Link
       Rect: 499, 246, 510, 254
      Annotation: 
       Subtype: Link
       Rect: 308, 235, 532, 243
      Annotation: 
       Subtype: Link
       Rect: 308, 224, 532, 232
      Annotation: 
       Subtype: Link
       Rect: 308, 213, 532, 221
      Annotation: 
       Subtype: Link
       Rect: 308, 202, 423, 210
      Annotation: 
       Subtype: Link
       Rect: 429, 202, 440, 210
      Annotation: 
       Subtype: Link
       Rect: 308, 191, 532, 199
      Annotation: 
       Subtype: Link
       Rect: 308, 181, 532, 188
      Annotation: 
       Subtype: Link
       Rect: 308, 170, 532, 177
      Annotation: 
       Subtype: Link
       Rect: 308, 159, 433, 166
      Annotation: 
       Subtype: Link
       Rect: 438, 159, 457, 166
      Annotation: 
       Subtype: Link
       Rect: 308, 148, 532, 155
      Annotation: 
       Subtype: Link
       Rect: 308, 137, 532, 144
      Annotation: 
       Subtype: Link
       Rect: 308, 126, 532, 133
      Annotation: 
       Subtype: Link
       Rect: 308, 115, 365, 122
      Annotation: 
       Subtype: Link
       Rect: 371, 115, 382, 122
      Annotation: 
       Subtype: Link
       Rect: 308, 104, 532, 111
      Annotation: 
       Subtype: Link
       Rect: 308, 93, 532, 100
      Annotation: 
       Subtype: Link
       Rect: 308, 82, 500, 89
      Annotation: 
       Subtype: Link
       Rect: 505, 82, 532, 89
      Annotation: 
       Subtype: Link
       Rect: 308, 71, 402, 78
      Annotation: 
       Subtype: Link
       Rect: 408, 71, 419, 78
      Annotation: 
       Subtype: Link
       Rect: 308, 60, 532, 67
      Annotation: 
       Subtype: Link
       Rect: 308, 49, 532, 56
      Annotation: 
       Subtype: Link
       Rect: 397, 19, 505, 25
      Annotation: 
       Subtype: Link
       Rect: 42, 13, 111, 19
    Page: 
     Label: 130
     Sequence: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 77, 704, 301, 712
      Annotation: 
       Subtype: Link
       Rect: 77, 693, 295, 701
      Annotation: 
       Subtype: Link
       Rect: 77, 682, 96, 690
      Annotation: 
       Subtype: Link
       Rect: 77, 671, 301, 679
      Annotation: 
       Subtype: Link
       Rect: 77, 660, 301, 668
      Annotation: 
       Subtype: Link
       Rect: 77, 649, 301, 657
      Annotation: 
       Subtype: Link
       Rect: 77, 638, 301, 646
      Annotation: 
       Subtype: Link
       Rect: 77, 627, 101, 635
      Annotation: 
       Subtype: Link
       Rect: 107, 627, 122, 635
      Annotation: 
       Subtype: Link
       Rect: 77, 616, 301, 624
      Annotation: 
       Subtype: Link
       Rect: 77, 605, 301, 613
      Annotation: 
       Subtype: Link
       Rect: 77, 595, 278, 602
      Annotation: 
       Subtype: Link
       Rect: 284, 595, 299, 602
      Annotation: 
       Subtype: Link
       Rect: 77, 584, 301, 591
      Annotation: 
       Subtype: Link
       Rect: 77, 573, 301, 580
      Annotation: 
       Subtype: Link
       Rect: 77, 562, 301, 569
      Annotation: 
       Subtype: Link
       Rect: 77, 551, 191, 558
      Annotation: 
       Subtype: Link
       Rect: 197, 551, 212, 558
      Annotation: 
       Subtype: Link
       Rect: 77, 540, 301, 547
      Annotation: 
       Subtype: Link
       Rect: 77, 529, 301, 536
      Annotation: 
       Subtype: Link
       Rect: 77, 518, 301, 525
      Annotation: 
       Subtype: Link
       Rect: 77, 507, 105, 514
      Annotation: 
       Subtype: Link
       Rect: 111, 507, 126, 514
      Annotation: 
       Subtype: Link
       Rect: 77, 496, 301, 503
      Annotation: 
       Subtype: Link
       Rect: 77, 485, 301, 492
      Annotation: 
       Subtype: Link
       Rect: 77, 474, 301, 482
      Annotation: 
       Subtype: Link
       Rect: 77, 463, 235, 471
      Annotation: 
       Subtype: Link
       Rect: 241, 463, 256, 471
      Annotation: 
       Subtype: Link
       Rect: 77, 452, 301, 460
      Annotation: 
       Subtype: Link
       Rect: 77, 441, 301, 449
      Annotation: 
       Subtype: Link
       Rect: 77, 430, 226, 438
      Annotation: 
       Subtype: Link
       Rect: 232, 430, 247, 438
      Annotation: 
       Subtype: Link
       Rect: 77, 419, 301, 427
      Annotation: 
       Subtype: Link
       Rect: 77, 408, 301, 416
      Annotation: 
       Subtype: Link
       Rect: 77, 397, 119, 405
      Annotation: 
       Subtype: Link
       Rect: 125, 397, 136, 405
      Annotation: 
       Subtype: Link
       Rect: 77, 386, 301, 394
      Annotation: 
       Subtype: Link
       Rect: 77, 375, 301, 383
      Annotation: 
       Subtype: Link
       Rect: 77, 364, 191, 372
      Annotation: 
       Subtype: Link
       Rect: 197, 364, 208, 372
      Annotation: 
       Subtype: Link
       Rect: 77, 353, 301, 361
      Annotation: 
       Subtype: Link
       Rect: 77, 342, 301, 350
      Annotation: 
       Subtype: Link
       Rect: 77, 332, 301, 339
      Annotation: 
       Subtype: Link
       Rect: 77, 321, 85, 328
      Annotation: 
       Subtype: Link
       Rect: 90, 321, 102, 328
      Annotation: 
       Subtype: Link
       Rect: 77, 310, 301, 317
      Annotation: 
       Subtype: Link
       Rect: 77, 299, 301, 306
      Annotation: 
       Subtype: Link
       Rect: 77, 288, 301, 295
      Annotation: 
       Subtype: Link
       Rect: 77, 277, 183, 284
      Annotation: 
       Subtype: Link
       Rect: 189, 277, 204, 284
      Annotation: 
       Subtype: Link
       Rect: 77, 266, 301, 273
      Annotation: 
       Subtype: Link
       Rect: 77, 255, 301, 262
      Annotation: 
       Subtype: Link
       Rect: 77, 244, 282, 251
      Annotation: 
       Subtype: Link
       Rect: 288, 244, 299, 251
      Annotation: 
       Subtype: Link
       Rect: 77, 233, 301, 240
      Annotation: 
       Subtype: Link
       Rect: 77, 222, 301, 229
      Annotation: 
       Subtype: Link
       Rect: 77, 211, 301, 218
      Annotation: 
       Subtype: Link
       Rect: 77, 200, 157, 208
      Annotation: 
       Subtype: Link
       Rect: 163, 200, 178, 208
      Annotation: 
       Subtype: Link
       Rect: 77, 189, 301, 197
      Annotation: 
       Subtype: Link
       Rect: 77, 178, 301, 186
      Annotation: 
       Subtype: Link
       Rect: 77, 167, 205, 175
      Annotation: 
       Subtype: Link
       Rect: 211, 167, 222, 175
      Annotation: 
       Subtype: Link
       Rect: 77, 156, 301, 164
      Annotation: 
       Subtype: Link
       Rect: 77, 145, 119, 153
      Annotation: 
       Subtype: Link
       Rect: 125, 145, 136, 153
      Annotation: 
       Subtype: Link
       Rect: 77, 134, 301, 142
      Annotation: 
       Subtype: Link
       Rect: 77, 123, 301, 131
      Annotation: 
       Subtype: Link
       Rect: 77, 112, 227, 120
      Annotation: 
       Subtype: Link
       Rect: 233, 112, 248, 120
      Annotation: 
       Subtype: Link
       Rect: 77, 101, 301, 109
      Annotation: 
       Subtype: Link
       Rect: 77, 90, 282, 98
      Annotation: 
       Subtype: Link
       Rect: 288, 90, 299, 98
      Annotation: 
       Subtype: Link
       Rect: 77, 79, 301, 87
      Annotation: 
       Subtype: Link
       Rect: 77, 69, 301, 76
      Annotation: 
       Subtype: Link
       Rect: 77, 58, 221, 65
      Annotation: 
       Subtype: Link
       Rect: 226, 58, 238, 65
      Annotation: 
       Subtype: Link
       Rect: 328, 704, 552, 712
      Annotation: 
       Subtype: Link
       Rect: 328, 693, 552, 701
      Annotation: 
       Subtype: Link
       Rect: 328, 682, 441, 690
      Annotation: 
       Subtype: Link
       Rect: 447, 682, 459, 690
      Annotation: 
       Subtype: Link
       Rect: 328, 671, 552, 679
      Annotation: 
       Subtype: Link
       Rect: 328, 660, 552, 668
      Annotation: 
       Subtype: Link
       Rect: 328, 649, 413, 657
      Annotation: 
       Subtype: Link
       Rect: 419, 649, 430, 657
      Annotation: 
       Subtype: Link
       Rect: 328, 638, 552, 646
      Annotation: 
       Subtype: Link
       Rect: 328, 627, 552, 635
      Annotation: 
       Subtype: Link
       Rect: 328, 616, 397, 624
      Annotation: 
       Subtype: Link
       Rect: 403, 616, 414, 624
      Annotation: 
       Subtype: Link
       Rect: 328, 605, 552, 613
      Annotation: 
       Subtype: Link
       Rect: 328, 595, 552, 602
      Annotation: 
       Subtype: Link
       Rect: 328, 584, 552, 591
      Annotation: 
       Subtype: Link
       Rect: 328, 573, 526, 580
      Annotation: 
       Subtype: Link
       Rect: 532, 573, 550, 580
      Annotation: 
       Subtype: Link
       Rect: 328, 562, 552, 569
      Annotation: 
       Subtype: Link
       Rect: 328, 551, 552, 558
      Annotation: 
       Subtype: Link
       Rect: 328, 540, 529, 547
      Annotation: 
       Subtype: Link
       Rect: 535, 540, 550, 547
      Annotation: 
       Subtype: Link
       Rect: 328, 529, 552, 536
      Annotation: 
       Subtype: Link
       Rect: 328, 518, 552, 525
      Annotation: 
       Subtype: Link
       Rect: 328, 507, 552, 514
      Annotation: 
       Subtype: Link
       Rect: 328, 496, 383, 503
      Annotation: 
       Subtype: Link
       Rect: 389, 496, 400, 503
      Annotation: 
       Subtype: Link
       Rect: 328, 485, 552, 492
      Annotation: 
       Subtype: Link
       Rect: 328, 474, 552, 482
      Annotation: 
       Subtype: Link
       Rect: 328, 463, 511, 471
      Annotation: 
       Subtype: Link
       Rect: 516, 463, 524, 471
      Annotation: 
       Subtype: Link
       Rect: 328, 452, 552, 460
      Annotation: 
       Subtype: Link
       Rect: 328, 441, 552, 449
      Annotation: 
       Subtype: Link
       Rect: 328, 430, 552, 438
      Annotation: 
       Subtype: Link
       Rect: 328, 419, 356, 427
      Annotation: 
       Subtype: Link
       Rect: 362, 419, 377, 427
      Annotation: 
       Subtype: Link
       Rect: 328, 408, 552, 416
      Annotation: 
       Subtype: Link
       Rect: 328, 397, 552, 405
      Annotation: 
       Subtype: Link
       Rect: 328, 386, 552, 394
      Annotation: 
       Subtype: Link
       Rect: 328, 375, 356, 383
      Annotation: 
       Subtype: Link
       Rect: 362, 375, 377, 383
      Annotation: 
       Subtype: Link
       Rect: 328, 364, 552, 372
      Annotation: 
       Subtype: Link
       Rect: 328, 353, 552, 361
      Annotation: 
       Subtype: Link
       Rect: 328, 342, 468, 350
      Annotation: 
       Subtype: Link
       Rect: 328, 332, 552, 339
      Annotation: 
       Subtype: Link
       Rect: 328, 321, 552, 328
      Annotation: 
       Subtype: Link
       Rect: 328, 310, 514, 317
      Annotation: 
       Subtype: Link
       Rect: 520, 310, 552, 317
      Annotation: 
       Subtype: Link
       Rect: 328, 299, 426, 306
      Annotation: 
       Subtype: Link
       Rect: 432, 299, 451, 306
      Annotation: 
       Subtype: Link
       Rect: 328, 288, 552, 295
      Annotation: 
       Subtype: Link
       Rect: 328, 277, 552, 284
      Annotation: 
       Subtype: Link
       Rect: 328, 266, 352, 273
      Annotation: 
       Subtype: Link
       Rect: 358, 266, 370, 273
      Annotation: 
       Subtype: Link
       Rect: 328, 255, 552, 262
      Annotation: 
       Subtype: Link
       Rect: 328, 244, 535, 251
      Annotation: 
       Subtype: Link
       Rect: 541, 244, 548, 251
      Annotation: 
       Subtype: Link
       Rect: 328, 233, 552, 240
      Annotation: 
       Subtype: Link
       Rect: 328, 222, 552, 229
      Annotation: 
       Subtype: Link
       Rect: 328, 211, 552, 218
      Annotation: 
       Subtype: Link
       Rect: 328, 200, 339, 208
      Annotation: 
       Subtype: Link
       Rect: 345, 200, 356, 208
      Annotation: 
       Subtype: Link
       Rect: 328, 189, 552, 197
      Annotation: 
       Subtype: Link
       Rect: 328, 178, 552, 186
      Annotation: 
       Subtype: Link
       Rect: 328, 167, 552, 175
      Annotation: 
       Subtype: Link
       Rect: 328, 156, 496, 164
      Annotation: 
       Subtype: Link
       Rect: 502, 156, 517, 164
      Annotation: 
       Subtype: Link
       Rect: 328, 145, 552, 153
      Annotation: 
       Subtype: Link
       Rect: 328, 134, 552, 142
      Annotation: 
       Subtype: Link
       Rect: 328, 123, 552, 131
      Annotation: 
       Subtype: Link
       Rect: 328, 112, 492, 120
      Annotation: 
       Subtype: Link
       Rect: 498, 112, 509, 120
      Annotation: 
       Subtype: Link
       Rect: 328, 101, 552, 109
      Annotation: 
       Subtype: Link
       Rect: 328, 90, 552, 98
      Annotation: 
       Subtype: Link
       Rect: 328, 79, 552, 87
      Annotation: 
       Subtype: Link
       Rect: 328, 69, 552, 76
      Annotation: 
       Subtype: Link
       Rect: 328, 58, 395, 65
      Annotation: 
       Subtype: Link
       Rect: 401, 58, 416, 65
      Annotation: 
       Subtype: Link
       Rect: 440, 19, 549, 25
      Annotation: 
       Subtype: Link
       Rect: 483, 13, 552, 19
    Page: 
     Label: 131
     Sequence: 15
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 57, 704, 281, 712
      Annotation: 
       Subtype: Link
       Rect: 57, 693, 281, 701
      Annotation: 
       Subtype: Link
       Rect: 57, 682, 281, 690
      Annotation: 
       Subtype: Link
       Rect: 57, 671, 262, 679
      Annotation: 
       Subtype: Link
       Rect: 268, 671, 279, 679
      Annotation: 
       Subtype: Link
       Rect: 57, 660, 281, 668
      Annotation: 
       Subtype: Link
       Rect: 57, 649, 281, 657
      Annotation: 
       Subtype: Link
       Rect: 57, 638, 281, 646
      Annotation: 
       Subtype: Link
       Rect: 57, 627, 281, 635
      Annotation: 
       Subtype: Link
       Rect: 57, 616, 158, 624
      Annotation: 
       Subtype: Link
       Rect: 163, 616, 178, 624
      Annotation: 
       Subtype: Link
       Rect: 57, 605, 281, 613
      Annotation: 
       Subtype: Link
       Rect: 57, 595, 281, 602
      Annotation: 
       Subtype: Link
       Rect: 57, 584, 281, 591
      Annotation: 
       Subtype: Link
       Rect: 308, 704, 532, 712
      Annotation: 
       Subtype: Link
       Rect: 308, 693, 323, 701
      Annotation: 
       Subtype: Link
       Rect: 329, 693, 344, 701
      Annotation: 
       Subtype: Link
       Rect: 308, 682, 532, 690
      Annotation: 
       Subtype: Link
       Rect: 308, 671, 532, 679
      Annotation: 
       Subtype: Link
       Rect: 308, 660, 532, 668
      Annotation: 
       Subtype: Link
       Rect: 308, 649, 423, 657
      Annotation: 
       Subtype: Link
       Rect: 429, 649, 444, 657
      Annotation: 
       Subtype: Link
       Rect: 308, 638, 532, 646
      Annotation: 
       Subtype: Link
       Rect: 308, 627, 532, 635
      Annotation: 
       Subtype: Link
       Rect: 308, 616, 477, 624
      Annotation: 
       Subtype: Link
       Rect: 482, 616, 494, 624
      Annotation: 
       Subtype: Link
       Rect: 308, 605, 532, 613
      Annotation: 
       Subtype: Link
       Rect: 308, 595, 532, 602
      Annotation: 
       Subtype: Link
       Rect: 308, 584, 405, 591
      Annotation: 
       Subtype: Link
       Rect: 411, 584, 426, 591
      Annotation: 
       Subtype: Link
       Rect: 397, 19, 505, 25
      Annotation: 
       Subtype: Link
       Rect: 42, 13, 111, 19
  Checksum: 177114b9
   Type: CRC32
  Checksum: 7757aa2e0b19fd726b0e78a3be63342f
   Type: MD5
  Checksum: e08675f6736c1c1dce62abece2379fc0ad96a5e3
   Type: SHA-1