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Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed17bee Item: Title: 2. Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2a33fae0 Children: Item: Title: 2.1. Postmortem samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@707f7052 Children: Item: Title: 2.1.1. Study population Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11028347 Item: Title: 2.1.2. Assessment of AD neuropathologic changes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@14899482 Item: Title: 2.1.3. Regional brain samples and dissection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@21588809 Item: Title: 2.2. CSF/plasma samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2aae9190 Item: Title: 2.3. Reversed-phase HPLC Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2f333739 Item: Title: 2.4. Statistics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77468bd9 Item: Title: 3. Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12bb4df8 Children: Item: Title: 3.1. Monoaminergic characterization of postmortem brain tissue Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4cc77c2e Children: Item: Title: 3.1.1. Noradrenergic system Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a7b0070 Item: Title: 3.1.2. Dopaminergic system Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@39a054a5 Item: Title: 3.1.3. Serotonergic system Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@71bc1ae4 Item: Title: 3.2. Monoaminergic characterization of (paired) CSF/plasma samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6ed3ef1 Item: Title: 4. Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2437c6dc Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1f89ab83 Item: Title: Supplementary data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e73f9ac Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@61064425 Info: Title: Monoaminergic impairment in Down syndrome with Alzheimer's disease compared to early-onset Alzheimer's disease Author: Alain D. Dekker Subject: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 10 (2018) 99-111. doi:10.1016/j.dadm.2017.11.001 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Fri Dec 22 04:43:59 CET 2017 ModDate: Fri Dec 22 04:44:39 CET 2017 ID: 0x355a7e44c8a7382b21a531e05ca15da3, 0x35293c06961b1344a7536bfeab7e84b8 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 120 ImageHeight: 120 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 251 ImageHeight: 276 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 1500 ImageHeight: 1142 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 1996 ImageHeight: 996 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: GJCNBL+AdvPSA88A FontSubset: true FirstChar: 25 LastChar: 151 FontDescriptor: FontName: GJCNBL+AdvPSA88A Flags: Serif, Nonsymbolic FontBBox: -166, -208, 1000, 781 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: GJCNDA+AdvPSSym FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: GJCNDA+AdvPSSym Flags: Symbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: GJCNCP+AdvPS3F4C13 FontSubset: true FirstChar: 98 LastChar: 98 FontDescriptor: FontName: GJCNCP+AdvPS3F4C13 Flags: Nonsymbolic FontBBox: 0, -291, 875, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GJCNKP+AdvPS4721B4 FontSubset: true FirstChar: 99 LastChar: 99 FontDescriptor: FontName: GJCNKP+AdvPS4721B4 Flags: Nonsymbolic FontBBox: 0, -208, 843, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GJCNBM+AdvP4C4E59 FontSubset: true FirstChar: 1 LastChar: 160 FontDescriptor: FontName: GJCNBM+AdvP4C4E59 Flags: Symbolic FontBBox: -31, -250, 1000, 750 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GJCNCM+AdvPSA88C FontSubset: true FirstChar: 38 LastChar: 151 FontDescriptor: FontName: GJCNCM+AdvPSA88C Flags: Serif, Nonsymbolic FontBBox: -166, -208, 1010, 781 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GJDBKG+AdvOTd877c31c+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: GJDBKG+AdvOTd877c31c+03 Flags: Symbolic FontBBox: 24, -10, 407, 460 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GJCNCN+AdvPSA88B FontSubset: true FirstChar: 46 LastChar: 121 FontDescriptor: FontName: GJCNCN+AdvPSA88B Flags: Serif, Nonsymbolic FontBBox: -166, -208, 1000, 781 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GJCNCO+AdvPS586B FontSubset: true FirstChar: 44 LastChar: 53 FontDescriptor: FontName: GJCNCO+AdvPS586B Flags: Nonsymbolic FontBBox: -20, -229, 1010, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GJCNJO+AdvP4C4E74 FontSubset: true FirstChar: 1 LastChar: 120 FontDescriptor: FontName: GJCNJO+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: application/pdf doi:10.1016/j.dadm.2017.11.001 Monoaminergic impairment in Down syndrome with Alzheimer's disease compared to early-onset Alzheimer's disease Alain D. Dekker Yannick Vermeiren Maria Carmona-Iragui Bessy Benejam Laura Videla Ellen Gelpi Tony Aerts Debby Van Dam Susana Fernández Alberto Lleó Sebastian Videla Anne Sieben Jean-Jacques Martin Rafael Blesa Juan Fortea Peter P. De Deyn Netherlands Brain Bankg Alzheimer's disease Cerebrospinal fluid Dementia Dopamine Down syndrome Monoamines MHPG Neurotransmitter Noradrenaline Plasma Serotonin Trisomy 21 Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 10 (2018) 99-111. doi:10.1016/j.dadm.2017.11.001 Elsevier Inc. journal Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring  © 2017 The Authors. 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539, 624 Annotation: Subtype: Link Rect: 317, 606, 400, 614 Annotation: Subtype: Link Rect: 317, 596, 539, 604 Annotation: Subtype: Link Rect: 317, 586, 539, 594 Annotation: Subtype: Link Rect: 317, 576, 537, 584 Annotation: Subtype: Link Rect: 317, 566, 539, 574 Annotation: Subtype: Link Rect: 317, 556, 539, 564 Annotation: Subtype: Link Rect: 317, 546, 539, 554 Annotation: Subtype: Link Rect: 317, 536, 539, 544 Annotation: Subtype: Link Rect: 317, 526, 419, 534 Annotation: Subtype: Link Rect: 317, 516, 539, 524 Annotation: Subtype: Link Rect: 317, 506, 539, 514 Annotation: Subtype: Link Rect: 317, 496, 539, 504 Annotation: Subtype: Link Rect: 317, 486, 399, 494 Annotation: Subtype: Link Rect: 317, 476, 539, 484 Annotation: Subtype: Link Rect: 317, 466, 539, 474 Annotation: Subtype: Link Rect: 317, 457, 539, 464 Annotation: Subtype: Link Rect: 317, 447, 427, 455 Annotation: Subtype: Link Rect: 317, 437, 539, 445 Annotation: Subtype: Link Rect: 317, 427, 539, 435 Annotation: Subtype: Link Rect: 317, 417, 521, 425 Annotation: Subtype: Link Rect: 317, 407, 539, 415 Annotation: Subtype: Link Rect: 317, 397, 539, 405 Annotation: Subtype: Link Rect: 317, 387, 428, 395 Annotation: Subtype: Link Rect: 317, 377, 539, 385 Annotation: Subtype: Link Rect: 317, 367, 539, 375 Annotation: Subtype: Link Rect: 317, 357, 539, 365 Annotation: Subtype: Link Rect: 317, 347, 373, 355 Annotation: Subtype: Link Rect: 317, 337, 539, 345 Annotation: Subtype: Link Rect: 317, 327, 539, 335 Annotation: Subtype: Link Rect: 317, 317, 442, 325 Annotation: Subtype: Link Rect: 317, 307, 539, 315 Annotation: Subtype: Link Rect: 317, 297, 539, 305 Annotation: Subtype: Link Rect: 317, 287, 383, 295 Annotation: Subtype: Link Rect: 317, 277, 539, 285 Annotation: Subtype: Link Rect: 317, 267, 539, 275 Annotation: Subtype: Link Rect: 317, 257, 499, 265 Annotation: Subtype: Link Rect: 317, 247, 362, 255 Annotation: Subtype: Link Rect: 366, 247, 539, 255 Annotation: Subtype: Link Rect: 317, 237, 332, 245 Annotation: Subtype: Link Rect: 335, 237, 345, 245 Annotation: Subtype: Link Rect: 348, 237, 539, 245 Annotation: Subtype: Link Rect: 317, 227, 452, 235 Annotation: Subtype: Link Rect: 317, 217, 539, 225 Annotation: Subtype: Link Rect: 317, 207, 539, 215 Annotation: Subtype: Link Rect: 317, 197, 499, 205 Annotation: Subtype: Link Rect: 317, 187, 539, 195 Annotation: Subtype: Link Rect: 317, 178, 539, 186 Annotation: Subtype: Link Rect: 317, 168, 525, 176 Annotation: Subtype: Link Rect: 317, 158, 539, 166 Annotation: Subtype: Link Rect: 317, 148, 539, 156 Annotation: Subtype: Link Rect: 317, 138, 480, 146 Annotation: Subtype: Link Rect: 317, 128, 539, 136 Annotation: Subtype: Link Rect: 317, 118, 539, 126 Annotation: Subtype: Link Rect: 317, 108, 481, 116 Annotation: Subtype: Link Rect: 317, 98, 539, 106 Annotation: Subtype: Link Rect: 317, 88, 539, 96 Annotation: Subtype: Link Rect: 317, 78, 510, 86 Annotation: Subtype: Link Rect: 317, 68, 539, 76 Annotation: Subtype: Link Rect: 317, 58, 539, 66 Annotation: Subtype: Link Rect: 317, 48, 424, 56 Page: Label: 111 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 54, 696, 276, 704 Annotation: Subtype: Link Rect: 54, 686, 276, 694 Annotation: Subtype: Link Rect: 54, 676, 276, 684 Annotation: Subtype: Link Rect: 54, 666, 172, 674 Annotation: Subtype: Link Rect: 54, 656, 276, 664 Annotation: Subtype: Link Rect: 54, 646, 276, 654 Annotation: Subtype: Link Rect: 54, 636, 276, 644 Annotation: Subtype: Link Rect: 54, 626, 100, 634 Annotation: Subtype: Link Rect: 54, 616, 276, 624 Annotation: Subtype: Link Rect: 54, 606, 276, 614 Annotation: Subtype: Link Rect: 54, 596, 254, 604 Annotation: Subtype: Link Rect: 54, 586, 276, 594 Annotation: Subtype: Link Rect: 54, 576, 276, 584 Annotation: Subtype: Link Rect: 54, 566, 144, 574 Annotation: Subtype: Link Rect: 54, 556, 276, 564 Annotation: Subtype: Link Rect: 54, 546, 254, 554 Annotation: Subtype: Link Rect: 54, 536, 276, 544 Annotation: Subtype: Link Rect: 54, 526, 276, 534 Annotation: Subtype: Link Rect: 54, 516, 254, 524 Annotation: Subtype: Link Rect: 54, 506, 276, 514 Annotation: Subtype: Link Rect: 54, 496, 276, 504 Annotation: Subtype: Link Rect: 54, 486, 152, 494 Annotation: Subtype: Link Rect: 317, 696, 539, 704 Annotation: Subtype: Link Rect: 317, 686, 522, 694 Annotation: Subtype: Link Rect: 317, 676, 539, 684 Annotation: Subtype: Link Rect: 317, 666, 539, 674 Annotation: Subtype: Link Rect: 317, 656, 507, 664 Annotation: Subtype: Link Rect: 317, 646, 539, 654 Annotation: Subtype: Link Rect: 317, 636, 539, 644 Annotation: Subtype: Link Rect: 317, 626, 417, 634 Annotation: Subtype: Link Rect: 317, 616, 539, 624 Annotation: Subtype: Link Rect: 317, 606, 539, 614 Annotation: Subtype: Link Rect: 317, 596, 539, 604 Annotation: Subtype: Link Rect: 317, 586, 424, 594 Annotation: Subtype: Link Rect: 317, 576, 539, 584 Annotation: Subtype: Link Rect: 317, 566, 539, 574 Annotation: Subtype: Link Rect: 317, 556, 496, 564 Annotation: Subtype: Link Rect: 316, 546, 539, 554 Annotation: Subtype: Link Rect: 316, 536, 539, 544 Annotation: Subtype: Link Rect: 316, 526, 531, 534 Annotation: Subtype: Link Rect: 317, 516, 539, 524 Annotation: Subtype: Link Rect: 317, 506, 539, 514 Annotation: Subtype: Link Rect: 317, 496, 539, 504 Annotation: Subtype: Link Rect: 317, 486, 484, 494 Checksum: 644b1cff Type: CRC32 Checksum: 4cbae0a416486efdf33de3e9ceb6083a Type: MD5 Checksum: e4a30672a4c44d01be9fe56b0987de01a5eb65a9 Type: SHA-1