c0c8eadfff341ef4b9609c71700e511c natcom_a2018v9a967.pdf c283270b5152da0329f90e05c12701abf6445c1a natcom_a2018v9a967.pdf af5cb13707f34cef38efe6ce593c71539545dec3d7ad03f4698754e5cc66954e natcom_a2018v9a967.pdf Title: Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1 Subject: Nature Communications, doi:10.1038/s41467-018-03433-3 Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Wed Feb 28 06:39:03 2018 CET ModDate: Tue Mar 6 14:41:09 2018 CET Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1870151 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DAFAEP+AdvOTea1a7398 Type 1C WinAnsi yes yes no 739 0 DAFBEK+AdvOT9bd21c25.I Type 1C WinAnsi yes yes no 741 0 DAFBFL+AdvOTea1a7398+fb Type 1C Custom yes 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object 'bm_CR45' cannot be found Offset: 1839843 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_MOESM1' cannot be found Offset: 1839843 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_MOESM1' cannot be found Offset: 1839843 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_MOESM1' cannot be found Offset: 1839843 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42f30e0a Children: Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@24273305 Children: Item: Title: EDC4 interacts with TOPBP1 and associates with BRCA1 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5b1d2887 Item: Title: EDC4 is involved in DNA damage response Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46f5f779 Item: Title: Independent roles of EDC4 in mRNA decapping and DNA repair Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1c2c22f3 Item: Title: EDC4 regulates HR-mediated repair and works with BRCA1 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@18e8568 Item: Title: Germline EDC4 mutations in breast cancer patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33e5ccce Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5a42bbf4 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@270421f5 Children: Item: Title: Immunoprecipitation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52d455b8 Item: Title: Cell fractionation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4f4a7090 Item: Title: Immunoblot analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@18ef96 Item: Title: FANCD2 monoubiquitination analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6956de9 Item: Title: MMC survival and G2 arrest after siRNA-mediated inhibitions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@769c9116 Item: Title: Chromosome fragility assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6aceb1a5 Item: Title: Diepoxybutane survival Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2d6d8735 Item: Title: Cell cultures and plasmids Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ba4d54 Item: Title: Laser micro-irradiation experiments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12bc6874 Item: Title: Plasmid transfection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@de0a01f Item: Title: Plasmid construction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4c75cab9 Item: Title: CRISPR-Cas9 KO generation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1ef7fe8e Item: Title: Genotyping of EDC4 KO clones Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6f79caec Item: Title: Generation of lentiviral particles Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@67117f44 Item: Title: HR assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5d3411d Item: Title: End-resection assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2471cca7 Item: Title: Immunofluorescence and foci formation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5fe5c6f Item: Title: PARP inhibitors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6979e8cb Item: Title: RNA interference Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@763d9750 Item: Title: Antibodies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5c0369c4 Item: Title: Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2be94b0f Item: Title: Mutation identification in pooled samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@d70c109 Item: Title: Flow cytometric micronuclei assay and cell cycle analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@17ed40e0 Item: Title: Statistics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50675690 Item: Title: Data availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@31b7dea0 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ac42916 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@47d384ee Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2d6a9952 Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@22a71081 Item: Title: ACKNOWLEDGEMENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3930015a Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 365 ImageHeight: 242 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 316 ImageHeight: 4 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 289 ImageHeight: 4 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 365 ImageHeight: 183 BitsPerSample: 8 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http://dx.doi.org/10.1038/s41467-018-03433-3 journal Nature Communications © 2018, The Author(s) 2041-1723 10.1038/s41467-018-03433-3 springer.com springerlink.com 2010-04-23 True 10.1038/s41467-018-03433-3 springer.com springerlink.com Springer 2018-03-06T14:41:09+01:00 2018-02-28T11:09:03+05:30 2018-03-06T14:41:09+01:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) VoR uuid:a9d5fe95-159d-4fca-b45f-15552f9061e0 uuid:abf146de-3793-4112-9e46-41121db1a4da default 1 converted uuid:4a6f9d71-6885-46ff-9380-7eaa36c7759d converted to PDF/A-2b pdfToolbox 2018-02-28T11:09:53+05:30 2 B http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://springernature.com/ns/xmpExtensions/2.0/ sn Springer Nature ORCID Schema external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). 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