3472ebb1691a3c3dbdf2fc858da88595 nutrients_a2018v10n10p1348.pdf 4b48b09187939669075c0a5e68198a14649c0a57 nutrients_a2018v10n10p1348.pdf b5b252e1a4a5349cbf332a8b8fe17c0ec759d2c819f766da7bba090c5434223f nutrients_a2018v10n10p1348.pdf Title: Effect of A Very Low-Calorie Ketogenic Diet on Food and Alcohol Cravings, Physical and Sexual Activity, Sleep Disturbances, and Quality of Life in Obese Patients Subject: Psychological well-being and hunger and food control are two relevant factors involved in the success of weight-loss therapy in treating obesity. Thus, this study aims to evaluate food and alcohol cravings, physical and sexual activity, sleep, and life quality (QoL) in obese patients following a very low-calorie ketogenic (VLCK) diet, as well as the role of weight lost and ketosis on these parameters. A battery of psychological test was performed in twenty obese patients (12 females, 47.2 10.2 year and BMI of 35.5 4.4) through the course of a 4-month VLCK diet on four subsequent visits: baseline, maximum ketosis, reduced ketosis, and endpoint. Each subject acted as their own control. Relevantly, the dietary-induced changes in body composition (7.7 units of BMI lost, 18 kg of fat mass (1.2 kg of visceral fat mass)) were associated with a statistically significant improvement in food craving scores, physical activity, sleepiness, and female sexual function. Overall, these results also translated in a notable enhancement in QoL of the treated obese patients. Therefore, the rapid and sustained weight and fat mass (FM) loss induced by the VLCK diet is associated with good food control and improvements in the psychological well-being parameters in obese subjects, which could contribute to the long-term success of this therapy. Keywords: ketogenic diet; very low-energy diet; PNK method; protein diet; obesity; food addition; sleep quality; sexual function; QoL Author: Ana I. Castro, Diego Gomez-Arbelaez, Ana B. Crujeiras, Roser Granero, Zaida Aguera, Susana Jimenez-Murcia, Ignacio Sajoux, Patricio Lopez-Jaramillo, Fernando Fernandez-Aranda and Felipe F. 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