10e2b7e445e9c089950c1df8caf45d28 amejouhumgen_a2018v103n2p221.pdf 3cd2890b501c972a1374c316caca51b8e7041ccb amejouhumgen_a2018v103n2p221.pdf 274313b528e811b62169d6e2d4c8c8be39d892ed3189c76c60b0c7c19a9f49a2 amejouhumgen_a2018v103n2p221.pdf Title: Mutations in TOP3A Cause a Bloom Syndrome-like Disorder Subject: The American Journal of Human Genetics, 103 (2018) 221-231. doi:10.1016/j.ajhg.2018.07.001 Author: Carol-Anne Martin Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Wed Aug 22 14:01:15 2018 CEST ModDate: Wed Aug 22 14:02:42 2018 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 602.986 x 782.986 pts Page rot: 0 File size: 1300902 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NNJDBF+AdvPS977E Type 1C MacRoman yes yes no 853 0 NNJDBG+AdvPS9779 Type 1C WinAnsi yes yes no 855 0 NNJDBH+AdvPS9785 Type 1C WinAnsi yes yes no 857 0 NNJDBI+AdvP9725 Type 1C Custom yes yes no 860 0 NNJDCJ+AdvP9794 Type 1C WinAnsi yes yes no 864 0 NNJDCK+AdvPS3F4C13 Type 1C WinAnsi yes yes no 866 0 NNJDCL+AdvPS9788 Type 1C MacRoman yes yes no 869 0 NNJDGK+AdvPSSym Type 1C Custom yes yes no 877 0 NNJDIN+AdvP7DED Type 1C WinAnsi yes yes no 503 0 NNJDIK+AdvPS978B Type 1C MacRoman yes yes no 504 0 NNJDIL+AdvPS3ECA66 Type 1C WinAnsi yes yes no 491 0 NNJDIM+AdvP4C4E74 Type 1C Custom yes yes yes 494 0 NNJDJO+AdvPS9781 Type 1C WinAnsi yes yes no 508 0 NNJDJP+AdvP4C4E51 Type 1C WinAnsi yes yes no 510 0 NNJDKP+AdvPS586D Type 1C WinAnsi yes yes no 518 0 NNJDLA+AdvPS4BD310 Type 1C WinAnsi yes yes no 519 0 NNJMOF+AdvPS4731B1 Type 1C WinAnsi yes yes no 532 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-04-12 03:44:56 CEST RepresentationInformation: amejouhumgen_a2018v103n2p221.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2018-11-02 09:17:52 CET Size: 1300902 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fn1' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fn1' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fn1' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fn1' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff10' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff11' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff12' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff13' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff14' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff15' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff16' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff17' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff17' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff13' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff18' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff17' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff10' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff10' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff19' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff20' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff16' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff14' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff21' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff13' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff22' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff15' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff23' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fn2' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff10' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff24' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fn2' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff25' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fn2' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff20' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fn2' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff22' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fn2' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff13' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fn2' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fn2' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'cor2' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib4' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib14' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib16' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib17' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib18' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib19' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib20' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib21' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib24' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib13' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib24' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib25' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib14' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib27' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib28' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib30' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib31' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib33' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib32' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib21' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib32' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib32' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib34' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib19' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib19' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib35' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib21' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tblfn10' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tblfn11' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib36' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib19' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib38' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib12' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib13' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib32' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc1' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib34' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib19' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib39' cannot be found Offset: 1266983 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib40' cannot be found Offset: 1266983 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 930 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Mutations in TOP3A Cause a Bloom Syndrome-like Disorder Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@768debd Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@490d6c15 Item: Title: Material and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7d4793a8 Children: Item: Title: Research Subjects Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@449b2d27 Item: Title: Exome Sequencing and Sanger Sequencing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5479e3f Item: Title: Plasmid Construct and Protein Purification Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@27082746 Children: Item: Title: Cloning of the Mutant hTopIIIα Expression Vector Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66133adc Item: Title: Expression and Purification of TRR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7bfcd12c Item: Title: dHJ Dissolution Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42f30e0a Item: Title: Cell Culture Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@24273305 Item: Title: Sister Chromatid Exchange Assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5b1d2887 Children: Item: Title: SCE Methodology for Analysis of P7 and P8 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46f5f779 Item: Title: Immunofluorescence and microscopy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1c2c22f3 Item: Title: Immunoblotting Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@18e8568 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33e5ccce Children: Item: Title: Identification of Mutations in TOP3A Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5a42bbf4 Item: Title: Prenatal-Onset Growth Restriction and Microcephaly in Individuals with TOP3A Mutations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@270421f5 Item: Title: Cardiomyopathy Is Present in Some Individuals with TOP3A Mutations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52d455b8 Item: Title: TOP3A Mutations Lead to Markedly Reduced Cellular Amounts of Enzyme TopIIIα Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4f4a7090 Item: Title: SCEs Are Markedly Elevated in Individuals with TOP3A Mutations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@18ef96 Item: Title: Chromosome Segregation Defects and Genome Instability Occur in Cells with TOP3A Mutations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6956de9 Item: Title: A Homozygous Truncating Variant in RMI1 Is Associated with Microcephalic Dwarfism Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@769c9116 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6aceb1a5 Item: Title: Supplemental Data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2d6d8735 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ba4d54 Item: Title: Declaration of Interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12bc6874 Item: Title: Web Resources Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@de0a01f Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4c75cab9 Info: Title: Mutations in TOP3A Cause a Bloom Syndrome-like Disorder Author: Carol-Anne Martin Subject: The American Journal of Human Genetics, 103 (2018) 221-231. doi:10.1016/j.ajhg.2018.07.001 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Wed Aug 22 14:31:15 CEST 2018 ModDate: Wed Aug 22 14:32:42 CEST 2018 ID: 0x2dfe5235e222c84499aa44faa3229d47, 0xcdaaebaed155e1408b41f0bd101c7e5a Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 69 ImageHeight: 68 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1340 ImageHeight: 651 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1335 ImageHeight: 1248 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 986 ImageHeight: 1830 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1739 ImageHeight: 1789 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Fonts: Type1: Font: BaseFont: NNJDCJ+AdvP9794 FontSubset: true FirstChar: 46 LastChar: 118 FontDescriptor: FontName: NNJDCJ+AdvP9794 Flags: Nonsymbolic FontBBox: -208, -250, 1291, 760 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NNJDCK+AdvPS3F4C13 FontSubset: true FirstChar: 97 LastChar: 109 FontDescriptor: FontName: NNJDCK+AdvPS3F4C13 Flags: Nonsymbolic FontBBox: 0, -291, 875, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NNJDCL+AdvPS9788 FontSubset: true FirstChar: 44 LastChar: 223 FontDescriptor: FontName: NNJDCL+AdvPS9788 Flags: Nonsymbolic FontBBox: -177, -239, 1395, 770 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: NNJDKP+AdvPS586D FontSubset: true FirstChar: 53 LastChar: 53 FontDescriptor: FontName: NNJDKP+AdvPS586D Flags: Nonsymbolic FontBBox: 0, -218, 989, 760 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NNJDLA+AdvPS4BD310 FontSubset: true FirstChar: 97 LastChar: 97 FontDescriptor: FontName: NNJDLA+AdvPS4BD310 Flags: Nonsymbolic FontBBox: 0, -208, 989, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NNJDIL+AdvPS3ECA66 FontSubset: true FirstChar: 97 LastChar: 97 FontDescriptor: FontName: NNJDIL+AdvPS3ECA66 Flags: Nonsymbolic FontBBox: 0, -208, 927, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NNJDGK+AdvPSSym FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: NNJDGK+AdvPSSym Flags: Symbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: NNJDIM+AdvP4C4E74 FontSubset: true FirstChar: 2 LastChar: 188 FontDescriptor: FontName: NNJDIM+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NNJMOF+AdvPS4731B1 FontSubset: true FirstChar: 82 LastChar: 82 FontDescriptor: FontName: NNJMOF+AdvPS4731B1 Flags: Nonsymbolic FontBBox: 0, -208, 1572, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NNJDBF+AdvPS977E FontSubset: true FirstChar: 40 LastChar: 222 FontDescriptor: FontName: NNJDBF+AdvPS977E Flags: Nonsymbolic FontBBox: -156, -239, 1531, 781 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: NNJDBG+AdvPS9779 FontSubset: true FirstChar: 40 LastChar: 150 FontDescriptor: FontName: NNJDBG+AdvPS9779 Flags: Nonsymbolic FontBBox: -177, -239, 1291, 760 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NNJDIN+AdvP7DED FontSubset: true FirstChar: 51 LastChar: 51 FontDescriptor: FontName: NNJDIN+AdvP7DED Flags: Nonsymbolic FontBBox: -20, -229, 927, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NNJDIK+AdvPS978B FontSubset: true FirstChar: 49 LastChar: 222 FontDescriptor: FontName: NNJDIK+AdvPS978B Flags: Nonsymbolic FontBBox: -145, -250, 1302, 770 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: NNJDBH+AdvPS9785 FontSubset: true FirstChar: 48 LastChar: 90 FontDescriptor: FontName: NNJDBH+AdvPS9785 Flags: Nonsymbolic FontBBox: -187, -239, 1208, 760 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NNJDBI+AdvP9725 FontSubset: true FirstChar: 25 LastChar: 248 FontDescriptor: FontName: NNJDBI+AdvP9725 Flags: Serif, Nonsymbolic FontBBox: -197, -239, 1270, 770 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: NNJDJO+AdvPS9781 FontSubset: true FirstChar: 49 LastChar: 90 FontDescriptor: FontName: NNJDJO+AdvPS9781 Flags: Nonsymbolic FontBBox: -166, -239, 1447, 781 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NNJDJP+AdvP4C4E51 FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: NNJDJP+AdvP4C4E51 Flags: Nonsymbolic FontBBox: -31, -239, 1041, 750 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.ajhg.2018.07.001 Mutations in TOP3A Cause a Bloom Syndrome-like Disorder Carol-Anne Martin Kata Sarlós Clare V. Logan Roshan Singh Thakur David A. Parry Anna H. Bizard Andrea Leitch Louise Cleal Nadia Shaukat Ali Mohammed A. Al-Owain William Allen Janine Altmüller Miriam Aza-Carmona Bushra A.Y. Barakat Jimena Barraza-García Amber Begtrup Massimo Bogliolo Megan T. Cho Jaime Cruz-Rojo Hassan Ali Mundi Dhahrabi Nursel H. Elcioglu Gráinne S. Gorman Rebekah Jobling Ian Kesterton Yoshihito Kishita Masakazu Kohda Polona Le Quesne Stabej Asam Jassim Malallah Peter Nürnberg Akira Ohtake Yasushi Okazaki Roser Pujol Maria José Ramirez Anya Revah-Politi Masaru Shimura Paul Stevens Robert W. Taylor Lesley Turner Hywel Williams Carolyn Wilson Gökhan Yigit Laura Zahavich Fowzan S. Alkuraya Jordi Surralles Alejandro Iglesias Kei Murayama Bernd Wollnik Mehul Dattani Karen E. Heath Ian D. Hickson Andrew P. Jackson GOSgene13 topoisomerase III RecQ helicases BLM genomic instability double Holliday junction dissolution Bloom syndrome The American Journal of Human Genetics, 103 (2018) 221-231. doi:10.1016/j.ajhg.2018.07.001 ElsevierCompany. journal The American Journal of Human Genetics © 2018 The Authors. 0002-9297 103 2 2 August 2018 2018-08-02 221-231 221 231 10.1016/j.ajhg.2018.07.001 https://doi.org/10.1016/j.ajhg.2018.07.001 2010-04-23 true 10.1016/j.ajhg.2018.07.001 elsevier.com sciencedirect.com VoR 6.5 10.1016/j.ajhg.2018.07.001 noindex 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2018-08-22T17:31:15+05:30 2018-08-22T17:32:42+05:30 2018-08-22T17:32:42+05:30 True Acrobat Distiller 8.1.0 (Windows) uuid:92415eb5-12d3-4957-ae30-dc57e4233ac2 uuid:d10cee3a-8441-487e-a154-b4ccd4968b3e http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 221 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 148, 682, 152, 692 Destination: 734 Annotation: Subtype: Link Rect: 154, 682, 163, 692 Destination: null Annotation: Subtype: Link Rect: 222, 682, 227, 692 Destination: 734 Annotation: Subtype: Link Rect: 229, 682, 237, 692 Destination: null Annotation: Subtype: Link Rect: 316, 682, 320, 692 Destination: 734 Annotation: Subtype: Link Rect: 322, 682, 331, 692 Destination: null Annotation: Subtype: Link Rect: 441, 682, 445, 692 Destination: 734 Annotation: Subtype: Link Rect: 447, 682, 456, 692 Destination: null Annotation: Subtype: Link Rect: 533, 682, 537, 692 Destination: 734 Annotation: Subtype: Link Rect: 133, 670, 137, 680 Destination: 734 Annotation: Subtype: Link Rect: 211, 670, 215, 680 Destination: 734 Annotation: Subtype: Link Rect: 280, 670, 284, 680 Destination: 734 Annotation: Subtype: Link Rect: 378, 670, 382, 680 Destination: 734 Annotation: Subtype: Link Rect: 509, 670, 513, 680 Destination: 734 Annotation: Subtype: Link Rect: 125, 658, 129, 668 Destination: 734 Annotation: Subtype: Link Rect: 214, 658, 218, 668 Destination: 734 Annotation: Subtype: Link Rect: 326, 658, 331, 668 Destination: 734 Annotation: Subtype: Link Rect: 333, 658, 337, 668 Destination: 734 Annotation: Subtype: Link Rect: 438, 658, 442, 668 Destination: 734 Annotation: Subtype: Link Rect: 162, 646, 166, 656 Destination: 734 Annotation: Subtype: Link Rect: 168, 646, 172, 656 Destination: 734 Annotation: Subtype: Link Rect: 251, 646, 255, 656 Destination: 734 Annotation: Subtype: Link Rect: 346, 646, 351, 656 Destination: 734 Annotation: Subtype: Link Rect: 353, 646, 361, 656 Destination: null Annotation: Subtype: Link Rect: 438, 646, 442, 656 Destination: 734 Annotation: Subtype: Link Rect: 526, 646, 535, 656 Destination: null Annotation: Subtype: Link Rect: 194, 634, 198, 644 Destination: 734 Annotation: Subtype: Link Rect: 292, 634, 301, 644 Destination: null Annotation: Subtype: Link Rect: 351, 634, 359, 644 Destination: null Annotation: Subtype: Link Rect: 461, 634, 469, 644 Destination: null Annotation: Subtype: Link Rect: 135, 622, 144, 632 Destination: null Annotation: Subtype: Link Rect: 214, 622, 222, 632 Destination: null Annotation: Subtype: Link Rect: 310, 622, 318, 632 Destination: null Annotation: Subtype: Link Rect: 404, 622, 413, 632 Destination: null Annotation: Subtype: Link Rect: 538, 622, 547, 632 Destination: null Annotation: Subtype: Link Rect: 163, 610, 167, 620 Destination: 734 Annotation: Subtype: Link Rect: 246, 610, 251, 620 Destination: 734 Annotation: Subtype: Link Rect: 320, 610, 329, 620 Destination: null Annotation: Subtype: Link Rect: 412, 610, 421, 620 Destination: null Annotation: Subtype: Link Rect: 481, 610, 486, 620 Destination: 734 Annotation: Subtype: Link Rect: 488, 610, 496, 620 Destination: null Annotation: Subtype: Link Rect: 150, 598, 154, 608 Destination: 734 Annotation: Subtype: Link Rect: 156, 598, 165, 608 Destination: null Annotation: Subtype: Link Rect: 257, 598, 265, 608 Destination: null Annotation: Subtype: Link Rect: 350, 598, 358, 608 Destination: null Annotation: Subtype: Link Rect: 425, 598, 433, 608 Destination: null Annotation: Subtype: Link Rect: 521, 598, 530, 608 Destination: null Annotation: Subtype: Link Rect: 122, 586, 130, 596 Destination: null Annotation: Subtype: Link Rect: 213, 586, 221, 596 Destination: null Annotation: Subtype: Link Rect: 303, 586, 308, 596 Destination: 734 Annotation: Subtype: Link Rect: 378, 586, 387, 596 Destination: null Annotation: Subtype: Link Rect: 467, 586, 475, 596 Destination: null Annotation: Subtype: Link Rect: 152, 574, 161, 584 Destination: null Annotation: Subtype: Link Rect: 163, 574, 171, 584 Destination: null Annotation: Subtype: Link Rect: 244, 574, 248, 584 Destination: 734 Annotation: Subtype: Link Rect: 250, 574, 259, 584 Destination: null Annotation: Subtype: Link Rect: 261, 574, 270, 584 Destination: null Annotation: Subtype: Link Rect: 272, 574, 280, 584 Destination: null Annotation: Subtype: Link Rect: 370, 574, 379, 584 Destination: null Annotation: Subtype: Link Rect: 381, 574, 389, 584 Destination: null Annotation: Subtype: Link Rect: 465, 574, 474, 584 Destination: null Annotation: Subtype: Link Rect: 476, 574, 485, 584 Destination: null Annotation: Subtype: Link Rect: 128, 562, 136, 572 Destination: null Annotation: Subtype: Link Rect: 138, 562, 147, 572 Destination: null Annotation: Subtype: Link Rect: 224, 562, 232, 572 Destination: null Annotation: Subtype: Link Rect: 234, 562, 243, 572 Destination: null Annotation: Subtype: Link Rect: 324, 562, 328, 572 Destination: 734 Annotation: Subtype: Link Rect: 330, 562, 334, 572 Destination: 734 Annotation: Subtype: Link Rect: 336, 562, 345, 572 Destination: null Annotation: Subtype: Link Rect: 425, 562, 430, 572 Destination: 734 Annotation: Subtype: Link Rect: 432, 562, 436, 572 Destination: 734 Annotation: Subtype: Link Rect: 166, 550, 171, 560 Destination: 734 Annotation: Subtype: Link Rect: 173, 550, 177, 560 Destination: null Annotation: Subtype: Link Rect: 91, 304, 94, 313 Destination: 129 Annotation: Subtype: Link Rect: 384, 352, 388, 361 Destination: 129 Annotation: Subtype: Link Rect: 424, 316, 428, 325 Destination: 129 Annotation: Subtype: Link Rect: 473, 292, 477, 301 Destination: null Annotation: Subtype: Link Rect: 115, 78, 175, 85 Annotation: Subtype: Link Rect: 205, 78, 307, 85 Annotation: Subtype: Link Rect: 56, 69, 194, 76 Annotation: Subtype: Link Rect: 56, 30, 72, 46 Annotation: Subtype: Link Rect: 329, 60, 494, 67 Page: Label: 222 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 276, 714, 295, 723 Destination: 129 Annotation: Subtype: Link Rect: 56, 702, 97, 711 Destination: 129 Annotation: Subtype: Link Rect: 142, 670, 146, 679 Destination: 129 Annotation: Subtype: Link Rect: 193, 658, 196, 667 Destination: 129 Annotation: Subtype: Link Rect: 68, 574, 83, 583 Destination: 129 Annotation: Subtype: Link Rect: 185, 527, 203, 536 Destination: null Annotation: Subtype: Link Rect: 137, 431, 145, 440 Destination: null Annotation: Subtype: Link Rect: 84, 407, 92, 416 Destination: null Annotation: Subtype: Link Rect: 245, 395, 253, 404 Destination: null Annotation: Subtype: Link Rect: 175, 359, 183, 368 Destination: null Annotation: Subtype: Link Rect: 443, 731, 450, 739 Destination: null Annotation: Subtype: Link Rect: 522, 720, 529, 728 Destination: null Annotation: Subtype: Link Rect: 368, 630, 383, 638 Destination: null Annotation: Subtype: Link Rect: 500, 561, 507, 569 Destination: null Annotation: Subtype: Link Rect: 539, 484, 546, 492 Destination: null Annotation: Subtype: Link Rect: 360, 473, 367, 481 Destination: null Annotation: Subtype: Link Rect: 519, 320, 534, 328 Destination: null Annotation: Subtype: Link Rect: 424, 287, 431, 295 Destination: null Page: Label: 223 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 262, 315, 269, 322 Destination: null Annotation: Subtype: Link Rect: 133, 265, 148, 273 Destination: null Annotation: Subtype: Link Rect: 129, 122, 136, 130 Destination: null Annotation: Subtype: Link Rect: 496, 253, 504, 262 Destination: null Annotation: Subtype: Link Rect: 464, 213, 493, 222 Destination: 23 Annotation: Subtype: Link Rect: 349, 157, 357, 166 Destination: null Annotation: Subtype: Link Rect: 258, 638, 260, 645 Destination: 23 Annotation: Subtype: Link Rect: 105, 515, 108, 522 Destination: 23 Annotation: Subtype: Link Rect: 274, 482, 280, 489 Destination: null Page: Label: 224 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 121, 415, 150, 424 Destination: 36 Annotation: Subtype: Link Rect: 170, 415, 203, 424 Destination: 54 Annotation: Subtype: Link Rect: 209, 347, 217, 356 Destination: null Annotation: Subtype: Link Rect: 56, 284, 85, 292 Destination: 75 Annotation: Subtype: Link Rect: 106, 284, 140, 292 Destination: 54 Annotation: Subtype: Link Rect: 56, 200, 86, 209 Destination: 23 Annotation: Subtype: Link Rect: 92, 204, 100, 213 Destination: null Annotation: Subtype: Link Rect: 486, 272, 519, 281 Destination: 85 Annotation: Subtype: Link Rect: 463, 188, 496, 197 Destination: 85 Annotation: Subtype: Link Rect: 218, 683, 221, 690 Destination: 36 Annotation: Subtype: Link Rect: 423, 683, 426, 690 Destination: 36 Annotation: Subtype: Link Rect: 349, 560, 352, 567 Destination: 36 Annotation: Subtype: Link Rect: 72, 483, 74, 490 Destination: 36 Annotation: Subtype: Link Rect: 431, 442, 437, 449 Destination: null Page: Label: 225 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 59, 441, 93, 450 Destination: 85 Annotation: Subtype: Link Rect: 280, 381, 295, 390 Destination: 85 Annotation: Subtype: Link Rect: 56, 369, 83, 378 Destination: 85 Annotation: Subtype: Link Rect: 225, 262, 262, 271 Destination: null Annotation: Subtype: Link Rect: 137, 250, 170, 259 Destination: 85 Annotation: Subtype: Link Rect: 172, 218, 179, 227 Destination: null Annotation: Subtype: Link Rect: 461, 513, 495, 522 Destination: 101 Annotation: Subtype: Link Rect: 434, 453, 473, 462 Destination: 101 Annotation: Subtype: Link Rect: 392, 405, 424, 414 Destination: 101 Annotation: Subtype: Link Rect: 377, 288, 385, 296 Destination: null Annotation: Subtype: Link Rect: 483, 212, 521, 221 Destination: 119 Annotation: Subtype: Link Rect: 438, 168, 446, 177 Destination: null Annotation: Subtype: Link Rect: 351, 116, 390, 125 Destination: 119 Annotation: Subtype: Link Rect: 468, 108, 476, 117 Destination: null Annotation: Subtype: Link Rect: 456, 580, 463, 588 Destination: null Page: Label: 226 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 240, 425, 247, 428 Destination: 75 Annotation: Subtype: Link Rect: 255, 94, 262, 97 Destination: 75 Annotation: Subtype: Link Rect: 317, 176, 324, 179 Destination: 75 Annotation: Subtype: Link Rect: 317, 608, 324, 611 Destination: 75 Annotation: Subtype: Link Rect: 347, 508, 354, 510 Destination: null Annotation: Subtype: Link Rect: 403, 579, 410, 580 Destination: null Rotate: 90 Page: Label: 227 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 101, 335, 109, 344 Destination: null Annotation: Subtype: Link Rect: 100, 264, 107, 273 Destination: null Annotation: Subtype: Link Rect: 134, 165, 163, 174 Destination: 23 Annotation: Subtype: Link Rect: 184, 165, 221, 174 Destination: null Annotation: Subtype: Link Rect: 152, 129, 184, 138 Destination: 54 Annotation: Subtype: Link Rect: 209, 129, 241, 138 Destination: 36 Annotation: Subtype: Link Rect: 260, 129, 265, 138 Destination: 75 Annotation: Subtype: Link Rect: 327, 180, 350, 189 Destination: 129 Annotation: Subtype: Link Rect: 511, 140, 546, 149 Destination: 129 Annotation: Subtype: Link Rect: 307, 128, 337, 137 Destination: 129 Page: Label: 228 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 397, 742, 405, 751 Destination: null Annotation: Subtype: Link Rect: 328, 718, 335, 727 Destination: null Annotation: Subtype: Link Rect: 387, 658, 395, 667 Destination: null Annotation: Subtype: Link Rect: 542, 634, 546, 643 Destination: 129 Annotation: Subtype: Link Rect: 485, 467, 493, 476 Destination: null Annotation: Subtype: Link Rect: 454, 403, 487, 412 Destination: 36 Annotation: Subtype: Link Rect: 403, 379, 443, 388 Destination: null Annotation: Subtype: Link Rect: 356, 264, 363, 273 Destination: null Annotation: Subtype: Link Rect: 456, 180, 463, 189 Destination: null Annotation: Subtype: Link Rect: 331, 156, 339, 165 Destination: null Annotation: Subtype: Link Rect: 438, 144, 456, 153 Destination: null Annotation: Subtype: Link Rect: 538, 144, 546, 153 Destination: 313 Page: Label: 229 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 183, 139, 295, 147 Annotation: Subtype: Link Rect: 56, 128, 101, 136 Page: Label: 230 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 94, 406, 244, 414 Annotation: Subtype: Link Rect: 156, 384, 295, 392 Annotation: Subtype: Link Rect: 64, 373, 102, 381 Annotation: Subtype: Link Rect: 96, 362, 218, 370 Annotation: Subtype: Link Rect: 85, 351, 166, 359 Annotation: Subtype: Link Rect: 71, 310, 295, 318 Annotation: Subtype: Link Rect: 71, 299, 295, 307 Annotation: Subtype: Link Rect: 71, 288, 143, 296 Annotation: Subtype: Link Rect: 71, 277, 295, 285 Annotation: Subtype: Link Rect: 71, 266, 295, 274 Annotation: Subtype: Link Rect: 71, 255, 220, 263 Annotation: Subtype: Link Rect: 71, 244, 295, 252 Annotation: Subtype: Link Rect: 71, 233, 232, 241 Annotation: Subtype: Link Rect: 71, 222, 295, 230 Annotation: Subtype: Link Rect: 71, 211, 295, 219 Annotation: Subtype: Link Rect: 71, 200, 295, 208 Annotation: Subtype: Link Rect: 71, 189, 111, 197 Annotation: Subtype: Link Rect: 71, 178, 295, 186 Annotation: Subtype: Link Rect: 71, 167, 295, 175 Annotation: Subtype: Link Rect: 71, 156, 295, 164 Annotation: Subtype: Link Rect: 71, 145, 116, 153 Annotation: Subtype: Link Rect: 71, 134, 295, 142 Annotation: Subtype: Link Rect: 71, 123, 295, 131 Annotation: Subtype: Link Rect: 71, 112, 295, 120 Annotation: Subtype: Link Rect: 71, 101, 102, 109 Annotation: Subtype: Link Rect: 71, 90, 295, 98 Annotation: Subtype: Link Rect: 71, 80, 295, 87 Annotation: Subtype: Link Rect: 71, 69, 295, 77 Annotation: Subtype: Link Rect: 322, 739, 546, 747 Annotation: Subtype: Link Rect: 322, 728, 441, 736 Annotation: Subtype: Link Rect: 322, 717, 546, 725 Annotation: Subtype: Link Rect: 322, 706, 546, 714 Annotation: Subtype: Link Rect: 322, 695, 546, 703 Annotation: Subtype: Link Rect: 322, 684, 434, 692 Annotation: Subtype: Link Rect: 322, 673, 546, 681 Annotation: Subtype: Link Rect: 322, 662, 546, 670 Annotation: Subtype: Link Rect: 322, 651, 511, 659 Annotation: Subtype: Link Rect: 322, 640, 546, 648 Annotation: Subtype: Link Rect: 322, 629, 546, 637 Annotation: Subtype: Link Rect: 322, 618, 546, 626 Annotation: Subtype: Link Rect: 322, 607, 546, 615 Annotation: Subtype: Link Rect: 322, 596, 399, 604 Annotation: Subtype: Link Rect: 322, 585, 546, 593 Annotation: Subtype: Link Rect: 322, 574, 546, 582 Annotation: Subtype: Link Rect: 322, 563, 546, 571 Annotation: Subtype: Link Rect: 322, 552, 410, 560 Annotation: Subtype: Link Rect: 322, 541, 546, 549 Annotation: Subtype: Link Rect: 322, 531, 546, 539 Annotation: Subtype: Link Rect: 322, 520, 546, 528 Annotation: Subtype: Link Rect: 322, 509, 546, 517 Annotation: Subtype: Link Rect: 322, 498, 546, 506 Annotation: Subtype: Link Rect: 322, 487, 341, 495 Annotation: Subtype: Link Rect: 322, 476, 546, 484 Annotation: Subtype: Link Rect: 322, 465, 546, 473 Annotation: Subtype: Link Rect: 322, 454, 546, 462 Annotation: Subtype: Link Rect: 322, 443, 546, 451 Annotation: Subtype: Link Rect: 322, 432, 363, 440 Annotation: Subtype: Link Rect: 322, 421, 546, 429 Annotation: Subtype: Link Rect: 322, 410, 546, 418 Annotation: Subtype: Link Rect: 322, 399, 419, 407 Annotation: Subtype: Link Rect: 322, 388, 546, 396 Annotation: Subtype: Link Rect: 322, 377, 546, 385 Annotation: Subtype: Link Rect: 322, 366, 546, 374 Annotation: Subtype: Link Rect: 322, 355, 486, 363 Annotation: Subtype: Link Rect: 322, 344, 546, 352 Annotation: Subtype: Link Rect: 322, 333, 546, 341 Annotation: Subtype: Link Rect: 322, 322, 490, 330 Annotation: Subtype: Link Rect: 322, 311, 546, 319 Annotation: Subtype: Link Rect: 322, 300, 546, 308 Annotation: Subtype: Link Rect: 322, 289, 546, 297 Annotation: Subtype: Link Rect: 322, 278, 546, 286 Annotation: Subtype: Link Rect: 322, 268, 546, 275 Annotation: Subtype: Link Rect: 322, 257, 403, 265 Annotation: Subtype: Link Rect: 322, 246, 546, 254 Annotation: Subtype: Link Rect: 322, 235, 546, 243 Annotation: Subtype: Link Rect: 322, 224, 546, 232 Annotation: Subtype: Link Rect: 322, 213, 527, 221 Annotation: Subtype: Link Rect: 322, 202, 546, 210 Annotation: Subtype: Link Rect: 322, 191, 546, 199 Annotation: Subtype: Link Rect: 322, 180, 546, 188 Annotation: Subtype: Link Rect: 322, 169, 363, 177 Annotation: Subtype: Link Rect: 322, 158, 546, 166 Annotation: Subtype: Link Rect: 322, 147, 546, 155 Annotation: Subtype: Link Rect: 322, 136, 546, 144 Annotation: Subtype: Link Rect: 322, 125, 430, 133 Annotation: Subtype: Link Rect: 322, 114, 546, 122 Annotation: Subtype: Link Rect: 322, 103, 546, 111 Annotation: Subtype: Link Rect: 322, 92, 409, 100 Annotation: Subtype: Link Rect: 322, 80, 546, 88 Annotation: Subtype: Link Rect: 322, 69, 546, 77 Page: Label: 231 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 71, 739, 295, 747 Annotation: Subtype: Link Rect: 71, 728, 295, 736 Annotation: Subtype: Link Rect: 71, 717, 107, 725 Annotation: Subtype: Link Rect: 71, 706, 295, 714 Annotation: Subtype: Link Rect: 71, 695, 295, 703 Annotation: Subtype: Link Rect: 71, 684, 295, 692 Annotation: Subtype: Link Rect: 71, 673, 295, 681 Annotation: Subtype: Link Rect: 71, 662, 191, 670 Annotation: Subtype: Link Rect: 71, 651, 295, 659 Annotation: Subtype: Link Rect: 71, 640, 295, 648 Annotation: Subtype: Link Rect: 71, 629, 295, 637 Annotation: Subtype: Link Rect: 71, 618, 112, 626 Annotation: Subtype: Link Rect: 71, 607, 295, 615 Annotation: Subtype: Link Rect: 71, 596, 225, 604 Annotation: Subtype: Link Rect: 227, 596, 235, 604 Annotation: Subtype: Link Rect: 237, 596, 295, 604 Annotation: Subtype: Link Rect: 71, 585, 192, 593 Annotation: Subtype: Link Rect: 71, 574, 295, 582 Annotation: Subtype: Link Rect: 71, 563, 295, 571 Annotation: Subtype: Link Rect: 71, 552, 295, 560 Annotation: Subtype: Link Rect: 71, 541, 121, 549 Annotation: Subtype: Link Rect: 71, 531, 295, 539 Annotation: Subtype: Link Rect: 71, 520, 295, 528 Annotation: Subtype: Link Rect: 71, 509, 92, 517 Annotation: Subtype: Link Rect: 71, 498, 295, 506 Annotation: Subtype: Link Rect: 71, 487, 295, 495 Annotation: Subtype: Link Rect: 71, 476, 127, 484 Annotation: Subtype: Link Rect: 71, 465, 295, 473 Annotation: Subtype: Link Rect: 71, 454, 295, 462 Annotation: Subtype: Link Rect: 71, 443, 204, 451 Annotation: Subtype: Link Rect: 71, 432, 295, 440 Annotation: Subtype: Link Rect: 71, 421, 295, 429 Annotation: Subtype: Link Rect: 71, 410, 295, 418 Annotation: Subtype: Link Rect: 71, 399, 295, 407 Annotation: Subtype: Link Rect: 71, 388, 156, 396 Annotation: Subtype: Link Rect: 71, 377, 295, 385 Annotation: Subtype: Link Rect: 71, 366, 295, 374 Annotation: Subtype: Link Rect: 71, 355, 295, 363 Annotation: Subtype: Link Rect: 71, 344, 103, 352 Annotation: Subtype: Link Rect: 71, 333, 295, 341 Annotation: Subtype: Link Rect: 71, 322, 295, 330 Annotation: Subtype: Link Rect: 71, 311, 295, 319 Annotation: Subtype: Link Rect: 71, 300, 295, 308 Annotation: Subtype: Link Rect: 71, 289, 130, 297 Annotation: Subtype: Link Rect: 322, 739, 546, 747 Annotation: Subtype: Link Rect: 322, 728, 546, 736 Annotation: Subtype: Link Rect: 322, 717, 546, 725 Annotation: Subtype: Link Rect: 322, 706, 546, 714 Annotation: Subtype: Link Rect: 322, 695, 461, 703 Annotation: Subtype: Link Rect: 322, 684, 546, 692 Annotation: Subtype: Link Rect: 322, 673, 546, 681 Annotation: Subtype: Link Rect: 322, 662, 432, 670 Annotation: Subtype: Link Rect: 322, 651, 546, 659 Annotation: Subtype: Link Rect: 322, 640, 546, 648 Annotation: Subtype: Link Rect: 322, 629, 509, 637 Annotation: Subtype: Link Rect: 322, 618, 546, 626 Annotation: Subtype: Link Rect: 322, 607, 546, 615 Annotation: Subtype: Link Rect: 322, 596, 546, 604 Annotation: Subtype: Link Rect: 322, 585, 546, 593 Annotation: Subtype: Link Rect: 322, 574, 536, 582 Annotation: Subtype: Link Rect: 322, 563, 546, 571 Annotation: Subtype: Link Rect: 322, 552, 546, 560 Annotation: Subtype: Link Rect: 322, 541, 546, 549 Annotation: Subtype: Link Rect: 322, 531, 546, 539 Annotation: Subtype: Link Rect: 322, 520, 511, 528 Annotation: Subtype: Link Rect: 322, 509, 546, 517 Annotation: Subtype: Link Rect: 322, 498, 546, 506 Annotation: Subtype: Link Rect: 322, 487, 546, 495 Annotation: Subtype: Link Rect: 322, 476, 419, 484 Annotation: Subtype: Link Rect: 322, 465, 546, 473 Annotation: Subtype: Link Rect: 322, 454, 546, 462 Annotation: Subtype: Link Rect: 322, 443, 546, 451 Annotation: Subtype: Link Rect: 322, 432, 546, 440 Annotation: Subtype: Link Rect: 322, 421, 546, 429 Annotation: Subtype: Link Rect: 322, 410, 420, 418 Annotation: Subtype: Link Rect: 322, 399, 546, 407 Annotation: Subtype: Link Rect: 322, 388, 546, 396 Annotation: Subtype: Link Rect: 322, 377, 546, 385 Annotation: Subtype: Link Rect: 322, 366, 400, 374 Annotation: Subtype: Link Rect: 322, 355, 546, 363 Annotation: Subtype: Link Rect: 322, 344, 546, 352 Annotation: Subtype: Link Rect: 322, 333, 423, 341 Annotation: Subtype: Link Rect: 322, 322, 546, 330 Annotation: Subtype: Link Rect: 322, 311, 546, 319 Annotation: Subtype: Link Rect: 322, 300, 546, 308 Annotation: Subtype: Link Rect: 322, 289, 502, 297 Checksum: 2b577a5e Type: CRC32 Checksum: 10e2b7e445e9c089950c1df8caf45d28 Type: MD5 Checksum: 3cd2890b501c972a1374c316caca51b8e7041ccb Type: SHA-1