b33a4f114a7f6307ef4ae7923c646e3b scirep_a2018v8p11005.pdf 32956051bc3172d50849f479227758358fb70757 scirep_a2018v8p11005.pdf 37d9aa38833176c966bb9363e7ac171d6e5be167a134a7cb26f34b43732a4795 scirep_a2018v8p11005.pdf Title: Genetic diversity and selection signatures of the beef ‘Charolais de Cuba’ breed Subject: Scientific Reports, doi:10.1038/s41598-018-29453-z Keywords: Author: Yoel Rodriguez-Valera Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Sat Jul 14 11:08:27 2018 CEST ModDate: Mon Jul 16 12:33:21 2018 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1404968 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KCUSPD+Corbel CID TrueType Identity-H yes yes yes 342 0 EEMRFX+Corbel-BoldItalic Type 1C WinAnsi yes yes yes 343 0 MinionPro-Regular Type 1C Custom yes no yes 52 0 DUEHGG+Corbel-Bold2 Type 1C WinAnsi yes yes yes 48 0 MinionPro-It Type 1C Custom yes no yes 47 0 MKSHAP+Corbel2 Type 1C WinAnsi yes yes yes 50 0 PCIWHT+Corbel-Bold CID TrueType Identity-H yes yes yes 51 0 EuclidSymbol-Bold Type 1C Custom yes no yes 344 0 YHJGDB+TimesNewRomanPSMT Type 1C WinAnsi yes yes yes 345 0 DUEHGG+Corbel-Bold2 Type 1C WinAnsi yes yes yes 264 0 MKSHAP+Corbel2 Type 1C WinAnsi yes yes yes 265 0 KCUSPD+Corbel CID TrueType Identity-H yes yes yes 387 0 MyriadPro-It Type 1C WinAnsi yes no yes 267 0 MinionPro-Bold Type 1C WinAnsi yes no yes 46 0 EuclidSymbol Type 1C Custom yes no yes 49 0 MKSHAP+Corbel2 Type 1C WinAnsi yes yes yes 276 0 KCUSPD+Corbel CID TrueType Identity-H yes yes yes 266 0 KCUSPD+Corbel CID TrueType Identity-H yes yes yes 282 0 DLFGVR+Arial-BoldMT Type 1C WinAnsi yes yes no 153 0 DLFGVR+ArialMT Type 1C WinAnsi yes yes no 154 0 DLFGVR+Calibri Type 1C Custom yes yes no 191 0 VUEKNH+STIXGeneral-Regular Type 1C Custom yes yes yes 243 0 Jhove (Rel. 1.6, 2011-01-04) Date: 2019-06-19 04:58:02 CEST RepresentationInformation: scirep_a2018v8p11005.pdf ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22) LastModified: 2019-06-18 11:16:45 CEST Size: 1404968 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid destination object Offset: 829816 ErrorMessage: Invalid destination object Offset: 806398 ErrorMessage: Invalid destination object Offset: 829816 ErrorMessage: Invalid destination object Offset: 806398 ErrorMessage: Invalid destination object Offset: 829816 ErrorMessage: Invalid destination object Offset: 829816 ErrorMessage: Invalid destination object Offset: 829816 ErrorMessage: Invalid destination object Offset: 806398 ErrorMessage: Invalid destination object Offset: 829816 ErrorMessage: Invalid destination object Offset: 829816 ErrorMessage: Invalid destination object Offset: 829816 ErrorMessage: Invalid destination object Offset: 829816 MIMEtype: application/pdf PDFMetadata: Objects: 437 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Genetic diversity and selection signatures of the beef ‘Charolais de Cuba’ breed Children: Item: Title: Results and Discussion Children: Item: Title: Charolais de Cuba genetic diversity pattern. Item: Title: Genetic differentiation among CHCU and others beef breeds. Item: Title: Patterns of LD and detection of selective sweeps between CHA and CHCU breeds. Item: Title: Candidate regions and genes related to thermo-tolerance. Item: Title: Pathways related to adaptation to tropical conditions in CHCU and muscle development in CHA. Item: Title: Conclusions Item: Title: Materials and Methods Children: Item: Title: Samples and genotyping. Item: Title: Structure of the CHCU population. Item: Title: Analytical workflow. Item: Title: Identification of genetic regions under selection. Item: Title: Pathways enrichment analysis. Item: Title: Acknowledgements Item: Title: Figure 1 Principal component analysis using all samples. Item: Title: Figure 2 (A) Ancestry models with 2 ancestral populations (K = 2) the color correspond to: Black (Bos taurus) and red (Bos indicus). Item: Title: Figure 3 Distribution of the Fst after randomization of the dataset. Item: Title: Figure 4 Linkage disequilibrium (r2) decay in CHA and CHCU populations. Item: Title: Figure 5 Graphical representation of the EHH pattern in the BTA5 chromosomal interval reported as associated with parasite resistance, yearling weight, body condition score, coat color and penile sheath score (Porto-Neto et al. Item: Title: Figure 6 Over-represented canonical pathways considering all the EHH intervals. Item: Title: Table 1 Matrix of Representation of the Fst corresponding to 19 beef breeds. Item: Title: Table 2 Description of the samples used in the analysis. 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PCIWHT+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true XMP: application/pdf doi:10.1038/s41598-018-29453-z Springer US Scientific Reports, doi:10.1038/s41598-018-29453-z Genetic diversity and selection signatures of the beef ‘Charolais de Cuba’ breed Yoel Rodriguez-Valera Gilles Renand Michel Naves Yidix Fonseca-Jimamp#x000E9;nez Teresa Inamp#x000E9;s Moreno-Probance Sebastian Ramos-Onsins Dominique Rocha Yuliaxis Ramayo-Caldas 10.1038/s41598-018-29453-z http://dx.doi.org/10.1038/s41598-018-29453-z journal Scientific Reports © 2018, The Author(s) 2045-2322 10.1038/s41598-018-29453-z Springer 2018-07-16T12:33:21+02:00 2018-07-14T14:38:27+05:30 2018-07-16T12:33:21+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) VoR uuid:ea9ae853-75d9-4bd0-955d-be772dd8f228 uuid:c0ffdce0-dce4-4968-a6f4-bcec591deb32 default 1 converted uuid:3392daf5-f679-4f27-b742-6d7502aa1b8e converted to PDF/A-2b pdfToolbox 2018-07-14T14:38:58+05:30 2 B 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