69016b5a5b0243b2e22c00273794bff7 natcom_a2018m11v9p4657.pdf 41e6051b4010d0c31a0ba091a42eed2cb921a4ba natcom_a2018m11v9p4657.pdf f294ba897d147cedbba8cdfe9197a3848fe1b47d3630beafe2ca59fb406b9d95 natcom_a2018m11v9p4657.pdf Title: Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity Subject: Nature Communications, doi:10.1038/s41467-018-06565-8 Keywords: Author: Qing Liu Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Tue Oct 30 02:07:25 2018 CET ModDate: Fri Feb 7 20:35:38 2020 CET Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1803752 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JKOMDC+AdvOTea1a7398 Type 1C WinAnsi yes yes no 672 0 JKOOND+AdvOT9bd21c25.I Type 1C WinAnsi yes 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object 'bm_CR36' cannot be found Offset: 1755294 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 761 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7d4793a8 Children: Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@449b2d27 Children: Item: Title: CYP71 activity on costunolide and parthenolide Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5479e3f Item: Title: Functional characterization of selected CYP71s in yeast Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@27082746 Item: Title: In silico docking of costunolide in TpKLS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66133adc Item: Title: 3α-Hydroxycostunolide is intermediate substrate of TpKLS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7bfcd12c Item: Title: In planta reconstruction of kauniolide biosynthetic pathway Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42f30e0a Item: Title: Reconstruction of kauniolide biosynthetic pathway in yeast Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@24273305 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5b1d2887 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46f5f779 Children: Item: Title: RNA-sequencing and expression analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1c2c22f3 Item: Title: Gene expression analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@18e8568 Item: Title: Isolation and cloning of candidate genes from feverfew Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33e5ccce Item: Title: Plasmid construction for gene expression in yeast Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5a42bbf4 Item: Title: Yeast microsome isolation and in’vitro microsome assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@270421f5 Item: Title: Plasmid construction for expression in N. benthamiana Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52d455b8 Item: Title: Transient expression in N. benthamiana Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4f4a7090 Item: Title: LC-MS analysis of yeast microsome assay and leaf extracts Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@18ef96 Item: Title: Cysteine conjugation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6956de9 Item: Title: Chemical synthesis of 3α-hydroxycostunolide Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@769c9116 Item: Title: GC-MS analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6aceb1a5 Item: Title: Homology modelling Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2d6d8735 Item: Title: Substrate modelling Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ba4d54 Item: Title: Enzyme–nobreaksubstrate interaction modelling Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12bc6874 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@de0a01f Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4c75cab9 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1ef7fe8e Item: Title: ACKNOWLEDGEMENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6f79caec Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@67117f44 Item: Title: Competing interests Destination: 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FontName: JKPAKK+AdvOTea1a7398+fb Flags: Symbolic FontBBox: 0, -197, 750, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: application/pdf doi:10.1038/s41467-018-06565-8 Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity Qing Liu Arman Beyraghdar Kashkooli David Manzano Irini Pateraki Lea Richard Pim Kolkman Maria Fátima Lucas Victor Guallar Ric C.H. de Vos Maurice C. R. Franssen Alexander van der Krol Harro Bouwmeester Springer US Nature Communications, doi:10.1038/s41467-018-06565-8 10.1038/s41467-018-06565-8 http://dx.doi.org/10.1038/s41467-018-06565-8 journal Nature Communications © 2018, The Author(s) 2041-1723 10.1038/s41467-018-06565-8 springer.com springerlink.com 2010-04-23 True 10.1038/s41467-018-06565-8 springer.com springerlink.com Springer 2020-02-07T20:35:38+01:00 2018-10-30T06:37:25+05:30 2020-02-07T20:35:38+01:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) VoR uuid:1fc39b9c-7e32-4ce2-8ac6-998c1a72e51d uuid:44ac31da-0acc-46fe-aeba-1a6350ebab5d default 1 converted uuid:16b4e853-cd78-4127-a33c-3e7d7b3c0de4 converted to PDF/A-2b pdfToolbox 2018-10-30T06:38:29+05:30 2 B Irini Pateraki http://orcid.org/0000-0002-7526-2334 Alexander van der Krol http://orcid.org/0000-0001-6585-7572 Harro Bouwmeester http://orcid.org/0000-0003-0907-2732 http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://springernature.com/ns/xmpExtensions/2.0/ sn Springer Nature ORCID Schema external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). 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