f96f47f9bb95a09eb4ebe45a2c1698f7 scirep_a2018v8n16157.pdf bd6d906339985e0f03c5b466dde6ec9a436b969f scirep_a2018v8n16157.pdf 1284e742cd392726237e0cd77cf8f23ad0e1b0d8ecfed9ace137bd3d7799ca14 scirep_a2018v8n16157.pdf Title: Uranium (VI) detection in groundwater using a gold nanoparticle/paper-based lateral flow device Subject: Scientific Reports, doi:10.1038/s41598-018-34610-5 Keywords: Author: Daniel Quesada-Gonzamp#x000E1;lez Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Fri Oct 26 06:28:44 2018 CEST ModDate: Fri Oct 26 11:57:23 2018 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1135066 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MPMSZZ+Corbel CID TrueType Identity-H yes yes yes 276 0 TLCOHU+Corbel-BoldItalic Type 1C WinAnsi yes yes yes 277 0 EuclidSymbol Type 1C Custom yes no yes 73 0 YAASHD+Corbel-Bold2 Type 1C WinAnsi yes yes yes 74 0 CIRRPT+STIXGeneral-Regular Type 1C Custom yes yes yes 75 0 HDPEVI+Corbel2 Type 1C WinAnsi yes yes yes 76 0 VIWPVH+Corbel-Bold CID TrueType Identity-H yes yes yes 77 0 MinionPro-Regular Type 1C Custom yes no yes 78 0 ZBDZZZ+TimesNewRomanPSMT Type 1C WinAnsi yes yes yes 278 0 YAASHD+Corbel-Bold2 Type 1C WinAnsi yes yes yes 196 0 HDPEVI+Corbel2 Type 1C WinAnsi yes yes yes 197 0 MPMSZZ+Corbel CID TrueType Identity-H yes yes yes 318 0 MyriadPro-It Type 1C WinAnsi yes no yes 198 0 HDPEVI+Corbel2 Type 1C WinAnsi yes yes yes 190 0 MPMSZZ+Corbel CID TrueType Identity-H yes yes yes 193 0 MPMSZZ+Corbel CID TrueType Identity-H yes yes yes 201 0 MinionPro-Bold Type 1C WinAnsi yes no yes 130 0 MinionPro-It Type 1C Custom yes no yes 159 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-08-10 13:29:55 CEST RepresentationInformation: scirep_a2018v8n16157.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-06-17 14:56:57 CEST Size: 1135066 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 2. Noubactep, C., Meinrath, G., Dietrich, P. & Merkel, B. Mitigating Uranium in Groundwater:⁜琀 倀爀漀猀瀀攀挀琀猀 愀渀搀 䰀椀洀椀琀愀琀椀漀渀猀⸀⃾＀䔀渀瘀椀爀漀渀洀攀渀琀愀氀 匀挀椀攀渀挀攀 ☀ 吀攀挀栀渀漀氀漀最秾＀⃾＀㌀㟾＀㄀㠀Ⰰ 㐀㌀　㐠ጀ㐀㌀　㠀 ㈀　　㌀⻾＀㨀㈀㌩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㌹㘮㌸′㤰⸳㔷″㤹⸲〴′㜸⸲ㄶ崯䠯丯䅐㰼⽎′㔶‰⁒㸾㸾੥湤潢樊㈵㘠〠潢樊㰼⽔祰支塏扪散琯剥獯畲捥猼㰾㸯卵扴祰支䙯牭⽂䉯硛〮〠〮〠㈮㠲㐰ㄠㄮそ⽌敮杴栠㄰⽆楬瑥爯䙬慴敄散潤放㹳瑲敡洊䢉Ȉ　੥湤獴牥慭੥湤潢樊㈴ㄠ〠潢樊㰼⽆‴⽔祰支䅮湯琯䑥獴⣾＀匀瀀爀椀渀最攀爀一愀琀甀爀攀开匀挀椀刀攀瀀开㌀㐀㘀㄀　⸀椀渀搀搀㫾＀￾＀㌀⻾￾＀￾＀䰀愀渀搀愀Ⰰ 䔀⸀ 刀⸀ 一愀琀甀爀愀氀氀礀 漀挀挀甀爀爀椀渀最 爀愀搀椀漀渀甀挀氀椀搀攀猀 昀爀漀洀 椀渀搀甀猀琀爀椀愀氀 猀漀甀爀挀攀猀㨀 挀栀愀爀愀挀琀攀爀椀猀琀椀挀猀 愀渀搀 昀愀琀攀 椀渀 琀栀攀 攀渀瘀椀爀漀渀洀攀渀琀⸀ 䤀渀⃾＀刀愀搀椀漀愀挀琀椀瘀椀琀礀 椀渀 琀栀攀 䔀渀瘀椀爀漀渀洀攀渀瓾＀Ⰰ 匀栀愀眀Ⰰ 䜀⸀Ⰰ 䔀搀⸀ 䔀氀猀攀瘀椀攀爀㨀 嘀漀氀⸀ ㄀　Ⰰ 瀀瀀 ㈀㄀ㄠጀ㈀㌀㜀 ㈀　　㜀⻾＀㨀㈀㐩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛ㄶ㘮〷㘠㈸〮㌵㜠ㄶ㠮㠸㤠㈶㠮㈱㙝⽈⽎⽁值㰯丠㈵㜠〠刾㸾㸊敮摯扪ਲ㔷‰扪਼㰯呹灥⽘佢橥捴⽒敳潵牣敳㰼㸾⽓畢瑹灥⽆潲洯䉂潸嬰⸰‰⸰′⸸ㄳ‱⸰崯䱥湧瑨‱〯䙩汴敲⽆污瑥䑥捯摥㸾獴牥慭ੈ褂࠰Ċ敮摳瑲敡洊敮摯扪ਲ㐲‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_34610.indd: 4. Raińska, E. et al. Assessment of Phosphatic Fertilizer Production Impact on Occupational Staff Based on NAA of Hair, Nails, and Inhald Particles. Journal of Environmental Science and Health, Part A 40(12), 2137–2152 (2005). :25' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 3. Landa, E. R. Naturally occurring radionuclides from industrial sources: characteristics and fate in the environment. In Radioactivity in the Environment, Shaw, G., Ed. Elsevier: Vol. 10, pp 211–237 (2007). :24' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 4. Raińska, E. et al. Assessment of Phosphatic Fertilizer Production Impact on Occupational Staff Based on NAA of Hair, Nails, and Inhald Particles. Journal of Environmental Science and Health, Part A 40(12), 2137–2152 (2005). :25' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 20. Davies, G. et al. Tight metal binding by humic acids and its role in biomineralization. J. Chem. Soc., Dalton Trans. (21), 4047–4060 (1997) :42' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 21. Bernhard, G., Geipel, G., Brendler, V. & Nitsche, H. Speciation of uranium in seepage waters of a mine tailing pile studied by time-resolved laser-induced fluorescence spectroscopy (TRLFS). Radiochim. Acta 74, 87–91 (1996). :43' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 25. Kelly, S. D. et al. Ca-UO2-CO3 complexation - implications for bioremediation of U(VI). Phys. Scr., T 2005, T115 (12th X-Ray Absorption Fine Structure International Conference (XAFS12), 2003), 915–917 (2015). :44' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 26. Blake, D. A. et al. Metal binding properties of a monoclonal antibody directed toward metal-chelate complexes. Journal of Biological Chemistry 271(44), 27677–85 (1996). :45' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 29. Zhu, X., Kriegel, A. M., Boustany, C. A. & Blake, D. A. Single-Chain Variable Fragment (scFv) Antibodies Optimized for Environmental Analysis of Uranium. Anal Chem 83(10), 3717–24 (2011). :46' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 30. Darwish, I. A. & Blake, D. A. One-step competitive immunoassay for cadmium ions: development and validation for environmental water samples. Analytical chemistry 73(8), 1889–95 (2001). :47' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 33. Lopez, M. A. M., Pons, J., Blake, D. A. & Merkoci, A. All-integrated and highly sensitive paper based device with sample treatment platform for Cd2+ immunodetection in drinking/tap waters. Anal Chem 85(7), 3532–8 (2013). :48' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 34. Parolo, C. & Merkoci, A. Paper-based nanobiosensors for diagnostics. Chemical Society Reviews 42(2), 450–457 (2013). :49' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 37. Yetisen, A. K., Akram, M. S. & Lowe, C. R. Paper-based microfluidic point-of-care diagnostic devices. Lab on a Chip 13(12), 2210–2251 (2013). :50' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 38. Mazumdar, D., Liu, J., Lu, G., Zhou, J. & Lu, Y. Easy-to-use dipstick tests for detection of lead in paints using non-cross-linked gold nanoparticle–DNAzyme conjugates(). Chemical Communications (Cambridge, England) 46(9), 1416–1418 (20:51' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 39. López Marzo, A. M., Pons, J., Blake, D. A. & Merkoçi, A. High sensitive gold-nanoparticle based lateral flow Immunodevice for Cd2+ detection in drinking waters. Biosens Bioelectron 47, 190–8 (2013). :52' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 40. Torabi, S.-F. & Lu, Y. Small-molecule diagnostics based on functional DNA nanotechnology: a dipstick test for mercury. Faraday Discussions 149(0), 125–135 (2011). :53' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 27. Blake, R. C. II. et al. Novel monoclonal antibodies with specificity for chelated uranium(VI): isolation and binding properties. Bioconjug Chem 15(5), 1125–36 (2004). :54' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 27. Blake, R. C. II. et al. Novel monoclonal antibodies with specificity for chelated uranium(VI): isolation and binding properties. Bioconjug Chem 15(5), 1125–36 (2004). :55' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 36. Quesada-González, D. & Merkoçi, A. Nanoparticle-based lateral flow biosensors. Biosensors and Bioelectronics 73, 47–63 (2015). :56' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 41. Parolo, C. et al. Design, Preparation, and Evaluation of a Fixed-Orientation Antibody/Gold-Nanoparticle Conjugate as an Immunosensing Label. ACS Applied Materials & Interfaces 5(21), 10753–10759 (2013). :57' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 44. Quesada-González, D. & Merkoçi, A. Nanomaterial-based devices for point-of-care diagnostic applications. Chemical Society Reviews 47(13), 4697–4709 (2018). :58' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 32. Melton, S. J. et al. Field-based detection and monitoring of uranium in contaminated groundwater using two immunosensors. Environ Sci Technol 43(17), 6703–9 (2009). :60' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 45. Zhu, X., Ban, B., Yang, X., S. Shevkoplas, S. & Blake, D. Development of an Immunochromatographic Strip for Rapid, Instrument-Free, On-Site Detection of Uranium. ; p 499–504 (2012) :61' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 46. Turkevich, J., Stevenson, P. C. & Hillier, J. A study of the nucleation and growth processes in the synthesis of colloidal gold. Discussions of the Faraday Society 11(0), 55–75 (1951). :62' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 27. Blake, R. C. II. et al. Novel monoclonal antibodies with specificity for chelated uranium(VI): isolation and binding properties. Bioconjug Chem 15(5), 1125–36 (2004). :63' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 47. Hoffman, W. L., Jump, A. A., Kelly, P. J. & Ruggles, A. O. Binding of antibodies and other proteins to nitrocellulose in acidic, basic, and chaotropic buffers. Analytical Biochemistry 198(1), 112–118 (1991). :64' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 27. Blake, R. C. II. et al. Novel monoclonal antibodies with specificity for chelated uranium(VI): isolation and binding properties. Bioconjug Chem 15(5), 1125–36 (2004). :68' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 27. Blake, R. C. II. et al. Novel monoclonal antibodies with specificity for chelated uranium(VI): isolation and binding properties. Bioconjug Chem 15(5), 1125–36 (2004). :70' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 36. Quesada-González, D. & Merkoçi, A. Nanoparticle-based lateral flow biosensors. Biosensors and Bioelectronics 73, 47–63 (2015). :71' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 39. López Marzo, A. M., Pons, J., Blake, D. A. & Merkoçi, A. High sensitive gold-nanoparticle based lateral flow Immunodevice for Cd2+ detection in drinking waters. Biosens Bioelectron 47, 190–8 (2013). :72' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd:Figure 1. Schematic (not drawn to scale) of the configuration and operating principle of the lateral flow strip for the detection of U(VI). The intensity on the strips can be measured by using a mobile phone camera.:73' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd:Figure 2. (A) Evaluation of the conjugation of 12F6 antibody at different concentrations on AuNPs at pH 7, 8 and 9 by means of the variation of absorbance (ΔAbs.) caused by the addition of NaCl and (B) the corresponding coefficient of variat:75' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd:Figure 2. (A) Evaluation of the conjugation of 12F6 antibody at different concentrations on AuNPs at pH 7, 8 and 9 by means of the variation of absorbance (ΔAbs.) caused by the addition of NaCl and (B) the corresponding coefficient of varia:76' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd:Figure 2. (A) Evaluation of the conjugation of 12F6 antibody at different concentrations on AuNPs at pH 7, 8 and 9 by means of the variation of absorbance (ΔAbs.) caused by the addition of NaCl and (B) the corresponding coefficient of vari:77' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd:Figure 2. (A) Evaluation of the conjugation of 12F6 antibody at different concentrations on AuNPs at pH 7, 8 and 9 by means of the variation of absorbance (ΔAbs.) caused by the addition of NaCl and (B) the corresponding coefficient of var:78' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd:Figure 3. (A) LFs response at U(VI) concentrations between 0 and 200⁜琀渀䴀 椀渀 䠀䈀匀 戀甀昀昀攀爀 愀渀搀 ＀䋾＀ 琀栀攀 挀漀爀爀攀猀瀀漀渀搀椀渀最 眀漀爀欀椀渀最 爀愀渀最攀 攀焀甀愀琀椀漀渀⸀ 吀栀攀 搀愀琀愀 猀栀漀眀渀 椀渀 ＀䋾＀ 眀愀猀 挀漀氀氀攀挀琀攀搀 昀爀漀洀 琀眀漀 搀椀昀昀攀爀攀渀琀 攀砀瀀攀爀椀洀攀渀琀猀Ⰰ 瀀攀爀昀漀爀洀攀搀 漀渀攀 洀漀渀琀栀 愀瀀愀爀琀Ⰰ 眀椀琀栀 琀眀漀㨀㜀㤩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㌳㐮㌴㘠㐱ㄮ㈶㌠㌴㐮㤹ㄠ㌹㤮ㄲ㉝⽈⽎⽁值㰯丠ㄲ㌠〠刾㸾㸊敮摯扪਱ㄷ‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_34610.indd:Figure 3. (A) LFs response at U(VI) concentrations between 0 and 200⁜琀渀䴀 椀渀 䠀䈀匀 戀甀昀昀攀爀 愀渀搀 ＀䋾＀ 琀栀攀 挀漀爀爀攀猀瀀漀渀搀椀渀最 眀漀爀欀椀渀最 爀愀渀最攀 攀焀甀愀琀椀漀渀⸀ 吀栀攀 搀愀琀愀 猀栀漀眀渀 椀渀 ＀䋾＀ 眀愀猀 挀漀氀氀攀挀琀攀搀 昀爀漀洀 琀眀漀 搀椀昀昀攀爀攀渀琀 攀砀瀀攀爀椀洀攀渀琀猀Ⰰ 瀀攀爀昀漀爀洀攀搀 漀渀攀 洀漀渀琀栀 愀瀀愀爀琀Ⰰ 眀椀琀栀 琀眀㨀㠀〩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㔰㜮ㄵ㠠㐱ㄮ㈶㌠㔱㘮㠷㘠㌹㤮ㄲ㉝⽈⽎⽁值㰯丠ㄲ㐠〠刾㸾㸊敮摯扪਱ㄸ‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_34610.indd: 56. Brooks, S. C. et al. Inhibition of Bacterial U(VI) Reduction by Calcium. Environmental Science & Technology 37(9), 1850–1858 (2003). :81' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd:Figure 3. (A) LFs response at U(VI) concentrations between 0 and 200⁜琀渀䴀 椀渀 䠀䈀匀 戀甀昀昀攀爀 愀渀搀 ＀䋾＀ 琀栀攀 挀漀爀爀攀猀瀀漀渀搀椀渀最 眀漀爀欀椀渀最 爀愀渀最攀 攀焀甀愀琀椀漀渀⸀ 吀栀攀 搀愀琀愀 猀栀漀眀渀 椀渀 ＀䋾＀ 眀愀猀 挀漀氀氀攀挀琀攀搀 昀爀漀洀 琀眀漀 搀椀昀昀攀爀攀渀琀 攀砀瀀攀爀椀洀攀渀琀猀Ⰰ 瀀攀爀昀漀爀洀攀搀 漀渀攀 洀漀渀琀栀 愀瀀愀爀琀Ⰰ 眀椀琀栀 琀眀㨀㠀〩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㔰㜮ㄵ㠠㐱ㄮ㈶㌠㔱㘮㠷㘠㌹㤮ㄲ㉝⽈⽎⽁值㰯丠ㄲ㐠〠刾㸾㸊敮摯扪਱ㄸ‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_34610.indd: 56. Brooks, S. C. et al. Inhibition of Bacterial U(VI) Reduction by Calcium. Environmental Science & Technology 37(9), 1850–1858 (2003). :81' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: 32. Melton, S. J. et al. Field-based detection and monitoring of uranium in contaminated groundwater using two immunosensors. Environ Sci Technol 43(17), 6703–9 (2009). :82' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd:Figure 3. (A) LFs response at U(VI) concentrations between 0 and 200⁜琀渀䴀 椀渀 䠀䈀匀 戀甀昀昀攀爀 愀渀搀 ＀䋾＀ 琀栀攀 挀漀爀爀攀猀瀀漀渀搀椀渀最 眀漀爀欀椀渀最 爀愀渀最攀 攀焀甀愀琀椀漀渀⸀ 吀栀攀 搀愀琀愀 猀栀漀眀渀 椀渀 ＀䋾＀ 眀愀猀 挀漀氀氀攀挀琀攀搀 昀爀漀洀 琀眀漀 搀椀昀昀攀爀攀渀琀 攀砀瀀攀爀椀洀攀渀琀猀Ⰰ 瀀攀爀昀漀爀洀攀搀 漀渀攀 洀漀渀琀栀 愀瀀愀爀琀Ⰰ 眀椀琀栀 琀㨀㠀㔩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㌱㤮㌰㘠㈵㌮㈶㌠㌲㤮㘱ㄠ㈴ㄮㄲ㉝⽈⽎⽁值㰯丠ㄴ〠〠刾㸾㸊敮摯扪਱㌸‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_34610.indd:Figure 3. (A) LFs response at U(VI) concentrations between 0 and 200⁜琀渀䴀 椀渀 䠀䈀匀 戀甀昀昀攀爀 愀渀搀 ＀䋾＀ 琀栀攀 挀漀爀爀攀猀瀀漀渀搀椀渀最 眀漀爀欀椀渀最 爀愀渀最攀 攀焀甀愀琀椀漀渀⸀ 吀栀攀 搀愀琀愀 猀栀漀眀渀 椀渀 ＀䋾＀ 眀愀猀 挀漀氀氀攀挀琀攀搀 昀爀漀洀 琀眀漀 搀椀昀昀攀爀攀渀琀 攀砀瀀攀爀椀洀攀渀琀猀Ⰰ 瀀攀爀昀漀爀洀攀搀 漀渀攀 洀漀渀琀栀 愀瀀愀爀琀Ⰰ 眀椀琀栀 㨀㠀㘩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㌵㠮㌵㈠㈵㌮㈶㌠㌶㤮㈸㜠㈴ㄮㄲ㉝⽈⽎⽁值㰯丠ㄴㄠ〠刾㸾㸊敮摯扪਱㌹‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_34610.indd: Table 1. Evaluation of environmental groundwater samples. Comparison of LFs and ICP-MS.:87' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd:Figure 3. (A) LFs response at U(VI) concentrations between 0 and 200⁜琀渀䴀 椀渀 䠀䈀匀 戀甀昀昀攀爀 愀渀搀 ＀䋾＀ 琀栀攀 挀漀爀爀攀猀瀀漀渀搀椀渀最 眀漀爀欀椀渀最 爀愀渀最攀 攀焀甀愀琀椀漀渀⸀ 吀栀攀 搀愀琀愀 猀栀漀眀渀 椀渀 ＀䋾＀ 眀愀猀 挀漀氀氀攀挀琀攀搀 昀爀漀洀 琀眀漀 搀椀昀昀攀爀攀渀琀 攀砀瀀攀爀椀洀攀渀琀猀Ⰰ 瀀攀爀昀漀爀洀攀搀 漀渀攀 洀漀渀琀栀 愀瀀愀爀琀Ⰰ 眀椀琀栀 㨀㠀㘩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㌵㠮㌵㈠㈵㌮㈶㌠㌶㤮㈸㜠㈴ㄮㄲ㉝⽈⽎⽁值㰯丠ㄴㄠ〠刾㸾㸊敮摯扪਱㌹‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_34610.indd: Table 1. Evaluation of environmental groundwater samples. Comparison of LFs and ICP-MS.:87' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd: Table 1. Evaluation of environmental groundwater samples. Comparison of LFs and ICP-MS.:87' cannot be found Offset: 744236 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_34610.indd:Figure 1. Schematic (not drawn to scale) of the configuration and operating principle of the lateral flow strip for the detection of U(VI). The intensity on the strips can be measured by using a mobile phone camera.:89' cannot be found Offset: 744236 MIMEtype: application/pdf PDFMetadata: Objects: 360 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Uranium (VI) detection in groundwater using a gold nanoparticle/paper-based lateral flow device Children: Item: Title: Materials and Methods Children: Item: Title: Materials. Item: Title: Synthesis of gold nanoparticles (AuNPs). Item: Title: Preparation of the 12F6-AuNP conjugate. Item: Title: Preparation of the U(VI)-DCP-bovine serum albumin conjugate. Item: Title: Preparation of the lateral flow strips. Item: Title: Assay performance. Item: Title: Evaluation of strips with contaminated groundwater samples. Item: Title: Results and Discussion Children: Item: Title: Design of the AuNP-based LFs for the detection of U(VI). Item: Title: Optimization of assay conditions. Item: Title: Detection and quantification of U(VI) in contaminated groundwater samples. Item: Title: Conclusions Item: Title: Acknowledgements Item: Title: Figure 1 Schematic (not drawn to scale) of the configuration and operating principle of the lateral flow strip for the detection of U(VI). Item: Title: Figure 2 (A) Evaluation of the conjugation of 12F6 antibody at different concentrations on AuNPs at pH 7, 8 and 9 by means of the variation of absorbance (ΔAbs. Item: Title: Figure 3 (A) LFs response at U(VI) concentrations between 0 and 200 nM in HBS buffer and (B) the corresponding working range equation. Item: Title: Table 1 Evaluation of environmental groundwater samples. Info: Title: Uranium (VI) detection in groundwater using a gold nanoparticle/paper-based lateral flow device Author: Daniel Quesada-Gonzamp#x000E1;lez Subject: Scientific Reports, doi:10.1038/s41598-018-34610-5 Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Fri Oct 26 06:58:44 CEST 2018 ModDate: Fri Oct 26 11:57:23 CEST 2018 ID: 0x6de4d0fe3be5089f2205f58a1574197f, 0x3e527145e07ea0c64803590ccacb9c43 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1000 ImageHeight: 952 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1000 ImageHeight: 1563 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1500 ImageHeight: 749 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: MPMSZZ+Corbel Encoding: Identity-H ToUnicode: true Font: BaseFont: VIWPVH+Corbel-Bold Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: TLCOHU+Corbel-BoldItalic FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: TLCOHU+Corbel-BoldItalic Flags: Nonsymbolic, Italic FontBBox: -494, -239, 1194, 952 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: ZBDZZZ+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 120 FontDescriptor: FontName: ZBDZZZ+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: EuclidSymbol FirstChar: 0 LastChar: 255 FontDescriptor: FontName: EuclidSymbol Flags: Symbolic FontBBox: -166, -253, 1090, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: YAASHD+Corbel-Bold2 FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: YAASHD+Corbel-Bold2 Flags: Nonsymbolic FontBBox: -556, -239, 1155, 952 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: CIRRPT+STIXGeneral-Regular FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: CIRRPT+STIXGeneral-Regular Flags: Serif, Symbolic FontBBox: -995, -455, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: HDPEVI+Corbel2 FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: HDPEVI+Corbel2 Flags: Nonsymbolic FontBBox: -553, -239, 1110, 952 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: MPMSZZ+Corbel CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: MPMSZZ+Corbel Flags: Symbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Font: BaseFont: VIWPVH+Corbel-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: VIWPVH+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true XMP: application/pdf doi:10.1038/s41598-018-34610-5 Springer US Scientific Reports, doi:10.1038/s41598-018-34610-5 Uranium (VI) detection in groundwater using a gold nanoparticle/paper-based lateral flow device Daniel Quesada-Gonzamp#x000E1;lez Grace A. Jairo Robert C. Blake Diane A. Blake Arben Merkoamp#x000E7;i 10.1038/s41598-018-34610-5 http://dx.doi.org/10.1038/s41598-018-34610-5 journal Scientific Reports © 2018, The Author(s) 2045-2322 10.1038/s41598-018-34610-5 Springer 2018-10-26T11:57:23+02:00 2018-10-26T09:58:44+05:30 2018-10-26T11:57:23+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) VoR uuid:99bc2325-67e8-42fd-832b-81a952cc9e91 uuid:28849192-7346-48b4-b25b-e284e71b503d default 1 converted uuid:d6612ea1-b23e-4857-8455-4091a77654b6 converted to PDF/A-2b pdfToolbox 2018-10-26T09:59:31+05:30 2 B http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. 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