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Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Patients and Methods Destination: flink2 Children: Item: Title: Study Design and Patients Destination: slink1 Item: Title: Randomization and Masking Destination: slink2 Item: Title: Procedures Destination: slink3 Item: Title: Outcomes Destination: slink4 Item: Title: Statistical Analysis Destination: slink5 Item: Title: Results Destination: flink3 Children: Item: Title: Common AEs Destination: slink6 Item: Title: Grade 3/4 AEs Destination: slink7 Item: Title: Serious AEs Destination: slink8 Item: Title: Dose Reductions, Discontinuations, and Deaths From AEs Destination: slink9 Item: Title: Hematologic Toxicities Destination: slink10 Item: Title: Infections Destination: slink11 Item: Title: Diarrhea Destination: slink12 Item: Title: Hypertension Destination: slink13 Item: Title: Cardiac AEs Destination: slink14 Item: Title: Hepatobiliary Disorders Destination: slink15 Item: Title: Bleeding Events Destination: slink16 Item: Title: Interstitial Lung Disease Destination: slink17 Item: Title: Second Primary Malignancies Destination: slink18 Item: Title: Discussion Destination: flink4 Item: Title: Conclusion Destination: flink5 Children: Item: Title: Clinical Practice Points Destination: slink19 Item: Title: Acknowledgments Destination: blink1 Item: Title: Disclosure Destination: aclink1 Item: Title: References Destination: blink2 Item: Title: Supplemental Data Destination: flink1 Item: Title: Supplemental Appendix Destination: flink1 Children: Item: Title: Randomization and Masking Destination: slink1 Info: Title: Safety Analysis of Four Randomized Controlled Studies of Ibrutinib in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Mantle Cell Lymphoma Author: Susan O'Brien Subject: Clinical Lymphoma, Myeloma and Leukemia, 18 (2018) 648-672. doi:10.1016/j.clml.2018.06.016 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Thu Sep 20 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Flags: Serif, Nonsymbolic FontBBox: -72, -260, 1010, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PHPECC+AdvOTd1f5cc91.B+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: PHPECC+AdvOTd1f5cc91.B+20 Flags: Nonsymbolic FontBBox: -156, -166, 1072, 718 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PHPELG+AdvP4C4E51 FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: PHPELG+AdvP4C4E51 Flags: Nonsymbolic FontBBox: -31, -239, 1041, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PHPDPP+AdvOT6ff10959.B FontSubset: true FirstChar: 65 LastChar: 121 FontDescriptor: FontName: PHPDPP+AdvOT6ff10959.B Flags: Nonsymbolic FontBBox: -104, -208, 1145, 979 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.clml.2018.06.016 Safety Analysis of Four Randomized Controlled Studies of Ibrutinib in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Mantle Cell Lymphoma Susan O'Brien Peter Hillmen Steven Coutre Paul M. Barr Graeme Fraser Alessandra Tedeschi Jan A. Burger Marie-Sarah Dilhuydy Georg Hess Carol Moreno Paula Cramer Emily Liu Stephen Chang Jessica Vermeulen Lori Styles Angela Howes Danelle F. James Kalpesh Patel Thorsten Graef Rudolph Valentino Adverse events Benefit/risk profile Bruton's tyrosine kinase inhibitor Exposure-adjusted incidence rate Pooled analysis Clinical Lymphoma, Myeloma and Leukemia, 18 (2018) 648-672. doi:10.1016/j.clml.2018.06.016 Elsevier Inc. journal Clinical Lymphoma, Myeloma and Leukemia © 2018 The Authors. Published by Elsevier Inc. 2152-2650 18 10 October 2018 648-657.e15 648 657.e15 10.1016/j.clml.2018.06.016 https://doi.org/10.1016/j.clml.2018.06.016 2010-04-23 true 10.1016/j.clml.2018.06.016 elsevier.com sciencedirect.com VoR 6.5 10.1016/j.clml.2018.06.016 noindex 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2018-09-20T20:15:26+05:30 2018-09-20T20:16:17+05:30 2018-09-20T20:16:17+05:30 True Acrobat Distiller 8.1.0 (Windows) uuid:11241f5b-4db5-4cdc-897a-12889f2469c2 uuid:a2346443-bcb7-4570-86c6-dcf7ec7f52d2 http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 648 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 146, 561, 151, 576 Destination: null Annotation: Subtype: Link Rect: 243, 561, 248, 576 Destination: null Annotation: Subtype: Link Rect: 340, 561, 345, 576 Destination: null Annotation: Subtype: Link Rect: 431, 561, 437, 576 Destination: null Annotation: Subtype: Link Rect: 530, 561, 536, 576 Destination: null Annotation: Subtype: Link Rect: 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Destination: 255 Page: Label: 657.e3 Sequence: 13 Rotate: 90 Page: Label: 657.e4 Sequence: 14 Rotate: 90 Page: Label: 657.e5 Sequence: 15 Rotate: 90 Page: Label: 657.e6 Sequence: 16 Page: Label: 657.e7 Sequence: 17 Page: Label: 657.e8 Sequence: 18 Annotations: Annotation: Subtype: Link Rect: 449, 691, 452, 699 Destination: 289 Annotation: Subtype: Link Rect: 519, 691, 522, 699 Destination: 289 Page: Label: 657.e9 Sequence: 19 Annotations: Annotation: Subtype: Link Rect: 449, 691, 452, 700 Destination: 289 Annotation: Subtype: Link Rect: 519, 691, 522, 700 Destination: 289 Page: Label: 657.e10 Sequence: 20 Annotations: Annotation: Subtype: Link Rect: 464, 681, 467, 690 Destination: 295 Annotation: Subtype: Link Rect: 524, 681, 527, 690 Destination: 295 Page: Label: 657.e11 Sequence: 21 Annotations: Annotation: Subtype: Link Rect: 461, 681, 464, 690 Destination: 301 Annotation: Subtype: Link Rect: 523, 681, 526, 690 Destination: 301 Page: Label: 657.e12 Sequence: 22 Page: Label: 657.e13 Sequence: 23 Page: Label: 657.e14 Sequence: 24 Page: Label: 657.e15 Sequence: 25 Checksum: a2145517 Type: CRC32 Checksum: 00b683678e6e634d9ca34b2e5f8b846d Type: MD5 Checksum: c69f1c6a8183baa26ec2ff707ee0e426633efb64 Type: SHA-1 Checksum: 5481977769013f4aac1ff968528adb4f446819b3df6cf53f4451998db4f472be Type: SHA-256