35b6ba79d71f5eef7d7f58f2d8f0a0c6 286872.pdf b8df55bfe3b6faeaa3c6cf64226ff1e3ca426b99 286872.pdf f5cdde8e15229ccba588bcc544961ccbd553e08f6bc47ced3cfb6111db9e14a8 286872.pdf Title: Improvement in Parameters of Hematologic and Immunologic Function and Patient Well-being in the Phase III RESONATE Study of Ibrutinib Versus Ofatumumab in Patients With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Keywords: Bruton’s tyrosine kinase, Disease-related symptoms, Fatigue, Quality of life, Relapsed/refractory CLL/SLL Author: Jacqueline C. Barrientos, Susan O’Brien, Jennifer R. Brown, Neil E. Kay, Nishitha M. Reddy, Steven Coutre, Constantine Tam, Stephen Mulligan, Ulrich Jaeger, Stephen Devereux, Christopher Pocock, Tadeusz Robak, Stephen J. Schuster, Anna Schuh, Devinder Gill, Adrian Bloor, Claire Dearden, Carol Moreno, Gavin Cull, Mike Hamblin, Jeffrey A. Jones, Karl Eckert, Isabelle G. Solman, Samuel Suzuki, Emily Hsu, Danelle F. James, John C. Byrd, Peter Hillmen Creator: AH XSL Formatter V6.3 R1 for Linux64 : 6.3.1.23495 (2016/02/03 14:39JST) Producer: Antenna House PDF Output Library 6.3.752 (Linux64) CreationDate: Mon May 20 22:51:01 2019 CEST ModDate: Mon May 20 22:51:01 2019 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 19 Encrypted: no Page size: 612 x 792 pts (letter) Page rot: 0 File size: 614812 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- Times-Roman Type 1 Custom no no yes 11 0 Helvetica-Bold Type 1 Custom no no yes 13 0 Helvetica Type 1 Custom no no yes 16 0 Times-Bold Type 1 Custom no no yes 348 0 Times-BoldItalic Type 1 Standard no no no 507 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-01-12 02:33:41 CET RepresentationInformation: 286872.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-01-11 13:58:57 CET Size: 614812 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 0 FreeObjects: 59 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Abstract Item: Title: Introduction Item: Title: Patients and Methods Children: Item: Title: Patients Item: Title: Study Design Item: Title: Study Endpoints Item: Title: Results Children: Item: Title: Baseline Characteristics and Patient Disposition Item: Title: Sustained Hematologic Improvement Item: Title: Patient-Reported Outcomes Children: Item: Title: FACIT-F. Item: Title: EORTC QLQ-C30. Item: Title: Reduction in Disease Burden Item: Title: Disease-Related Symptoms and Medical Resource Utilization Item: Title: White Blood Cell Count, Lymphocyte Counts, and Serum Immunoglobulin Levels Item: Title: Adverse Events Item: Title: Discussion Item: Title: Conclusion Item: Title: References Item: Title: Figure 1 Item: Title: Figure 2 Item: Title: Figure 3 Item: Title: Figure 4 Item: Title: Figure 5 Item: Title: Table 1 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 152 ImageHeight: 152 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1050 ImageHeight: 896 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 716 ImageHeight: 1050 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1047 ImageHeight: 1050 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1050 ImageHeight: 699 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 714 ImageHeight: 1050 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: Helvetica FirstChar: 32 LastChar: 128 FontDescriptor: FontName: Helvetica Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Times-Roman FirstChar: 32 LastChar: 136 FontDescriptor: FontName: Times-Roman Flags: Nonsymbolic FontBBox: -168, -218, 1000, 898 EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Times-BoldItalic Font: BaseFont: Times-Bold FirstChar: 32 LastChar: 128 FontDescriptor: FontName: Times-Bold Flags: Nonsymbolic FontBBox: -168, -218, 1000, 935 EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Helvetica-Bold FirstChar: 32 LastChar: 129 FontDescriptor: FontName: Helvetica-Bold Flags: Nonsymbolic FontBBox: -170, -228, 1003, 962 EncodingDictionary: Differences: true ToUnicode: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 297, 124, 458, 132 LastModified: D:20190520155101-05'00' Annotation: Subtype: Link Rect: 416, 82, 512, 90 LastModified: D:20190520155101-05'00' Annotation: Subtype: Link Rect: 90, 72, 130, 80 LastModified: D:20190520155101-05'00' Page: Sequence: 2 Page: Sequence: 3 Page: Sequence: 4 Page: Sequence: 5 Page: Sequence: 6 Page: Sequence: 7 Page: Sequence: 8 Page: Sequence: 9 Page: Sequence: 10 Page: Sequence: 11 Page: Sequence: 12 Page: Sequence: 13 Page: Sequence: 14 Page: Sequence: 15 Page: Sequence: 16 Page: Sequence: 17 Page: Sequence: 18 Page: Sequence: 19 Checksum: 4c33cff8 Type: CRC32 Checksum: 35b6ba79d71f5eef7d7f58f2d8f0a0c6 Type: MD5 Checksum: b8df55bfe3b6faeaa3c6cf64226ff1e3ca426b99 Type: SHA-1 Checksum: f5cdde8e15229ccba588bcc544961ccbd553e08f6bc47ced3cfb6111db9e14a8 Type: SHA-256