70baaa55f315e8b1e638f0cb35f34f12 286885.pdf 2b8d9317a81a6acc59d0328b2c728f89a272e314 286885.pdf 46866ff6387726395b4fc347bc04d711a4a0a447b51736263b508826c3f0234f 286885.pdf Title: Moderate Beer Intake and Cardiovascular Health in Overweight Individuals Subject: Consistent epidemiological evidence indicates that low-to-moderate alcohol consumption is inversely associated with cardiovascular event presentation, while high levels of alcohol intake are associated to increased cardiovascular risk. Little is known on the effects of moderate beer intake in the metabolic syndrome. The aim of this study is to investigate the effects of moderate and regular daily intake of beer with meals in overweight (body mass index (BMI) of 28–29.9 kg/m2) or obese class 1 (BMI of 30–35 kg/m2) individuals without other cardiovascular risk factors (dyslipidemia, type 2-diabetes, hypertension) focusing on the effects related to changes in weight, in lipoproteins and vascular endothelial function. We have performed an open, prospective two-arms longitudinal crossover study to investigate the effects associated with regular consumption (four week) of alcohol-free-beer (0 g alcohol/day) or traditional-beer (30 g alcohol/day in men and 15 g alcohol/day in women) on anthropometrical and biochemical parameters, liver and kidney function biomarkers, and vascular endothelial function. After four-week intervention with traditional and/or alcohol-free beer, BMI did not show any significant change and values for liver and kidney functions were within the normal levels. Moderate traditional beer intake did not affect lipid levels—however it significantly increased the antioxidant capacity of high density lipoprotein (HDL). In addition, apoB-depleted serum (after the four-week intervention period) showed a higher potential to promote cholesterol efflux from macrophages. Beer consumption did not induce vascular endothelial dysfunction or stiffness. In summary, our results based on a 12-week prospective study provide evidence that moderate intake of beer (traditional and alcohol-free) does not exert vascular detrimental effects nor increases body weight in obese healthy individuals. In contrast, moderate intake of beer increases the anti-oxidative properties of HDL and facilitates cholesterol efflux, which may prevent lipid deposition in the vessel wall. Keywords: cardiovascular-risk-factors; overweight; obesity; fermented-beverage; lipoprotein-oxidation; HDL-antioxidant-capacity; cholesterol-efflux; endothelial-function Author: Teresa Padro, Natàlia Muñoz-García, Gemma Vilahur, Patricia Chagas, Alba Deyà, Rosa Maria Antonijoan and Lina Badimon Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Wed Sep 5 10:32:08 2018 CEST ModDate: Wed Sep 5 10:32:08 2018 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 20 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 866973 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- TRJIKO+URWPalladioL-Ital Type 1 Custom yes yes no 147 0 ZVIZQE+URWPalladioL-Bold Type 1 Custom yes yes no 148 0 PYPZKK+VnURWPalladioL-Bold Type 1 Custom yes yes no 149 0 OXBKYU+TeXGyreAdventor-Bold Type 1 Custom yes yes no 150 0 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Date: 2024-01-12 02:33:35 CET RepresentationInformation: 286885.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-01-11 14:00:51 CET Size: 866973 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはの〠 Item: Title: きちぴづひどちぬび〠ちのつ〠きづぴとはつび〠 Children: Item: Title: こふぢなづっぴび〠 Item: Title: こぴふつべ〠いづびどでの〠ちのつ〠いどづぴちひべ〠きはのどぴはひどので〠 Item: Title: あぬははつ〠こちねばぬづび〠 Item: Title: ぁのぴとひはばはねづぴひどっ〠いちぴち〬〠あぬははつ〠ぐひづびびふひづ〬〠こづひふね〠がどばどつ〠ぐひはてどぬづ〠ちのつ〠くぴとづひ〠あどはっとづねどっちぬ〠きづちびふひづねづのぴび〠 Item: Title: がいが〠ちのつ〠えいが〠こちねばぬづ〠ぐひづばちひちぴどはの〬〠ぐふひどぴべ〠ぃはのぴひはぬ〠ちのつ〠くへどつちぴどはの〠ぁびびちべび〠 Children: Item: Title: がどばはばひはぴづどの〠ぐひづばちひちぴどはの〠 Item: Title: ぃはのなふでちぴづつ〠いどづのづび〠ぁびびちべ〠 Item: Title: えいが〠ぁのぴどはへどつちのぴ〠ぐはぴづのぴどちぬ〠 Item: Title: えいが〠ぃとはぬづびぴづひはぬ〠ぅててぬふへ〠ぃちばちっどぴべ〠ぁびびちべ〠 Item: Title: ざちびっふぬちひ〠ぅのつはぴとづぬどちぬ〠うふのっぴどはの〠ちのつ〠ぁひぴづひどちぬ〠こぴどててのづびび〠 Item: Title: ぉのてぬちねねちぴはひべ〠きちひにづひび〠 Item: Title: こぴちぴどびぴどっちぬ〠ぁのちぬべびどび〠 Item: Title: げづびふぬぴび〠 Children: Item: Title: あちびづぬどのづ〠ぃとちひちっぴづひどびぴどっび〠はて〠ぴとづ〠こぴふつべ〠ぐはばふぬちぴどはの〠ちのつ〠こどつづ〠ぅててづっぴび〠はて〠あづづひ〠ぃはのびふねばぴどはの〠 Item: Title: ぅててづっぴび〠はて〠あづづひ〠ぃはのびふねばぴどはの〠はの〠しづどでとぴ〠ぉのつづへづび〠 Item: Title: ぅててづっぴ〠はて〠あづづひ〠ぃはのびふねばぴどはの〠はの〠がどばどつ〠ぐひはてどぬづ〠ちのつ〠がどばはばひはぴづどの〠うふのっぴどはのちぬどぴべ〠 Children: Item: Title: がどばどつ〠ぐひはてどぬづ〠 Item: Title: がいが〠こふびっづばぴどぢどぬどぴべ〠ぴは〠くへどつちぴどはの〠 Item: Title: えいが〠ぁのぴどはへどつちのぴ〠ぃちばちっどぴべ〠 Item: Title: ぅててづっぴ〠はて〠あづづひ〠ぉのぴちにづ〠はの〠えいが〠ぃとはぬづびぴづひはぬ〠ぅててぬふへ〠ぃちばちっどぴべ〠 Item: Title: ぐぬちびねち〠ぉのてぬちねねちぴはひべ〠きちひにづひび〠ちのつ〠あづづひ〠ぉのぴづひぶづのぴどはの〠 Item: Title: ざちびっふぬちひ〠ぅのつはぴとづぬどちぬ〠うふのっぴどはの〠ちのつ〠ぁひぴづひどちぬ〠こぴどててのづびび〠ぢづてはひづ〠ちのつ〠ちてぴづひ〠ぉのぴづひぶづのぴどはの〠 Item: Title: あづづひ〠ぃはのびふねばぴどはの〠ちのつ〠ぃちひつどはぶちびっふぬちひ〠げどびに〠こっはひづ〠 Item: Title: いどびっふびびどはの〠 Item: Title: ぃはのっぬふびどはのび〠 Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: TRJIKO+URWPalladioL-Ital FontSubset: true FirstChar: 2 LastChar: 150 FontDescriptor: FontName: TRJIKO+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: ZVIZQE+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 241 FontDescriptor: FontName: ZVIZQE+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: PYPZKK+VnURWPalladioL-Bold FontSubset: true FirstChar: 160 LastChar: 189 FontDescriptor: FontName: PYPZKK+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: 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