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Introduction Destination: flink1 Item: Title: 2. Methods Destination: flink2 Children: Item: Title: 2.1. Patient/control study populations Destination: slink1 Item: Title: 2.2. Ethical assurances Destination: slink2 Item: Title: 2.3. SORT1 sequencing Destination: slink3 Item: Title: 2.4. Haplotype sharing analysis Destination: slink4 Item: Title: 2.5. In silico predictions Destination: slink5 Item: Title: 2.6. Statistical analysis Destination: slink6 Item: Title: 3. Results Destination: flink3 Children: Item: Title: 3.1. SORT1 variants in the Belgian cohorts Destination: slink7 Item: Title: 3.2. SORT1 variants in the European cohorts Destination: slink8 Item: Title: 3.3. Clinical characteristics of SORT1 patient-only variant carriers Destination: slink9 Item: Title: 4. Discussion Destination: flink4 Item: Title: Disclosure statement Destination: flink5 Item: Title: Acknowledgements Destination: aclink2 Item: Title: Appendix A. Supplementary data Destination: flink6 Item: Title: References Destination: blink1 Info: Title: Rare nonsynonymous variants in SORT1 are associated with increased risk for frontotemporal dementia Author: Stéphanie Philtjens Subject: Neurobiology of Aging, 66 (2018) 181.e3-181.e10. doi:10.1016/j.neurobiolaging.2018.02.011 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Sat Apr 21 14:01:13 CEST 2018 ModDate: Sat Apr 21 14:01:47 CEST 2018 ID: 0xeefe365f3fd7ad6c32ce9f2e04af7987, 0x83f693ace431764dbe4dc5f43f345c44 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 116 ImageHeight: 116 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 237 ImageHeight: 296 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg 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variants in SORT1 are associated with increased risk for frontotemporal dementia Stéphanie Philtjens Sara Van Mossevelde Julie van der Zee Eline Wauters Lubina Dillen Mathieu Vandenbulcke Rik Vandenberghe Adrian Ivanoiu Anne Sieben Christiana Willems Luisa Benussi Roberta Ghidoni Giuliano Binetti Barbara Borroni Alessandro Padovani Pau Pastor Monica Diez-Fairen Miquel Aguilar Alexandre de Mendonça Gabriel Miltenberger-Miltényi Isabel Hernández Merce Boada Agustín Ruiz Benedetta Nacmias Sandro Sorbi Maria Rosário Almeida Isabel Santana Jordi Clarimón Alberto Lleó Giovanni B. Frisoni Raquel Sanchez-Valle Albert Lladó Estrella Gómez-Tortosa Ellen Gelpi Marleen Van den Broeck Karin Peeters Patrick Cras Peter P. De Deyn Sebastiaan Engelborghs Marc Cruts Christine Van Broeckhoven BELNEU Consortiuma1 EU EOD Consortiuma Frontotemporal dementia Sortilin Granulin Rare variants Genetic association Neurobiology of Aging, 66 (2018) 181.e3-181.e10. doi:10.1016/j.neurobiolaging.2018.02.011 Elsevier Inc journal Neurobiology of Aging © 2018 The Authors. 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