2f275c5ddc393db5fec1ad90f8f3dd93  287386.pdf
e5b14414fae46c0af510c000a5d213841afc88f2  287386.pdf
abe39fa47da915510527be7df003fdca82fa3c1f57c2f7f45a74cb379ba429af  287386.pdf

Title:          MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis
Subject:        Nature Communications, doi:10.1038/s41467-018-03351-4
Keywords:       
Author:         Cristina Clemente
Creator:        Springer
Producer:       iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
CreationDate:   Fri Feb 23 11:37:05 2018 CET
ModDate:        Mon Feb 26 13:54:27 2018 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           AcroForm
JavaScript:     no
Pages:          16
Encrypted:      no
Page size:      595.276 x 782.362 pts
Page rot:       0
File size:      3554579 bytes
Optimized:      no
PDF version:    1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
IBILGA+AdvOTea1a7398                 Type 1C           WinAnsi          yes yes no      99  0
IBILGB+AdvOTea1a7398+fb              Type 1C           Custom           yes yes yes    231  0
IBIMAO+AdvTTab7e17fd                 Type 1C           WinAnsi          yes yes no     100  0
IBIMAP+AdvOTcb88df00                 Type 1C           WinAnsi          yes yes no     102  0
Arial-BoldMT                         Type 1C           WinAnsi          yes no  no     894  0
IBIMEP+AdvOTf23bb480                 Type 1C           WinAnsi          yes yes no     895  0
IBIMGB+AdvTTda6f6cb8.B               Type 1C           WinAnsi          yes yes no     107  0
IBIMGA+AdvOTf23bb480+fb              Type 1C           Custom           yes yes yes    896  0
IBIMLB+AdvOT1ef757c0                 Type 1C           WinAnsi          yes yes no     101  0
IBIMLC+AdvOT1ef757c0+fb              Type 1C           Custom           yes yes yes    103  0
IBIMNE+AdvOT7d6df7ab.I               Type 1C           WinAnsi          yes yes no     104  0
IBIMKA+AdvOT125c650c                 Type 1C           WinAnsi          yes yes no     105  0
IBIMNF+AdvOT1ef757c0+20              Type 1C           WinAnsi          yes yes no     106  0
IBIMMC+AdvOT1ef757c0+03              Type 1C           Custom           yes yes yes    108  0
IBIMMD+AdvOTb65e897d.B               Type 1C           WinAnsi          yes yes no     109  0
IBIMOG+AdvTTab7e17fd+22              Type 1C           Custom           yes yes no     110  0
IBJBNJ+Helvetica                     Type 1C           WinAnsi          yes yes no     132  0
Helvetica-Oblique                    Type 1C           WinAnsi          yes no  no     133  0
IBJBLJ+Helvetica-Bold                Type 1C           WinAnsi          yes yes no     134  0
IBJCEJ+AdvOT8608a8d1+03              Type 1C           Custom           yes yes yes    232  0
IBJCFJ+AdvOT9bd21c25.I               Type 1C           WinAnsi          yes yes no     233  0
IBJCFK+AdvOT8608a8d1                 Type 1C           WinAnsi          yes yes no     234  0
IBJCGL+AdvOTea1a7398+20              Type 1C           WinAnsi          yes yes no     235  0
Helvetica2                           Type 1C           WinAnsi          yes no  no     265  0
IBJGMC+AdvOTdd3b7348.I+03            Type 1C           Custom           yes yes yes    266  0
IBJJDE+Symbol                        Type 1C           Custom           yes yes yes    291  0
IBLBAD+AdvOT8608a8d1+20              Type 1C           Custom           yes yes yes    613  0
IBLBBE+AdvOTcb88df00+fb              Type 1C           Custom           yes yes yes    614  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-01-17 02:31:43 CET
 RepresentationInformation: 287386.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2024-01-16 13:36:55 CET
  Size: 3554579
  Format: PDF
  Version: 1.4
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ErrorMessage: Invalid indirect destination - referenced object 'bm_MOESM5' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_MOESM6' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_MOESM4' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_MOESM8' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_MOESM1' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_MOESM5' cannot be found
   ID: PDF-HUL-122
   Offset: 3261768
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_MOESM6' cannot be found
   ID: PDF-HUL-122
   Offset: 3261768
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_MOESM8' cannot be found
   ID: PDF-HUL-122
   Offset: 3261768
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_MOESM1' cannot be found
   ID: PDF-HUL-122
   Offset: 3261768
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_MOESM4' cannot be found
   ID: PDF-HUL-122
   Offset: 3261768
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 975
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis
      Destination: title_link
      Children: 
       Item: 
        Title: Results
        Destination: A1
        Children: 
         Item: 
          Title: MT4-MMP-null macrophages accumulate in atherosclerotic plaques
          Destination: B1
         Item: 
          Title: MT4-MMP absence boosts patrolling monocyte crawling
          Destination: B2
         Item: 
          Title: MT4-MMP absence increases Mafb+AIM+ macrophages in early AT
          Destination: B3
         Item: 
          Title: CCR5 inhibition hinders accelerated AT in MT4-MMP absence
          Destination: B4
       Item: 
        Title: Discussion
        Destination: A2
       Item: 
        Title: Methods
        Destination: A3
        Children: 
         Item: 
          Title: Animal procedures
          Destination: B5
         Item: 
          Title: Human artery sampling and preservation
          Destination: B6
         Item: 
          Title: Genotyping of BM-transplanted mice
          Destination: B7
         Item: 
          Title: Biochemical analysis
          Destination: B8
         Item: 
          Title: Atherosclerotic lesion analysis
          Destination: B9
         Item: 
          Title: Histological and immunohistochemical analysis
          Destination: B10
         Item: 
          Title: Real time quantitative PCR
          Destination: B11
         Item: 
          Title: Western blotting
          Destination: B12
         Item: 
          Title: In silico modeling of MT4-MMP dimer/Itgam-Itgb2 integrin heterodimer
          Destination: B13
         Item: 
          Title: Identification of cleavage sites and in’vitro digestion assay
          Destination: B14
         Item: 
          Title: Peritoneal macrophage analysis
          Destination: B15
         Item: 
          Title: In vivo macrophage infection
          Destination: B16
         Item: 
          Title: Flow cytometry
          Destination: B17
         Item: 
          Title: Cell spreading assay
          Destination: B18
         Item: 
          Title: Whole-mount staining of peritoneal membranes
          Destination: B19
         Item: 
          Title: Intravital microscopy in the cremaster muscle
          Destination: B20
         Item: 
          Title: Statistical analysis
          Destination: B21
         Item: 
          Title: Data availability
          Destination: B22
       Item: 
        Title: References
        Destination: A4
       Item: 
        Title: Acknowledgements
        Destination: A5
       Item: 
        Title: Author contributions
        Destination: A6
       Item: 
        Title: ACKNOWLEDGEMENTS
        Destination: M1
       Item: 
        Title: Competing interests
        Destination: A7
       Item: 
        Title: ACKNOWLEDGEMENTS
        Destination: M1
   Info: 
    Title: MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis
    Author: Cristina Clemente
    Subject: Nature Communications, doi:10.1038/s41467-018-03351-4
    Keywords: 
    Creator: Springer
    Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
    CreationDate: Fri Feb 23 12:07:05 CET 2018
    ModDate: Mon Feb 26 13:54:27 CET 2018
   ID: 0x2780de6171b70141776b48134d1e1b76, 0xeb33b1865d8a58872b8094dd5d5d5038
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1516
      ImageHeight: 412
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 274
      ImageHeight: 350
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 493
      ImageHeight: 385
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 692
      ImageHeight: 458
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 766
      ImageHeight: 1198
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 322
      ImageHeight: 642
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 536
      ImageHeight: 353
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 534
      ImageHeight: 307
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 618
      ImageHeight: 304
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 582
      ImageHeight: 316
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 395
      ImageHeight: 251
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 509
      ImageHeight: 336
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 613
      ImageHeight: 463
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 289
      ImageHeight: 252
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 472
      ImageHeight: 325
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 792
      ImageHeight: 695
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 313
      ImageHeight: 438
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1120
      ImageHeight: 321
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 648
      ImageHeight: 219
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 389
      ImageHeight: 467
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 378
      ImageHeight: 304
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1078
      ImageHeight: 312
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1224
      ImageHeight: 694
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 544
      ImageHeight: 373
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 881
      ImageHeight: 352
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 675
      ImageHeight: 461
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 479
      ImageHeight: 357
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 406
      ImageHeight: 354
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1090
      ImageHeight: 369
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 311
      ImageHeight: 289
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1239
      ImageHeight: 494
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1239
      ImageHeight: 495
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 263
      ImageHeight: 299
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1063
      ImageHeight: 527
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1354
      ImageHeight: 559
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 289
      ImageHeight: 286
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 263
      ImageHeight: 314
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 54
      ImageHeight: 87
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1224
      ImageHeight: 325
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 467
      ImageHeight: 317
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 396
      ImageHeight: 263
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 405
      ImageHeight: 437
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1353
      ImageHeight: 273
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 337
      ImageHeight: 360
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 401
      ImageHeight: 365
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 537
      ImageHeight: 257
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1352
      ImageHeight: 343
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 606
      ImageHeight: 383
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
   Fonts: 
    Type1: 
     Font: 
      BaseFont: IBIMGA+AdvOTf23bb480+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: IBIMGA+AdvOTf23bb480+fb
       Flags: Symbolic
       FontBBox: 0, -197, 718, 791
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IBJBNJ+Helvetica
      FontSubset: true
      FirstChar: 32
      LastChar: 215
      FontDescriptor: 
       FontName: IBJBNJ+Helvetica
       Flags: Nonsymbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: Helvetica-Oblique
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: Helvetica-Oblique
       Flags: Nonsymbolic, Italic
       FontBBox: -170, -225, 1116, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IBJBLJ+Helvetica-Bold
      FontSubset: true
      FirstChar: 97
      LastChar: 103
      FontDescriptor: 
       FontName: IBJBLJ+Helvetica-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: Helvetica2
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: Helvetica2
       Flags: Nonsymbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IBJGMC+AdvOTdd3b7348.I+03
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: IBJGMC+AdvOTdd3b7348.I+03
       Flags: Symbolic
       FontBBox: -104, -208, 864, 854
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IBILGA+AdvOTea1a7398
      FontSubset: true
      FirstChar: 35
      LastChar: 250
      FontDescriptor: 
       FontName: IBILGA+AdvOTea1a7398
       Flags: Nonsymbolic
       FontBBox: -31, -197, 979, 906
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IBJJDE+Symbol
      FontSubset: true
      FirstChar: 2
      LastChar: 181
      FontDescriptor: 
       FontName: IBJJDE+Symbol
       Flags: Symbolic
       FontBBox: -180, -293, 1090, 1010
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IBIMAO+AdvTTab7e17fd
      FontSubset: true
      FirstChar: 43
      LastChar: 61
      FontDescriptor: 
       FontName: IBIMAO+AdvTTab7e17fd
       Flags: Nonsymbolic
       FontBBox: -156, -250, 1072, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IBIMLB+AdvOT1ef757c0
      FontSubset: true
      FirstChar: 37
      LastChar: 243
      FontDescriptor: 
       FontName: IBIMLB+AdvOT1ef757c0
       Flags: Serif, Nonsymbolic
       FontBBox: -20, -250, 947, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IBLBAD+AdvOT8608a8d1+20
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: IBLBAD+AdvOT8608a8d1+20
       Flags: Symbolic
       FontBBox: -968, -333, 2000, 1020
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IBIMAP+AdvOTcb88df00
      FontSubset: true
      FirstChar: 45
      LastChar: 121
      FontDescriptor: 
       FontName: IBIMAP+AdvOTcb88df00
       Flags: Nonsymbolic
       FontBBox: -41, -197, 968, 906
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IBLBBE+AdvOTcb88df00+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: IBLBBE+AdvOTcb88df00+fb
       Flags: Symbolic
       FontBBox: 0, -197, 895, 791
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IBILGB+AdvOTea1a7398+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: IBILGB+AdvOTea1a7398+fb
       Flags: Symbolic
       FontBBox: 0, -197, 750, 791
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IBIMLC+AdvOT1ef757c0+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: IBIMLC+AdvOT1ef757c0+fb
       Flags: Symbolic
       FontBBox: 0, -10, 781, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IBIMNE+AdvOT7d6df7ab.I
      FontSubset: true
      FirstChar: 41
      LastChar: 121
      FontDescriptor: 
       FontName: IBIMNE+AdvOT7d6df7ab.I
       Flags: Serif, Nonsymbolic
       FontBBox: -135, -250, 1000, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IBJCEJ+AdvOT8608a8d1+03
      FontSubset: true
      FirstChar: 1
      LastChar: 4
      FontDescriptor: 
       FontName: IBJCEJ+AdvOT8608a8d1+03
       Flags: Symbolic
       FontBBox: -479, -364, 854, 927
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IBIMKA+AdvOT125c650c
      FontSubset: true
      FirstChar: 65
      LastChar: 65
      FontDescriptor: 
       FontName: IBIMKA+AdvOT125c650c
       Flags: Nonsymbolic
       FontBBox: -31, -197, 979, 906
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IBJCFJ+AdvOT9bd21c25.I
      FontSubset: true
      FirstChar: 76
      LastChar: 116
      FontDescriptor: 
       FontName: IBJCFJ+AdvOT9bd21c25.I
       Flags: Nonsymbolic
       FontBBox: -83, -197, 1010, 906
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IBIMNF+AdvOT1ef757c0+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: IBIMNF+AdvOT1ef757c0+20
       Flags: Nonsymbolic
       FontBBox: -135, -187, 1010, 833
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IBJCFK+AdvOT8608a8d1
      FontSubset: true
      FirstChar: 181
      LastChar: 181
      FontDescriptor: 
       FontName: IBJCFK+AdvOT8608a8d1
       Flags: Nonsymbolic
       FontBBox: -62, -208, 927, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IBIMGB+AdvTTda6f6cb8.B
      FontSubset: true
      FirstChar: 48
      LastChar: 57
      FontDescriptor: 
       FontName: IBIMGB+AdvTTda6f6cb8.B
       Flags: Nonsymbolic
       FontBBox: -72, -218, 895, 927
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IBJCGL+AdvOTea1a7398+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: IBJCGL+AdvOTea1a7398+20
       Flags: Nonsymbolic
       FontBBox: -93, -197, 843, 791
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IBIMMC+AdvOT1ef757c0+03
      FontSubset: true
      FirstChar: 1
      LastChar: 4
      FontDescriptor: 
       FontName: IBIMMC+AdvOT1ef757c0+03
       Flags: Symbolic
       FontBBox: -125, -270, 854, 791
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IBIMMD+AdvOTb65e897d.B
      FontSubset: true
      FirstChar: 39
      LastChar: 121
      FontDescriptor: 
       FontName: IBIMMD+AdvOTb65e897d.B
       Flags: Serif, Nonsymbolic
       FontBBox: -20, -250, 968, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IBIMOG+AdvTTab7e17fd+22
      FontSubset: true
      FirstChar: 21
      LastChar: 21
      FontDescriptor: 
       FontName: IBIMOG+AdvTTab7e17fd+22
       Flags: Nonsymbolic
       FontBBox: -156, -218, 937, 947
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: Arial-BoldMT
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: Arial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IBIMEP+AdvOTf23bb480
      FontSubset: true
      FirstChar: 40
      LastChar: 243
      FontDescriptor: 
       FontName: IBIMEP+AdvOTf23bb480
       Flags: Nonsymbolic
       FontBBox: -31, -197, 968, 916
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.2-c001 63.143651, 2012/04/05-09:01:49        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1038/s41467-018-03351-4</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Cristina Clemente</rdf:li>
               <rdf:li>Cristina Rius</rdf:li>
               <rdf:li>Laura Alonso-Herranz</rdf:li>
               <rdf:li>Mara Martín-Alonso</rdf:li>
               <rdf:li>Ángela Pollán</rdf:li>
               <rdf:li>Emilio Camafeita</rdf:li>
               <rdf:li>Fernando Martínez</rdf:li>
               <rdf:li>Rubén A. Mota</rdf:li>
               <rdf:li>Vanessa Núñez</rdf:li>
               <rdf:li>Cristina Rodríguez</rdf:li>
               <rdf:li>Motoharu Seiki</rdf:li>
               <rdf:li>José Martínez-González</rdf:li>
               <rdf:li>Vicente Andrés</rdf:li>
               <rdf:li>Mercedes Ricote</rdf:li>
               <rdf:li>Alicia G. Arroyo</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer US</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:subject>
            <rdf:Bag></rdf:Bag>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Nature Communications, doi:10.1038/s41467-018-03351-4</rdf:li>
            </rdf:Alt>
         </dc:description>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/">
         <prism:doi>10.1038/s41467-018-03351-4</prism:doi>
         <prism:url>http://dx.doi.org/10.1038/s41467-018-03351-4</prism:url>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Nature Communications</prism:publicationName>
         <prism:copyright>© 2018, The Author(s)</prism:copyright>
         <prism:issn>2041-1723</prism:issn>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:doi>10.1038/s41467-018-03351-4</pdfx:doi>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>True</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1038/s41467-018-03351-4</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2018-02-26T13:54:27+01:00</xmp:ModifyDate>
         <xmp:CreateDate>2018-02-23T16:07:05+05:30</xmp:CreateDate>
         <xmp:MetadataDate>2018-02-26T13:54:27+01:00</xmp:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Keywords></pdf:Keywords>
      <pdf:Producer>iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)</pdf:Producer></rdf:Description>
      <rdf:Description rdf:about="" xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:293d4771-d0a4-48b5-8d59-6e8d203862c3</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:4d41153a-8284-4251-90bb-76087fa7a08d</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:cc2b1f91-30d9-4aaf-b0d5-c2032b7ca1be</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2018-02-23T16:07:51+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/">
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:author="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/" xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/">
         <sn:authorInfo>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Emilio Camafeita</author:name>
                  <author:orcid>http://orcid.org/0000-0002-4577-5331</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Fernando Martínez</author:name>
                  <author:orcid>http://orcid.org/0000-0003-1904-5164</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Alicia G. Arroyo</author:name>
                  <author:orcid>http://orcid.org/0000-0002-1536-3846</author:orcid>
               </rdf:li>
            </rdf:Bag>
         </sn:authorInfo>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#">
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>pdfx</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>crossmark</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was published.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. 
Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

</pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright </pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 121, 497, 122, 508
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 121, 497, 122, 508
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 129, 497, 130, 508
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 120, 497, 130, 508
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 130, 497, 133, 508
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 231, 497, 232, 508
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 231, 497, 232, 508
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 239, 497, 241, 508
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 230, 497, 241, 508
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 241, 497, 243, 508
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 511, 481, 512, 492
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 511, 481, 512, 492
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 520, 481, 521, 492
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 510, 481, 521, 492
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 521, 481, 524, 492
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 92, 43, 149, 51
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 342, 23, 457, 30
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 547, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 239, 705, 243, 713
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 146, 642, 149, 650
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 151, 642, 155, 650
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 121, 611, 125, 619
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 107, 580, 111, 587
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 286, 538, 289, 545
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 280, 486, 284, 493
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 286, 486, 289, 493
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 147, 423, 150, 430
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 248, 381, 252, 389
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 254, 381, 261, 389
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 210, 329, 217, 336
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 219, 329, 226, 336
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 71, 308, 78, 315
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 79, 308, 87, 315
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 116, 287, 123, 294
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 71, 245, 78, 253
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 115, 151, 119, 158
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 120, 151, 128, 158
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 284, 46, 291, 54
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 325, 722, 329, 732
       Flags: Print
       AppearanceDictionary: true
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 527, 726, 534, 734
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 521, 701, 526, 711
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 323, 649, 328, 658
       Flags: Print
       AppearanceDictionary: true
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 338, 642, 345, 650
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 436, 639, 441, 648
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 414, 618, 419, 627
       Flags: Print
       AppearanceDictionary: true
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 325, 586, 330, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 325, 576, 330, 585
       Flags: Print
       AppearanceDictionary: true
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 446, 555, 451, 564
       Flags: Print
       AppearanceDictionary: true
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 478, 503, 483, 512
       Flags: Print
       AppearanceDictionary: true
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 384, 408, 388, 418
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 432, 367, 436, 376
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 389, 325, 393, 334
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 427, 283, 432, 292
       Flags: Print
       AppearanceDictionary: true
       Destination: 236
      Annotation: 
       Subtype: Link
       Rect: 408, 252, 412, 261
       Flags: Print
       AppearanceDictionary: true
       Destination: 236
      Annotation: 
       Subtype: Link
       Rect: 429, 231, 433, 240
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 318, 224, 326, 232
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 389, 189, 394, 198
       Flags: Print
       AppearanceDictionary: true
       Destination: 236
      Annotation: 
       Subtype: Link
       Rect: 523, 189, 527, 198
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 414, 157, 419, 167
       Flags: Print
       AppearanceDictionary: true
       Destination: 236
      Annotation: 
       Subtype: Link
       Rect: 387, 105, 391, 114
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 398, 42, 402, 52
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 184, 701, 189, 711
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 474, 705, 482, 713
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 342, 23, 457, 30
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 547, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 101, 628, 106, 638
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 166, 504, 170, 513
       Flags: Print
       AppearanceDictionary: true
       Destination: 275
      Annotation: 
       Subtype: Link
       Rect: 195, 504, 199, 513
       Flags: Print
       AppearanceDictionary: true
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 169, 483, 174, 493
       Flags: Print
       AppearanceDictionary: true
       Destination: 275
      Annotation: 
       Subtype: Link
       Rect: 199, 483, 203, 493
       Flags: Print
       AppearanceDictionary: true
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 159, 431, 164, 440
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 226, 399, 231, 409
       Flags: Print
       AppearanceDictionary: true
       Destination: 275
      Annotation: 
       Subtype: Link
       Rect: 118, 316, 123, 325
       Flags: Print
       AppearanceDictionary: true
       Destination: 275
      Annotation: 
       Subtype: Link
       Rect: 85, 309, 92, 317
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 260, 253, 265, 262
       Flags: Print
       AppearanceDictionary: true
       Destination: 275
      Annotation: 
       Subtype: Link
       Rect: 123, 243, 128, 252
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 63, 201, 67, 210
       Flags: Print
       AppearanceDictionary: true
       Destination: 275
      Annotation: 
       Subtype: Link
       Rect: 542, 680, 546, 690
       Flags: Print
       AppearanceDictionary: true
       Destination: 275
      Annotation: 
       Subtype: Link
       Rect: 457, 653, 464, 661
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 502, 622, 509, 629
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 511, 622, 518, 629
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 388, 590, 395, 598
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 448, 565, 453, 575
       Flags: Print
       AppearanceDictionary: true
       Destination: 306
      Annotation: 
       Subtype: Link
       Rect: 336, 555, 340, 564
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 347, 555, 352, 564
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 537, 544, 542, 554
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 324, 513, 329, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 306
      Annotation: 
       Subtype: Link
       Rect: 540, 482, 545, 491
       Flags: Print
       AppearanceDictionary: true
       Destination: 306
      Annotation: 
       Subtype: Link
       Rect: 424, 471, 428, 481
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 433, 471, 438, 481
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 487, 440, 492, 449
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 500, 444, 507, 451
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 389, 382, 396, 390
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 398, 382, 405, 390
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 538, 337, 542, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 347
      Annotation: 
       Subtype: Link
       Rect: 346, 309, 353, 317
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 379, 267, 386, 275
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 388, 267, 395, 275
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 324, 253, 329, 262
       Flags: Print
       AppearanceDictionary: true
       Destination: 347
      Annotation: 
       Subtype: Link
       Rect: 323, 201, 327, 210
       Flags: Print
       AppearanceDictionary: true
       Destination: 347
      Annotation: 
       Subtype: Link
       Rect: 426, 201, 431, 210
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 282, 110, 289, 118
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 122, 65, 126, 74
       Flags: Print
       AppearanceDictionary: true
       Destination: 407
      Annotation: 
       Subtype: Link
       Rect: 381, 110, 388, 118
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 315, 100, 323, 108
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 324, 100, 332, 108
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 341, 54, 346, 64
       Flags: Print
       AppearanceDictionary: true
       Destination: 407
      Annotation: 
       Subtype: Link
       Rect: 342, 23, 457, 30
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 547, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 161, 66, 165, 75
       Flags: Print
       AppearanceDictionary: true
       Destination: 407
      Annotation: 
       Subtype: Link
       Rect: 144, 59, 151, 67
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 266, 194, 271, 203
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 194, 187, 201, 195
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 165, 141, 170, 151
       Flags: Print
       AppearanceDictionary: true
       Destination: 407
      Annotation: 
       Subtype: Link
       Rect: 222, 114, 229, 122
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 66, 47, 70, 57
       Flags: Print
       AppearanceDictionary: true
       Destination: 435
      Annotation: 
       Subtype: Link
       Rect: 428, 215, 437, 224
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 326, 183, 330, 193
       Flags: Print
       AppearanceDictionary: true
       Destination: 435
      Annotation: 
       Subtype: Link
       Rect: 402, 177, 409, 184
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 511, 141, 516, 151
       Flags: Print
       AppearanceDictionary: true
       Destination: 435
      Annotation: 
       Subtype: Link
       Rect: 321, 121, 330, 130
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 532, 89, 541, 99
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 342, 23, 457, 30
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 547, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 63, 316, 67, 326
       Flags: Print
       AppearanceDictionary: true
       Destination: 347
      Annotation: 
       Subtype: Link
       Rect: 201, 306, 206, 315
       Flags: Print
       AppearanceDictionary: true
       Destination: 407
      Annotation: 
       Subtype: Link
       Rect: 240, 306, 244, 315
       Flags: Print
       AppearanceDictionary: true
       Destination: 236
      Annotation: 
       Subtype: Link
       Rect: 272, 289, 279, 296
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 132, 268, 139, 275
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 242, 257, 249, 265
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 277, 222, 282, 232
       Flags: Print
       AppearanceDictionary: true
       Destination: 507
      Annotation: 
       Subtype: Link
       Rect: 98, 153, 105, 160
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 128, 149, 133, 158
       Flags: Print
       AppearanceDictionary: true
       Destination: 507
      Annotation: 
       Subtype: Link
       Rect: 243, 149, 252, 158
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 91, 57, 98, 64
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 345, 299, 349, 307
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 350, 299, 354, 307
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 356, 299, 363, 307
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 458, 278, 465, 286
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 433, 257, 440, 265
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 355, 163, 362, 171
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 370, 132, 374, 139
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 375, 132, 382, 139
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 490, 90, 497, 98
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 436, 69, 440, 77
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 80, 68, 84, 75
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 126, 57, 133, 65
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 417, 109, 424, 117
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 425, 109, 433, 117
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 342, 23, 457, 30
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 547, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 144, 695, 152, 702
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 64, 663, 71, 671
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 204, 642, 211, 650
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 215, 642, 223, 650
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 446, 716, 453, 723
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 463, 622, 470, 629
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 349, 611, 356, 619
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 542, 601, 549, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 342, 23, 457, 30
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 543, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 239, 674, 246, 681
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 222, 653, 230, 661
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 220, 611, 227, 619
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 225, 580, 233, 587
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 142, 507, 145, 514
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 125, 412, 133, 420
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 134, 412, 142, 420
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 143, 412, 151, 420
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 125, 391, 132, 399
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 133, 391, 141, 399
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 142, 391, 150, 399
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 197, 360, 204, 368
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 206, 360, 213, 368
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 59, 339, 66, 347
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 68, 339, 75, 347
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 239, 287, 246, 294
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 248, 287, 255, 294
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 257, 287, 264, 294
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 143, 266, 150, 273
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 474, 726, 481, 734
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 485, 726, 493, 734
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 424, 705, 431, 713
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 435, 705, 442, 713
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 371, 695, 378, 702
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 430, 684, 438, 692
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 437, 580, 441, 587
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 443, 580, 450, 587
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 452, 580, 459, 587
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 331, 513, 337, 519
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 451, 513, 457, 519
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 121, 438, 195, 445
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 118, 221, 192, 229
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 199, 141, 203, 148
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 100, 46, 105, 52
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 439, 562, 446, 569
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 313, 516, 318, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 306, 471, 384, 478
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 386, 474, 392, 480
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 387, 454, 435, 461
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 385, 423, 391, 429
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 485, 383, 491, 389
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 495, 380, 551, 387
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 303, 371, 367, 378
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 508, 363, 551, 370
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 303, 354, 342, 362
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 428, 346, 518, 353
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 342, 23, 457, 30
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 543, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 118, 680, 192, 688
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 189, 633, 195, 639
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 126, 544, 132, 550
       Flags: Print
       AppearanceDictionary: true
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 164, 288, 238, 295
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 122, 174, 196, 181
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 182, 148, 188, 153
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 283, 97, 289, 103
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 495, 692, 501, 698
       Flags: Print
       AppearanceDictionary: true
       Destination: 648
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 15
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 342, 23, 457, 30
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 543, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 16
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 203, 685, 291, 692
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 43, 676, 78, 683
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 215, 641, 278, 648
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 43, 632, 111, 639
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 472, 642, 551, 649
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 303, 633, 346, 640
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: 83428870
   Type: CRC32
  Checksum: 2f275c5ddc393db5fec1ad90f8f3dd93
   Type: MD5
  Checksum: e5b14414fae46c0af510c000a5d213841afc88f2
   Type: SHA-1
  Checksum: abe39fa47da915510527be7df003fdca82fa3c1f57c2f7f45a74cb379ba429af
   Type: SHA-256