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Introduction Destination: flink1 Item: Title: 2. Materials and methods Destination: flink2 Children: Item: Title: 2.1. Study population Destination: slink1 Item: Title: 2.2. Standard protocol approvals, registrations, and patient consents Destination: slink2 Item: Title: 2.3. Genotyping Destination: slink3 Item: Title: 2.4. RNA sequencing Destination: slink4 Item: Title: 2.5. Statistical analysis Destination: slink5 Item: Title: 2.6. In vitro NFκB activity Destination: slink6 Item: Title: 3. Results Destination: flink3 Children: Item: Title: 3.1. TBK1 mutation screening Destination: slink7 Item: Title: 3.2. Clinical characteristics of LoF mutation (TBK1 p.Thr79del) carrier Destination: slink8 Item: Title: 3.3. Effect of rare TBK1 variants on NFκB activation Destination: slink9 Item: Title: 3.4. Rare variant association analysis Destination: slink10 Item: Title: 3.5. Single-variant association analysis of low-frequency and common variants Destination: slink11 Item: Title: 4. Discussion Destination: flink4 Item: Title: Disclosure statement Destination: flink5 Item: Title: Acknowledgements Destination: aclink3 Item: Title: Appendix A. Supplementary data Destination: flink6 Item: Title: References Destination: blink1 Info: Title: Common and rare TBK1 variants in early-onset Alzheimer disease in a European cohort Author: Jan Verheijen Subject: Neurobiology of Aging, 62 (2017) 245.e1-245.e7. doi:10.1016/j.neurobiolaging.2017.10.012 Creator: Elsevier CreationDate: Fri Dec 22 20:11:41 CET 2017 ModDate: Fri Dec 22 20:16:38 CET 2017 ID: 0x4baecc6feaa80ae64ec01254532216fa, 0xf971040c4b3c21419c9d17ab9b501597 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 116 ImageHeight: 116 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 237 ImageHeight: 296 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 254 ImageHeight: 278 ColorSpace: RGB 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FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IJLAPH+AdvOTb83ee1dd.B FontSubset: true FirstChar: 46 LastChar: 121 FontDescriptor: FontName: IJLAPH+AdvOTb83ee1dd.B Flags: Serif, Nonsymbolic FontBBox: -93, -250, 1041, 989 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IJLAGP+AdvOTb92eb7df.I FontSubset: true FirstChar: 40 LastChar: 252 FontDescriptor: FontName: IJLAGP+AdvOTb92eb7df.I Flags: Serif, Nonsymbolic FontBBox: -135, -229, 1052, 968 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.neurobiolaging.2017.10.012 Common and rare TBK1 variants in early-onset Alzheimer disease in a European cohort Jan Verheijen Julie van der Zee Ilse Gijselinck Tobi Van den Bossche Lubina Dillen Bavo Heeman Estrella Gómez-Tortosa Albert Lladó Raquel Sanchez-Valle Caroline Graff Pau Pastor Maria A. Pastor Luisa Benussi Roberta Ghidoni Giuliano Binetti Jordi Clarimon Alexandre de Mendonça Ellen Gelpi Magda Tsolaki Janine Diehl-Schmid Benedetta Nacmias Maria Rosário Almeida Barbara Borroni Radoslav Matej Agustín Ruiz Sebastiaan Engelborghs Rik Vandenberghe Peter P. De Deyn Marc Cruts Christine Van Broeckhoven Kristel Sleegers the BELNEU Consortium Johan Goeman Dirk Nuytten Mathieu Vandenbulcke Patrick Santens Jan De Bleecker Anne Sieben Bart Dermaut Jan Versijpt Alex Michotte Olivier Deryck Bruno Bergmans Christiana Willems Adrian Ivanoiu Eric Salmon the EU EOD Consortium Panagiotis Alexopoulos Sandro Sorbi Valentina Bessi Silvia Bagnoli Isabel Santana Frederico Simões do Couto Madalena Martins Håkan Thonberg Laura Fratiglioni Alessandro Padovani Zdenek Rohan Cristina Razquin Elena Lorenzo Elena Iglesias Manuel Seijo-Martínez Ramon Rene Jordi Gascon Jaume Campdelacreu Maria Koutroumani Alberto Lleó Juan Fortea Rafael Blesa Early onset Alzheimer's disease TBK1 Loss-of-function Frontotemporal dementia RNA sequencing Neurobiology of Aging, 62 (2017) 245.e1-245.e7. doi:10.1016/j.neurobiolaging.2017.10.012 Elsevier journal Neurobiology of Aging © 2017 The Author(s). Published by Elsevier. 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