faf6691bef451e8c53b14e32197f5115 287901.pdf 2fcccae2c3978b6b0bb89803b8d4b5fe1867e641 287901.pdf 3f6a2bda1cc3dc5c7a37a073cecd854a020ef4e0fe3feaaf08e78ffc4ee63f90 287901.pdf Title: HDDMA_6243529 1..7 Creator: Aspose Ltd. Producer: Aspose.Pdf for .NET 10.1.0; modified using iTextSharp™ 5.4.0 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Tue Aug 28 22:50:45 2018 CEST ModDate: Thu Sep 13 14:06:05 2018 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 7 Encrypted: no Page size: 599.981 x 799.994 pts Page rot: 0 File size: 861250 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MinionPro-Regular2 CID Type 0C Identity-H yes no yes 277 0 MinionPro-Regular CID Type 0C Identity-H yes no yes 278 0 IEONFD+MinionProIt Type 1C WinAnsi yes yes no 29 0 IEONFE+Minion-Black Type 1C WinAnsi yes yes no 28 0 IEONIE+MinionProBold Type 1C WinAnsi yes yes no 279 0 IEONKE+MinionProRegular Type 1C WinAnsi yes yes no 24 0 IEONLF+MinionMath-Regular Type 1C WinAnsi yes yes no 27 0 IEONLG+MinionMathItalic Type 1C WinAnsi yes yes no 58 0 IEONLI+MinionProRegular+fb Type 1C Custom yes yes yes 26 0 IEONLJ+MinionProRegular+20 Type 1C WinAnsi yes yes no 25 0 BIFTLJ+MinionPro-Regular CID TrueType Identity-H yes yes yes 1 0 IEONMJ+MinionMath-Regular+22 Type 1C Custom yes yes yes 30 0 MinionPro-Regular2 Type 1C Custom yes no yes 31 0 IEOONF+MinionMath-Regular-Graphic Type 1C WinAnsi yes yes no 32 0 IEOOOG+MinionScUnic Type 1C WinAnsi yes yes no 33 0 IEOOPG+MinionMathItalic+03 Type 1C Custom yes yes yes 57 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-01-31 02:39:38 CET RepresentationInformation: 287901.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-01-30 13:45:56 CET Size: 861250 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 329 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: High-Sensitivity Troponin T and Soluble Form of AXL as Long-Term Prognostic Biomarkers after Heart Transplantation Destination: maintitle Item: Title: 1. Introduction Destination: section1 Item: Title: 2. Material and Methods Destination: section2 Children: Item: Title: 2.1. Study Design Destination: section3 Item: Title: 2.2. Clinical Variables Destination: section4 Item: Title: 2.3. Biomarkers Destination: section5 Item: Title: 2.4. Statistical Analysis Destination: section6 Item: Title: 3. Results Destination: section7 Item: Title: 4. Discussion Destination: section8 Children: Item: Title: 4.1. Study Limitations Destination: section9 Item: Title: Data Availability Destination: section10 Item: Title: Conflicts of Interest Destination: section11 Item: Title: Acknowledgments Destination: section12 Info: Title: HDDMA_6243529 1..7 Creator: Aspose Ltd. 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Cardiac allograft vasculopathy (CAV) is a frequent complication limiting the long-term (>1 year) survival after heart transplantation (HTx). CAV is initiated by endothelial dysfunction and can lead to severe cardiovascular (CV) complications. Since CAV is often clinically silent, biomarkers could help identifying HTx patients at risk of CAV and their severe complications. Aim. Evaluate the clinical yield of high-sensitivity cardiac troponin T (hs-cTnT), marker of cardiomyocyte damage, and the soluble form of AXL (sAXL), biomarker of endothelial dysfunction, to assess the prognosis of long-term cardiovascular (CV) events occurring after HTx. Methods. 96 patients were evaluated at least > 1 year after HTx. CAV was evaluated by coronary angiography or multisliced tomography, and hs-cTnT and sAXL measured 6 months before or after CAV evaluation. Patients were followed during 42 ± 15 months for a combined end point including cardiac death, angina or acute myocardial infarction, left ventricular ejection fraction < 50%, or heart failure not due to an acute rejection. Results. 51 patients (53%) presented CAV at evaluation; 21 of them had CV events. Hs-cTnT (56 ± 45 versus 20 ± 18 ng/L; p=0.04) and sAXL concentrations (98 ± 51 versus 26 ± 26 ng/L; p=0.01) were significantly higher in patients with CV events. Hs-cTnT (HR 1.03; 95% CI 1.015–1.042, p=0.0001) and sAXL (HR 1.01; 95% CI 1.001–1.019, p=0.02) were independent predictors of CV events. A hs-cTnT concentration < 21 ng/L, detected by AUC ROC, predicted the absence of CV events with a predictive value of 91%; sAXL did not add more predictive value to hs-cTnT. Survival free of CV events was 92% in patients with hs-cTnT < 21 ng/L and 57% in those with hs-cTnT > 21 ng/L (p<0.001). Conclusion. Hs-cTnT, but not sAXL, measured during the long-term follow-up of HTx patients appears as a helpful biomarker to identify patients at low risk of adverse CV outcomes.Disease MarkersHindawi2018/08/29Research articledoi:10.1155/2018/6243529en Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 159, 557, 169, 567 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 422, 557, 433, 567 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 164, 89, 168, 99 Flags: Print AppearanceDictionary: true Destination: 96 Annotation: Subtype: Link Rect: 172, 89, 177, 99 Flags: Print AppearanceDictionary: true Destination: 96 Annotation: Subtype: Link Rect: 424, 133, 429, 143 Flags: Print AppearanceDictionary: true Destination: 96 Annotation: Subtype: Link Rect: 369, 55, 374, 65 Flags: Print AppearanceDictionary: true Destination: 96 Annotation: Subtype: Link Rect: 50, 705, 168, 713 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 89, 317, 94, 327 Flags: Print AppearanceDictionary: true Destination: 96 Annotation: Subtype: Link Rect: 99, 317, 108, 327 Flags: Print AppearanceDictionary: true Destination: 96 Annotation: Subtype: Link Rect: 275, 237, 285, 247 Flags: Print AppearanceDictionary: true Destination: 96 Annotation: Subtype: Link Rect: 119, 203, 128, 213 Flags: Print AppearanceDictionary: true Destination: 110 Annotation: Subtype: Link Rect: 156, 192, 166, 202 Flags: Print AppearanceDictionary: true Destination: 110 Annotation: Subtype: Link Rect: 490, 283, 495, 293 Flags: Print AppearanceDictionary: true Destination: 11 Annotation: Subtype: Link Rect: 418, 112, 428, 122 Flags: Print AppearanceDictionary: true Destination: 110 Annotation: Subtype: Link Rect: 490, 89, 500, 99 Flags: Print AppearanceDictionary: true Destination: 110 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 106, 357, 116, 367 Flags: Print AppearanceDictionary: true Destination: 110 Annotation: Subtype: Link Rect: 121, 357, 131, 367 Flags: Print AppearanceDictionary: true Destination: 110 Annotation: Subtype: Link Rect: 68, 334, 78, 344 Flags: Print AppearanceDictionary: true Destination: 110 Annotation: Subtype: Link Rect: 194, 177, 204, 187 Flags: Print AppearanceDictionary: true Destination: 110 Annotation: Subtype: Link Rect: 312, 140, 322, 150 Flags: Print AppearanceDictionary: true Destination: 110 Annotation: Subtype: Link Rect: 326, 140, 335, 150 Flags: Print AppearanceDictionary: true Destination: 110 Annotation: Subtype: Link Rect: 333, 66, 338, 76 Flags: Print AppearanceDictionary: true Destination: 47 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 150, 180, 155, 190 Flags: Print AppearanceDictionary: true Destination: 47 Annotation: Subtype: Link Rect: 80, 146, 85, 156 Flags: Print AppearanceDictionary: true Destination: 70 Annotation: Subtype: Link Rect: 237, 55, 242, 65 Flags: Print AppearanceDictionary: true Destination: 88 Annotation: Subtype: Link Rect: 386, 534, 391, 544 Flags: Print AppearanceDictionary: true Destination: 88 Annotation: Subtype: Link Rect: 499, 260, 508, 270 Flags: Print AppearanceDictionary: true Destination: 110 Annotation: Subtype: Link Rect: 515, 260, 524, 270 Flags: Print AppearanceDictionary: true Destination: 110 Annotation: Subtype: Link Rect: 410, 157, 420, 167 Flags: Print AppearanceDictionary: true Destination: 110 Annotation: Subtype: Link Rect: 465, 66, 475, 76 Flags: Print AppearanceDictionary: true Destination: 110 Page: Label: 5 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 250, 648, 260, 658 Flags: Print AppearanceDictionary: true Destination: 110 Annotation: Subtype: Link Rect: 260, 568, 269, 578 Flags: Print AppearanceDictionary: true Destination: 110 Annotation: Subtype: Link Rect: 275, 568, 285, 578 Flags: Print AppearanceDictionary: true Destination: 110 Annotation: Subtype: Link Rect: 119, 465, 129, 475 Flags: Print AppearanceDictionary: true Destination: 110 Annotation: Subtype: Link Rect: 197, 159, 207, 169 Flags: Print AppearanceDictionary: true Destination: 110 Annotation: Subtype: Link Rect: 211, 159, 221, 169 Flags: Print AppearanceDictionary: true Destination: 110 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 69, 163, 287, 172 Flags: Print AppearanceDictionary: true Checksum: ad056f5e Type: CRC32 Checksum: faf6691bef451e8c53b14e32197f5115 Type: MD5 Checksum: 2fcccae2c3978b6b0bb89803b8d4b5fe1867e641 Type: SHA-1 Checksum: 3f6a2bda1cc3dc5c7a37a073cecd854a020ef4e0fe3feaaf08e78ffc4ee63f90 Type: SHA-256